Gene pats1
pats1
Species: D.discoideum
Alias: DDB_G0269250, pats1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of pats1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Myotub-related | pats1.AA | Myotub-related | 869-1107 | 12 | 1e-07 | 31.69 | Pfam | 2-121 (121) | Show / Hide |
Range on Protein: 869-1107
Range on HMM: 2-121/121
Sequence Identity: 12% (34 aa)
KLCEHYPPTSVVPKSVSDNIVVTSAYYRSYG-FPVLAWSHPTQKSSITRAT----------SPED---------QNNGSSNYLLTPNSPNSSSSNLANNN
..|. ||.. |||||.|| .. .| .|| | |||| | |. ...|.|. . || .|
EICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANA-D---------------------
NSNNNNINNNNNNNNNNNNNNNNNSNNNNNNNNNNNNNNNNNNNNNGGGSGSRSTTIDNGQTSILNKNISNTPLIQSPTPNLPPSQHSLNLLMSPQTSSP
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RIHQSISSSSIPQVCQEDIDFLRGILDIKSSSMLNVFDT----------GSGGSYSSTMIGCQIEFLNL
.| | |. ..|. ||.| .. ..|| ..
--------------------------MIQSRKMY-IVDARPYTNAMANRAKGGGYENEEHYPNWEFVFM
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| Phosphatase | pats1.AA | Family.Myotubularin.PD | 1131-1262 | 48 | 2.2e-41 | 129.1 | In-house | 6-141 (141) | Show / Hide |
Range on Protein: 1131-1262 Range on HMM: 6-141/141 Sequence Identity: 48% (67 aa) EW-SETIRFFWLDPLKPILSAAINIAMHVDQG-RSVLIQnSSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHHK---TSDDGF .| || ||. .| .|.||..|. .|.. .|||. | | | ||.||||.||||||||..||.|||||||||.|. |..|. |. .|.. kwlselestkWlehiklllkaavkivekvekektsvlvh-csdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseeer SPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVY ||.|.||| |.|. | |||.|.||| .|...||..| sPvflqfidcvyqltkqfptafefnesflikildhly |
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| Small_GTPase | pats1.AA | ROC | 1720-1902 | 34 | 1.1e-82 | 275.93 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 1720-1902
Range on HMM: 1-215/215
Sequence Identity: 34% (78 aa)
CYKMKLMIVGQENVGKTTLLKTLKEKKKKATPS-----GPNISTDGIA-IDQWVFSCLFEELDETSQNGRLIKKKQDITLSIWDFAGQEIYYTTHQFFLS
|. ||||..||..||||.|.|.|. |...... | . .|.|| |.|||. | .... .||...|....|||.|||||. ||||||.
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMF---------RKKEDEIKFNVWDFGGQEIYHATHQFFLT
E-RSVYIVAWNCAL-----AEE----ESR--VEFWLQSITTRAKD--------APIIIVGTHLDDVNRTT-----AKMQKKRMKEKYLIRYQNI------
. ||||.. |.|.. ..| |.. .|.||..|..|... .|.||||||.| |.|. .|... ||..|. ...||
NHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCC-RMWQKLRNKFPNICHSWMQ
----KAIKLVSCTSG-KGITSLREK
... |.|..| ||| .||..
