Gene plip
plip
Species: D.discoideum
Alias: plip, DDB_G0272835
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of plip.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | plip.AA | Subfamily.CDC14.PD | 73-188 | 24 | 1e-10 | 32.6 | In-house | 118-227 (258) | Show / Hide |
Range on Protein: 73-188 Range on HMM: 118-227/258 Sequence Identity: 24% (28 aa) LRGPFISQLDDNVYLGAMPmgSDVTLLFYKYKINSIVNLCDEYQGpTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQfILKQIelGNRVYIHCKAGRGR | || .. .. | | . | | ....|| | . ...|. |.. | . .| |. .|..| .. |. .. ..||||| || lagphnkskvedGytllaP--eklleyfrknnvttivrLnkklYd-akkftdaGfahlDlffiDGtvPsdailkkfle-iteka--eGaiavhCkaGLGr SGAIAICWIAYSRRVS |.. |.. . |.. tgtligcylikhyrft |
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| Phosphatase | plip.AA | Subfamily.PTPMT1.PD | 80-218 | 31 | 1.5e-52 | 168.3 | In-house | 1-145 (146) | Show / Hide |
Range on Protein: 80-218 Range on HMM: 1-145/146 Sequence Identity: 31% (46 aa) QLDDNVYLGAMPMGSDVTLLFYKYKINSIVNLCDEYQ-----GPTQHYTQYGMQQLYVPVVDHFE-PDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRS ..|..|.|||.|. |... |..|......|.|..||. ..|......|..||....||..| |..| .|....|| |....|..||.||||||.|| ridetvilGalPfrsltkeLvekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRs GAIAICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYYS .....|........| |.|.|.| .||...|.. . . ...... atlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke |
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| Phosphatase | plip.AA | Family.DSP.PD | 78-225 | 27 | 3.6e-28 | 89.9 | In-house | 107-252 (387) | Show / Hide |
Range on Protein: 78-225 Range on HMM: 107-252/387 Sequence Identity: 27% (41 aa) ISQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCdeyQGPTQHYTQYGMQQLYVPVVDHFEPDVEI-IEKSIQFILKQIELGNRVYIHCKAGRGRSGAI .|. ...||| . .. . | ..... ||||. ....|.. . |.. | .|. ||..|..|. .||.|.|| .. . ...|..|||||.|||| . pseilphlylgsllaaknlewl-kelgvtkivnlt---ddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtl AICWIAYSRRVSLEVAQKILLEKRK-IVRKQLYKQKNVNQYYSSYCLNSN |... .|....|| | . . .||. ... . |.. ....... |. iiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvss |
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| Phosphatase | plip.AA | Subfamily.DSP12.PD | 79-204 | 25 | 1.2e-17 | 55.2 | In-house | 3-126 (143) | Show / Hide |
Range on Protein: 79-204 Range on HMM: 3-126/143 Sequence Identity: 25% (32 aa) SQLDDNVYLGAMPMGSDvTLLFYKYKINSIVNLCDEYQgpTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIA |......||| ... . . | ..||.... . | . ... ...|.........|. | |. . ... ..|| . .| .. |..||.|| || .| seilpglylggleavqe-rellkelkithvlsvikeel--pelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiv ICWIAYSRRVSLEVAQKILLEKRKIVR | .. .....||| | |.. ||.| .. iAYlmkkeklslekAlklvkekkkeie |
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| Phosphatase | plip.AA | Subfamily.DSP8.PD | 80-218 | 27 | 1.9e-16 | 51.3 | In-house | 4-140 (143) | Show / Hide |
Range on Protein: 80-218 Range on HMM: 4-140/143 Sequence Identity: 27% (38 aa) QLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYqgPTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAI .. .|.|||. | .|| |. |. ..|. . | . . . | .|| |..| .. ....|...|| | . .| .|| ||.|| ..||. rilpnlylGsqkdsldeell-kklgisyvlnisesc--pkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvai CWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYYS .| ..||. | . . |||. . ..| . .|. ayimktlemsldeayrfvkekrptispnlnflgqLleyek |
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| Phosphatase | plip.AA | Subfamily.DSP1.PD | 83-205 | 29 | 7.8e-16 | 49.3 | In-house | 7-125 (139) | Show / Hide |
