Gene DDB_G0292920
DDB_G0292920
Species: D.discoideum
Alias: DDB_G0292920
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DDB_G0292920.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DDB_G0292920.AA | Subfamily.PTPDC1.PD | 23-149 | 29 | 2.7e-14 | 44.6 | In-house | 62-193 (229) | Show / Hide |
Range on Protein: 23-149 Range on HMM: 62-193/229 Sequence Identity: 29% (39 aa) QDGfnLDLSYITERILAMGYPADS------IHKAF-RNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNV---IVMGFEDHTPPPFLLLLDIIET || | ...|| |||. | . . | . |. | | |. || . ||. .. . .|..|. ...|||. .. adg--lystwvtenilalarpsselldqykllekfkesGikavinLqeagehahCGagleesGfsYdpeelmrqgiyfynfglkDygvasleriLdivkv MNKWLdsdEQNVIAVHCKAGKGRTGTVISSYLINQMK | |. ||||| ||.|||| .|..||. . . vdfal---eegkiavHCHAGlGRtGvliacylvyakr |
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| Phosphatase | DDB_G0292920.AA | Subfamily.PTEN.PD | 29-204 | 30 | 1.9e-56 | 183.1 | In-house | 1-166 (305) | Show / Hide |
Range on Protein: 29-204 Range on HMM: 1-166/305 Sequence Identity: 30% (53 aa) DLSYITERILAMGYPADSIHKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVH |.||| .....||.....| ........ ... . .. |. ..... .. .... |.|.|..|.||.||.. || .|.|...|||..|..||.||| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKAGKGRTGTVISSYLINQMKRTTPDlfyssdtilyNTISFFNQMRANNSECVTVPSQKRYVGYYIQYLRDQVTHA |||||||||..|..||.........| .........|......||.|||.||| |. .... | .. CkaGkGRtGvmicayLlksgikksad----------ealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpys |
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| Phosphatase | DDB_G0292920.AA | Family.DSP.PD | 60-206 | 24 | 6.9e-25 | 79.5 | In-house | 124-253 (387) | Show / Hide |
Range on Protein: 60-206 Range on HMM: 124-253/387 Sequence Identity: 24% (33 aa) NFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLldIIETMNkWLDS--DEQNVIAVHCKAGKGRTGTVISSYLINQmkrttpdlfy |. . . . ||.|.. . . | . | ... ....||..||. .| ... .. .... |...|..|||||||||.||.|. ||. .. | .. . nlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmks---------- sSDTILYNTISFFNQMRannsECVTVPSQKrYVGYYIQYLRDQVTHASL ... | .|. |.|. .. .. ... ... | -egltleealdwvrskR----pgvitpnqg-flkqlkdlekeklkvsse |
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| Phosphatase | DDB_G0292920.AA | PTEN_C2 | 210-348 | 18 | 3.6e-23 | 85.08 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 210-348 Range on HMM: 1-141/141 Sequence Identity: 18% (28 aa) AQFKILNIDVIGL-YTSTQTPHFNIEIHLNY-NPKIR---NLPII--IRGSNTGIVFY-QDFYSYILREKGIIAKGDTLIKF-----NS--LDSPQCVFR ..|.|... | . .. |.|... . .|.|. | ... ....... | |. ... ..... .|| .|.. . . . .|.|| PPPKPLFLHCIIMDHGI---PNFKQGG--GCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFR FLFHTSFLLTPTTQDSQSIITLYFQKDNLDGGSGGAFLDSKYKTDFAIRVLLEP | |.|.|. . . .|.|.|..||. . . . ... ||...|.... FWFNTCFIEH-------NNNRLTFPKNELDK-AWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | DDB_G0292920.AA | Subfamily.Tensin.PD | 90-325 | 27 | 1.1e-22 | 72.0 | In-house | 5-218 (237) | Show / Hide |
Range on Protein: 90-325 Range on HMM: 5-218/237 Sequence Identity: 27% (65 aa) VIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTtpdlfySSDTILyNTISfFNQMRANNSECVTVPSQKRY | .|. |. ||. | |..... ||..| |||...||| ||||.| |||.|. . . |.|. | .... .... . .|| |||.||| vldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisa------sadaal-drfa-lkrfyddkvsgvtqPsqrry VGYYIQYLRDQVTHASllSPAQFKILNIDVIGLYTSTQTPHFNIEIHLNYNPKIRNLPIIIRGSNTGIVfyqdfysYILREKGIIAKGDTLIKFNSLDS- |. ..| ... .| || .. .. | . | . . . |. .. . |..| . || ... ||| |.| . veyfsgllsgsiklns--splflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterl-------citiepalllkgdvlvkcyhkklr ---PQCVFRFLFHTSflltpTTQDSQsiitLYFQKDNLDG . ||| |||. . .| . | |.|..|| sttrdvvfrvqfhtg-----aikdlk----lvfekedlde |
