• Phosphatome.Net

Gene DDB_G0288731

DDB_G0288731
Species: D.discoideum
Alias: DDB_G0288731
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTM_unclassified
Protein domain

Protein domains of DDB_G0288731.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PX DDB_G0288731.AA PX 118-305 12 2.6e-14 51.62 Pfam 1-120 (120) Show / Hide 
Range on Protein: 118-305
Range on HMM: 1-120/120
Sequence Identity: 12% (25 aa)

SQFSLHITSTETVV----QRKKSYTVYVIRVKSD---QHQWEVVRRYKHFRVFSIQINNEVFNSNSSSSTPSSTCPPSSSTSSLGSSNNNINNTNTTNNN
 .|. .........     ....|.|| | ....   .. |.| |||..|. .  |. ..                                        
DHFLQVHVVDPETHKHYGDKMHYYYVYEIHMNTNPFQKKEWHVWRRYSDFHWLHKQLKRHFP--------------------------------------

PNNNNANILSSSSSSSSSSSSSSSSSSSSSLNLSTQLSLTNSIQSFEFPSKKLIGN---MNPNFIKNRKEQLEKFLQLIASSQVAKL-SRNLKVFLDPN
                                          ..  ..|.|...|.   ....||. |...||..|| ...  .    .. .. || |.
-----------------------------------------MCIIPPLPPKHWFGRYNNFDEEFIEKRRQMLEQYLQRVCQHPELCNHCEVFHDFLHPD
PX DDB_G0288731.AA PX 122-305 11 1.2e-14 55.91 SMART 1-142 (142) Show / Hide 
Range on Protein: 122-305
Range on HMM: 1-142/142
Sequence Identity: 11% (24 aa)

LHITSTETVVQRK--------KSYTVYVIRVKSDQ----HQWEVVRRYKHFRVFSIQINNEVFNSNSSSSTPSSTCPPSSSTSSLGSSNNNINNTNTTNN
 ||    ||| ..        .....||....       ..| | |||..|. .  |.... .. .                                  
DHIFI-ITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEK----------------------------------

NPNNNNANILSSSSSSSSSSSSSSSSSSSSSLNLSTQLSLTNSIQSFEFPSKKLIGN------------------MNPNFIKNRKEQLEKFLQLIASSQV
                                         ....  ..|.|.....                  ....||  |...||..|| ...  .
-----------------------------------------RMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFNNFDEDFIEKRRRGLERYLQRLCHHPE

AKL----SRNLKVFLDPN
       .  .. |....
WINHYMVCEVVYEFFESS
PH DDB_G0288731.AA PH 316-483 14 3.2e-13 51.17 SMART 1-82 (82) Show / Hide 
Range on Protein: 316-483
Range on HMM: 1-82/82
Sequence Identity: 14% (24 aa)

PSKEGFLYLLKPQSKYSSLLNSKKQWIKVYCIATNSNLFYWKNREQPYAEARGVIQLCHCSTRIMTKQDKKCIQLNENSNNTSNSGDNSKYLLTNSKGHK
. |||.|| ..           | .| |.... .|. |.|.|..     . .|.| | .| |  . .    |...   ..                    
VIKEGWLYKKS-----------K-RWKKRWFVLFNDCLYYYKDK-----KPKGSIPLSDC-TVRE-P----CFEIHH-DR--------------------

SFSHKINPNDIYNNINNVNNNNNSANNNNNNNNNNNNVDSNEVYYLSADSDVILEQWVETIEKETFRY
                                          .||....|.  ...|.. |.| . ..
------------------------------------------TYYFQCESEEEMQEWMQAIQKAIHNN
Myotub-related DDB_G0288731.AA Myotub-related 839-958 46 1.1e-50 179.48 Pfam 1-121 (121) Show / Hide 
Range on Protein: 839-958
Range on HMM: 1-121/121
Sequence Identity: 46% (57 aa)

YQFSPTYPNLLIVPKRITDQELINTTSFRSKGRIPTLVWKSPNSNSVITRCSQPVIGVTKKRSLDDEKLIESILLANP---QSEKVYIMDARPQLNAVAN
| ..|||| .|.||| |.|.|| .  .|||.||.| |.|  ... .||.||||| .|.  .|. .||||...|. ||.   || |.||.|||| .||.||
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN

QMMGLGYEDTNNQSYNNCILKFL
...| |||.. .  |.|. . |.
RAKGGGYENEEH--YPNWEFVFM
PH DDB_G0288731.AA PH 316-481 13 5.8e-13 49.4 Pfam 1-92 (92) Show / Hide 
Range on Protein: 316-481
Range on HMM: 1-92/92
Sequence Identity: 13% (23 aa)

PSKEGFLYLLKPQSKYSSLLNSKKQWIKVYCIATNSNLFYWKNREQPYAEARGVIQLCHCSTRIMTKQ-DKKCIQLNENSNNTSNSGDNSKYLLTNSKGH
. |||.|....          ..|.| |.... .|..|.|.|..    .. .|.| | .|. .. ... .. |.|.   ..                   
VIKEGWLHKKG----------KRKSWKKRWFVLFNNCLYYYKDDK---YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR-------------------

KSFSHKINPNDIYNNINNVNNNNNSANNNNNNNNNNNNVDSNEVYYLSADSDVILEQWVETIEKETF
                                          ..||..|.|.  ...|.. |..   
------------------------------------------RTYYFQAESEEEMNDWMQAIQSACR
Phosphatase DDB_G0288731.AA Family.Myotubularin.PD 1023-1151 62 1.5e-61 194.8 In-house 14-141 (141) Show / Hide 
Range on Protein: 1023-1151
Range on HMM: 14-141/141
Sequence Identity: 62% (79 aa)

