Gene DDB_G0289979
DDB_G0289979
Species: D.discoideum
Alias: DDB_G0289979
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DDB_G0289979.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DDB_G0289979.AA | Subfamily.PTEN.PD | 28-185 | 38 | 7.2e-46 | 147.7 | In-house | 1-158 (305) | Show / Hide |
Range on Protein: 28-185 Range on HMM: 1-158/305 Sequence Identity: 38% (61 aa) DLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLS-ERKYDYSLFNGMVLdWCGFPDHHAPPLGLLFKIVMTIYSWLEKDPMNVVVV |..|| .|..|.|.. .| ... . |. .||.| .|... ...|. ......| |.| | .| ||..|.| || .|| .. .||..| |||.| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrva-vypfdDhnpptleLleeivedvdkwLkedksnVvav HCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNNNYGITGPSQIRYTQYFSDI || |||||||..|.| | . | .. |..|..... ||.... |.| ||| || |||| . HCkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfskl |
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| Phosphatase | DDB_G0289979.AA | Subfamily.Tensin.PD | 85-323 | 37 | 1.9e-43 | 139.4 | In-house | 2-231 (237) | Show / Hide |
Range on Protein: 85-323 Range on HMM: 2-231/237 Sequence Identity: 37% (89 aa) NGMVLDwCGFPDHHAPPLGLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKR--SNNNYGITGPSQIRYTQYF | ||| |.||..|||| | |. .. |||. || ||||.|| ||||.| |||| ..| . ..|. |. ||.|| . |.|||| || .||| nekvld-lGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf SDIYFGGKELNPGPVFLKSISMVTLPKFflgPLKQGVCPVLNIYSATQKgvrIFTSAPIEGDTKETRtyqsgNATIVFEVRKIVRGDILLVFSHITPFYR .. | .|| |.||. . . ..|.| | |. | |.|| | | ..|| . ...|. . .|. |...||.|. | . . sgllsgsiklnssplflhyvilhgipnf---dskggcrpflkiyqalql---vytsgvynvagedte-----rlcitiepalllkgdvlvkcyhkklrst V-EQICRANFHTGMFSFPTLILTKSDLDGADGDKRFSSDFHL . | .|||| .|.. |.||| | |.|| . .. trdvvfrvqfhtgaikdlklvfekedldealkderfpeyakv |
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| Phosphatase | DDB_G0289979.AA | PTEN_C2 | 192-329 | 26 | 8e-35 | 126.7 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 192-329 Range on HMM: 1-141/141 Sequence Identity: 26% (40 aa) LNPGPVFLKSISM-VTLPKFFLGPLKQGVC--PVLNIYSATQKGVRIFTSAPIEGDTKETRTY-QSGNATIVFEVRKIVRGDILLVFSHIT----PFYRV ..| |.||..| | ...|.| ..|.| | . ||. || . ..... .. . | | ... ..|. . .| ||... . |. | .. PPPKPLFLHCIIMDHGIPNF----KQGGGCWRPYIQIYQNDQKVF------YTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYE EQICRANFHTGMFS--FPTLILTKSDLDGADGD---KRFSSDFHLRLDFQE |...| |.|.... ..|...|..||.|. | |||..||.... |.| ECMFRFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| PH | DDB_G0289979.AA | PH | 415-513 | 37 | 2.5e-27 | 101.2 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 415-513 Range on HMM: 1-92/92 Sequence Identity: 37% (37 aa) GVHSGYLFKKGHNFKSWRRRWFVLKDNILSYYKSPKDTAPAGIIPINEIVNIEIECEISQAEGYDYCFQISTSKA-NYLISAENERDLEDWTEILRSAKR ...|.|.||| .|||..|||||..| |.|||..| | |.||.... .... . . ..||||.| |...||.| ...|| . ..|| | VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN----KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR |
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| Phosphatase | DDB_G0289979.AA | Subfamily.TPIP.PD | 95-187 | 37 | 6.1e-25 | 79.0 | In-house | 11-108 (245) | Show / Hide |
Range on Protein: 95-187 Range on HMM: 11-108/245 Sequence Identity: 37% (36 aa) PDHHAPPLGLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNNN-----YGITGPSQIRYTQYFSDIYF || | | |... . ||.||. |||..|| |||||||.. ||| . ..|. | ... ||. .| ... |. ||| || .|. .. ddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgylaqvkh |
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| Phosphatase | DDB_G0289979.AA | Family.DSP.PD | 88-318 | 22 | 1.7e-22 | 71.1 | In-house | 154-365 (387) | Show / Hide |
