Gene roco9
roco9
Species: D.discoideum
Alias: roco9, DDB_G0288183
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of roco9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| RhoGAP | roco9.AA | RhoGAP | 256-540 | 12 | 1.2e-07 | 17.12 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 256-540
Range on HMM: 1-193/193
Sequence Identity: 12% (40 aa)
LSIPILLEKSISFLEGHCHVEDLFFRKY-NNEKVKFMRNSFERTGDFN-----------FYYPDPQDPYDVAALLVEFIASLPDQLLNVELYNAIKNHTS
|||...| |...| |. . .|| |. ... .||.|.| .| . | . .|..||| .| .. .||. |. ||| . . .
SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK
A-------------LNSQYGGYWDIQYLAQKLSVESREFLQRLLFFLKKHVSACLFKQQQQQQQQRESTEVLTLSLSSSTSTLEPEPQPLPLSTSTQRLP
.. . .. | ..|. . |. |..|. .|..
CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVA-------------------------------------------------
QQSSDDNSNNDNNNKNDNDNDNDNDNNNDNNNINNDNGEIIPPSIQVTPPTSPQTQPKQQQPPQPPQ-KTLIEKLSELFTPLFVNYKTHSAFYSSTSTLI
. .. | .. |. |.|.. . . .. .
--------------------------------------------------------------EHSDVNKMNAHNLAICFGPTLFWPP-----MMDMRHQN
TSCEDIFVHID
. .| . .| |
KCVEFLIEHYD
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| Phosphatase | roco9.AA | Family.Myotubularin.PD | 1169-1386 | 38 | 7.1e-34 | 104.8 | In-house | 8-139 (141) | Show / Hide |
Range on Protein: 1169-1386
Range on HMM: 8-139/141
Sequence Identity: 38% (51 aa)
WKSIEESKWVDSVKLLLEGCVKVSNLLDEGSSVLLKPPIDSPLHTldlASISSLTMVLSDPFYRTLDGFLILIEKEWIQYGFPFNNINYHKEQNNLNNnn
....|..||.. .||||...||. . ... .. .| .| | | ..||...| ||.|||..|| .||||||...| |.. . |..... ..||
lselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrt---aqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksesee--
gnkensssssssssststtpsitkkssgsiskgssgiaslindldkydsnfvlpdtihtesqkkktylfqdqyessilvnrSFSPIFVQFLDAVWQLQRQ
.|.||.|.|.||..||| .||||||.|. ....
---------------------------------------------------------------------------------ersPvflqfidcvyqltkq
FPFHFEFNESLLLLLVKE
fptafefnesflikildh
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| RhoGAP | roco9.AA | RhoGAP | 259-379 | 23 | 5e-06 | 21.83 | Pfam | 1-123 (156) | Show / Hide |
Range on Protein: 259-379 Range on HMM: 1-123/156 Sequence Identity: 23% (29 aa) PILLEKSISFLEGHC-HVEDLFFRKYNNEKVKFMRNSFERTGDFNFYYPDPQDPYDVAALLVEFIASLPDQLLNVELYNAIKNH--TSALNSQYGGYWDI |. ..| |...| |. ..| .. . | ..| .|. |.| | . .. .|..||| .| ... .||. |. |||.. ... . PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFI-EAMAAKIEDEEERIEAM QYLAQKLSVESREFLQRLLFFLKK . | .|| . .. |..|...|.. RELIRKLPPPNYDTLRYLMRHLHR |
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| Phosphatase | roco9.AA | Subfamily.MTMR1.PD | 1169-1265 | 34 | 3.5e-19 | 57.3 | In-house | 16-109 (149) | Show / Hide |
Range on Protein: 1169-1265 Range on HMM: 16-109/149 Sequence Identity: 34% (32 aa) WKSIEESKWVDSVKLLLEGCVKVSNLLDEGSSVLLKPPIDSPLHTldlASISSLTMVLSDPFYRTLDGFLILIEKEWIQYGFPFNNINYHKEQNNLN ...||.||.. .||.|.|.|.... ... .. .. | | | ..||.|.| |..|||. || .||||||. .| |..| ..| . lsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrt---aqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhad |
