Gene DDB_G0288707
DDB_G0288707
Species: D.discoideum
Alias: DDB_G0288707
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DDB_G0288707.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DDB_G0288707.AA | Subfamily.FCP1.PD | 573-736 | 37 | 1.8e-55 | 176.3 | In-house | 1-149 (150) | Show / Hide |
Range on Protein: 573-736 Range on HMM: 1-149/150 Sequence Identity: 37% (61 aa) PKMYLIVDIDHTLLHSTKDPNAESYYLKDNSINKFTITETNETFYVKQRPNAIEFLSSLSSQFKIYLYSFHPKYYVEQLALILDPNRSIFT-KVITKEvi .|..|.||.|.||.|.||||..|... |...|.|||..|..|..|||.|||..|||..||.......|......|.||.| ||||....|....... rklvLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrd-- epvEPLPPINSIGKPYIVFNNQNfskifnfeaiNQMIILDDREDVWrNFQDNLILLDTFKFFNTN |.|.......|....|.... ....|.||||||| ||..||| ....|||... ---ellnassktkklkklfptgd----------smvviiDDredvW-nfaenlikvkpykfFkgv |
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| Phosphatase | DDB_G0288707.AA | Family.FCP.PD | 574-731 | 28 | 5e-33 | 103.3 | In-house | 2-139 (164) | Show / Hide |
Range on Protein: 574-731 Range on HMM: 2-139/164 Sequence Identity: 28% (45 aa) KMYLIVDIDHTLLHSTKDPNAESYYLKdnsinKFTITETNETFYVKQRPNAIEFLSSLSSQFKIYLYSFHPKYYVEQLALILDPNRSIFTKVITKEVIEP |..|..|.|.||.||...|.... . . |..|.|..||.|||.||.. |||...|....|...... . |....| ||||....|.| ..... | kklLVlDLdetLvhselkpknkpdfvv-----kveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdecvl VEPlPPINsigkpyivfnnqNFSKIfnFEAINQMIILDDREDVWRNFQDNLILLDTFK . .. . ||. . ...||.||..|......||.| ...|| vkg-nyvk------------dLskl--grdlskviiiDdspdsyklnpdnaikvksfk |
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| Phosphatase | DDB_G0288707.AA | CPDc | 573-737 | 19 | 1.4e-16 | 62.32 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 573-737 Range on HMM: 1-173/173 Sequence Identity: 19% (37 aa) PKMYLIVDIDHTLLHSTKDPNA--ESYYLK---DNSINKFTIT-ETNE-------------TFYVKQRPNAIEFLSSLSSQFKIYLYSFHPKYYVEQLAL .| |..|.||||.||...|. . .||. ... ..|.. .... .||| || . |||. .| . ..... . |..... KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD ILDPNR-SIFTKVITKEVIEPVEPL----PPINSIGKPYIVFNNQNFSKIFN-FEAINQMIILDDREDVWRNFQDNLILLDTFKFFNTNS .|||.| ......... ... . ...| .. . ||.||..|.|. . .|.| ...| . MLDPKRKYFIYRRLYRDHCVYHKGKTYVKD----------------TLSLVNRCDL-SMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | DDB_G0288707.AA | Group.HAD.PD | 576-734 | 12 | 5e-15 | 45.1 | In-house | 3-165 (190) | Show / Hide |
Range on Protein: 576-734 Range on HMM: 3-165/190 Sequence Identity: 12% (23 aa) YLIVDIDHTLL-HSTKDPNAESYYLKDNSINKFTiTETNETFYVKQR------------PNAIEFLSSLSSQFKIYLYSFHPKYYVEQLALILDPNRSIF |..|.|..| |.. .|.. ... . |. .. . |. .|...| |.. ||| ... ... .... .. |..... ..|. ..| . tlvlDldgvlwlhgspepleglrskgkvlifltn-natksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeaf TKVITKEVIEPVEPlPPIN---------SIGKPYIvfnnqnfskifnfeainQMIILDDREDVWRN--FQDNLILLDTFkFFN . ... . | . ... . . .|.|.. .|. . .| ... | ... syrklrdacvylkg-pgalllatnrdlgalvrdle-----------------kvviidnkpsvfafecnpenalmigdf-idd |
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| Phosphatase | DDB_G0288707.AA | Subfamily.DULLARD.PD | 575-730 | 20 | 4.4e-12 | 34.9 | In-house | 3-146 (172) | Show / Hide |
Range on Protein: 575-730
Range on HMM: 3-146/172
Sequence Identity: 20% (33 aa)
MYLIVDIDHTLLHSTKDPNAESYYLK---DNSINKFTITETNETFYVKQRPNAIEFLSSLSSQFKIYLYSFHPKYYVEQLALILDPNRSIFTKVITKEVI
|..|.|.||.||..| ..| . . . | .|.... .||| .|| .||. .| . . .. . | .... || .|.|... ..
ktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhC
EPVeplppinsigkpyI--------VFnnqnfskifnFEAINQMIILDDREDVWRNFQDNLILLDTF
. | ....||||. .|.. || | ....
tle-------------sgkytkdlslv----------sedlssviilDnspvayrknpdnaipiksw
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| Phosphatase | DDB_G0288707.AA | NIF | 575-731 | 18 | 8.1e-12 | 44.97 | Pfam | 1-153 (189) | Show / Hide |
Range on Protein: 575-731 Range on HMM: 1-153/189 Sequence Identity: 18% (33 aa) MYLIVDIDHTLLHSTKDPNAESYYLKDNSINKFTITETNETFYVKQ-RPNAIEFLSSLSSQFKIYLYSFHPKYYVEQLALILDPN-RSIF--TKVI---T |. |.|.||.|.. ... ..... | ...... | ..||. || . ||| ..| . |.... | |.... ..||. . .| .... . KTLVLDLDETLVHCN---PWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWY KE---VIEPVEPLPPINSIGKPYIVFNNQ-NF-S-KIFNFEAI-------NQMIILDDREDVWRNFQDNLILLDT-FK | . . |. |. | . . ...||.|.. ..| .||.|. .. .. REHCWL-------------------YRNGGNYYVKK--DLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWY |
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| Phosphatase | DDB_G0288707.AA | Subfamily.HSPC129.PD | 573-665 | 26 | 2.4e-11 | 32.6 | In-house | 1-88 (164) | Show / Hide |
Range on Protein: 573-665 Range on HMM: 1-88/164 Sequence Identity: 26% (24 aa) PKMYLIVDIDHTLLHSTKDPNAESyylkdnsINKFTITETN--ETFYVKQRPNAIEFLSSLSSQFKIYLYSFHPKYYVEQLALILDPNRSIFTKV |.. |..|.| ||.|.. . .. .|... . . ||. || . |||. .| .|.. |.. | | ..| .|||... . pefslvldldetlvhcslakleda-------tlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhr |
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| Phosphatase | DDB_G0288707.AA | Subfamily.SCP.PD | 574-666 | 27 | 9.8e-11 | 30.5 | In-house | 2-89 (163) | Show / Hide |
Range on Protein: 574-666 Range on HMM: 2-89/163 Sequence Identity: 27% (25 aa) KMYLIVDIDHTLLHSTKDPNAESYYlkdnsINKFTITETNETFYVKQRPNAIEFLSSLSSQFKIYLYSFHPKYYVEQLALILDPNRSIFTKVI |. |..|.| ||.||. | .. . . | .|. ||..|| |||. .. |.. |.. . | ...| .||... | ... kkclvldldetlvhssfkpvenadf-----vvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknvikarlf |
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| BRCT | DDB_G0288707.AA | BRCT | 880-964 | 17 | 4.4e-10 | 40.74 | SMART | 1-93 (93) | Show / Hide |
Range on Protein: 880-964 Range on HMM: 1-93/93 Sequence Identity: 17% (17 aa) SSVLMDCNIVFSGIFPKQIDPSKLCHTRVSKITESFGAKISLEIDS----TTTHLIFIKEGTSKAQQ---------ALKNPNIKVVHFAWLRDCVHRW . .. .| ....| .. ... . .. |..|.|.. .... .|||.| .....| . . . .|..||. |. ||. .| MKPFKGCTFCITG-DDIEGNFD-M-RDELKEMIEMHGGKVT-SVSRKRCPDTTHVIC-SPENPKYETWNRMMTKYMKAIAWGIWIVHPDWIWDCIKKW |
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| BRCT | DDB_G0288707.AA | BRCT | 910-961 | 28 | 8.8e-10 | 38.8 | Pfam | 28-84 (84) | Show / Hide |
Range on Protein: 910-961 Range on HMM: 28-84/84 Sequence Identity: 28% (16 aa) KITESFGAKISLEIDSTTTHLI--FIKE--GTSKA-QQALKNPNIKVVHFAWLRDCV .. |..|.|.. .....|||.| .. ..| . |..||..||. |. ||. EMIEKHGGKVTDSVSKQTTHVIPWVGEPHCTRTKKFYWKAKEWNIPIVHPDWIWDCI |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB_G0288707.AA | Protein | None | 985 | None | Fasta, JSON |
| DDB_G0288707.NA | RNA | None | 2958 | None | Fasta, JSON |
| DDB_G0288707.AA.PD_573-737 | Protein Phosphatase Domain | None | 165 | None | Fasta, JSON |