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| Phosphatase | DDB_G0292920.AA | Subfamily.TPIP.PD | 93-196 | 33 | 5.7e-22 | 69.9 | In-house | 8-106 (245) | Show / Hide |
Range on Protein: 93-196 Range on HMM: 8-106/245 Sequence Identity: 33% (35 aa) MGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTpdlfySSDTILYNTISFFNQMRANNSECVTVPSQKRYVGY . .|| | . |. . . ...||. |..||.|.||| |||||||.. ..||. .| . ... | . .. ..|. | |||.||||| imiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseiflt-----aeesldyfgerrtdkthsnkfqGvetPsqnryvgy YIQY . | laqv |
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| Phosphatase | DDB_G0292920.AA | Subfamily.CDC14.PD | 54-154 | 31 | 9.8e-12 | 36.4 | In-house | 135-230 (258) | Show / Hide |
Range on Protein: 54-154 Range on HMM: 135-230/258 Sequence Identity: 31% (31 aa) DINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWldsdeQNVIAVHCKAGKGRTGTVISSYLINQMKRTTP ......| | . || . . |. | . . |.| | |. .| .| ..| . |||||||| |||||.|..|||.. . | .. aPeklleyfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyrftaa D e |
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| Phosphatase | DDB_G0292920.AA | Subfamily.PTPMT1.PD | 83-151 | 27 | 4.1e-10 | 31.1 | In-house | 48-115 (146) | Show / Hide |
Range on Protein: 83-151 Range on HMM: 48-115/146 Sequence Identity: 27% (19 aa) TTKVGGNVIVMGFEDHTP-PPFLLLLDIIETMNKWLDsdEQNVIAVHCKAGKGRTGTVISSYLINQMKRT .| | . . . |.| | . | . .| ..| . ... . ||||||..| .|....||... | . wkklGveqlqlatvDfteapslekleegvefiekvas--kgssvYvHCkAGrtRsatlvacylmkkkkls |
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| Phosphatase | DDB_G0292920.AA | Subfamily.PRL.PD | 57-147 | 26 | 5e-10 | 30.7 | In-house | 13-106 (140) | Show / Hide |
Range on Protein: 57-147 Range on HMM: 13-106/140 Sequence Identity: 26% (25 aa) EVYNFFEKYHSAHWKILNVAMEISYSTTKV---GGNVIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQ .| .| |. . . | . . |.||...|. | .|. . |.| ..|| .. . .| ... ......|||| || ||. ... ||.. tvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea |
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| Phosphatase | DDB_G0292920.AA | Subfamily.DSP23.PD | 90-152 | 22 | 9.7e-10 | 30.0 | In-house | 36-96 (128) | Show / Hide |
Range on Protein: 90-152 Range on HMM: 36-96/128 Sequence Identity: 22% (14 aa) VIVMGFEDHTPPPFLLLLDIIETMNKWLDSdeQNVIAVHCKAGKGRTGTVISSYLINQMKRTT . .. .|..|| . ... ... .. .. ..||| | |||||... ||... . .. lrridipdfcPPaleqvarlvriveeaekk--eeavgvhcalGlGrtGtllacylvkeeglaa |
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| Phosphatase | DDB_G0292920.AA | Subfamily.N12.PD | 97-152 | 36 | 3.8e-09 | 27.4 | In-house | 174-230 (270) | Show / Hide |
Range on Protein: 97-152 Range on HMM: 174-230/270 Sequence Identity: 36% (21 aa) DHT-PPPFLLLLDIIETMNKWLDsDEQNVIAVHCKAGKGRTGTVISS-YLINQMKRTT || | ||..||.... . .|.. ..||| || |||||.|. | ...|. . DhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtGtiiaidyvrellkaek |
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| Phosphatase | DDB_G0292920.AA | Subfamily.RB.PD | 65-150 | 28 | 2.3e-08 | 25.2 | In-house | 135-222 (261) | Show / Hide |
Range on Protein: 65-150 Range on HMM: 135-222/261 Sequence Identity: 28% (25 aa) YHSAHWKILNVAMEISYSTTKVGgNVIVMGFEDHT-PPPFLLLLDIIETMNKWLDSD-EQNVIAVHCKAGKGRTGTVIS-SYLINQMKR . .| | ....| ...|| .. . . || | |||...|........ ... | ||| || ||||| |. |...... keldewvirefkiekgkekrkvr-qyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqaiee |