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| Phosphatase | roco9.AA | Subfamily.MTMR3.PD | 1171-1265 | 34 | 1.2e-15 | 45.9 | In-house | 4-95 (135) | Show / Hide |
Range on Protein: 1171-1265 Range on HMM: 4-95/135 Sequence Identity: 34% (32 aa) SIEESKWVDSVKLLLEGCVKVSNLLDEGSSVLLKPPIDSPLHTldlASISSLTMVLSDPFYRTLDGFLILIEKEWIQYGFPFNNINYHKEQNNLN ..|..||.. . ||. .|||.| .|. . .| | | . | .|. .| ||.||||.|| .|.|.||...| | . |.|... alektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrt---pqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddl |
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| Phosphatase | roco9.AA | Subfamily.C2-MTMR1.PD | 1170-1258 | 30 | 4.6e-13 | 37.7 | In-house | 8-93 (137) | Show / Hide |
Range on Protein: 1170-1258 Range on HMM: 8-93/137 Sequence Identity: 30% (26 aa) KSIEESKWVDSVKLLLEGCVKVSNLLDE-GSSVLLKpPIDSPLHTLDLAsisSLTMVLSDPFYRTLDGFLILIEKEWIQYGFPFNNINYH .|...|. .| .|... .. ... . | |.. | | .|. .|. .| ||.|||.||. .||||||. .| |... sqlestqwlayikavlkaaraiarkveklavsalvh-csdgwdrtsqlv---llaqllldpyyrtidglivliekewlafghkfderlgg |
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| Phosphatase | roco9.AA | Subfamily.MTMR1.PD | 1351-1386 | 54 | 1.2e-12 | 36.1 | In-house | 112-147 (149) | Show / Hide |
Range on Protein: 1351-1386 Range on HMM: 112-147/149 Sequence Identity: 54% (19 aa) FSPIFVQFLDAVWQLQRQFPFHFEFNESLLLLLVKE ||.|.||.|.|||..|||| |||||..|. .. . rspvflqfidcvwqvtrqfptafefneeflitildh |
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| Phosphatase | roco9.AA | Subfamily.MTMR3.PD | 1352-1387 | 52 | 1.1e-10 | 30.0 | In-house | 99-134 (135) | Show / Hide |
Range on Protein: 1352-1387 Range on HMM: 99-134/135 Sequence Identity: 52% (19 aa) SPIFVQFLDAVWQLQRQFPFHFEFNESLLLLLVKES .|.|.|.||.|.||..||| |||||. |. ||. . cpvflqwldcvhqlkkqfptsfefneaflvklvqht |
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| Phosphatase | roco9.AA | Subfamily.C2-MTMR1.PD | 1350-1384 | 56 | 1.2e-10 | 29.9 | In-house | 99-133 (137) | Show / Hide |
Range on Protein: 1350-1384 Range on HMM: 99-133/137 Sequence Identity: 56% (18 aa) SFSPIFVQFLDAVWQLQRQFPFHFEFNESLLLLLV ||||.|||| ..|...||| ||.. ||| | erspiflqfldclyqvtkqfpsafeytarlllkla |
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| COR | roco9.AA | COR | 2410-2657 | 12 | 1.9e-09 | 26.45 | In-house | 316-502 (434) | Show / Hide |
Range on Protein: 2410-2657
Range on HMM: 316-502/434
Sequence Identity: 12% (37 aa)
IKNVFLNFKP-------FGTKVSSSQKLFEKHIKTL--------QTPFISKKELFSIGEMCK-----------LDKIETKNTCELLTELGLLFWSE---D
| .. ...| .. | | .... .. . |..|.||.. | ... .|. | . .| .|| ... . .
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH
----HDWVILDPIWLSNTLNLLLTLKQSSSAPSTPPQIPLNSTNLNNTSIPSQITTTSTNSSSTSTSTSTSTSTSTSTSTSTSTSTPLQTPTSLVSLSNI
.| |.||| |.. . ... | | . .
DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHK-------------------------------------------------------------------
SLSTISIPIQPNTSSILLDSSMNDSFNKESSGSNKVANPTIRKRDI-ILMSNLEGIWND------------IPTRLYPYLLTLAKKFNIAYQID
. .. | . . || |||. |. ...||. | .||...|.||
----------------------------------------LHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPID
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| Kinase | roco9.AA | MLK | 3002-3262 | 29 | 1.9e-47 | 162.68 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 3002-3262 Range on HMM: 1-291/291 Sequence Identity: 29% (89 aa) IDFKEVELDPNPIGEGGTATVYKGKWRQSD-----VAIKLLKTDVVGSDFSKV---FAEYRREIFCLSSFIHDN----ILDLKGFCLEP---LAIITEFQ |.|.|. ||.|. |.||.|| | ||.| ... | |. . ..|. |. . | | | ..| ||.| ..|..|. IQFHEW------IGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF--DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYC SGGNLYDYIHDLKN-------------PLDWQLRIKIAKGIAASLQTLHDSRP-SVVHRDLKSPNILLSS--KDSLTMECHLCDFSLSGFSTTV-ANRSV .|| ||...|. .. | .. ...|. .| .. || | ..||||||.|||.. .| . . ||| .| . .. .|. EGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMS Q--NPVWLAPEVI---NNELCSDKSDVYAYGVILFELLSRTRFFS-NITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKL . .. | ||||| .| .| |.||. .||.| |.|.| .. . | . . .| || .|| . .|...|| ||| |||| .| ..| NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | roco9.AA | LRRK | 3004-3264 | 30 | 2.1e-132 | 446.16 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 3004-3264 Range on HMM: 1-351/351 Sequence Identity: 30% (108 aa) FKEVELDPNPIGEGGTA-TVYKGKWRQ----------------------------SDVAIKLLKTD-----------------------------VVGSD .|. |. ||.||.. .||..|||. ..|||| ...| ....| LKIEEQ----IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHED FSKVFAEYRREIFCLSSFIHDNILDLKGFCLEPLAIITEFQSGGNLYDYIHDLK-NP-------LDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPN ....| |.|.|....|.. |.||..|||||..||....|... |.||...|. | .. ..|.|..||| || .. ||...|...|||||||| CCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN ILL-SSK-DS------LTMECHLCDFSLSG----FSTTVANRSVQNPVWLAPEVIN---NELCSDKSDVYAYGVILFELLSRT-RFFSNIT------FMS ||| ||. .. .. ....||..|. | ..||...|.||.|.|||... .| ...|.|.|..|.||.|||.|. ..| ... .|. ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME EVEGLITEGVRPSLPSH-NLP-----EYDSLLNICWAQDPTCRPSFIEITKKLEE ..| .|.|| ||..|.| ..| .|..|.. ||..||..||.|..|.|.|.. QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | roco9.AA | TKL | 3014-3262 | 25 | 6e-86 | 291.85 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 3014-3262 Range on HMM: 1-364/364 Sequence Identity: 25% (94 aa) IGEGGTATVYKGKWRQ----------SDVAIKLLKTDVVGS----------------------DFSKVFAEYRREIFCLSSFIHDNILDLKG-------- ||.|| ..|||||||. |||.| .|.. . . . |. . . ..|| ..|.. |.||. ..| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -FCLEP------LAIITEFQSGGNLYDYIHDLKNPLDWQLRIKIAKGIAASLQTLHDSR------PSVVHRDLKSPNILLSSKDS----------LTMEC .|..| |.|..|. .||.|..|.| |..|...|..|| .. || .. | ..||||||.|||. .. . | CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC HLCDFSLSGFSTTV----------------------ANRSVQNPVWLAPEVINNE----------------LCSDKSDVYAYGVILFELLSRTRFFSNIT .||| || | .. .. . .| |.||||.... | |.|||..|..|.|.|.| | .... KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP FMSEV---------EGLITEGVRPSLP------------SHNLPEYDSLLNICWAQDPTCRPSFIEITKKL .|... .. . .| || .| .. .|.. .|. ||..||. |||| ||.|.| YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | roco9.AA | TKL-Unique | 3010-3262 | 32 | 7.6e-70 | 238.36 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 3010-3262
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)
DPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFS-KVFAEYRREIFCLSSFI-HDNILDLKGFCL----EPL--AIITEFQSGGNLYDYIH-----
. | ||||| ..|||||||...|||| .. . .|.| .. | ..|. .. . |.||. . |.| | |..|. .||.|||..|
FWNKIGEGGYGQVYKGKWRGYPVAIKQFH--P-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN
----DLKNPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSK-DSLTMECHLCDFSLSGFSTTV----ANRS--------VQNPVWLAPEV