IEHYQGFFHVDCETGCKGIDKLRHH
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| Phosphatase | pats1.AA | Subfamily.MTMR1.PD | 1131-1262 | 46 | 2.1e-39 | 123.0 | In-house | 14-149 (149) | Show / Hide |
Range on Protein: 1131-1262 Range on HMM: 14-149/149 Sequence Identity: 46% (62 aa) EWSETI-RFFWLDPLKPILSAAINIAMHVDQGRSVLIQNSSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHH---KTSDDGFS .| ... ||. .| ||. |..|| .|.. .. .. | | | ||.||| .|||.||||. ||.|||||||||.|. |..| |. .|. ||.| kwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhadadrs PIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVY .||| |||. ..||| |.|||..|.|.||..| pvflqfidcvwqvtrqfptafefneeflitildhly |
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| Phosphatase | pats1.AA | Subfamily.C2-MTMR1.PD | 1138-1261 | 47 | 8.6e-38 | 117.8 | In-house | 13-136 (137) | Show / Hide |
Range on Protein: 1138-1261 Range on HMM: 13-136/137 Sequence Identity: 47% (56 aa) FFWLDPLKPILSAAINIAMHVDQ-GRSVLIQnSSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHHKTSDDGFSPIFMQFIFLV || .| .|.|| || .|.. . | |.. | | | || .|||.||||||||.||..||||||||..|. | .| . .|||||.||. ..|. |. tqwlayikavlkaaraiarkveklavsalvh-csdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggadsvserspiflqfldcl WQIWKEFPTHFQFNEYYLLTLLDNV ||. |... .|| | | . yqvtkqfpsafeytarlllkladys |
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| Phosphatase | pats1.AA | Subfamily.MTMR3.PD | 1139-1262 | 46 | 5e-35 | 108.7 | In-house | 9-135 (135) | Show / Hide |
Range on Protein: 1139-1262 Range on HMM: 9-135/135 Sequence Identity: 46% (57 aa) FWLDPLKPILSAAINIAMHVDQ-GRSVLIqNSSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHHKTSDD---GFSPIFMQFIF ||. | .| ||.... ||. || ||. | | | |. .||..||||||||..|||||.|.|||..|. |. || |.. |.|.|.|.. .|.|. kwlqhlsvllkaavkvvnavdkegrpvlv-hcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercpvflqwld LVWQIWKEFPTHFQFNEYYLLTLLDNVY |.||| |.||| .|. |.. | cvhqlkkqfptsfefneaflvklvqhty |
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| Kinase | pats1.AA | LRRK | 2247-2513 | 39 | 1.9e-157 | 529.35 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 2247-2513 Range on HMM: 1-351/351 Sequence Identity: 39% (139 aa) LMIEELIGEGGAA-LVYRARWQG----------------------------QTVAVKKLKTI----------------------ENLDSPIEINDISLSK |.|||.||.|| . .||||.|.| |.||.||.... |.... ...|...... LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR AFNEFRRECWVMSELEHPNIVQLKGLCLDPLCIVTEYLPHGNLYSFLHKPE-ME-------FSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILL ||.|||.|.|.||.|.|||||.|||.|..|||.|.||.|||.||.|||... .. .|| ..||.||.|..||..|||..||||||||||||||| AFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL ASINEN-------AQTIAKVVDFGLSG----LQHTITNRGVENPLWLAPEILNKT--KEASTQTDVYAFGVILWELVTRK-DYFGEIG------FMTLIE |...| |...||..|||.|. ........ |.||.|.||||.... .| ....|.|.||.|||||.||. ..|.|. .|..|| WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE EKVINGERPKIPED-CPE-----MYSKLIVECWQTDASQRPKFSEIEDRLIK .|.|.| ||.||.. ||. ||..||..|||.| .||.||.| .|| DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| COR | pats1.AA | COR | 1903-2227 | 25 | 2.3e-126 | 412.0 | In-house | 1-434 (434) | Show / Hide |
Range on Protein: 1903-2227 Range on HMM: 1-434/434 Sequence Identity: 25% (112 aa) LEALVQSQSN-------MGESLPRSYMLLENLVKEETK----KRIIPTIPWTEFIQMGTICT----------ITDEAELLRATMFLHQLGSLVYFP---K . . .... . |....|.|...... ..|..| .. |...|.||.|. . |.||.||....|.||.||....| . IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH EPGLKQFVILDPQWITTMLSSIITTKHSY-----AKDGI-LNHKSLKQIWRPP----------QYPTHLHPHLISLLEKFEISYNLSPDSTSF---ETGT .|.||.||.|||||...|...|.. |.|. .. || ..|. |..||.|| .||.|.|..|..|.||||..|...||.|.| ||.| DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTT SLIPSLLLNDRPAIF-PSLWGS---FNQLVRQFGRIYQF------EFVPNGFFSRLMVRILNFARVEAKC----------YWKNGMILQHDEE---TIFL .|||.|| .|||.. .. | . ... |...|.|.. | |.||..|..||...|. ..|| ||.||| |.. .. .... YLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRNGMVLKWEGHNKNEALV EMNNAKKSLSFTVRGGAN-----STTLSRDVIETIQSLLDDS---FQLP-------TYVFVPCFHCIFLSLP-QCY--YFPLDVCENAAVKGTGYLKCLT ...|.......||||. . .. | . ....||...... .|. .....|| |||. .. .|. |. .| |..|...|. ...| . KCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPK YD------------------------ANV-RTDL .| ... | . CDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD |
