fcpA
Species: D.discoideum
Alias: DDB_G0294376, fcpA
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: FCP
Subfamily: SCP
Protein domain

Protein domains of fcpA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase fcpA.AA CPDc 135-278 46 2.9e-79 270.57 SMART 1-173 (173) Show / Hide
Range on Protein: 135-278
Range on HMM: 1-173/173
Sequence Identity: 46% (81 aa)

GLKTLVLDLDETLVHS--------------SFKPVHNPDFIVP----------VEIEGTIHQVYVVKRPFVDDFLRAIAEKFEIVVFTASLAKYADPVLD
. ||||||||.|||||              |||. ...|||.|          |||.|..||.||.|||.|..||  ... .|..|||... .|||||||
KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD

FLD-TG-RVIHYRLFRESCHNHKGN-YVKD-LSRLGR-DLKSTIIVDNSPSSYLFHPENAIPIDSWFDDKDDR
.|| .. ..|. ||.|..|..|||. |||| ||...| ||...||.|.||.|...|||||||| .||....|.
MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT

Phosphatase fcpA.AA Subfamily.SCP.PD 137-297 75 3.4e-89 285.8 In-house 3-163 (163) Show / Hide
Range on Protein: 137-297
Range on HMM: 3-163/163
Sequence Identity: 75% (121 aa)

KTLVLDLDETLVHSSFKPVHNPDFIVPVEIEGTIHQVYVVKRPFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDTGRVIHYRLFRESCHNHKGNYVK
|.|||||||||||||||||.|.||.|||||.||.|||||.||||||.||....| ||.|.||||||||||||.|.||. .||..|||||||..|||||||
kclvldldetlvhssfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknvikarlfrescvfhkgnyvk

DLSRLGRDLKSTIIVDNSPSSYLFHPENAIPIDSWFDDKDDRELLDLLPLLDDLIKVEDVR
||||||||||...||||||.||.|||.||.|..|||||..|.|||||||||..| |||||.
dlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedvl

Phosphatase fcpA.AA NIF 137-297 47 3.6e-88 304.03 Pfam 1-189 (189) Show / Hide
Range on Protein: 137-297
Range on HMM: 1-189/189
Sequence Identity: 47% (90 aa)

KTLVLDLDETLVHSS--FKPVHNPDFIVPVEIEGTIHQVYVVK-RPFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDT--GRVI--HYRL---FRES
|||||||||||||..  ..|....|||||. ..| .||.|| | ||..|.||. ... .|||..|||. .|||||.|..|.  ....  |.||   .||.
KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYREH

CH-NHKG-NY-V-KDLSRL--GR-DLKSTIIVDNSPSSYLFHPENAIPIDS-WFD-----D-KDD--RELLDLLPLL-DDLI-KV-EDVR
|    .| || | ||||.|  .| ||...||||||| |. ..|.|.|||.. |..     | .||  .|||||||.| . |  .. .|||
CWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR

Phosphatase fcpA.AA Family.FCP.PD 137-297 58 2.2e-65 208.8 In-house 3-164 (164) Show / Hide
Range on Protein: 137-297
Range on HMM: 3-164/164
Sequence Identity: 58% (94 aa)

KTLVLDLDETLVHSSFKPVHNPDFIVPVEIEGTIHQVYVVKRPFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDT-GRVIHYRLFRESCHNHKGNYV
|.||||||||||||..||...|||.|.|||... ..||| |||..|.||. ..| .|||.|||| .||||||.|.||. ......||.|..|...|||||
klLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkgnyv

KDLSRLGRDLKSTIIVDNSPSSYLFHPENAIPIDSWFDDKDDRELLDLLPLLDDLIKVEDVR
||||.|||||...||.|.||.|| ..|.|||...|...|..|.|||||||.|..| |.||||
kdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedvr

Phosphatase fcpA.AA Subfamily.HSPC129.PD 138-297 52 1.5e-58 186.4 In-house 4-164 (164) Show / Hide
Range on Protein: 138-297
Range on HMM: 4-164/164
Sequence Identity: 52% (84 aa)

TLVLDLDETLVHSSFKPVHNPDFIVPVEIEGTIHQVYVVKRPFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDTG-RVIHYRLFRESCHNHKGNYVK
.|||||||||||.|......  .  .|| . ...||||  |||. .||. ... ||...||||   ||| .||.||   . ...||||||   .|||.||
slvldldetlvhcslakledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgnyik

DLSRLGRDLKSTIIVDNSPSSYLFHPENAIPIDSWFDDKDDRELLDLLPLLDDLIKVEDVR
|| |||||. |||||||| .. .  || |||.|||.|..|.|||.|||.|..|.. |||| 
dlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedvr

Phosphatase fcpA.AA Subfamily.DULLARD.PD 137-297 48 1.5e-56 179.8 In-house 3-172 (172) Show / Hide
Range on Protein: 137-297
Range on HMM: 3-172/172
Sequence Identity: 48% (82 aa)

KTLVLDLDETLVHS--------SFKPVHNPDFIVPVEIEGTIHQVYVVKRPFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDTGR-VIHYRLFRESC
|||||||||||.||        . |....|||.. | || .  ..|| |||.|| ||  ... ...|.||||. .||..|.|.||.||... |..|..| 
ktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhC

HNHKGNYVKDLSRLGRDLKSTIIVDNSPSSYLFHPENAIPIDSWFDDKDDRELLDLLPLLDDLIKVEDVR
 ..|.|.|||| .  ||.|.||.||||..|  .|.|||||.||. | .| .||.|||.|| |  ..||| 
tlesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdvr

Phosphatase fcpA.AA Group.HAD.PD 137-292 37 5.6e-47 149.5 In-house 2-185 (190) Show / Hide
Range on Protein: 137-292
Range on HMM: 2-185/190
Sequence Identity: 37% (67 aa)

KTLVLDLDETLV-HSSFKPVHNPDFIVPVEIEGTI----HQVYVVKR------------PFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDTG-RVI
.|||||||..|. |.|..| .. .. ..|.|. |.    ...|..||            |..| || .. | .|.|||||.. .|||||.. .| |....
dtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeaf

HYRLFRESCHNHKGNYVK------DLSRLGRDLKSTIIVDNSPSSYLF--HPENAIPIDSWFDDKDDRELLDLLPLLDDLI--K
||..|..|. .||....      ||. |.|||....|.||.||.. |  .||||..| ...|| .| |||.|.| |. .     
syrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrf

Phosphatase fcpA.AA Subfamily.TIM50.PD 138-297 43 8.1e-38 119.0 In-house 4-150 (150) Show / Hide
Range on Protein: 138-297
Range on HMM: 4-150/150
Sequence Identity: 43% (70 aa)

TLVLDLDETLVHSSFKPVHnpdfivpveieGtihqVYVVKRPFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDTGRVIHYRLFRESCHNHKGNYVKD
||||.|...|||. ..  .           |      . |||.|| || ..||.|||||||.. . .| |..| ||   .|.|||||.....|. |||||
tlvlelkdvlvhpewtykt-----------G----wrfkkrPgvdafleelaelfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkd

LSRLGRDLKSTIIVDNSPSSYLFHPENAIPIDSWFDDKDDRELLDLLPLLDDLI--KVEDVR
 | |||.  |.||  ..|. ..||||. .. |  ..|||||||||..|  .   .|||||  
lsklnrdlskvivvdldkesvklqpenalalkkwkGnaddrelldllaflktiatsevedvr

Phosphatase fcpA.AA Subfamily.FCP1.PD 138-268 24 3.3e-14 42.6 In-house 4-140 (150) Show / Hide
Range on Protein: 138-268
Range on HMM: 4-140/150
Sequence Identity: 24% (33 aa)

TLVLDLDETLVHSSFKPV-----HNPDFIVPVEIEGTIHQVYVVKRPFVDDFLRAIAEKFEIVVFTASLAKYADPVLDFLDTGRVIHY-R-LFRESCHNH
.||.|||.||.|.. .|      ..   |   ..  . .  || .|| . .||. ... .|. ..| .  .||. .  .||  . .   | ||. . | .
vLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdellna

KGNYVKDLSRLGRDLKSTIIVDNSPSSYLFHpENAIPI
 .  |  . . .. .  .|.|.    . |. || | . 
ssktkklkklfptgdsmvviiDDredvWnfa-enlikv

Sequence
Name Sequence Type Origin Length Description Download
fcpA.AA Protein None 306 None Fasta, JSON
fcpA.NA RNA None 921 None Fasta, JSON
fcpA.AA.PD_135-297 Protein Phosphatase Domain None 163 None Fasta, JSON