...|..|.|.|.|. || . .|| . | . ||||||.|.|.... . . .|||.|| |... .|.. . .. |.||||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV
INN--ELCSDKSDVYAYGVILFELLSRTR------FFSNITFMSEVEGLIT--EGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKL
... .. | |||||..|..| |...|.. ...... . | . . |. || .|.| .|| |.. ||..||. ||||.|| ..|
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
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| Kinase | roco9.AA | TK | 3021-3262 | 15 | 5.2e-40 | 131.31 | In-house | 17-486 (486) | Show / Hide |
Range on Protein: 3021-3262
Range on HMM: 17-486/486
Sequence Identity: 15% (74 aa)
TVYKGKWRQ---------------------------SDVAIKLLK--TDVVGSDFSK-VFAEYR-------REIFCLSSFI-----HDNILDLKGFCL--
.||||.||. .||.| || .. .| .. . | .| .. . |.||. | | |.
EVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQG
------------EPLAIITEFQSGGN----LYDYIHDLKNP-----------------------------------------------------------
||. |..|. ..|. | || .. ...
EPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTK
----------------LDWQLRIKIAKGIAASLQTLHDSRP----SVVHRDLKSPNILLSSKDSLT-------MECHLCDFSLS--------------GF
|. . .. .. ||. .. ||. . .||||| |.|..... . . | ..|| || .
DLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDD
STTVANRSV--------------------QNPV---WLAPEVINNEL---------CSDKSDVYAYGVILFELLS--RTRFFSNITF--------MSEVE
... .... . . |.|||..| .. ||||...|| ..|... .. . ... . ||
YYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVM
GLITEG--------------VRPSLPSHNL--------------PEYDSLLNICWAQDPTCRPSFIEITKKL
....| |. | | .||. |. ||. || ||.| .. ..|
EYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | roco9.AA | DRK | 3012-3264 | 31 | 4.6e-39 | 129.96 | In-house | 5-258 (258) | Show / Hide |
Range on Protein: 3012-3264 Range on HMM: 5-258/258 Sequence Identity: 31% (82 aa) NPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCLEP--LAIITEFQSGGNLYDYIHDLKNPLDWQLRIK | || |. . |. | || . ||.| |. . . . . | .||| .. | || | |..| |..|. . | || || . .|| |... NRIGRGNYGEVFRGTWRGTQVAVKMLFNHNI--NDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQ IAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSG-----FSTTVANRSVQNPVWLAPEVINNELCSDKSDVYAYGVILFELLSR .. .| . || . | ..|||||| | | || || . . | . | | |||| |. | ||| ....| |.. | MMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEH----WQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR TRFFSNITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKLEE . . . | .| || | | | |.| || ||. |||. |. . || QDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | roco9.AA | Dicty4-Unclassified | 3007-3262 | 28 | 1.7e-37 | 125.98 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 3007-3262 Range on HMM: 1-263/263 Sequence Identity: 28% (77 aa) VELDPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSK--VFAEYRREIFCLSSFIHDNILDLKGFCLEP------LAIITEFQSGGNLYDYIH-- . | ||.| . |.|| |. |||.| . ... . ....|. | | | | . ..| |. | . |..|| ||| || IQID-QFIGKGHFSKVHKGNWKGKDVAVKKFNE---NKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSK --DLKNPLDWQL--RIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLS-GFSTTVANRSVQ-NPVWLAPEVINNELCSDKSD . . |. ||.| || .| || .| ..|||.|| |||. || .| . . . | | .||. | ||| PSEQQQPIKLDDTLIIKYAFDIAQGMQHLH-TR-NFIHRDIKSSNILMDKH----FNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSD VYAYGVILFELLSRTRFFSNIT-FMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKL || |...|.||. . | | . || .|. . . .| || || ||.. .|...| VYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | roco9.AA | S_TKc | 3008-3268 | 23 | 3.6e-34 | 120.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 3008-3268
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)
ELDPNPIGEGGTATVYKGKWRQ--SDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCL-EPLAIITEFQSG--GNLYDYIHDLKNP-
..||.|. ..|||.... |||| .| |||| .|.. |.|| |.... . | ...|. .| |.|.|||.. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSGFSTTVANRSVQNPVWLAPEVINNELCSD-KSDVYAYGV
.. .... |. |. .|. ..||||| ||||.. . .||| |. . . . | ..||||. . |.|... |.
