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Gene DDB_G0290005

DDB_G0290005
Species: D.discoideum
Alias: DDB_G0290005
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTM_unclassified
Protein domain

Protein domains of DDB_G0290005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Myotub-related DDB_G0290005.AA Myotub-related 383-510 30 3.7e-28 104.68 Pfam 1-121 (121) Show / Hide 
Range on Protein: 383-510
Range on HMM: 1-121/121
Sequence Identity: 30% (43 aa)

YELCSTYPQHFIIPFSISDYLLNKSSSHRNKNRFPVVTWRHKQTHATLSRSSQ-QTGKS--RCEEDELLIQAIRKSKTILPNNNNQQQQPQQQQQTLYII
||.|.|||. ...| ||||  | |... | ..||||..|||....|.. |.|| ..| .  || ||| |.|||.|.              . | . .||.
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANA-D----------MIQSRKMYIV

DI---------KSTSSSPTSSSSSHCEDISHYSQCQIESE
|          . ..        . .|. .||... .   
DARPYTNAMANRAKG--------GGYENEEHYPNWEFVFM
Phosphatase DDB_G0290005.AA Subfamily.MTMR1.PD 531-625 51 3.3e-31 96.3 In-house 9-103 (149) Show / Hide 
Range on Protein: 531-625
Range on HMM: 9-103/149
Sequence Identity: 51% (47 aa)

NWNEKKGWSEIQSTGWLDQLSKLLMVTKKILTHLHLEGFSCLIHCIDGWDRTCQLSSLVQLCADPYYRTIKGFIVLISKEWLSFGHKFMTRNGQS
. .|.|  |....| ||...  .|  . .|  ... |  | ..|| ||||||.||.||  |  |.||||||||.||| |||||||||| .||   
sideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighg
Phosphatase DDB_G0290005.AA Family.Myotubularin.PD 533-704 48 5.2e-65 205.7 In-house 2-140 (141) Show / Hide 
Range on Protein: 533-704
Range on HMM: 2-140/141
Sequence Identity: 48% (84 aa)

NEKKGW-SEIQSTGWLDQLSKLLMVTKKILTHLHLEGFSCLIHCIDGWDRTCQLSSLVQLCADPYYRTIKGFIVLISKEWLSFGHKFMTRNGQSISSTST
.|.| | ||..|| ||.....||....||..... |..|.|.||.||||||.||.||.||..|||||||.||.|||.||||||||||..|.|.. .|.|.
aeekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksese

TttnsssngqltssssntsissnattttttttsskQTSPVFLQFIDVVWQLTKQFPTSFEFSDSFLSVILHHL
.                                  ..|||||||||.|.||||||||.|||..|||..||.||
e----------------------------------ersPvflqfidcvyqltkqfptafefnesflikildhl
Phosphatase DDB_G0290005.AA Subfamily.C2-MTMR1.PD 538-630 50 3.6e-32 99.6 In-house 7-99 (137) Show / Hide 
Range on Protein: 538-630
Range on HMM: 7-99/137
Sequence Identity: 50% (46 aa)

WSEIQSTGWLDQLSKLLMVTKKILTHLHLEGFSCLIHCIDGWDRTCQLSSLVQLCADPYYRTIKGFIVLISKEWLSFGHKFMTRNGQSISSTS
.|...||.||  .. .|  .. |  ...  . |.|.|| |||||| || .| ||  |||||||.|.|||| ||||.|||||  | |..|..  
lsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggadsvse
Phosphatase DDB_G0290005.AA Subfamily.MTMR3.PD 539-627 49 1e-31 98.0 In-house 3-91 (135) Show / Hide 
Range on Protein: 539-627
Range on HMM: 3-91/135
Sequence Identity: 49% (43 aa)