Range on Protein: 83-205 Range on HMM: 7-125/139 Sequence Identity: 29% (36 aa) DNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYQGPTQHYTQYgmqqLYVPVVDHFEPDVE-IIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWI | .|||. |. || . || ..|.. | . ... .| .|| |. . |. .|. |.|| . . | ||..||.|| ||.| . .. dfLyLGsaehasnlqlL-kelkitallnvsaelpnvfeelfky----ksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayL AYSRRVSLEVAQKILLEKRKIVRK ...|.|| | . . ..|.|. mkekkvrleeafefvkqrrsiisP |
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| Phosphatase | plip.AA | Subfamily.DSP19.PD | 78-204 | 22 | 3.4e-15 | 47.1 | In-house | 2-124 (139) | Show / Hide |
Range on Protein: 78-204 Range on HMM: 2-124/139 Sequence Identity: 22% (29 aa) ISQLDDNVYLGAMPMGSDVTLLFyKYKINSIVNLCDEYqgpTQHYTQyGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAI .... ...|||.. .| . | | || |.|. . ..... .. . ....|. | .. ........|| . . ..||..||.||. || .. vaevkprlylgsqdvaadkeilk-klkitHilnvavgv---pnvfpk-dftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasv AICWIAYSRRVSLEVAQKILLEKRKIVR .| .. ....||| | . . |.|. .. viaylmkdeelslekalekvrearpcik |
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| Phosphatase | plip.AA | Subfamily.DSP6.PD | 81-201 | 22 | 2.1e-13 | 41.1 | In-house | 5-123 (141) | Show / Hide |
Range on Protein: 81-201 Range on HMM: 5-123/141 Sequence Identity: 22% (27 aa) LDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYqgPTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAIC . ...|||. |.. .| |.||. ..|. .. | .. . .. . .|. ||.. .. . . ..|.|| . . . | .|| |||| ....... ilpllylGsakdasnlevl-kklkikyvlnvtsnl--pnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtla WIAYSRRVSLEVAQKILLEKRK .. .||. | ... .|. ylmkklalslndaydlvkkkks |
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| Phosphatase | plip.AA | Subfamily.PTEN.PD | 98-224 | 26 | 2.1e-13 | 41.2 | In-house | 33-162 (305) | Show / Hide |
Range on Protein: 98-224 Range on HMM: 33-162/305 Sequence Identity: 26% (34 aa) LLFYKYKIN-SIVNLCDEyqgPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIEL--GNRVYIHCKAGRGRSGAIAICWIAYSRRVSLE-VAQ || .|| . . .|. . ....... . .|. ||. | .|..|. .. . | .. | | .|||||.||.| . ... .|. . | .| llltvykgkgklrilnar---gekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadeal KILLEKRKIVRKQL--YKQKNVNQYYSSYCLNS ||| .| |. ||.|.. .| aiydekRtkdkkGVtiPSQrRYvqYfsklvkss |
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| Phosphatase | plip.AA | Subfamily.DSP10.PD | 96-205 | 25 | 3.7e-13 | 40.5 | In-house | 19-127 (141) | Show / Hide |
Range on Protein: 96-205 Range on HMM: 19-127/141 Sequence Identity: 25% (27 aa) VTLLFYKYKINSIVNLCDeyQGPTQHYTQYGMQQLYVPVVDHFEPDVE-IIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQK . .. .. |. ..|. . |.... . .. .|| | . ... |....|| . . |.|| .||.|| || ...| ....||. | |.. || dkdaldrlgikyvlnvtt--svPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseayk ILLEKRKIVRK | |. fvkekrPiisP |
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| Phosphatase | plip.AA | Subfamily.Laforin.PD | 121-203 | 34 | 1.2e-12 | 38.7 | In-house | 65-148 (165) | Show / Hide |
Range on Protein: 121-203 Range on HMM: 65-148/165 Sequence Identity: 34% (29 aa) HYTQYGMQQLYVPVVDH-FEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRKIV | . |. ...|. | | || . ... .. .| | .||.||.|| ||| || .. | || | || || .| lykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv |
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| Phosphatase | plip.AA | Subfamily.DSP14.PD | 78-205 | 21 | 3.2e-12 | 37.6 | In-house | 2-124 (138) | Show / Hide |
Range on Protein: 78-205 Range on HMM: 2-124/138 Sequence Identity: 21% (28 aa) ISQLDDNVYLGAMPMGSDvtLLFYKYKINSIVNLCDeyQGPTQHYTqyGMQQLYVPVVDHFEPDVEI-IEKSIQFILKQIELGNRVYIHCKAGRGRSGAI .|.. ...||... .. . | ||. |||. . |..... ..... ..| |. | .. .. . | . . | .. .||.||. || .. lseitesLylsgaaalkk--eklkkkkitlivnvtt--elpetkle--dvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAsl AICWIAYSRRVSLEVAQKILLEKRKIVRK .. .. ...||. | |.. ..| |.| vlaylmkyeklsLreayklvksaRpiirP |