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC
ILFELLSRTRFFSNITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITK---KLEEIELI
||.|.|.. |. . .. . .. || .... |. ||. ||. |. . . . .
ILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | roco9.AA | Pkinase | 3013-3262 | 21 | 3.7e-33 | 118.33 | Pfam | 6-293 (293) | Show / Hide |
Range on Protein: 3013-3262 Range on HMM: 6-293/293 Sequence Identity: 21% (64 aa) PIGEGGTATVYKGKWRQSD--VAIKLLKTDVVGSDFSKVFAEYRR--EIFCLSSFIHDNILDLKGFCLEP--LAIITEFQSGG----NLYDYIH-DLKNP .||.|. ..|||.... . ||.| .| . .. |.. . || || . .. |.||. |.... .. . ...|. || |.|||. . ... KIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGC L--DWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLS----GFSTTVANRSVQNPVWLAPEVIN-NELCSDKSDVYAY . ... ..... |. |. .|. . ...|||||. |||..... . ..||| |. . . .. . | ..|||||. .. . |.|.... FYFSEWECKFYMYQILRGLEYCHS-M-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVILFELLSRTRFFSNI------TFMSEVEGLITEGVRPSLPSHNL-------------------PEYDSLLNICWAQDPTCRPSFIEITKK--L |.||.|.|.. |.. . | .. .. . | . .| .... |...||..||.. .| . . GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | roco9.AA | TyrKc | 3007-3262 | 26 | 3.2e-32 | 114.29 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 3007-3262 Range on HMM: 1-280/280 Sequence Identity: 26% (77 aa) VELDPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSF--IHDNILDLKGFCL---------EPLAIITEFQSGGNLYDYI ..|. .||| .||||.|. .||.| || | .. .||. .... |.||. | | |. ||| |..|. ..|.| ||. ITLG-KKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL HDLKNPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSGFSTTV--------ANR-----SVQ--NPV-WLAPEV .. .. | .. .... ||. . ||. ..|||| |.|.... . .|| || . . | . |. |.|||. RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC INNELCSDKSDVYAYGVILFELLSRTRFFSNI-----TFMSEVEGLITEGVRPSLPSH--------NLPEYDSLLNICWAQDPTCRPSFIEITKKL || .. ||||...|| ..|.... .|| .. .| |. | . .| .. ||. || .||.| || ... INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | roco9.AA | Dicty4 | 3014-3139 | 33 | 7.1e-30 | 96.96 | In-house | 7-146 (277) | Show / Hide |
Range on Protein: 3014-3139 Range on HMM: 7-146/277 Sequence Identity: 33% (48 aa) IGEGGTATVYKGKWRQSDVAIKLL---KTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCL----EP--LAIITEFQSGGNLYDYIHD------L ||.|. ..||||.||...||.|.| .... ... | |.|. ... | ||. ..| |. .| . | ||. . |||| .|| IGKGSFGEVYKGTWRGKEVAVKKLNNHNQNF----DENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ KNPLDWQLRIK---IAKGIAASLQTLHDSRPSVVHRDLKSPNIL . .||| |... .|. .| .. || . | ..|||||| |.| SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL |
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| Kinase | roco9.AA | Pkinase_Tyr | 3007-3204 | 26 | 2e-27 | 93.5 | Pfam | 100-309 (270) | Show / Hide |