Range on Protein: 88-318 Range on HMM: 154-365/387 Sequence Identity: 22% (51 aa) VLDWcGFPDHHAPPLGLLFKIVMTiysWLEK--DPMNVVVVHCMAGKGRTGTVISALLQYGgLFEGASDAMRYFAVKRsnnNyGITGPSQIrYTQYFSDI .|.. ...||.|||| .|| .. ..|. |. .||.|||.|||||.||.|.| | . ...|..... || . |.. |.| . ....| ylri-pidDhnapplenlfekaid---fieegndskgvVlVHCkaGkgRsgtliiaYlmks-egltleealdwvrskR---p-gvitpnqg-flkqlkdl YFGGKELNPGPVFLKSISMVTLPKFFlgplKQGVCPVLNIYSATQKGVriftsaPIEGDTkeTRTYQSGNATIVFEVRKIVRGDILLVFSHITPF-YRVE . ... ...|. . . ... ...|. .. .||.| . . .. . . . | . .. ||... . .. . . | ekeklkvssevmelrfvissivqnlg----svevsvsvlkkvatekak------ldrlki--LvideqekvvitikdglplsgDVkvelfkknldkiird QICRANFHTGMFSFPTLILTKSDLDGADGDKRFS . |.|.. | | | .|| . .|.| iilntfFvtnyikdeslvlvkkeldelhkskifd |
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| Phosphatase | DDB_G0289979.AA | Subfamily.PTPDC1.PD | 86-183 | 27 | 3.3e-10 | 30.6 | In-house | 134-224 (229) | Show / Hide |
Range on Protein: 86-183 Range on HMM: 134-224/229 Sequence Identity: 27% (27 aa) GMVLDWCGFPDHHAPPLGLLFKIVMTIYSWLEKdpmNVVVVHCMAGKGRTGTVISALLQYGGLFEgASDAMRYFAVKRSNnnyGITGPSQIRYTQYFS |.. .|..|. ...| . || . . ||. . ||| ||.|||| .|.. | | .. |..|.. ||.. | .|.. . |. giyfynfglkDygvasleriLdivkvvdfalee---gkiavHCHAGlGRtGvliacylvyakrlt-aeeaiklvrskrpk---siqtreqvelveeFa |
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| Phosphatase | DDB_G0289979.AA | Subfamily.RB.PD | 60-140 | 31 | 3e-08 | 24.2 | In-house | 131-212 (261) | Show / Hide |
Range on Protein: 60-140 Range on HMM: 131-212/261 Sequence Identity: 31% (26 aa) LLNTSHKDHYLIYNLSERKyDYSLFNGMVLDWCGFPDHHAPPL-GLLFKIVMTIYSWLEKD-PMNVVVVHCMAGKGRTGTVIS ||.....|.. | ... .| . . . . ... .||| | | ..| |. ...||. .. .|||| || ||||| |. llaekeldewvirefkiek-gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfia |
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| Phosphatase | DDB_G0289979.AA | Subfamily.PRL.PD | 71-164 | 27 | 9.1e-08 | 22.9 | In-house | 29-122 (140) | Show / Hide |
Range on Protein: 71-164 Range on HMM: 29-122/140 Sequence Identity: 27% (26 aa) IYNLSERKYDYSLF--NG-MVLDWCgFPDHHAPPLGLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQYGGLfeGASDAMRYFAVKRS . | .|| . . .| |||.. | | .|| .. . . . . ...| ..| |||.|| ||. ... | |. ||. .|| vvrvcepsydaeklkeegievldla-fddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kyedavefirekrr |
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| Phosphatase | DDB_G0289979.AA | Subfamily.N_Nematode_1.PD | 89-142 | 32 | 1.6e-07 | 21.7 | In-house | 168-217 (265) | Show / Hide |
Range on Protein: 89-142 Range on HMM: 168-217/265 Sequence Identity: 32% (17 aa) LDWCGFPDHHAPPLGLLfKIvmTIYSWLEKDpMNVVVVHCMAGKGRTGTVISAL ..| .||. .|| | . . . ... . .|||| || |||||... yqWtdWPdrGvPpadla-al--elleavrgs-kgPivvhCsaGiGrtGtivaie |
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| Phosphatase | DDB_G0289979.AA | Subfamily.N12.PD | 55-140 | 26 | 3e-07 | 20.7 | In-house | 134-218 (270) | Show / Hide |
Range on Protein: 55-140 Range on HMM: 134-218/270 Sequence Identity: 26% (23 aa) YDVSKLLNTSHKDHYLIYNLSERKYdYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKDPMnVVVVHCMAGKGRTGTVIS . |.. . .| .|| | .. . ... .||| | |.... .. . |.. . .|||| || |||||.|. fevtleeekavdddflirtLkveaq-kesrkvyqfhytaWPDhgvPssaksllelielvrelqeseda-PlvvhCsaGvGrtGtiia |
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| Phosphatase | DDB_G0289979.AA | Subfamily.CDC14.PD | 30-163 | 29 | 4.8e-07 | 20.5 | In-house | 109-239 (258) | Show / Hide |
Range on Protein: 30-163 Range on HMM: 109-239/258 Sequence Identity: 29% (40 aa) TYITERVIAMSFPADG--VESAYrnSIYDVSKLLNTSHK-DHYLIYNLSERKYDYSLFNGMVLDWC--GFPDHHAPPLGLLFKIVmTIyswLEKDpMNVV | | ...||.. | . ||. | . |||. .| . | | .. || . |. . .. | | |. .| | . .|.|| ..|| tiipnkfialagphnkskvedGy--tllaPeklleyfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfl-ei---teka-eGai VVHCMAGKGRTGTVISALLQYGGLFEgASDAMRYFAVKR | || |||||.|.. | . |. |.... .. . | avhCkaGLGrtgtligcylikhyrft-aaetiawlriar |
