Gene DDB_G0271690
DDB_G0271690
Species: D.discoideum
Alias: DDB_G0271690
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DDB_G0271690.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DDB_G0271690.AA | Subfamily.FCP1.PD | 134-285 | 45 | 9.2e-61 | 193.5 | In-house | 1-149 (150) | Show / Hide |
Range on Protein: 134-285 Range on HMM: 1-149/150 Sequence Identity: 45% (71 aa) KKLSLVLDLDHTVIHAVTEQGFnSSPEwrnkdKNKNGIHTITV-NGPMNYCIKKRPHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDPESSIFKERI .|| ||.|||.|.||..... . ...| .....|...|. . ...|..|.||.| .||....|.|||||||||||.||..|||..|||...|.||| rklvLvvDlDqtlihttkdpti-evke-----eklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFseri LSRDD--GNGINFKSLQRLFPCDDSMVLIVDDRSDVWKKSKNLIQISPYVYFTDV ||||. . ..|.|..|||..||||.|.|||.|||....|||...||..|..| lsrdellnassktkklkklfptgdsmvviiDDredvWnfaenlikvkpykfFkgv |
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| Phosphatase | DDB_G0271690.AA | CPDc | 134-286 | 33 | 1.1e-48 | 169.0 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 134-286 Range on HMM: 1-173/173 Sequence Identity: 33% (58 aa) KKLSLVLDLDHTVIHA-------VTEQGFNSSPEWRNK----DKNKNGIH----TITVNGPMNYCIKKRPHLVKFLTEVNKIYELHIYTMGTRNYANEIA ||..|||||||| .|. . . .| .||... .|.. | . . |. . .|||||. ||....| ||.|..|||.|.|| ... KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWF-HMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVL KLIDPESSIFKERILSRDDGNGINFKS----LQRLFPC-DDSMVLIVDDRSDVWKKSK-NLIQISPYVYFTDVV ...||. | |.|.||. . |. . .|... |.|||.|.||..|.|.. . |.|.|.|. || . DMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | DDB_G0271690.AA | Family.FCP.PD | 134-280 | 35 | 1e-40 | 128.3 | In-house | 1-139 (164) | Show / Hide |
Range on Protein: 134-280 Range on HMM: 1-139/164 Sequence Identity: 35% (53 aa) KKLSLVLDLDHTVIHAvteqgfnsspEWRNKdKNKNGIHTITVNG-PMNYCIKKRPHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDPESSIFKERI ||. ||||||.|..| |...| .... ........ ......|||||| .||..|...||..|.|..||.||...|...|||...||.|. kkklLVlDLdetLvhs----------elkpk-nkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrl LsRDD---GNGINFKSLQRLfPCDDSMVLIVDDRSDVWKKSK-NLIQISPYV | ||. .| . |.|..| ..|.|.|.|.||..|..| . |.|..... l-rdecvlvkgnyvkdLskl-grdlskviiiDdspdsyklnpdnaikvksfk |
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| Phosphatase | DDB_G0271690.AA | NIF | 136-282 | 27 | 2.4e-29 | 108.39 | Pfam | 1-153 (189) | Show / Hide |
Range on Protein: 136-282 Range on HMM: 1-153/189 Sequence Identity: 27% (47 aa) LSLVLDLDHTVIHAVTEQGFNSSPEWRNKDKNKNGIHTITV-----NGPMNYCIKK-RPHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDPE-SSIF . ||||||.| .|.. |.|. .. | ..| ...... ..| ||.. || ...|.||..|.|.....||... . |||. .| KTLVLDLDETLVHCN--------PWWEPPN-----WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYF -KERIL---SRD----DGNG----INFKSLQRLFPCD-D-SMVLIVDDRSDVWKK-SKNLIQISPYVYF . ..| .|. || . .| | .|... | | |.|||.....| |.|.|.|| .. DGHHRLICWYREHCWLYRNGGNYYV-KKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPY-WY |
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| Phosphatase | DDB_G0271690.AA | Group.HAD.PD | 136-286 | 22 | 7.3e-23 | 70.6 | In-house | 2-167 (190) | Show / Hide |
Range on Protein: 136-286 Range on HMM: 2-167/190 Sequence Identity: 22% (39 aa) LSLVLDLDHTVIhavTEQGFNSSPEWRNKDKNKNGIHTitVNGPMNYCIKKR------------PHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDP .||||||.... . ... .| |.|.. .. . .... ..|| ||| .||. | ..|||...|.|||.||......|.. dtlvlDldgvlw---lhgspepleglrskgkvlifltn--natksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdv ESSIFKERILSRDDG----NGINFKSL--QRLFPCDDSM-VLIVDDRSDVWK---KSKNLIQISPYvyFTDVV .|. |.| .. .| .. . ... | . | |.|....|.. . .| . | .. ..|. gdeafsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdf--iddil |
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| Phosphatase | DDB_G0271690.AA | Subfamily.DULLARD.PD | 135-288 | 27 | 2.5e-21 | 65.0 | In-house | 2-153 (172) | Show / Hide |
