Gene DDB_G0285967
DDB_G0285967
Species: D.discoideum
Alias: DDB_G0285967
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DDB_G0285967.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DDB_G0285967.AA | Family.DSP.PD | 6-302 | 22 | 8.8e-42 | 134.1 | In-house | 77-364 (387) | Show / Hide |
Range on Protein: 6-302 Range on HMM: 77-364/387 Sequence Identity: 22% (68 aa) KMVSKKKRRFEMYNFDLDlSYITDRVIAMGFPSESLEGLYRNRMRDVQRFFNTLHADHYKVYNLCSERKYehcrFED-R---VSEYPFDDHCPPTLNIIs . ...... .. .|||| .| .. | ||| |..|| ...... . . .. . |. ||. ... |. . ..|.||| .|.|... akqaelngfidvhtfdld-tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnltddkpq----ftkelgikylripidDhnapplenl- eFCNDMEmWLDQ--NPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGsESMRLFANKRthnsKGVTIPSQIryvrYFEALLQYGKPIPKPPSITKVLSM |..... .... ....||.|||||||||.||. ...|...... |...... || .||..|.| ... | .. |.. |.|.. .| . -fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskR----pgvitpnqg----flkqlkdlekeklkvssevmelrf IKMNSLPNFNIGGGCEPYLSIVQqGKSVFYSKPVKLKKGTIHQQVELDCGNILLVNDVQIQFFNRNSKG----HMFSYCFHTAFIEGTKIHIRRQEIDKA ... .|. ... . | |. .... . . . |. . | . . | .||....|..| . .. |.| .|.. . ..|.|..||. vissivqnlgsvevsvsvlkkva-tekakldrlkiLvideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkkeldel HKDlKHF | | hks-kif |
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| Phosphatase | DDB_G0285967.AA | Subfamily.PTEN.PD | 23-312 | 33 | 1.6e-68 | 221.7 | In-house | 1-303 (305) | Show / Hide |
Range on Protein: 23-312
Range on HMM: 1-303/305
Sequence Identity: 33% (99 aa)
DLSYITDRVIAMGFPSESLEGLYRNRMRDVQRFFNTLHADHYKVYNLCSERKYEHCRFEDRVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVH
|.||| .|....| |..|.|... . |. ....| . ...|...|......|.. |..||..||||||.||||....|...|...||....|||||||
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH
CKAGKGRTGTMLACWLLYNKQCQTGSESMRLFANKRTHNSKGVTIPSQIRYVRYFEALLQYGKPIPKppsITKVLSMIKMNSLPNFNIGGGCEPYLSIVQ
||||||||.|....||.........|.......|||...|||||||| |||.||. |.. | | .. . |.... | | .|.... ..
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpysk---vslnvceirfsesscvqnlgmvecsisvlh
QGkSVFYSKPVKLKKGTIHQQVELD---CGNILLVNDVQIQFFNRNSKGHMFSYCFHTAFIE--------GT---KIH-IRRQEIDKAHKDLKH--FHSN
.|| .|| | | . .| . ||.... ... . . . | |. |||| . . ||| ||| .| | .| | ..|
ds-atenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkkspdkiichfwlntffvrnyspcesdgtvnkyihtlskseiddvhkdsehkrfsee
FSIELIF
fkisivf
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| Phosphatase | DDB_G0285967.AA | Subfamily.Tensin.PD | 81-312 | 30 | 8.3e-42 | 133.6 | In-house | 2-235 (237) | Show / Hide |
Range on Protein: 81-312 Range on HMM: 2-235/237 Sequence Identity: 30% (72 aa) EDRVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGSESMRLFANKRTHNSK--GVTIPSQIRYVRYFE ...| .. . |. |.|. .. |. .| ||. .|.|||..||| ||||.| ...... | | ... .... || || . | ||| ||| |||.||. nekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfs ALLQYGKPIPKPPSitkVLSMIKMNSLPNFNIGGGCEPYLSIVQQGKSVFYSKPVKLKKGTIHQQVELDCGNILLVNDVQIQFFNRNSKG----HMFSYC .||. . | | . ....|||. .|||.|.| | | . |. | .. .. . . .|| ||.. . .. .. .| | gllsgsiklnsspl---flhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvq FHTAFIEGTKIHIRRQEIDKAHKDlKHFHSNFSIELIF ||. |...|. . ....|.|.|| . | .. ..||.| fhtgaikdlklvfekedldealkd-erfpeyakvelvf |
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| Phosphatase | DDB_G0285967.AA | Subfamily.TPIP.PD | 80-313 | 34 | 4e-40 | 128.3 | In-house | 1-244 (245) | Show / Hide |