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| Phosphatase | DDB_G0289979.AA | Subfamily.DSP23.PD | 85-142 | 30 | 6.1e-07 | 20.4 | In-house | 32-87 (128) | Show / Hide |
Range on Protein: 85-142 Range on HMM: 32-87/128 Sequence Identity: 30% (17 aa) NGMVLDWCGFPDHHAPPLGLLFKIVMTIYSWLEKDpmNVVVVHCMAGKGRTGTVISAL ... | . ||.. | | . ..| .. .|. . | |||. | |||||... psltlrridipdfcPPaleqvarlvriveeaekke--eavgvhcalGlGrtGtllacy |
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| Phosphatase | DDB_G0289979.AA | Subfamily.RK.PD | 89-140 | 32 | 9.4e-07 | 19.1 | In-house | 165-218 (267) | Show / Hide |
Range on Protein: 89-140 Range on HMM: 165-218/267 Sequence Identity: 32% (17 aa) LDWCGFPDH-HAPPL-GLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVIS ... |.|.. . | |.|.. . .. |.. .||||.|| ||.|| | fqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfia |
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| Phosphatase | DDB_G0289979.AA | Subfamily.R_Anemone_2.PD | 91-140 | 34 | 1.2e-06 | 19.1 | In-house | 163-213 (262) | Show / Hide |
Range on Protein: 91-140 Range on HMM: 163-213/262 Sequence Identity: 34% (17 aa) WCGFPDHHAPPLG-LLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVIS . .||. .| | |...| .. .. .. ....|||| || ||||. | ytsWpdegvpesgaslldlvrqvekaqqesgagpivvhcsaGvGrtGvfia |
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| Phosphatase | DDB_G0289979.AA | Subfamily.N13.PD | 87-140 | 32 | 1.3e-06 | 18.9 | In-house | 158-210 (259) | Show / Hide |
Range on Protein: 87-140 Range on HMM: 158-210/259 Sequence Identity: 32% (18 aa) MVLDWCGFPDHHAPPLGLL-FKIVMTIySWLEKDpMNVVVVHCMAGKGRTGTVIS . |.. .||| | ..|. . |..| .|||| || ||.|..|. ahlnfvkwPdhgvPssaaelvqfvaev-rllqtd-agPivvhcsaGiGrsGvlit |
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| Phosphatase | DDB_G0289979.AA | Subfamily.RNGTT.PD | 111-168 | 33 | 1.3e-06 | 19.0 | In-house | 69-125 (140) | Show / Hide |
Range on Protein: 111-168 Range on HMM: 69-125/140 Sequence Identity: 33% (19 aa) TIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQYGgLFEGASDAMRYFAVKRSNNNY . ..|.| | .|. ||| | ||| .| | | . . ..|. || | . | lvkeflkkkPdevigvhCthGfnrtGflivayLvek-edwsveaavalfakarppGiy |
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| Phosphatase | DDB_G0289979.AA | Subfamily.N5_RR.PD | 62-142 | 25 | 2.2e-06 | 18.1 | In-house | 135-218 (265) | Show / Hide |
Range on Protein: 62-142 Range on HMM: 135-218/265 Sequence Identity: 25% (21 aa) NTSHKDHYLIYNLSERKYDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKDPMN--VVVVHCMAGKGRTGTVISAL .. ....| . .|. .. . . . .|||..| |...|. . . |.. .. ||||| || |||| |... eiverndysvrklvlkylerversvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiais |
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| Phosphatase | DDB_G0289979.AA | Subfamily.N_Nematode_6.PD | 89-139 | 39 | 3.8e-06 | 17.4 | In-house | 157-203 (253) | Show / Hide |
Range on Protein: 89-139 Range on HMM: 157-203/253 Sequence Identity: 39% (20 aa) LDWCGFPDHHAPPLgllFKIVMTIYSWLEKDpMNVVVVHCMAGKGRTGTVI ..| .||| | |. . . | . || .|||| || |||||.. ihWanWPdhGvPds---flsalrllsvvkkd-kkPivvhCsaGvGrtGtla |
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| PH | DDB_G0289979.AA | PH | 415-515 | 25 | 2.8e-25 | 91.22 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 415-515 Range on HMM: 1-82/82 Sequence Identity: 25% (26 aa) GVHSGYLFKKGHNFKSWRRRWFVLKDNILSYYKSPKDTAPAGIIPINEIVNIEIECEISQAEGYDYCFQISTSKANYLISAENERDLEDWTEILRSAKRM ...|.| ||. . .|..|||||... |.|||.. .| |.||.... .. ||.|.. . |....|.| ....| . ...| . VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P----------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHN V N |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB_G0289979.AA | Protein | None | 904 | None | Fasta, JSON |
| DDB_G0289979.NA | RNA | None | 2715 | None | Fasta, JSON |