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| Small_GTPase | pats1.AA | Miro | 1724-1857 | 16 | 3.2e-11 | 42.26 | Pfam | 1-140 (140) | Show / Hide |
Range on Protein: 1724-1857 Range on HMM: 1-140/140 Sequence Identity: 16% (26 aa) KLMIVGQENVGKTTLLKTLK--EKK--------KKATPSGPNISTDGIAIDQWVFSCLFEELDETSQNGRLIKKKQDIT----------LSIWDFAGQEI |....| . .||..... . |. .| .|. .. ......| .. ..... ..|||..|.|. KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPR--EMHGHTYYVD------------------TMQVDWDTQSENVDRVKMCYFHIWDCGGREY YYTTHQFF--LSERSVYIVAWNCALAE--EE-SRVEFWLQSITTRAKD-APIIIVGTHLD . .|..| . ....... | | .. |.. ||... ..| |.|.||...| WKFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD |
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| Kinase | pats1.AA | TKL | 2253-2511 | 30 | 1.2e-105 | 357.29 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 2253-2511 Range on HMM: 1-364/364 Sequence Identity: 30% (114 aa) IGEGGAALVYRARWQG----------QTVAVKKLKTIENLDSPIEIND-------------ISLSKAFNEFRRECW-VMSELEHPNIVQLKG-------- ||.|| . ||...|.| ..|||||.|. .. . . ... .. |..|..| . .|| | ||||||..| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -LCLDP------LCIVTEYLPHGNLYSFLHKPEMEFSWLFRLKVALDISSGMAFLHSST------PPIIHRDLKSPNILLASI---------NENAQTIA |..| ||||.|| |.|.|...|| | |.. ||||..||..|||.. ||||||||||.|||. . |.||. . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KVVDFGLSG----------------------LQHTITNRGVENPLWLAPEILNKT---------------KEASTQTDVYAFGVILWELVTRKDYFGEIG |. ||||| .... |.. . .| |.|||.|... .|.|...|||.||..|||..||. . ... KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP FMTLI---------EEKVINGERPKIP------------EDCPEMYSKLIVECWQTDASQRPKFSEIEDRL .|. | . . .|.|| || .|||. ..||. .||..|...|| |.|| .|| YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | pats1.AA | TKL-Unique | 2249-2511 | 35 | 1.6e-81 | 277.15 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2249-2511 Range on HMM: 1-290/290 Sequence Identity: 35% (107 aa) IEELIGEGGAALVYRARWQGQTVAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSELE-HPNIVQLKGLCL----DPL--CIVTEYLPHGNLYSF . ..|||||.. ||.. | | ||.|... ... |.... ||..| .|. |. |||||.. | | .| |||.||.|.|.||. FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQ---------EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDV LH---------KPEMEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLSGLQHTI---TNRG---------VENP || ......... |.| |.||..|| .||.. ||||||||||.|.|. . . |. .|..||||| .. .| ||.. . .. LHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSF LWLAPEILNKT-KEASTQTDVYAFGVILWELVTRKD------YFGEIGFMTLIEEKVI--NGERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIEDRL .|.|||.|. . |.. |||.||..|||..||| . .. . ..| . . ||.||..||. |..|| .|| | |||| |.|| || RWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | pats1.AA | Dicty4 | 2247-2513 | 36 | 1.2e-70 | 234.86 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 2247-2513 Range on HMM: 1-277/277 Sequence Identity: 36% (106 aa) LMIEELIGEGGAALVYRARWQGQTVAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSELEHPNIVQLKGLCL----DP--LCIVTEYLPHGNLYS . ||..||.|. . ||...| |. ||||||. |. . .. ||||.| |. . ||||....| |. | .||||||.| ||||| INIEQRIGKGSFGEVYKGTWRGKEVAVKKLN---------NHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYS FLHK------PEMEFSWLFRLK---VALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLSG-----LQHTI-TNRGVENPLWLAP ||. .. . .| ... |.|. ||. ||...| |||||||| |.| . .| . .|| ||||| .|. . . |.| || LLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL---VDKNWR--VKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAP EILNKTK--EASTQTDVYAFGVILWELVTRKDYFG-EIGFMTLIEEKVIN-GERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIEDR--LIK |.. . |.. ||| || .|||..||.. . .. . . | | ..||.|| .|| ...||..|| .| ..|| |.|| | | EVMMHQPYNEKA---DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | pats1.AA | MLK | 2247-2511 | 32 | 7.4e-69 | 235.08 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 2247-2511 Range on HMM: 1-291/291 Sequence Identity: 32% (97 aa) LMIEELIGEGGAALVYRARWQGQT-----VAVKKLK-TIENLDSPIEINDISLS-KAFNEFRRECWVMSELEHPN----IVQLKGLCLDP---LCIVTEY . ..| ||.|. |...||.... ||||. . .| . |.| . .|..|| . | ||| |.|..| ||.| .|||.|| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARI--------F-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEY LPHGNLYSFLHKPE-------------MEFSWLFRLKVALDISSGMAFLHSSTP-PIIHRDLKSPNILLAS--INENAQTIAKVVDFGLSG-LQHT---I ...| ||..|| . . . .. ||....||..||| | |||||||||.|||.. . .....|. |||.| .... CEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNM TN-RGVENPLWLAPEIL--NKTKEASTQTDVYAFGVILWELVTRKDYFG-EIGFMTLIEEKVINGERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIE .. .| .. | |||.. . | ||. .||.|||..||. . .. |. . . . ||.|| || .||| .||. .||..|...||.|..| MSNAG--TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIV DRL | QHL |