Range on Protein: 80-313 Range on HMM: 1-244/245 Sequence Identity: 34% (82 aa) FEDRVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGSESMRLFANKRTHNS-----KGVTIPSQIRYV |..||| ||| |||. . |..... ||....|||||.||| |||||||.. ..|.. ....| ||. |...|| .. .||||| ||| | fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv RYFEALLQYGKpIPKPPSitKVLsMIKMNSLPNFnIGGGCEPYLSIVQQGKSVFYSKpvKLKKGTIHQQVELDCGNI------LLVNDVQIQFFNRNSKG .. . . . || ..| .|| . . | |. . .| . | || | | . .| ...| | || .||..|||. | | . gylaqvkhlyn-wnlppr--ril-fikrfiiysi-rgdvcdlkvqvvmekkvvfsst--slgncsilhdietdkilinvydgpplyddvkvqffssnlpk ----HMFSYCFHTAFIEGTKIHIRRQEIDKAHKD--LKHFHSNFSIELIFL | |.||. .. . |.|.|. ||. | . .|..|..| yydncpfffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfg |
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| Phosphatase | DDB_G0285967.AA | PTEN_C2 | 190-314 | 30 | 1.8e-38 | 138.89 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 190-314 Range on HMM: 1-141/141 Sequence Identity: 30% (43 aa) PPSITKVLSMIKM-NSLPNFNIGGGC-EPYLSIVQQGKSV--FYSKPVKLKKG-TIHQQVELDCGNILLVNDVQIQFFNRN-------SKGHMFSYCFHT ||. .. |. | | ..|||..|||| ||. |.|. ..| ...| ..|| . .. ... ...... .|| ||..... .. .|| .|.| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT AFIE--GTKIHIRRQEIDKAHKDL--KHFHSNFSIELIFLE .||| .. . . ..|.|||.|| |.|...|..|..| | CFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | DDB_G0285967.AA | Subfamily.DSP23.PD | 89-147 | 36 | 9.2e-15 | 45.3 | In-house | 41-97 (128) | Show / Hide |
Range on Protein: 89-147 Range on HMM: 41-97/128 Sequence Identity: 36% (21 aa) FDDHCPPTLNIISEFCNDMEMWldQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTG .|.|||.|. .... . .| .. |. |.||| | |||||.|||.|. ... .. ipdfcPPaleqvarlvriveea--ekkeeavgvhcalGlGrtGtllacylvkeeglaad |
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| Phosphatase | DDB_G0285967.AA | Subfamily.PTPDC1.PD | 85-181 | 31 | 2e-14 | 44.0 | In-house | 138-227 (229) | Show / Hide |
Range on Protein: 85-181 Range on HMM: 138-227/229 Sequence Identity: 31% (30 aa) SEYPFDDHCPPTLNIISEFCNDMEMWLdqnPENVVAVHCKAGKGRTGTMLACWLLYNKQCqTGSESMRLFANKRThnsKGVTIPSQIRYVRYFEALL ....|. ..|. | . ... | | .|||| ||.|||| ..||.|.|.|. |..|...| .||. | . .|.. |. |. .| ynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyakrl-taeeaiklvrskrp---ksiqtreqvelveeFalfl |
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| Phosphatase | DDB_G0285967.AA | Subfamily.CDC14.PD | 73-143 | 32 | 5.9e-12 | 36.2 | In-house | 157-225 (258) | Show / Hide |
Range on Protein: 73-143 Range on HMM: 157-225/258 Sequence Identity: 32% (24 aa) RKYEHCRFEDRV---SEYPFDDHCPPTLNIISEFCNDMEMWldqnpENVVAVHCKAGKGRTGTMLACWLLYNKQ . |.. .|.| .. | | |. .|. .| . .| | .||||||| |||||...|.|... . klYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyr |
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| Phosphatase | DDB_G0285967.AA | Subfamily.PRL.PD | 51-140 | 26 | 6.5e-12 | 35.8 | In-house | 13-105 (140) | Show / Hide |
Range on Protein: 51-140 Range on HMM: 13-105/140 Sequence Identity: 26% (24 aa) DVQRFFNTLHADHYKVYNLCSERKYEHCRFED---RVSEYPFDDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLY |..| ..|. .. | . | .|. .... .| ...||| .|. ... |. . ... ..|...||||| || ||. ..| |. tvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalie |
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| Phosphatase | DDB_G0285967.AA | Subfamily.PTPMT1.PD | 87-160 | 28 | 6.8e-12 | 35.8 | In-house | 58-129 (146) | Show / Hide |
Range on Protein: 87-160 Range on HMM: 58-129/146 Sequence Identity: 28% (21 aa) YPFDDHCP-PTLNIISEFCNDMEMWldQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTgSESMRLFANKRTH .. |. |.|. ..| . .| .. .. | ||||||..| .|. ||.|...|.... |.......|| . latvDfteapslekleegvefiekv--askgssvYvHCkAGrtRsatlvacylmkkkklsp-eeavkflkkkRpq |
