Gene DDB_G0280067
DDB_G0280067
Species: D.discoideum
Alias: DDB_G0280067
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DDB_G0280067.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DDB_G0280067.AA | PP2Cc | 252-493 | 10 | 2e-13 | 51.86 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 252-493
Range on HMM: 1-338/338
Sequence Identity: 10% (39 aa)
GGEGNFHLNSGVCV-IPHPNKRHKGGEDAYFISIDQNVIGVADGVGGWGDVGIDPSEYSNTLMKGSKIGADSQKVE------------------------
.. ... ... . . .. . .|||... . ..||.|| .| | . ..|. . . .... .
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP---FFGVFDG---HG--GHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDKW
-RDPLIIMEQGYQYAQDVKGSSTCCIVVLSATNNILSANLGDSGFLVIRNNE----------VIFRTREQQH------------------------AFN-
.|. ....... . . .|....... . . ||.||| ..||.. ... |... . ..
FEDWEDALRKAFLRMDEEI--CTAVVALIRGNK-LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPMHRQWVMNWN
--MPFQLGT---QSIDRPI---------------------------------------HSITASF---PAEKGDLIIMGTDGVFDNLFDDEILEIGEKYD
. .|. . . | . .... .. | ...|..|...||..|.. ..|. .| |
CDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQEVVDIVRKCL
---------------------------DPQIIARQVAKRAFEVGCSTTIYTPFAKNAGHNGYIYNGGKLDDITVVVG
||. .|. ... | |..||.|
RKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI---------------------------CDNMTVIVV
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| Phosphatase | DDB_G0280067.AA | Subfamily.PPTC7.PD | 261-495 | 46 | 2.6e-96 | 311.0 | In-house | 2-263 (263) | Show / Hide |
Range on Protein: 261-495
Range on HMM: 2-263/263
Sequence Identity: 46% (122 aa)
SGVCVIPHPN------KRHKGGEDAYFISIDQ--NVIGVADGVGGWGDVGIDPSEYSNTLMKG-SKIGADSQKVERDPLIIMEQGYQYAQDVK----GSS
| ||...... ||.| ||||||.| .. .|.|||||||||...||||||.|..|||. ..| ..|...||.| .|.|..||....| ||||
svvcgfakdllkqkskkrskfGeDayFvssnkvadvlgVADgvggwreygidpsefskelmkkcerivkeskfkerkpkkileaayqelleekvpvvGss
TCCIVVLSATN-NILSANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQL--------GTQSIDRPIHSITASFPAEKGDLIIMGTDGVFDNLFDDEILEI
.|||||.... ...|||||||||||.||..|..|..||||.||.|.|| |....|.| .. ..||...|||||...||||||||..|||||.
tacivvldredkklesaNlGDSgflVvRngkvvhrskeqqhyFNtPyqLsipPeerdgkvildkpeaadstsfevkkgDlillatDGvfDNlsedeilev
-----GEKYDDPQIIARQVAKRAFEVGCSTTIYTPFAKNAGHNGYIYNGGKLDDITVVVGLV
...... |..|...|..|.|.........||||.| .||. ..||| ||||||. ||
lkelkerdeeelqllanslaekarelsldpkyespFakkakknglaasGGKpDDitvvlalv
|
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| Phosphatase | DDB_G0280067.AA | Family.PPTC7.PD | 270-495 | 42 | 4.3e-63 | 202.1 | In-house | 16-262 (262) | Show / Hide |
Range on Protein: 270-495 Range on HMM: 16-262/262 Sequence Identity: 42% (101 aa) NKRHKGGEDAYFISID--QNVIGVADGVGGWGDVGIDPSEYSNTLMKG-SKIGADSQKVERDPLIIMEQGYQYAQDV----KGSSTCCIVVLSA-TNNIL .|| | ||||||.| ..|.||||||||| . |.|.|. |..||| ... ..|. .. | .....|. .. |||| |.|||.... ||| kkrskfGeDayFvssnkvadvlgvADgvggwreygvdssafsselmkkcerlvkeskfkplkpkkllkaayaelleekvpvvGsstAcvvvldredkkle SANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQLGTQ-----S---IDRPIHSITASFPAEKGDLIIMGTDGVFDNLFDDEILEIGEKY-----DDPQII ||||||||.|. .|..|..|||| || |.|| . | | . . ||. .|||.|...|||||||| .|.|||. .... | .|...|..| sanlGDsgflvvRegkvvhrskeqqhyFntPyqLsipPeerdgkvisdspeaAdstsfevkkgDiillatDGvfDnlsedqileelkelkerdeeelqll ARQVAKRAFEVGCSTTIYTPFAKNAGHNGYIYNGGKLDDITVVVGLV |. .. |||..| ..| ..||| ||||||. | anslaekareLsfdpkyespFaqkakkrglaasGGKpDDitvvlavv |
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| Phosphatase | DDB_G0280067.AA | Group.PPM.PD | 253-384 | 18 | 6e-12 | 33.5 | In-house | 32-188 (459) | Show / Hide |