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| Phosphatase | plip.AA | Subfamily.DSP3.PD | 84-204 | 24 | 4.2e-12 | 37.1 | In-house | 8-134 (148) | Show / Hide |
Range on Protein: 84-204 Range on HMM: 8-134/148 Sequence Identity: 24% (31 aa) NVYLGAMPMGSDVTLLfYKYKINSIVNLCDE-----YQGPTQHYTQYGMQQLYVPVVDHFEPDVEI-IEKSIQFILKQIEL-GNRVYIHCKAGRGRSGAI .||.| . .| . | | | ..| ... .. .. |.. ... | |.| | .| |.. |.. .|| . .. . .|..||..| || .. kvyvgdeavakdkekL-kklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatl AICWIAYSRRVSLEVAQKILLEKRKIVR .. .. .|...|. | | .||.|. vlayLmirrkltlkeaiktvrkkreilP |
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| Phosphatase | plip.AA | Subfamily.PTPDC1.PD | 130-201 | 26 | 8.7e-11 | 32.6 | In-house | 138-208 (229) | Show / Hide |
Range on Protein: 130-201 Range on HMM: 138-208/229 Sequence Identity: 26% (18 aa) LYVPVVDHFEPDVEIIEKSIQFILKQIeLGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRK .. |. . .| | .. . . . .. .|| ||.|| | . |.. |..|.. | | |.. .|| ynfglkDygvasleriLdivkvvdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrp |
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| Phosphatase | plip.AA | Subfamily.Slingshot.PD | 79-207 | 27 | 1.2e-10 | 32.3 | In-house | 3-127 (139) | Show / Hide |
Range on Protein: 79-207 Range on HMM: 3-127/139 Sequence Identity: 27% (35 aa) SQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYQGPTQHytqyGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIA |.. | .|||. |.. | . ... |.|.. | . .. .. | . | |. | |. . ... .|| | | | .| .||| | || .. skifdhlylGsewnasnleel-kengveyilnvtkeidnffpe----kfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastv ICWIAYSRRVSLEVAQKILLEKRKIVRKQL | . . ..||| | . . |.|.|.. iayamkeyelsleealeyvkerrsiikpnk |
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| Phosphatase | plip.AA | Subfamily.DSP23.PD | 105-201 | 19 | 1.2e-10 | 32.5 | In-house | 14-108 (128) | Show / Hide |
Range on Protein: 105-201 Range on HMM: 14-108/128 Sequence Identity: 19% (18 aa) INSIVNLCDEYQGPTQHYTQYGMQQLyvPVVDHFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRK | .|.| .| . ... . ..... . |. | .| ... .. . . . .. | .|| |.||.|.. |.. ..... . |. ..|| irvlvslttegapyseaapsltlrri--dipdfcPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrk |
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| Phosphatase | plip.AA | DSPc | 85-204 | 21 | 3.5e-10 | 37.33 | Pfam | 1-136 (151) | Show / Hide |
Range on Protein: 85-204 Range on HMM: 1-136/151 Sequence Identity: 21% (30 aa) VYLGAMPMGS-DVTLLFYKYKINSIVNLCDEYQGPTQHYTQYGMQQLYVP-VVD----------HFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGR .|||. | . | .| |..| ..|. .| . |. . . . .| | | | . . ......|| . .. | .|..||.|| | LYLGSYPHHMADPAFL-QKHGITHVINCTMECPNN-WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISR SGAIAICWIAYSRRVSLEVAQKIL-----LEKR-KIVR |....|... ..|..|.. | .. ..| ... SACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMIS |
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| Phosphatase | plip.AA | Subfamily.DSP15.PD | 84-217 | 22 | 1.8e-09 | 28.6 | In-house | 8-136 (138) | Show / Hide |
Range on Protein: 84-217 Range on HMM: 8-136/138 Sequence Identity: 22% (30 aa) NVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYQGPTQHytqygMQQLYVPVVDHFEPDVE-IIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIA .|.| . .| ..| ..|| |. . |. . .. .. | ... | . |. ..||.|| | |. |..|| || ||.... .| GlyvGnfrdakdkeql-eenkithilsihdsakplled-----ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayim YSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYY .| | | |.. | . . .. ..... tvtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | plip.AA | Subfamily.STYXL1.PD | 82-203 | 25 | 1.9e-09 | 28.8 | In-house | 7-127 (143) | Show / Hide |