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| Phosphatase | DDB_G0292920.AA | Subfamily.R_Anemone_2.PD | 104-150 | 37 | 2.4e-08 | 25.3 | In-house | 176-223 (262) | Show / Hide |
Range on Protein: 104-150 Range on HMM: 176-223/262 Sequence Identity: 37% (17 aa) LLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVIS-SYLINQMKR |||.. ...|. . ....|.||| || ||||. | . |....| aslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiavdillerika |
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| Phosphatase | DDB_G0292920.AA | Subfamily.RNGTT.PD | 110-149 | 35 | 4.2e-08 | 24.4 | In-house | 67-106 (140) | Show / Hide |
Range on Protein: 110-149 Range on HMM: 67-106/140 Sequence Identity: 35% (14 aa) IETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMK |. ....|. ..||.||| | ||| .| .||..... iklvkeflkkkPdevigvhCthGfnrtGflivayLveked |
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| Phosphatase | DDB_G0292920.AA | Subfamily.RK.PD | 94-151 | 31 | 4.7e-08 | 23.9 | In-house | 169-228 (267) | Show / Hide |
Range on Protein: 94-151 Range on HMM: 169-228/267 Sequence Identity: 31% (19 aa) GFEDH--TPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRT |. .. .| ||..| ..|. . .|. | ||| || ||.|| | . .| .. gWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivlemier |
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| Phosphatase | DDB_G0292920.AA | Subfamily.DSP19.PD | 108-152 | 19 | 1.2e-07 | 23.1 | In-house | 63-109 (139) | Show / Hide |
Range on Protein: 108-152 Range on HMM: 63-109/139 Sequence Identity: 19% (9 aa) DIIETMNKWLDSD--EQNVIAVHCKAGKGRTGTVISSYLINQMKRTT ...... ..... ..... |||.|| |. .|. .||... . .. sylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelsl |
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| Phosphatase | DDB_G0292920.AA | Subfamily.DSP11.PD | 110-152 | 33 | 2.4e-07 | 22.1 | In-house | 67-111 (141) | Show / Hide |
Range on Protein: 110-152 Range on HMM: 67-111/141 Sequence Identity: 33% (15 aa) IETMNKWLD--SDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTT .|.....|. |....|.||| | ||| .| |||... . keavkefleknkdndkligvhCthGvnrtGyliCrylidvegysp |
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| Phosphatase | DDB_G0292920.AA | Subfamily.N_Nematode_1.PD | 110-149 | 32 | 6.1e-07 | 20.4 | In-house | 186-224 (265) | Show / Hide |
Range on Protein: 110-149 Range on HMM: 186-224/265 Sequence Identity: 32% (13 aa) IETMNKWldSDEQNVIAVHCKAGKGRTGTVIS-SYLINQMK .| ... ... |.||| || |||||... .|..... lelleav--rgskgPivvhCsaGiGrtGtivaieyildkll |
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| Phosphatase | DDB_G0292920.AA | Subfamily.N_Fungi_PTP1.PD | 109-141 | 40 | 7.5e-07 | 19.8 | In-house | 245-279 (343) | Show / Hide |
Range on Protein: 109-141 Range on HMM: 245-279/343 Sequence Identity: 40% (14 aa) IIETM--NKWLDSDEQNVIAVHCKAGKGRTGTVIS .|... ...||..... | ||| || |||||... liddlfaeshldnarsspilvhCsaGvGrtGtlvt |
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| Phosphatase | DDB_G0292920.AA | PTPc_motif | 86-196 | 19 | 8.2e-07 | 26.75 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 86-196
Range on HMM: 1-92/92
Sequence Identity: 19% (23 aa)
VGGNVIVMGFEDH-----TPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFYSSDTILYNTISFFNQMRANNSEC
. ... || | .|..|. ..| | ||| || |||||... ... |. . . .||
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQ---------------VDIFQTVKEMRKQRPGM
VTVPSQKRYVGYYIQY
|. | ... . |..