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| Kinase | pats1.AA | DRK | 2247-2513 | 39 | 1.3e-66 | 224.62 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 2247-2513 Range on HMM: 1-258/258 Sequence Identity: 39% (110 aa) LMIEELIGEGGAALVYRARWQGQTVAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSELEHPNIVQLKGLCLDP--LCIVTEYLPHGNLYSFLHK | || |. . |.| | | ||||.|. | ||| . |||.|| .|. | ||||.| | |. | ||..||.| | ||. || IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLF-NHN------INDENF---LNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHD PEMEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLSG-----LQHTITNRGVENPLWLAPEILNKTKEAST-QT . .| .| ... ..|. || .||...| |||||||| | | . |. | || ||||| .||. . . | | |||.| . | ESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLL---VDEHWQ--VKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVL--RNQRYTEKA DVYAFGVILWELVTRKD-YFGEIGFMTLIEEKVIN-GERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIEDRLIK ||| |...|||.|||.| ||| | . | |.|| .|. || | .|. .|| .| ..|| . |. || DVYSFAIVLWECVTRQDPYFGMPTFQVVFS--VGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | pats1.AA | TyrKc | 2247-2511 | 30 | 1.4e-59 | 205.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2247-2511 Range on HMM: 1-280/280 Sequence Identity: 30% (94 aa) LMIEELIGEGGAALVYRARWQGQTVAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSEL--EHPNIVQLKGLCL---------DPLCIVTEYLPH . .. .||| ||...| ..||||.|| .|.|| .|..| .|||||.| | |. .||.||.|| || ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH GNLYSFLHKPEMEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLSGLQHTI--------TNR-----GVE--NP |.| ..|.|.. .... |. ...|..||..||| ..||||| |.|... . ..|. ||||| . . | | | GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP L-WLAPEILNKTKEASTQTDVYAFGVILWELVTR--KDYFGEIG-FMTLIE--EKVINGERPKIPED--------CPEMYSKLIVECWQTDASQRPKFSE . |.||| . .... .|..||..||| .||. |. . | |.| .|. .| |.| .|.|...|.. ||. ... .||. |...|| ||| IRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE IEDRL | ... IHECF |
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| Kinase | pats1.AA | Pkinase_Tyr | 2247-2511 | 30 | 3e-59 | 201.31 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 2247-2511 Range on HMM: 1-270/270 Sequence Identity: 30% (90 aa) LMIEELIGEGGAALVYRARWQ------GQTVAVKKLKTIENLDSPIEINDISLSKA--FNEFRRECWVMSEL-EHPNIVQLKGLCL---DP--LCIVTEY . . . .||| ||...| ...||||.|| . . ... .| || .|..| |||||.| | |. .| ..||.|| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK------------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEY LPHGNLYSFLHKP---EMEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLSGLQ-----H-TITNRGVENPLWL |||.|...|.|. . .. |. ...|..||..|.| .||||| |.|... . ..|. ||||. . . . | |. MPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM APEILNKTKEASTQTDVYAFGVILWELVT--RKD-YFGEIGFMTLIEEKV-INGERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIEDRL ||| .| | .|..||..||| .||..| .. | | . . |.. .|.| ..||.||. .|. .||. |...|| |||| .| APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE--VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | pats1.AA | TK | 2247-2511 | 18 | 3.6e-58 | 193.27 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 2247-2511
Range on HMM: 1-486/486
Sequence Identity: 18% (91 aa)
LMIEELIGEGGAA---LVYRARWQG---------------------------QTVAVKKLKTIENLDSPIEINDISLSKAFNEFR-------RECWVMSE
. ... .||| ||...|.| ..|||| || . .. .. .. | .|. .|.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD------RDGGEDFLEEAEEMKM
LE-----HPNIVQLKGLCLDP--------------LCIVTEYLPHGN----LYSFLHKPEME--------------------------------------
. |||||.| | |... ..||.|| |||. | ..|.| .
MCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC
-------------------------------------FSWLFRLKVALDISSGMAFLHSSTP----PIIHRDLKSPNILLASINE------NAQTIAKVV
.. .| ...|..||..||| ..|||| |.|... | . . ..|.
PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
DFGLSG-----LQHTITN--------------------------------RGVENPLWLAPEILNK--------TKEASTQTDVYAFGVILWELVT--RK
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DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQE
DYFGEIGF--------MTLIEEKVING--------------ERPKIPEDCP--------------EMYSKLIVECWQTDASQRPKFSEIEDRL
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PYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | pats1.AA | Dicty4-Unclassified | 2247-2511 | 30 | 2.9e-50 | 170.33 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 2247-2511 Range on HMM: 1-263/263 Sequence Identity: 30% (87 aa) LMIEELIGEGGAALVYRARWQGQTVAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSELEHPNIVQLKGLCLDP------LCIVTEYLPHGNLYS . | ||.| . |.. | | |||||. || .. | .|..| .. . ||| |...| |. | .|||.| .. ||| IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFN--ENKFKFRE-------EMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFE FLH------KPEMEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLS-GLQHTITNRGVE-NPLWLAPEILNKTK | . . .|.|.|| ||..||. .||||.|| |||. . .|. |||.| . . . | | .||.| VIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFN-----IKIADFGISRVIDFNFNMTTIAGTPKWESPECL--MH EASTQ-TDVYAFGVILWELVTRKDYFGEIG-FMTLIEEKVINGERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIEDRL |. .| ||| ....|.||.| . || | . . |||||. |. ..|||. || | || . .| ..| ESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | pats1.AA | Gdt | 2247-2511 | 28 | 1.7e-46 | 157.24 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 2247-2511 Range on HMM: 1-289/289 Sequence Identity: 28% (86 aa) LMIEELIGEGGAALVYRARWQGQTVAVKKLKTIENLDSPIEIND--ISLSKAFNEFRRECWVMSELEHPNIVQLKG--LCLDPLCIVTEYLPHGNLYSFL . ..|....| ||.. | .. ||||..| .. .. |... |. || .| . |.||| . | .. .|||||| | | | . IDFKEYCSQGTFGMVYKGIWRSSQVAVKMFK--------HHYVNYTKTYSQSCDEIYREMDILSKIKHQNIVSFIGCVHFSSHHCIVTEYCPRGSLGYYI HKPE----------------------------MEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFG----LSGLQH |. | .. ..||. | .|||.. |||||||. |||. |.|||. ||. ||| . .. HQKKNQKKSNTNTITNTITNTNTNTNTSTSTSIKMSMIQKIRIMIDIAKGCQFLHQNG--IIHRDLKPDNILIFSTNENSEVCAKICDFGTSKEINEFHC TITNRGVENPLWLAPEILNKTKEASTQTDVYAFGVILWELVTRKDYFGEIGFMTLIEEKVINGERPKIPEDCPEM--YSKLIVECWQTDASQRPKFSEIE ||.| . . .||. . . ||||.||. . |. . | || | ..|. |.|| | ...| || . ..|| |.|| KNTNCG--TMNYMSNEIFEGENYQ-KSTDVYSFGILFYEMMIERIPFHEI-CHWEIPNFVQDGWRPTLDQDIFDDNDIRNIIECCWNKNPHKRPTFDEIS DRL . | KHL |
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| Kinase | pats1.AA | S_TKc | 2247-2518 | 25 | 1.8e-43 | 151.67 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2247-2518 Range on HMM: 1-231/231 Sequence Identity: 25% (72 aa) LMIEELIGEGGAALVYRARWQG--QTVAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSELEHPNIVQLKGLCL-DPLCIVTEYLPH--GNLYSF | ..||.|. . ||..|. . . ||.|..| . .||| .... |||||.|.. . | |..|.||... |.|... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDY LHKPEME-----FSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLSGLQHTITNRGVENPLWLAPEILNKTKEAST ..| . |. ... | ......|| ||||||| |||| . |. ||||. . . . | ..|||.| .. IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGK -QTDVYAFGVILWELVTRKDYFGEIGFMTLIEEKVINGERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIED--RLIKIAEAM |....|.||.|..... | | .. .|. ||. . .| |.| | ..|| |. ..||. . . CKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | pats1.AA | Pkinase | 2247-2502 | 23 | 1.6e-38 | 137.32 | Pfam | 1-282 (293) | Show / Hide |
