DDB_G0285967
Species: D.discoideum
Alias: DDB_G0285967
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: PTEN
Protein domain

Protein domains of DDB_G0285967.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase DDB_G0285967.AA Family.DSP.PD 6-302 22 8.8e-42 134.1 In-house 77-364 (387) Show / Hide
Range on Protein: 6-302
Range on HMM: 77-364/387
Sequence Identity: 22% (68 aa)

KMVSKKKRRFEMYNFDLDlSYITDRVIAMGFPSESLEGLYRNRMRDVQRFFNTLHADHYKVYNLCSERKYehcrFED-R---VSEYPFDDHCPPTLNIIs
. ......  .. .|||| .|     .. | ||| |..||  ...... . .  .. . |. ||. ...     |.      . ..|.||| .|.|... 
akqaelngfidvhtfdld-tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnltddkpq----ftkelgikylripidDhnapplenl-

eFCNDMEmWLDQ--NPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGsESMRLFANKRthnsKGVTIPSQIryvrYFEALLQYGKPIPKPPSITKVLSM
 |..... ....  ....||.|||||||||.||. ...|......    |...... ||    .||..|.|     ... | .. |.. |.|.. .|  .
-fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskR----pgvitpnqg----flkqlkdlekeklkvssevmelrf

IKMNSLPNFNIGGGCEPYLSIVQqGKSVFYSKPVKLKKGTIHQQVELDCGNILLVNDVQIQFFNRNSKG----HMFSYCFHTAFIEGTKIHIRRQEIDKA
...  .|.   ... . |  |. .... . . . |.     . |    . . | .||....|..| .      ..   |.| .|..  . ..|.|..||.
vissivqnlgsvevsvsvlkkva-tekakldrlkiLvideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkkeldel

HKDlKHF
 | |   
hks-kif

Phosphatase DDB_G0285967.AA Subfamily.PTEN.PD 23-312 33 1.6e-68 221.7 In-house 1-303 (305) Show / Hide
Range on Protein: 23-312
Range on HMM: 1-303/305
Sequence Identity: 33% (99 aa)

DLSYITDRVIAMGFPSESLEGLYRNRMRDVQRFFNTLHADHYKVYNLCSERKYEHCRFEDRVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVH
|.|||   .|....| |..|.|... . |. ....| . ...|...|......|.. |..||..||||||.||||....|...|...||....|||||||
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH

CKAGKGRTGTMLACWLLYNKQCQTGSESMRLFANKRTHNSKGVTIPSQIRYVRYFEALLQYGKPIPKppsITKVLSMIKMNSLPNFNIGGGCEPYLSIVQ
||||||||.|....||.........|.......|||...|||||||| |||.||. |..   |  |   ..  .  |....  |  |  .|....  .. 
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpysk---vslnvceirfsesscvqnlgmvecsisvlh

QGkSVFYSKPVKLKKGTIHQQVELD---CGNILLVNDVQIQFFNRNSKGHMFSYCFHTAFIE--------GT---KIH-IRRQEIDKAHKDLKH--FHSN
 .|| .||   |  |  .      .| .  ||.... ...    .  . . | |.         |||| . . |||  ||| .|  |  .| | ..|   
ds-atenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkkspdkiichfwlntffvrnyspcesdgtvnkyihtlskseiddvhkdsehkrfsee

FSIELIF
       
fkisivf

Phosphatase DDB_G0285967.AA Subfamily.Tensin.PD 81-312 30 8.3e-42 133.6 In-house 2-235 (237) Show / Hide
Range on Protein: 81-312
Range on HMM: 2-235/237
Sequence Identity: 30% (72 aa)

EDRVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGSESMRLFANKRTHNSK--GVTIPSQIRYVRYFE
...| .. . |.  |.|. ..  |. .| ||. .|.|||..||| ||||.| ...... | | ... ....  || ||  . |  ||| ||| |||.||.
nekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfs

ALLQYGKPIPKPPSitkVLSMIKMNSLPNFNIGGGCEPYLSIVQQGKSVFYSKPVKLKKGTIHQQVELDCGNILLVNDVQIQFFNRNSKG----HMFSYC
.||.    .   |     |  . ....|||. .|||.|.| | |  . |. |   ..     .. .    . .||  ||.. . .. ..     .|   |
gllsgsiklnsspl---flhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvq

FHTAFIEGTKIHIRRQEIDKAHKDlKHFHSNFSIELIF
||. |...|. . ....|.|.|| . | .. ..||.| 
fhtgaikdlklvfekedldealkd-erfpeyakvelvf