Range on Protein: 3007-3204 Range on HMM: 100-309/270 Sequence Identity: 26% (58 aa) VELDPNPIGEGGTATVYKGKWR------QSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSF-IHDNILDLKGFCL---EP--LAIITEFQSGGNLYDY .... .||| .||||.|. . .||.| || . .. .. ||. .... |.||. | | |. || . |..|. .|.|.|| ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY IHDL---KNPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSGFS-----T-TVANRSVQNPVWLAPEVINNELC .. |.||. . .... ||. .. |.. . .|||| |.|... .. . ||| |. ... . |.|||.||. . LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKF SDKSDVYAYGVILFELLSR . ||||...|| ..|.... TTKSDVWSFGVLMWEIFTY |
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| Kinase | roco9.AA | LISK | 3013-3155 | 33 | 8.2e-26 | 80.68 | In-house | 86-234 (296) | Show / Hide |
Range on Protein: 3013-3155 Range on HMM: 86-234/296 Sequence Identity: 33% (52 aa) PIGEGGTATVYKGKWR--QSDVAIKLLKT---DVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCLE---PLAIITEFQSGGNLYDYIHDLKN---P ||.|. . |||| .| ...||| ... |. .. | . ||. . .. | ||. | | . | |.||. .||.| .|..| . | EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFM---LREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIP LDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDF | |..|.|||..|| .. ||. ..|||||| |.|.. .|. . .||| LPWPQRVKIALDIACGMSYLHSM--NIIHRDLKSKNCLVRENDNNQWRIKVCDF |
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| Kinase | roco9.AA | Dicty4 | 3172-3264 | 35 | 2.7e-24 | 78.05 | In-house | 181-277 (277) | Show / Hide |
Range on Protein: 3172-3264 Range on HMM: 181-277/277 Sequence Identity: 35% (34 aa) PVWLAPEVINNELCSDKSDVYAYGVILFELLSRTRFFS--NITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKK--LEE | | |||| .. |.||| .| .|.|.| | .. . .| |.. .. ||..|. .| . .|.. || ||. |||| ||... ||. PCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | roco9.AA | TKL-ciliate2 | 3174-3263 | 36 | 2e-20 | 64.38 | In-house | 184-273 (273) | Show / Hide |
Range on Protein: 3174-3263 Range on HMM: 184-273/273 Sequence Identity: 36% (33 aa) WLAPEVINNELCSDKSDVYAYGVILFELLSRTRFFSNITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKLE |.||||| . .| ||..|..||.|. || . |. | . . .||..| |.. |. || .. |||| || |.|| WMAPEVIKAFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE |
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| Kinase | roco9.AA | TKL-ciliate2 | 3007-3134 | 33 | 1.1e-15 | 48.33 | In-house | 1-126 (273) | Show / Hide |
Range on Protein: 3007-3134 Range on HMM: 1-126/273 Sequence Identity: 33% (44 aa) VELDPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCLEP--LAIITEFQSGGNLYDYIHDLKNPLDW .|.. | | ||| .|| ||| ||.| | | | . .. | . | || | | . .|| |. | |. . . .| | LEIQ-NKITEGGYGIIYKAKWREIVVAVKKFKMDH---DNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTW QLRIKIAKGIAASLQTLHDSRPSVVHRDLK | .|| || || |.| ..||||| EDRRRIALDIARGVHYLHSSNPPIIHRDLK |
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| Kinase | roco9.AA | LISK | 3171-3204 | 32 | 1.3e-07 | 20.57 | In-house | 202-235 (296) | Show / Hide |
Range on Protein: 3171-3204 Range on HMM: 202-235/296 Sequence Identity: 32% (11 aa) NPVWLAPEVINNELCSDKSDVYAYGVILFELLSR .| | |||... . ....||. .|..| |. | TPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITR |
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