Range on Protein: 2247-2502 Range on HMM: 1-282/293 Sequence Identity: 23% (70 aa) LMIEELIGEGGAALVYRARWQGQT--VAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSELEHPNIVQLKGLCL--DPLCIVTEYLPHG----NL . |.. ||.|. . ||.....| ||||..| . .| ..... | .|. .| .| |||||.|.. . | ...|.||...| | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL--------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL YSFLH-KPEMEF--SWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASINENAQTIAKVVDFGLS----GLQHTITNRGVENPLWLAPEILNKT ..... . . | |. .... | .|....|| |||||||. |||. | . .. |. ||||. . .. . | ..|||.... FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG KEASTQTDVYAFGVILWELVTRKDYFGEI----GFMTLIEEKVINGERPKIPEDCP-----------------------EMYSKLIVECWQTDASQRP .. .. |....|.||.|..... | . . .. . ... . .|....|.| | ..| |.. | ..|| QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQM-QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP |
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| Kinase | pats1.AA | TKL-ciliate2 | 2247-2381 | 40 | 8.2e-34 | 109.84 | In-house | 1-126 (273) | Show / Hide |
Range on Protein: 2247-2381 Range on HMM: 1-126/273 Sequence Identity: 40% (56 aa) LMIEELIGEGGAALVYRARWQGQTVAVKKLKTIENLDSPIEINDISLSKAFNEFRRECWVMSELEHPNIVQLKGLCLDP--LCIVTEYLPHGNLYSFLHK | |.. | ||| ..|.|.| .||||| | . . | .| || | | ||||| | | . ||. || .| |.| | LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIR-----------DFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQN PEMEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLK .. .| | ..|||| |. .|||| ||||||||| QDVRLTWEDRRRIALDIARGVHYLHSSNPPIIHRDLK |
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| Kinase | pats1.AA | TKL-ciliate2 | 2422-2512 | 31 | 8.5e-16 | 48.66 | In-house | 184-273 (273) | Show / Hide |
Range on Protein: 2422-2512 Range on HMM: 184-273/273 Sequence Identity: 31% (29 aa) WLAPEILNKTKEASTQTDVYAFGVILWELVTRKDYFGEIGFMTLIEEKVINGERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIEDRLI |.|||.. |. . ||.....||||. | . .. |. . | || || .|| .. |. ||. . || | || | WMAPEVI-KAFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE |
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| WD40 | pats1.AA | WD40 | 2901-2937 | 20 | 1.5e-07 | 24.35 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 2901-2937 Range on HMM: 1-39/39 Sequence Identity: 20% (8 aa) LRVVQMTKAHERAIHAMIQVDD---HVWTASSDGTIKVWS ... . .|. .. .. ..| .. ..| ||||..|. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | pats1.AA | WD40 | 2940-2977 | 29 | 1e-06 | 21.71 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 2940-2977 Range on HMM: 1-39/39 Sequence Identity: 29% (12 aa) CQSVHTIENAHSSRIFTLELVGD---FVWSGSWDTTIKIWS .. .||. .|.. . . . | .. |||.| ||.||. WKCKHTF--GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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