Range on Protein: 82-203 Range on HMM: 7-127/143 Sequence Identity: 25% (30 aa) DDNVYLGAMPMGSDVtLLFYKYKINSIVNLCDEYQGpTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICW ...||| . . . . |. . ||.. . . .. .. . | ..| |. | |. | ... .||| | . |. | . . ||| |..|... | PgklylGnykqaqnp-aikkdlkvkahvnvssdaek-liagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiay IAYSRRVSLEVAQKILLEKRKIV |....|..| | | . .. | lmyskkitlkkaykylkkckenv |
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| Phosphatase | plip.AA | DSPc | 77-211 | 15 | 6e-08 | 32.54 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 77-211 Range on HMM: 1-172/172 Sequence Identity: 15% (27 aa) FISQLDDNVYLGAMPMGS-DVTLLFYKYKINSIVNLCDE--------------------YQGPTQHYTQYG-MQQ--------LYVPVVDHFEPDVEIIE .|. ..||| | . . .. |..| ..|. .| | .. ..| .. .. .......|. ...|. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH KSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKIL-----LEKR-KIVRKQ--------LYKQK .. . | .|..||.|| ||....|... ... |.. | .. ..| |.. .. .| DC-------RQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | plip.AA | Subfamily.PRL.PD | 100-205 | 21 | 6.6e-07 | 20.2 | In-house | 21-128 (140) | Show / Hide |
Range on Protein: 100-205 Range on HMM: 21-128/140 Sequence Identity: 21% (24 aa) FYKYKINSIVNLCDEyQGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIE--LGNRVYIHCKAGRGRSGAI-AICWIaySRRVSLEVAQKIL . |......| |. . ... . |.. | .. | | |.... .. . .. . .. | .|| || ||. . |.. | ..| | ... lkkenvkevvrvcep-sydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalali--eaGmkyedavefi LEKRK--IVRK |||. | .| rekrrgainsk |
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| Phosphatase | plip.AA | Subfamily.LRR-DSP.PD | 150-204 | 29 | 6.8e-07 | 20.1 | In-house | 69-122 (137) | Show / Hide |
Range on Protein: 150-204 Range on HMM: 69-122/137 Sequence Identity: 29% (16 aa) QFILKQIELGnRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRKIVR || . | | | |||.|| || ...|... ... .. | . .|| .. afidegrekg-gvlihcragvsrsatlviaylmkknslkfkealdlvikkrpriy |
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| Phosphatase | plip.AA | Subfamily.TPIP.PD | 147-187 | 36 | 2.8e-06 | 18.0 | In-house | 26-65 (245) | Show / Hide |
Range on Protein: 147-187 Range on HMM: 26-65/245 Sequence Identity: 36% (15 aa) KSIQFILKQiELGNRVYIHCKAGRGRSGAIAICWIAYSRRV | .. |.. .| | | |||| |.|| |.| ... .| . kevkewlak-dlenvvaihckGGkgrtGtivcalliaseif |
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| Phosphatase | plip.AA | Family.OCA.PD | 79-179 | 23 | 5.5e-06 | 17.1 | In-house | 8-112 (165) | Show / Hide |
Range on Protein: 79-179 Range on HMM: 8-112/165 Sequence Identity: 23% (25 aa) SQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEY--QGPT-QHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQI-ELGN-RVYIHCKAGRGRS | ....| . .|. | . |. .|. |..| | .. . .. .. .. | ......||| |.... .|| . . | |.|||. |. | stveeelyrssypnelnfsfl-ktLkLktiislspeelpqesllkfveeeniklihikvdkkkkdlveieeellkrvlkilldvdnypvlihcnkGkhrt GAIAIC | . | glvvgc |
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| Phosphatase | plip.AA | Subfamily.OCA.PD | 79-179 | 23 | 5.5e-06 | 17.1 | In-house | 8-112 (165) | Show / Hide |
Range on Protein: 79-179 Range on HMM: 8-112/165 Sequence Identity: 23% (25 aa) SQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEY--QGPT-QHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQI-ELGN-RVYIHCKAGRGRS | ....| . .|. | . |. .|. |..| | .. . .. .. .. | ......||| |.... .|| . . | |.|||. |. | stveeelyrssypnelnfsfl-ktLkLktiislspeelpqesllkfveeeniklihikvdkkkkdlveieeellkrvlkilldvdnypvlihcnkGkhrt GAIAIC | . | glvvgc |
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