VQTEEQYIFCYRCILE
|
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| Phosphatase | DDB_G0292920.AA | Subfamily.N6.PD | 105-193 | 25 | 9e-07 | 19.8 | In-house | 209-289 (295) | Show / Hide |
Range on Protein: 105-193 Range on HMM: 209-289/295 Sequence Identity: 25% (22 aa) LLLDIIETMNKWLdsDEQNVIAVHCKAGKGRTGTVIS-SYLINQMKRTTPDLfyssDTILYNTIsffNQMRANNSECVTVPSQKRYVGYY .|. ... .. | .. | ||| || |||||.| ........ |. | ....| ...|.. |. | | ..| . nfledvnkkqeel--ekagpivvhcsaGiGrtGtfividivlkiieqsgldv----didisksi---kdvrsqrsglvqteaqykfvyka |
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| Phosphatase | DDB_G0292920.AA | Subfamily.N13.PD | 96-146 | 28 | 9.9e-07 | 19.9 | In-house | 166-215 (259) | Show / Hide |
Range on Protein: 96-146 Range on HMM: 166-215/259 Sequence Identity: 28% (14 aa) EDHT-PPPFLLLLDIIETMNKWLDsdEQNVIAVHCKAGKGRTGTVISSYLIN || | |. .. ... . .. |.||| || ||.|..|. . . PdhgvPssaaelvqfvaevrllqt--dagPivvhcsaGiGrsGvlitidvvl |
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| Phosphatase | DDB_G0292920.AA | Subfamily.R_Sponge_2.PD | 96-150 | 30 | 1.1e-06 | 19.8 | In-house | 168-220 (262) | Show / Hide |
Range on Protein: 96-150 Range on HMM: 168-220/262 Sequence Identity: 30% (17 aa) EDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISsyLINQMKR |. .| ||..|..... .....| |.|..| ||||| | | ...| ehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfia--ldsvler |
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| Phosphatase | DDB_G0292920.AA | Subfamily.RA.PD | 106-149 | 33 | 1.2e-06 | 19.5 | In-house | 182-226 (266) | Show / Hide |
Range on Protein: 106-149 Range on HMM: 182-226/266 Sequence Identity: 33% (15 aa) LLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVIS-SYLINQMK .|.... ..| . .. |.||| || ||||| | . .....| mlkllkkvkklqqqsanhpivvhcsaGvGrtGtfivldavlervk |
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| Phosphatase | DDB_G0292920.AA | Subfamily.N_Nematode_4.PD | 95-155 | 24 | 1.3e-06 | 19.3 | In-house | 171-229 (264) | Show / Hide |
Range on Protein: 95-155 Range on HMM: 171-229/264 Sequence Identity: 24% (15 aa) FEDHTPPpfLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDL ..|.. | | .|. . . .... | ||| || ||| |.. .. ... | .... wrdqvaP--ldaapviklykavkkkkkekPivvhcsaGvGrtatlvGidyatirirensei |
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| Phosphatase | DDB_G0292920.AA | Subfamily.N_Choan_2.PD | 106-190 | 24 | 5.2e-06 | 17.2 | In-house | 181-257 (266) | Show / Hide |
Range on Protein: 106-190 Range on HMM: 181-257/266 Sequence Identity: 24% (21 aa) LLDIIETMNKWLDSDEQ-NVIAVHCKAGKGRTGTVISsylINQMKRTtpdLfysSDTILYNTISFFNQMRANNSECVTVPSQKRYV ||......... . .. . . ||| || |||||.| |... |. | . | .... ...| . ..| | | ... llkmlravrrvrkeldkaePllvHcsaGvgRtGtlia---iDiavrl---L---eetkkvdvlaiieelRkdRmalvqhpeqyell |
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| Phosphatase | DDB_G0292920.AA | Subfamily.N_Choan_1.PD | 106-150 | 30 | 8.6e-06 | 16.7 | In-house | 177-222 (262) | Show / Hide |
Range on Protein: 106-150 Range on HMM: 177-222/262 Sequence Identity: 30% (14 aa) LLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISS-YLINQMKR ||. . ..| ..... . .|| || ||||| |. |...... llefrkavlkatkkktkaplvihCsaGvGrtGtyialDrlvkavee |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB_G0292920.AA | Protein | None | 453 | None | Fasta, JSON |
| DDB_G0292920.NA | RNA | None | 1362 | None | Fasta, JSON |
| DDB_G0292920.AA.PD_86-196 | Protein Phosphatase Domain | None | 111 | None | Fasta, JSON |