Range on Protein: 253-384 Range on HMM: 32-188/459 Sequence Identity: 18% (30 aa) GEGNFHLNSGVCVIPhpNKRHKGgEDAY--FISIDQ--NVIGVADGVGGWGDVGIDPSEYSNTLMKGSKIG-------------------ADSQKVERDP .. . |. ||. ..|.. ||.. . ..|. ...|| || ||. . ..... |.| | .. .|.|. agsgnglrygvasmq--gwrkem-EDrhvivenfdnndsffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsa LIIMEQGYQYAQDVKG-----SSTCCIVVLSATNNILSANLGDSGFLVIRNNEVIFRTRE ... ... . |. | |...|.| ... ||.||| .. ||.... ... fleldedlseeanekeepgkdsGtTAvvalingkklyvANaGDSravLcrngkavplskd |
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| Phosphatase | DDB_G0280067.AA | Family.PPM.PD | 257-384 | 18 | 1.6e-09 | 25.3 | In-house | 13-160 (495) | Show / Hide |
Range on Protein: 257-384 Range on HMM: 13-160/495 Sequence Identity: 18% (28 aa) FHLNSGVCVIPhPNKRHKggEDAY--FISIDQ--NV--IGVADGVGGWGDVGIDPSEYSNTLMKGSKIG-------------ADSQKVERDPLIIMEQGY ..|. ||. .... |||. . .... .. .|| || || . ... ..| | . .. ... |. . ... . nglrygvasmq-gwrsem--eDahvvvenlennedfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeel QYAQDVKG----SSTCCIVVLSATNNILSANLGDSGFLVIRNNEVIFRTRE .. . | | |...||| .... ||.||| ...||.... ... seelneksagkdsGtTAvvvlirgkklyvAnaGDsravLcrngkavelskd |
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| Phosphatase | DDB_G0280067.AA | Family.PPM.PD | 414-496 | 19 | 9.9e-09 | 22.7 | In-house | 223-287 (495) | Show / Hide |
Range on Protein: 414-496 Range on HMM: 223-287/495 Sequence Identity: 19% (17 aa) EKGDLIIMGTDGVFDNLFDDEILEIGEKYD-----DPQIIARQVAKRAFEVGCSttiytpfaknaghngyiynggklDDITVVVGLVD |. . ... .||..| | ..|..|. ... |.. ||... ..| . |.. |.|||.| .. eedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsr-----------------------DNiTvlvvaly |
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| Phosphatase | DDB_G0280067.AA | PP2C_SIG | 261-495 | 14 | 3.4e-08 | 34.48 | SMART | 1-250 (250) | Show / Hide |
Range on Protein: 261-495 Range on HMM: 1-250/250 Sequence Identity: 14% (41 aa) SGVCVIPHPNKRHKG-GEDAYFISIDQN-----VIGVADGVGGWGDVGIDPSEYSNTLMKGSKIGADSQKVERDPLIIMEQGYQYAQDV------KGSST . .. |..... . . | |.. . . .. ..|..| | |. .... . . . ... .| |.| ... . .... DDHWDIYQYYEDATQVCGDWYDFWKIPEGQDRYFFVIGDVMG-WA-HGLPAALMMGMARTMMRTFWHE-----SPPQILERCNRWIYQNNHEECGMFTTM CCIVV--LSATNNILSANLGDSGFLVIR--NNEVIFRTRE-------------------QQHAFNMPFQLGTQSIDRPIHSITASFPAEKGDLIIMGTDG ||.|. ||... .. |.| ....| . . ...| . .. .... . ||... . ...|. |.||...| ||| CCCVYMPDFATHTLWYCHCGHSPPYLYRAMDGGRVEHTHDHYLVQHYVMRIIDEEDAKHHPWHNWTGPPLGMEPDYM---YDVQEFQYEPGDRFVMCTDG VFDN-------LFDDEILEIGEKYDDPQIIARQVAK-RAFEVGCSTTIYTPFAKNAGHNGYIYNGGKLDDITVVVGLV |... . .....|| |.. . ....|. .. |. .. . ||.||.|. | VTEARNPQGEFFGEEWLQEILEEHQ--CCCPQEIAQRIMQELMEHMGDHNG----------------HDDMTVIVVKV |
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| Phosphatase | DDB_G0280067.AA | Group.PPM.PD | 412-499 | 18 | 1.6e-07 | 18.9 | In-house | 245-325 (459) | Show / Hide |
Range on Protein: 412-499 Range on HMM: 245-325/459 Sequence Identity: 18% (18 aa) PAEKGD-LIIMGTDGVFDNLFDDEILEIGEKYDDP---------QIIARQVAKRAFEVGcsttiytpfaknaghnGYiYNGGKLDDITVVVGLVDDGP . .. | .....||..| | ..|..|. .. . . ||......| . | ..|.. |.|||.| ..|. klteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakg----------------st-gdgtscDNiTvivvtlndam |
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| Phosphatase | DDB_G0280067.AA | Subfamily.PPM1A.PD | 341-384 | 31 | 1.9e-06 | 16.0 | In-house | 108-151 (309) | Show / Hide |
Range on Protein: 341-384 Range on HMM: 108-151/309 Sequence Identity: 31% (14 aa) QDVKGSSTCCIVVLSATNNILSANLGDSGFLVIRNNEVIFRTRE . | . ..||| .... ||.||| ...||..|.| |.. kgedksGsTavvvlvspkklylancGDsRavlsrngkvvfateD |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB_G0280067.AA | Protein | None | 516 | None | Fasta, JSON |
| DDB_G0280067.NA | RNA | None | 1551 | None | Fasta, JSON |
| DDB_G0280067.AA.PD_252-495 | Protein Phosphatase Domain | None | 244 | None | Fasta, JSON |