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| LIM | DDB_G0285967.AA | LIM | 441-495 | 30 | 4.1e-11 | 44.18 | SMART | 1-52 (52) | Show / Hide |
Range on Protein: 441-495 Range on HMM: 1-52/52 Sequence Identity: 30% (17 aa) ICPKCNLPITATDPSINRNSENYHWKCVVCVKCSKPLGGESDCVFENNEMLCTDC .| .|| ||.. | .. . ...| .| .| .|.||||| ....... .| .| KCARCNKPIYG-DQVMRAMGKHWHPECFCCCHCNKPLGG--TFYEKDGKPYCKHC |
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| Phosphatase | DDB_G0285967.AA | Subfamily.RNGTT.PD | 95-159 | 28 | 9.8e-11 | 31.9 | In-house | 58-121 (140) | Show / Hide |
Range on Protein: 95-159 Range on HMM: 58-121/140 Sequence Identity: 28% (18 aa) PTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTgSESMRLFANKRT || . ...| . .. .|...|..|..||| | ||| .....|. ..... .... |||. | PtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsv-eaavalfakarp |
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| Phosphatase | DDB_G0285967.AA | Subfamily.DSP11.PD | 94-161 | 21 | 3.3e-08 | 23.8 | In-house | 57-125 (141) | Show / Hide |
Range on Protein: 94-161 Range on HMM: 57-125/141 Sequence Identity: 21% (15 aa) PPTLNIISEFCNDMEMWLD--QNPENVVAVHCKAGKGRTGTMLaCWLLYNKQCQTGSESMRLFANKRTHN | .....|.. .. .|. .. .....||| | ||| .. | | ... ..... | . | |. vpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyli-CrylidvegyspedaieafeearGhs |
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| Phosphatase | DDB_G0285967.AA | Subfamily.N12.PD | 86-141 | 26 | 6.4e-07 | 19.1 | In-house | 171-224 (270) | Show / Hide |
Range on Protein: 86-141 Range on HMM: 171-224/270 Sequence Identity: 26% (15 aa) EYPfDDHCPPTLNIISEFCNDMEMWLDQNpENVVAVHCKAGKGRTGTMLACWLLYN ..| | .| . . . |. .... ... .. ..||| || |||||..| . .. aWP-DhgvPssaksllelielvrelqese-daPlvvhCsaGvGrtGtiiaidyvre |
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| Phosphatase | DDB_G0285967.AA | Subfamily.RB.PD | 91-140 | 31 | 2.4e-06 | 17.5 | In-house | 166-217 (261) | Show / Hide |
Range on Protein: 91-140 Range on HMM: 166-217/261 Sequence Identity: 31% (16 aa) DH-CPPTLNIISEFCNDMEMWLDQN-PENVVAVHCKAGKGRTGTMLACWLLY || | . . . .|.. .. ..... .. . ||| || ||||| .| | dhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrll |
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| Phosphatase | DDB_G0285967.AA | Subfamily.RK.PD | 89-142 | 21 | 2.9e-06 | 17.0 | In-house | 170-225 (267) | Show / Hide |
Range on Protein: 89-142 Range on HMM: 170-225/267 Sequence Identity: 21% (12 aa) FDDH--CPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNK . .. | . . .. .... ... | . ||| || ||.|| .|. . . WpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivlem |
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| Phosphatase | DDB_G0285967.AA | Subfamily.N5_RR.PD | 55-138 | 22 | 3.4e-06 | 17.0 | In-house | 133-219 (265) | Show / Hide |
Range on Protein: 55-138 Range on HMM: 133-219/265 Sequence Identity: 22% (20 aa) FFNTLHADHYKVYNLCSERKYEHCRF--EDRVSEYPfDDHCPPTLNIISEFCNDMEMWLDQNPEN--VVAVHCKAGKGRTGTMLACWL . .... ..|.| .| . . .| ...| | . | | . ......| ... .. | ||| || |||| ..| . veeiverndysvrklvlkylerversvkhywytdWP-dhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisi |
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| Phosphatase | DDB_G0285967.AA | Subfamily.N_Choan_1.PD | 90-143 | 30 | 3.9e-06 | 16.8 | In-house | 167-220 (262) | Show / Hide |
Range on Protein: 90-143 Range on HMM: 167-220/262 Sequence Identity: 30% (16 aa) DDHCPPTLNIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYNKQ | | | . . || .... ... . . .|| || ||||| .| | .. dhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyialDrlvkav |
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| Phosphatase | DDB_G0285967.AA | Subfamily.R_Anemone_2.PD | 98-141 | 28 | 4.1e-06 | 16.9 | In-house | 176-219 (262) | Show / Hide |
Range on Protein: 98-141 Range on HMM: 176-219/262 Sequence Identity: 28% (12 aa) NIISEFCNDMEMWLDQNPENVVAVHCKAGKGRTGTMLACWLLYN . .. ...| . .. .....||| || ||||. .| | . aslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiavdille |
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| Phosphatase | DDB_G0285967.AA | Subfamily.DSP12.PD | 42-158 | 22 | 7e-06 | 16.6 | In-house | 7-122 (143) | Show / Hide |
Range on Protein: 42-158 Range on HMM: 7-122/143 Sequence Identity: 22% (26 aa) EGLYRNRMRDVQRFFNTLHADHYKVYNLCSERKYEHCRFEDRVS--EYPFDDHCPPTLNIISEFCNDMEMWLdqNPENVVAVHCKAGKGRTGTMLACWLL .||| ...|| . ... .| . .|. |. .. .| . .|. . |. . | .. .| | . |. | |||.|| ||. . .|... pglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieegl--ekegavlvHClagvSRSvtiviAYlm YNKQCQTgSESMRLFANKR .... .. ..| .|. kkeklsl-ekAlklvkekk |
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| Phosphatase | DDB_G0285967.AA | Subfamily.DSP19.PD | 114-149 | 22 | 7.6e-06 | 16.2 | In-house | 77-112 (139) | Show / Hide |
Range on Protein: 114-149 Range on HMM: 77-112/139 Sequence Identity: 22% (8 aa) NPENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGSE . ...| |||.|| |. .. .|. ... .. .. skdgrvlvHCnAGvSRsasvviaylmkdeelsleka |
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| LIM | DDB_G0285967.AA | LIM | 640-694 | 27 | 1.9e-08 | 35.31 | SMART | 1-52 (52) | Show / Hide |
Range on Protein: 640-694 Range on HMM: 1-52/52 Sequence Identity: 27% (15 aa) ICSKCELAINQSRPIILDCGIYHRECFQCSECFDETPMDPSLYYIRNDKPVCFDC .|..| .| .. . . .| |||.|..| ..|... .| ...|| | .| KCARCNKPIYGDQVMRAMGKHWHPECFCCCHC--NKPLGG-TFYEKDGKPYCKHC |
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| LIM | DDB_G0285967.AA | LIM | 708-759 | 30 | 4.7e-16 | 60.59 | SMART | 1-52 (52) | Show / Hide |
Range on Protein: 708-759 Range on HMM: 1-52/52 Sequence Identity: 30% (16 aa) TCYGCKLPIVDEVMMDALNFKWHVACLVCSKCAIQIEGQLGDHQGLIYCKDH | .|. ||.....| |.. .||..|..|..| ...| . | .|||.. KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGGTFYEKDGKPYCKHC |
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| LIM | DDB_G0285967.AA | LIM | 661-691 | 33 | 7e-06 | 23.7 | Pfam | 22-52 (60) | Show / Hide |
Range on Protein: 661-691 Range on HMM: 22-52/60 Sequence Identity: 33% (11 aa) YHRECFQCSECFDETPMDPSL-YYIRND-KPVC .|.|||.|..|. .|..|. .|.... |..| WHPECFCCCHCQ--KPLTPGDECYEHDGNKLYC |
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| LIM | DDB_G0285967.AA | LIM | 767-818 | 39 | 7e-13 | 50.03 | SMART | 1-52 (52) | Show / Hide |
Range on Protein: 767-818 Range on HMM: 1-52/52 Sequence Identity: 39% (21 aa) KCDQCNQYIDG-MFLKVNGKNLCPTCFRCFCCNEVLEGGKYFEKNGESICEKC || ||. |.| . ....||. .| ||.|..|| |.| ...||.|. |..| KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGG-TFYEKDGKPYCKHC |
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| LIM | DDB_G0285967.AA | LIM | 709-764 | 31 | 8.4e-12 | 44.67 | Pfam | 1-60 (60) | Show / Hide |
Range on Protein: 709-764 Range on HMM: 1-60/60 Sequence Identity: 31% (19 aa) CYGCKLPIV-DEVMMDALNFKWHVACLVCSKCAIQIEGQ--LGDHQG-LIYCKDHFEELV |.||. || ...| |.| .||..|..|. | ... | | ..||| .. .| CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB_G0285967.AA | Protein | None | 998 | None | Fasta, JSON |
| DDB_G0285967.NA | RNA | None | 2997 | None | Fasta, JSON |
| DDB_G0285967.AA.PD_81-182 | Protein Phosphatase Domain | None | 102 | None | Fasta, JSON |