Range on Protein: 135-288 Range on HMM: 2-153/172 Sequence Identity: 27% (42 aa) KLSLVLDLDHTVIHAVTEQGFNSspEWRNKDKNKNGIHTITVNGPMNYCIKKRPHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDPESSIFKERILS . ||||||.|.||. ... .| . ... ... .. .. . |... . ||||. ||. | | |.| |.| ....||.... .|. .|.|.| rktlvldldetlihsahdsvtks--tvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyr RDD--GNGINFKSLQRLFPcDDSMVLIVDDRSDVWK-KSKNLIQISPYvyFTDVVDS . .| |.| . . | | |.|.|. . .. . .| |.|. . ..| | qhCtlesgkytkdlslvse-dlssviilDnspvayrknpdnaipiksw--isdpsdt |
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| Phosphatase | DDB_G0271690.AA | Subfamily.HSPC129.PD | 135-267 | 25 | 2.5e-14 | 42.3 | In-house | 2-125 (164) | Show / Hide |
Range on Protein: 135-267 Range on HMM: 2-125/164 Sequence Identity: 25% (34 aa) KLSLVLDLDHTVIHAVTEQGFNSSPEWRNKDKNKngIhtitvngpMNYCIKKRPHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDPESSIFKERILs . ||||||| |..|. .. ... ... . ..| . .. .. ||.| .|| | |..|. ..| .. ||... .|.||| .. |. efslvldldetlvhcslakledatlsfkveyqdk--t--------yqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlf- RDDGNGIN---FKSLQrLFPCDDSMVLIVDDRSDVW |. .. | |. .. | | .|||. . . rehcvcvdgnyikdls-ilGrdlsktiivdnspqaf |
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| Phosphatase | DDB_G0271690.AA | Subfamily.SCP.PD | 135-299 | 26 | 1.4e-13 | 39.8 | In-house | 2-155 (163) | Show / Hide |
Range on Protein: 135-299 Range on HMM: 2-155/163 Sequence Identity: 26% (44 aa) KLSLVLDLDHTVIHAVTEQgfnsspeWrnkdKNKNGIHTITVNGPM-NYCIKKRPHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDPESsIFKERIL | .|||||| |..|. ... .| . . .. ..| . . ..|||.. .||..| ...|. ..| .||...|.|.|.....| |. kkclvldldetlvhssfkp-------v----enadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkkn-vikarlf sRDD---GNGINFKSLQRLFpCDDSMVLIVDDRSDVWK-KSKNLIQISpyVYFTDVVDSLHHEKQPLLQQ |. .| | | || | . |.|||. . ...| . .. .| | |. .. |||.. -rescvfhkgnyvkdlsrlG-rdlkkvvivdnspasyifhpdnavpve--swfddeedtelldllpllee |
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| BRCT | DDB_G0271690.AA | BRCT | 430-509 | 19 | 4.4e-12 | 47.17 | Pfam | 1-84 (84) | Show / Hide |
Range on Protein: 430-509 Range on HMM: 1-84/84 Sequence Identity: 19% (17 aa) VKKDILKGTYIVFSGVYPLGTPIQKQPLRWLAEEFGSVVQNDINNETTHVI--AQRK---GTSK-VNKALSKGLKVISPQWLIEST . ...|| ... | .. . . . .. ..|..| |..... .||||| ... .|.| ..||.........|.|.... H-EKPFKGCTFCITGGFDNMNRDEIH-WQEMIEKHGGKVTDSVSKQTTHVIPWVGEPHCTRTKKFYWKAKEWNIPIVHPDWIWDCI |
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| Phosphatase | DDB_G0271690.AA | Subfamily.TIM50.PD | 181-279 | 26 | 4.1e-10 | 28.8 | In-house | 23-122 (150) | Show / Hide |
Range on Protein: 181-279 Range on HMM: 23-122/150 Sequence Identity: 26% (27 aa) NYCIKKRPHLVKFLTEVNKIYELHIYTMGTRNYANEIAKLIDPESSIFKEriLSRDD---GNGINFKSLQRLFpCDDSMVLIVDDR-SDVWKKSKNLIQI . |||| . .|| |. . .|. ..| . .| .. .||.. | . | || .| . | |. | | | |..|| . |.. .| ..... GwrfkkrPgvdafleelaelfeivvftseqgltaaplidkldPkqlimyr--lfrdatkyvdGehvkdlskln-rdlskvivvdldkesvklqpenalal SPY . kkw |
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| BRCT | DDB_G0271690.AA | BRCT | 432-512 | 19 | 2.1e-09 | 38.49 | SMART | 1-93 (93) | Show / Hide |
Range on Protein: 432-512 Range on HMM: 1-93/93 Sequence Identity: 19% (19 aa) KDILKGTYIVFSGVYPL---GTPIQKQPLRWLAEEFGSVVQND-----INNETTHVIAQRKGTSKVN----------KALSKGLKVISPQWLIESTRIW ...|| ....| .. . .. |....|..| | . . ..|||||. . ...|. ||.. |.....|.|.... . | MKPFKGCTFCITG-DDIEGNFD-M-RDELKEMIEMHGGKVT-SVSRKRC-PDTTHVIC-SPENPKYETWNRMMTKYMKAIAWGIWIVHPDWIWDCIKKW |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB_G0271690.AA | Protein | None | 782 | None | Fasta, JSON |
| DDB_G0271690.NA | RNA | None | 2349 | None | Fasta, JSON |
| DDB_G0271690.AA.PD_134-286 | Protein Phosphatase Domain | None | 153 | None | Fasta, JSON |