SEIQSTGWLDQLSKLLMVTKKILTHLHLEGFSCLIHCIDGWDRTCQLSSLVQLCADPYYRTIKGFIVLISKEWLSFGHKFMTRNGQSIS
|....| ||..||.||  . |. . .. ||   |.|| |||||| |. .| .|. ||||||..|| ||. .|||.|||||  | |..  
salektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghged
Phosphatase DDB_G0290005.AA Subfamily.MTMR1.PD 663-704 63 5.8e-16 46.9 In-house 107-148 (149) Show / Hide 
Range on Protein: 663-704
Range on HMM: 107-148/149
Sequence Identity: 63% (26 aa)

TSSKQTSPVFLQFIDVVWQLTKQFPTSFEFSDSFLSVILHHL
. .. |||||||||.|||.|.||||.|||...|| .|| || 
hadadrspvflqfidcvwqvtrqfptafefneeflitildhl
Phosphatase DDB_G0290005.AA Subfamily.MTMR3.PD 664-703 55 5e-13 37.5 In-house 94-133 (135) Show / Hide 
Range on Protein: 664-703
Range on HMM: 94-133/135
Sequence Identity: 55% (21 aa)

SSKQTSPVFLQFIDVVWQLTKQFPTSFEFSDSFLSVILHH
.. .|||||..|.|.||.|||||||||...||  ...|  
dlnercpvflqwldcvhqlkkqfptsfefneaflvklvqh
Phosphatase DDB_G0290005.AA Subfamily.C2-MTMR1.PD 661-702 43 1e-12 36.6 In-house 93-134 (137) Show / Hide 
Range on Protein: 661-702
Range on HMM: 93-134/137
Sequence Identity: 43% (17 aa)

TTTSSKQTSPVFLQFIDVVWQLTKQFPTSFEFSDSFLSVILH
..|. . ||.||||.|...|.|||||..||..  .|  .   
gadsvserspiflqfldclyqvtkqfpsafeytarlllklad
SprA-related DDB_G0290005.AA SprA-related 756-1075 12 3.8e-08 30.18 Pfam 1-174 (321) Show / Hide 
Range on Protein: 756-1075
Range on HMM: 1-174/321
Sequence Identity: 12% (42 aa)

NE-TSSTTNLTATTSIPLTNSTTLDQQLQFKNNNDDGVLFPNPKGVQLWSDYFLKWRNPPKASRKSNTLIAHSLGVSYVNGDLIAFQKKKRSRRSKDGAS
.  |.|...... .. |.. . . ...                                                                         
MIITNSYPSISYYSGSPQGTEAARRNNT------------------------------------------------------------------------

GSSSGSSGSSSKHHHHHHHHHHHHHHRKSTDEKDSKEKSSKSSRSRTSSSSKRKSLSTSSNSITQPDIKINETITTTTTTPTNTTTLTNTSTTPRNTTTL
                                                                                      .  ... |..... 
--------------------------------------------------------------------------------------PRENIPQPSSSENS

T--------NASTTPTTTTTTTTTTTPTKDETINESVQVNNDKLKSPSGDDIKQEQDEMNQFTSQHPNN----QMESSSEINQQNEQSQLEQ-----QQE
.        ... |.  |.| .....  |..  .   | .  |.....  .  |. .| .. .||.  .    | ..  . .|...|.. ..     ||.
NNFPNSSSDATA-TS-QTSTAVANDQS-KQSEDGST-QPQFAKIFGQAQTQNGQASQEQQPQASQQNDEDKQEQERDEVGQEQPEQQQAQAGFENATQQS

QQQQQEQQLQHEQQQIEQQQLQKQQQQQEQQEQQELEQ
||.||. | |  ||| .|||.|.|||||.||.||...|
QQRQQQDQ-QTRQQQ-AQQQEQQQQQQQQQQQQQQVQQ
Sequence
Name Sequence Type Origin Length Description Download
DDB_G0290005.AA Protein None 1324 None Fasta, JSON
DDB_G0290005.NA RNA None 3975 None Fasta, JSON
DDB_G0290005.AA.PD_522-705 Protein Phosphatase Domain None 184 None Fasta, JSON