RDWLEHIKSILIGTLDIVDIIQFYKSSVVVHCSDGWDRTSQLCSLAQLLLDPYYRTVIGFQVLIEKEWCSFGHKFESRIGHTGKNeKKSDELSPIFLQFI
||||||..| ..  ||. ..  |.||.||||||||||.||.|||||||||||||. ||.|||||||.||||||..|.||. |.....| ||.||||||||
tkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdks-eseeersPvflqfi

DCVWQIMQQNPTSFQFNSKYLLEIIHHLY
.|...| ||.|.||...|..|..|||   
dcvyqltkqfptafefnesflikildhly
Phosphatase DDB_G0288731.AA Subfamily.MTMR1.PD 1018-1151 63 3.1e-61 194.1 In-house 19-149 (149) Show / Hide 
Range on Protein: 1018-1151
Range on HMM: 19-149/149
Sequence Identity: 63% (85 aa)

LEEStrDWLEHIKSILIGTLDIVDIIQFYKSSVVVHCSDGWDRTSQLCSLAQLLLDPYYRTVIGFQVLIEKEWCSFGHKFESRIGHTGKNEkKSDELSPI
|||.   ||||||.|| |.. |.| ..  |.|||||||||||||.|| ||| ||||.||||. ||.|||||||.||||||..||||  ||    .. ||.
leet--kwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknh-adadrspv

FLQFIDCVWQIMQQNPTSFQFNSKYLLEIIHHLY
||||||||||...| ||.|.|| ..|. |. |||
flqfidcvwqvtrqfptafefneeflitildhly
Phosphatase DDB_G0288731.AA Subfamily.C2-MTMR1.PD 1020-1149 54 1.5e-52 166.0 In-house 11-135 (137) Show / Hide 
Range on Protein: 1020-1149
Range on HMM: 11-135/137
Sequence Identity: 54% (66 aa)

ESTrDWLEHIKSILIGTLDIVDIIQFYKSSVVVHCSDGWDRTSQLCSLAQLLLDPYYRTVIGFQVLIEKEWCSFGHKFESRIGHTGKNekksDELSPIFL
||| .|| .||..| ..  |   ..    | .||||||||||||| .||||||||||||. |..||||||| .|||||. | |..| |||||||.||..|
est-qwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggadsv----serspifl

QFIDCVWQIMQQNPTSFQFNSKYLLEIIHH
. .| |..|......|| .  .        
qfldclyqvtkqfpsafeytarlllklady
Phosphatase DDB_G0288731.AA Subfamily.MTMR3.PD 1021-1151 48 5.6e-51 160.7 In-house 7-135 (135) Show / Hide 
Range on Protein: 1021-1151
Range on HMM: 7-135/135
Sequence Identity: 48% (63 aa)

STrDWLEHIKSILIGTLDIVDIIQFYKSSVVVHCSDGWDRTSQLCSLAQLLLDPYYRTVIGFQVLIEKEWCSFGHKFESRIGHTgKNEKKSDELSPIFLQ
.|  ||.|.  .|  .. .|. ..  .  |.||||||||||.|. .||.|||||||||. ||.||.|.|| .|||||  | ||. .. .. .| .|.|||
kt-kwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghg-edsddlnercpvflq

FIDCVWQIMQQNPTSFQFNSKYLLEIIHHLY
..|||.|. .| ||||.||. .|. ...| |
wldcvhqlkkqfptsfefneaflvklvqhty
Phosphatase DDB_G0288731.AA Subfamily.R_Nematode_3.PD 1035-1089 28 2.3e-08 22.0 In-house 186-229 (267) Show / Hide 
Range on Protein: 1035-1089
Range on HMM: 186-229/267
Sequence Identity: 28% (15 aa)

GTLDIVDIIQFYKSSVVVHCSDGWDRTSQLCSlaqllldpyyrTVIGFQVLIEKE
|....... .|..||||||||  |.  | .           . .|.| .|...  
ealelikfveksktpvvVHCsdGisRsatlaa-----------ielgyqliiksk
Phosphatase DDB_G0288731.AA PTPc_motif 951-1151 8 5.8e-07 28.22 SMART 1-92 (92) Show / Hide 
Range on Protein: 951-1151
Range on HMM: 1-92/92
Sequence Identity: 8% (17 aa)

NNCILKFLNIENI-----HKMRHSQKKLFKSIMSDSVIYGENNNNNINNNNSNNGSGGNGNNNNLNSINILNLEESTRDWLEHIKSILIGTLDIVDIIQF
    . ..|  .      ..  .|  ........                                                                  
TVHHYHYTNWPDHVEKDSGVPEDSILEFIRHVRK------------------------------------------------------------------

YKSSVVVHCSDGWDRTSQLCSLAQLLLDPYYRTVIGFQVLIEKEWCSFGHKFESRIGHTGKNEKKSDELSPIFLQFIDCVWQIMQQNPTSFQFNSKYLLE
   ..|||||.|..|| ..|..  .. .                                             . . ..|.....| | ..| .  |.  
---PIVVHCSAGCGRTGTFCAIDMMMQQ---------------------------------------------VDIFQTVKEMRKQRPGMVQTEEQYIFC

IIHHLY
.  .|.
YRCILE
Sequence
Name Sequence Type Origin Length Description Download
DDB_G0288731.AA Protein None 1227 None Fasta, JSON
DDB_G0288731.NA RNA None 3684 None Fasta, JSON