Phosphatase DDB_G0285967.AA Subfamily.TPIP.PD 80-313 34 4e-40 128.3 In-house 1-244 (245) Show / Hide
Range on Protein: 80-313
Range on HMM: 1-244/245
Sequence Identity: 34% (82 aa)

FEDRVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGSESMRLFANKRTHNS-----KGVTIPSQIRYV
|..|||    |||  |||. .  |..... ||....|||||.||| |||||||.. ..|.. ....|  ||.  |...|| ..     .||||| ||| |
fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv

RYFEALLQYGKpIPKPPSitKVLsMIKMNSLPNFnIGGGCEPYLSIVQQGKSVFYSKpvKLKKGTIHQQVELDCGNI------LLVNDVQIQFFNRNSKG
.. . .  .    ||   ..| .||   . .   |  |.  . .| . | || |    | . .| ...| |   || .||..|||. |         | .
gylaqvkhlyn-wnlppr--ril-fikrfiiysi-rgdvcdlkvqvvmekkvvfsst--slgncsilhdietdkilinvydgpplyddvkvqffssnlpk

----HMFSYCFHTAFIEGTKIHIRRQEIDKAHKD--LKHFHSNFSIELIFL
 | |.||.  .. . |.|.|. ||.   | .  .|..|..|          
yydncpfffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfg

Phosphatase DDB_G0285967.AA PTEN_C2 190-314 30 1.8e-38 138.89 Pfam 1-141 (141) Show / Hide
Range on Protein: 190-314
Range on HMM: 1-141/141
Sequence Identity: 30% (43 aa)

PPSITKVLSMIKM-NSLPNFNIGGGC-EPYLSIVQQGKSV--FYSKPVKLKKG-TIHQQVELDCGNILLVNDVQIQFFNRN-------SKGHMFSYCFHT
||. .. |. | |  ..|||..||||  ||. |.|. ..|  ...|  ..||  . .. ... ...... .|| ||.....       .. .||  .|.|
PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT

AFIE--GTKIHIRRQEIDKAHKDL--KHFHSNFSIELIFLE
.|||  .. . . ..|.|||.||   |.|...|..|..| |
CFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE

Phosphatase DDB_G0285967.AA Subfamily.DSP23.PD 89-147 36 9.2e-15 45.3 In-house 41-97 (128) Show / Hide
Range on Protein: 89-147
Range on HMM: 41-97/128
Sequence Identity: 36% (21 aa)

FDDHCPPTLNIISEFCNDMEMWldQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTG
.|.|||.|. .... . .|    .. |. |.|||  | |||||.|||.|. ...  .. 
ipdfcPPaleqvarlvriveea--ekkeeavgvhcalGlGrtGtllacylvkeeglaad

Phosphatase DDB_G0285967.AA Subfamily.PTPDC1.PD 85-181 31 2e-14 44.0 In-house 138-227 (229) Show / Hide
Range on Protein: 85-181
Range on HMM: 138-227/229
Sequence Identity: 31% (30 aa)

SEYPFDDHCPPTLNIISEFCNDMEMWLdqnPENVVAVHCKAGKGRTGTMLACWLLYNKQCqTGSESMRLFANKRThnsKGVTIPSQIRYVRYFEALL
....|.  ..|. | .    ... |    |  .|||| ||.|||| ..||.|.|.|.  |..|...|  .||.   | .   .|.. |. |. .|  
ynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyakrl-taeeaiklvrskrp---ksiqtreqvelveeFalfl

Phosphatase DDB_G0285967.AA Subfamily.CDC14.PD 73-143 32 5.9e-12 36.2 In-house 157-225 (258) Show / Hide
Range on Protein: 73-143
Range on HMM: 157-225/258
Sequence Identity: 32% (24 aa)

RKYEHCRFEDRV---SEYPFDDHCPPTLNIISEFCNDMEMWldqnpENVVAVHCKAGKGRTGTMLACWLLYNKQ
. |.. .|.|     ..  | |   |. .|. .| . .|       |  .||||||| |||||...|.|... .
klYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyr

Phosphatase DDB_G0285967.AA Subfamily.PRL.PD 51-140 26 6.5e-12 35.8 In-house 13-105 (140) Show / Hide
Range on Protein: 51-140
Range on HMM: 13-105/140
Sequence Identity: 26% (24 aa)

DVQRFFNTLHADHYKVYNLCSERKYEHCRFED---RVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLY
|..| ..|. .. |    . | .|.  ....   .| ...|||  .|. ... |. . ...   ..|...||||| || ||.  ..|  |.  
tvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalie

Phosphatase DDB_G0285967.AA Subfamily.PTPMT1.PD 87-160 28 6.8e-12 35.8 In-house 58-129 (146) Show / Hide
Range on Protein: 87-160
Range on HMM: 58-129/146
Sequence Identity: 28% (21 aa)

YPFDDHCP-PTLNIISEFCNDMEMWldQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTgSESMRLFANKRTH
..  |.   |.|. ..|  . .|    .. .. | ||||||..| .|. ||.|...|....  |.......|| .
latvDfteapslekleegvefiekv--askgssvYvHCkAGrtRsatlvacylmkkkklsp-eeavkflkkkRpq

LIM DDB_G0285967.AA LIM 441-495 30 4.1e-11 44.18 SMART 1-52 (52) Show / Hide
Range on Protein: 441-495
Range on HMM: 1-52/52
Sequence Identity: 30% (17 aa)

ICPKCNLPITATDPSINRNSENYHWKCVVCVKCSKPLGGESDCVFENNEMLCTDC
.| .|| ||.. |  .. . ...| .| .| .|.|||||   ....... .| .|
KCARCNKPIYG-DQVMRAMGKHWHPECFCCCHCNKPLGG--TFYEKDGKPYCKHC

Phosphatase DDB_G0285967.AA Subfamily.RNGTT.PD 95-159 28 9.8e-11 31.9 In-house 58-121 (140) Show / Hide
Range on Protein: 95-159
Range on HMM: 58-121/140
Sequence Identity: 28% (18 aa)

PTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTgSESMRLFANKRT
|| . ...| . .. .|...|..|..|||  |  ||| .....|. .....  .... |||. | 
PtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsv-eaavalfakarp

Phosphatase DDB_G0285967.AA Subfamily.DSP11.PD 94-161 21 3.3e-08 23.8 In-house 57-125 (141) Show / Hide
Range on Protein: 94-161
Range on HMM: 57-125/141
Sequence Identity: 21% (15 aa)

PPTLNIISEFCNDMEMWLD--QNPENVVAVHCKAGKGRTGTMLaCWLLYNKQCQTGSESMRLFANKRTHN
|  .....|.. .. .|.  .. .....|||  |  ||| .. |  | ...    ..... | . | |. 
vpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyli-CrylidvegyspedaieafeearGhs

Phosphatase DDB_G0285967.AA Subfamily.N12.PD 86-141 26 6.4e-07 19.1 In-house 171-224 (270) Show / Hide
Range on Protein: 86-141
Range on HMM: 171-224/270
Sequence Identity: 26% (15 aa)

EYPfDDHCPPTLNIISEFCNDMEMWLDQNpENVVAVHCKAGKGRTGTMLACWLLYN
..| |  .| . . . |. ....   ... .. ..||| || |||||..|  . ..
aWP-DhgvPssaksllelielvrelqese-daPlvvhCsaGvGrtGtiiaidyvre

Phosphatase DDB_G0285967.AA Subfamily.RB.PD 91-140 31 2.4e-06 17.5 In-house 166-217 (261) Show / Hide
Range on Protein: 91-140
Range on HMM: 166-217/261
Sequence Identity: 31% (16 aa)

DH-CPPTLNIISEFCNDMEMWLDQN-PENVVAVHCKAGKGRTGTMLACWLLY
||  | . . . .|.. .. .....  .. . ||| || ||||| .|   | 
dhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrll

Phosphatase DDB_G0285967.AA Subfamily.RK.PD 89-142 21 2.9e-06 17.0 In-house 170-225 (267) Show / Hide
Range on Protein: 89-142
Range on HMM: 170-225/267
Sequence Identity: 21% (12 aa)

FDDH--CPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNK
. ..   |   . . ..   .... ... |  . ||| || ||.|| .|.  . . 
WpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivlem

Phosphatase DDB_G0285967.AA Subfamily.N5_RR.PD 55-138 22 3.4e-06 17.0 In-house 133-219 (265) Show / Hide
Range on Protein: 55-138
Range on HMM: 133-219/265
Sequence Identity: 22% (20 aa)

FFNTLHADHYKVYNLCSERKYEHCRF--EDRVSEYPfDDHCPPTLNIISEFCNDMEMWLDQNPEN--VVAVHCKAGKGRTGTMLACWL
. .... ..|.| .|  .   . .|       ...| | . |   | . ......|   ... ..   | ||| || |||| ..|  .
veeiverndysvrklvlkylerversvkhywytdWP-dhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisi

Phosphatase DDB_G0285967.AA Subfamily.N_Choan_1.PD 90-143 30 3.9e-06 16.8 In-house 167-220 (262) Show / Hide
Range on Protein: 90-143
Range on HMM: 167-220/262
Sequence Identity: 30% (16 aa)

DDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQ
|   | | . . || ....   ... .  . .|| || ||||| .|   | .. 
dhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyialDrlvkav

Phosphatase DDB_G0285967.AA Subfamily.R_Anemone_2.PD 98-141 28 4.1e-06 16.9 In-house 176-219 (262) Show / Hide
Range on Protein: 98-141
Range on HMM: 176-219/262
Sequence Identity: 28% (12 aa)

NIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYN
. .. ...| .  .. .....||| || ||||. .|   | .  
aslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiavdille

Phosphatase DDB_G0285967.AA Subfamily.DSP12.PD 42-158 22 7e-06 16.6 In-house 7-122 (143) Show / Hide
Range on Protein: 42-158
Range on HMM: 7-122/143
Sequence Identity: 22% (26 aa)

EGLYRNRMRDVQRFFNTLHADHYKVYNLCSERKYEHCRFEDRVS--EYPFDDHCPPTLNIISEFCNDMEMWLdqNPENVVAVHCKAGKGRTGTMLACWLL
.|||   ...||   .  ...  .|  . .|.  |.   .. .|   . .|.   . |. . | .. .|  |  . |. | |||.||  ||. . .|...
pglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieegl--ekegavlvHClagvSRSvtiviAYlm

YNKQCQTgSESMRLFANKR
....  .. ..|  .|.  
kkeklsl-ekAlklvkekk

Phosphatase DDB_G0285967.AA Subfamily.DSP19.PD 114-149 22 7.6e-06 16.2 In-house 77-112 (139) Show / Hide
Range on Protein: 114-149
Range on HMM: 77-112/139
Sequence Identity: 22% (8 aa)

NPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGSE
. ...| |||.||  |. ..   .|. ... .. ..
skdgrvlvHCnAGvSRsasvviaylmkdeelsleka

LIM DDB_G0285967.AA LIM 640-694 27 1.9e-08 35.31 SMART 1-52 (52) Show / Hide
Range on Protein: 640-694
Range on HMM: 1-52/52
Sequence Identity: 27% (15 aa)

ICSKCELAINQSRPIILDCGIYHRECFQCSECFDETPMDPSLYYIRNDKPVCFDC
.|..|  .|  .. .  .   .| |||.|..|  ..|...  .| ...|| | .|
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHC--NKPLGG-TFYEKDGKPYCKHC

LIM DDB_G0285967.AA LIM 708-759 30 4.7e-16 60.59 SMART 1-52 (52) Show / Hide
Range on Protein: 708-759
Range on HMM: 1-52/52
Sequence Identity: 30% (16 aa)

TCYGCKLPIVDEVMMDALNFKWHVACLVCSKCAIQIEGQLGDHQGLIYCKDH
 | .|. ||.....| |.. .||..|..|..|  ...|    . | .|||..
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGGTFYEKDGKPYCKHC

LIM DDB_G0285967.AA LIM 661-691 33 7e-06 23.7 Pfam 22-52 (60) Show / Hide
Range on Protein: 661-691
Range on HMM: 22-52/60
Sequence Identity: 33% (11 aa)

YHRECFQCSECFDETPMDPSL-YYIRND-KPVC
.|.|||.|..|.  .|..|.  .|.... |..|
WHPECFCCCHCQ--KPLTPGDECYEHDGNKLYC

LIM DDB_G0285967.AA LIM 767-818 39 7e-13 50.03 SMART 1-52 (52) Show / Hide
Range on Protein: 767-818
Range on HMM: 1-52/52
Sequence Identity: 39% (21 aa)

KCDQCNQYIDG-MFLKVNGKNLCPTCFRCFCCNEVLEGGKYFEKNGESICEKC
||  ||. |.| . ....||. .| ||.|..||  |.| ...||.|.  |..|
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGG-TFYEKDGKPYCKHC

LIM DDB_G0285967.AA LIM 709-764 31 8.4e-12 44.67 Pfam 1-60 (60) Show / Hide
Range on Protein: 709-764
Range on HMM: 1-60/60
Sequence Identity: 31% (19 aa)

CYGCKLPIV-DEVMMDALNFKWHVACLVCSKCAIQIEGQ--LGDHQG-LIYCKDHFEELV
|.||. ||   ...| |.| .||..|..|. |  ...       | | ..||| .. .| 
CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF

Sequence
Name Sequence Type Origin Length Description Download
DDB_G0285967.AA Protein None 998 None Fasta, JSON
DDB_G0285967.NA RNA None 2997 None Fasta, JSON
DDB_G0285967.AA.PD_81-182 Protein Phosphatase Domain None 102 None Fasta, JSON