Ptp4E
Species: D.melanogaster
Alias: Ptp4E
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Classic_PTP
Subfamily: RB
Protein domain

Protein domains of Ptp4E.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Fn3 Ptp4E.AA FN3 151-232 18 2.6e-08 34.85 SMART 1-69 (69) Show / Hide
Range on Protein: 151-232
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

PDPPAN---LSVQLRSSK------SAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPG----GSYQVQAYSVYQ--GKES
|.|| |   |.|   .|       |. ..| ||           ..| .                    . |.||      |... . |.   . |.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR-----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Fn3 Ptp4E.AA FN3 244-329 18 8.3e-09 36.51 SMART 1-69 (69) Show / Hide
Range on Protein: 244-329
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

PNTPGK---FIVWFRNET------TLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPG----REYNISVQTVSE-DETSS
|  |.    . |   ..|      .. . |.||      ..||                          . ..||.||     ||...|. |.. |  ..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----IVGYR--------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG





Fn3 Ptp4E.AA FN3 434-522 13 1e-05 26.25 SMART 1-69 (69) Show / Hide
Range on Protein: 434-522
Range on HMM: 1-69/69
Sequence Identity: 13% (14 aa)

PRPVRS---LGGFLDDRS-----NALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAG----RRYLIAVQALSK--G
| |..    |     ...     . ...||.|         ...|.                          ||.. | .|     .| . |.| ..  .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR--------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDA

VAS
  .
GEG

Fn3 Ptp4E.AA FN3 620-697 19 3.3e-08 34.51 SMART 1-69 (69) Show / Hide
Range on Protein: 620-697
Range on HMM: 1-69/69
Sequence Identity: 19% (18 aa)

PKPPQN---LTLQTVHTN------LVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYG----ERYLVQVNTVSF--GVES
| ||.|   |..  | ..       |.|.|..|        .|.||                ..... . |     .| ..|  |.   . |.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Fn3 Ptp4E.AA FN3 709-794 18 7.6e-09 36.64 SMART 1-69 (69) Show / Hide
Range on Protein: 709-794
Range on HMM: 1-69/69
Sequence Identity: 18% (19 aa)

PQPVSN---VVPL-VDSR------NLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPG----RQYRFEVQASS-NGIRS
| |..|   ..   |.|.       .||.| .|   .  |.                               ...|.||     .|.| |.| . |.  .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP---IVGYR-----------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

G
|
G

Fn3 Ptp4E.AA FN3 900-978 19 3.3e-11 44.49 SMART 1-69 (69) Show / Hide
Range on Protein: 900-978
Range on HMM: 1-69/69
Sequence Identity: 19% (18 aa)

PLPISD---LKAIQVAAR------EITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPY----HNYTFTVVVRSG--SIQG
| | ..   |..  | ..       .||.|..|       ...|                    |. ||.|.    ..|.|.|....|    .|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Fn3 Ptp4E.AA FN3 1007-1090 20 1.6e-08 35.57 SMART 1-69 (69) Show / Hide
Range on Protein: 1007-1090
Range on HMM: 1-69/69
Sequence Identity: 20% (20 aa)

PGKVDY---FQPSDVQPG------EVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPG----NHYIFRIQAKSA--LGYG
|| .     .. .|| .        || .|. .|      | ..|                        ...||.||      | ||..|...   |.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP------IVGYR-----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Phosphatase Ptp4E.AA Subfamily.N6.PD 1327-1582 37 1.5e-68 222.5 In-house 12-291 (295) Show / Hide
Range on Protein: 1327-1582
Range on HMM: 12-291/295
Sequence Identity: 37% (104 aa)

FRFSEEFEELKH--VGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPV-DDDDGSDYINANYM--------PGHNSP-----REFIVTQGPLHSTRE
. |.||||||..  . .   .. .. . |. |||. ||||.||.| .|. . ..  |||||||||.         |.|.      ...|.|||.|..| .
lgfweefeelqkqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvs

EFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR---NCESRIMRHFHFTTWPDFGVPEPPQSLVRFV
.|||| |. ||| |||.|.  |.|..|| .|||  .    .|.|.|. | ... .|. . ||.||.   . |.| ....||..||| |||. |. .. |.
dFWrmvwqensrvivmttkevergknkCarYWPdeetkketGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfl

RAFR---DVIgTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDY---VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
.  .   . . ....||.||||||.|| |||| .| .|. |..| .   .||  ..  .|..|  .||||.||  ....  
edvnkkqeel-ekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavq

Phosphatase Ptp4E.AA PTPc 1328-1586 38 2e-129 437.17 SMART 1-308 (308) Show / Hide
Range on Protein: 1328-1586
Range on HMM: 1-308/308
Sequence Identity: 38% (122 aa)

RFSEEFEELKHVGRDQ---------ACSFANLPCNR--PKNRFT-NILPYDHSRFKLQPVDDD----DGSDYINANYMPGHNSPREFIVTQGPLHSTREE
 |.||||.|. .. ..          |. |..|.||   |||.. .|..|||.| ||.| ...     |||||||||..|...|...|.||||| .| | 
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPLPHTIED

FWRMCWESNSRAIVMLTRCFEK--------GREKCDQYWPVDRVAMFYGDIKVQLIIDTHYH-DWSISEFMVSRNC----------ESRIMRHFHFTTWP
||||.|. ....||||..|.||        |||||.|||| .   | ||.|.|...  ...  |. . .| |.             |.|...|.|.|.||
FWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYTNWP

DFGVPEPPQSLVRFVRAFRDVIGTDMR-------------------PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQ
|.|||| |.|. .|.|..|..  . .                    ||.||||||.||.|||.|.| ..|.|..   ||||.||  ||..| .|||||.|
DHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGMVQTEEQ

YVCIHQCLLAVLE
|. ...|.| ...
YIFCYRCILEYIK

Phosphatase Ptp4E.AA Subfamily.RB.PD 1328-1585 58 2.3e-123 402.0 In-house 1-260 (261) Show / Hide
Range on Protein: 1328-1585
Range on HMM: 1-260/261
Sequence Identity: 58% (151 aa)

RFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
|||||.||||.||.|||.. |....|| ||||||||||||||.||. ..|....|||||||.||.|||||.|.|||||..|...||||.||..|..||||
rfseeyeelkkvgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivml

TRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTD--MRPIIVHC
|...|||.|||..||| |. ...||||||.|. ......| | ||..... |.| .|..|||.|||.|||| ...|..|||..|. | ..  ..||.|||
tqlvEkgkekceeYWPadeepvlyGdikvtllaekeldewvirefkiekgkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHC

SAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
||||||.||||||||.||.|...||||.||.|  .|.||...||||.||..||.|||..|
saGvGRtGtfialdrllqaieendyvdvfgvvaelReeRnllvqtekqyifiheclldll

Phosphatase Ptp4E.AA Y_phosphatase 1353-1583 46 3.7e-121 413.61 Pfam 1-243 (243) Show / Hide
Range on Protein: 1353-1583
Range on HMM: 1-243/243
Sequence Identity: 46% (113 aa)

NRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPG-HNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGR-EK-CDQYWPV--DRV
|..|||...|..|||.| ||||...|..||||||||..| ...|...|.||||...| |.||||.|. ....||||..|.|.|| || |.||||   .  
NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNKEGQ

AMFYGDIKVQLIIDTHYHDWSISEFMVSRNC----ESRIMRHFHFTTWPDFGVPEP-PQSLVRFVRAFRDVIG-TDMR--PIIVHCSAGVGRSGTFIALD
 | |||..| ..  .|..|. . .|.|.  .    |.|...|.|.|.|||.||||  |.|...|.| .| . . .|.   ||.||||||.||.|||.|.|
PMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFCAID

RILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
 ..|...... ||||.||  ||. | .|||||.||. ..||.| 
IMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE

Phosphatase Ptp4E.AA Subfamily.R_Anemone_2.PD 1329-1585 44 3.8e-90 293.2 In-house 2-261 (262) Show / Hide
Range on Protein: 1329-1585
Range on HMM: 2-261/262
Sequence Identity: 44% (115 aa)

FSEEFEELKHVGRD-QACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
.|||.|.|... .    .. |. |.|. |||..|||.||..| |||..... |||||||||..|... ...| ||.||  | |.|||| || ||. ||||
lseeyerlsrseetsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsavivml

TRCFEKGREKCDQYWPvDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI-GTDMRPIIVH
|.. |.|. |...||| .. .. ||...|.|  .... |. . .| |.|.   |.|..| ||.|.||| |||| . ||. .||  . .   ....||.||
tqeeergkakvhryWP-skgsrsygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgagpivvh

CSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
||||||| |.|||.| .|..|..   ||.|..|  .|..|  ||||..||. |.. ||  |
csaGvGrtGvfiavdillerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvlleal

Phosphatase Ptp4E.AA Subfamily.N_Choan_1.PD 1329-1585 36 7.8e-81 262.6 In-house 2-261 (262) Show / Hide
Range on Protein: 1329-1585
Range on HMM: 2-261/262
Sequence Identity: 36% (96 aa)

FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT
| ||.|.|...|.|.... .. . |. |||..||  ||..| |..| ...  .||||||..|| ....|.|.||||. .. ..||.| || . .||||.|
fieeyeklaeigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvt

RCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMV-SRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDM-RPIIVHCS
|  |.|. || .||| .. .. .||..|. .  .. . .   .|..  ...|.| ......|.||| |||. .. |. | .| . .  ..   |...|||
reieagklkChryWPdenselklgdvtvkslseeekktyierkfkleresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktkaplvihCs

AGVGRSGTFIALDRILQHIHKSDYV-DIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
|||||.||.|||||........  . |.  .|  .|||| .||||  ||  .....| .|
aGvGrtGtyialDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvykavldal

Phosphatase Ptp4E.AA Subfamily.RA.PD 1329-1582 40 6.7e-80 259.5 In-house 2-262 (266) Show / Hide
Range on Protein: 1329-1582
Range on HMM: 2-262/266
Sequence Identity: 40% (106 aa)

FSEEFEELKHVGRD-QACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
. |||..|  |    . .  ||.. |. |||. .|||||.||  |. ..  . |||||| .. |..   .|| .|||.. | |.|||| ||.| .|||||
leeefkkltsvkiqkeklrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekdkfiaaqGpkeetvedfwrmiweqksativml

TRCFEKGREKCDQYWPVDRvAMFYGDIKVQLIIDTHYHDWSISEFMVS------RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMR-P
   |...||| |||| .  .. ||.|.|..  .|   |... .|.|       |. .||..| ||||.||..|||  .. ....... . .       ||
telkerkeekcaqywpdeG-lvtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanhp

IIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
.|||||||||.||||.|| .|. ..  . .|.|..|  .|..|  ||||..||. |.. || 
ivvhcsaGvGrtGtfivldavlervkaerkldvfeavkrlrlqrpqmvqtleqyefiykvll

Phosphatase Ptp4E.AA Subfamily.R_Anemone_1.PD 1329-1585 39 1.2e-79 258.9 In-house 2-257 (258) Show / Hide
Range on Protein: 1329-1585
Range on HMM: 2-257/258
Sequence Identity: 39% (103 aa)

FSEEFEELKhVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT
...||..||  ....  . |. ..|. |||...|...||||  |. ...|. |||||| |. ...  |.||.||.||..| |.|||| |. .. .|||||
yaaefqrlk-eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdktrafiatqapleetvedFWrmvwqekigviVmLt

RCFEKGREKCDQYWPVdrVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCS
   |.  .|| ||||    .  ||...|.|  . .. |. | ....|..   |.|.....|||.||| |||.  .......|  ..   .. ||..||||
nliegekkkchqYwPd--stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqksslagarpvvvhCs

AGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
|||||.|.|...| .|....|.  |||| .| |.|..|  ||||..|||||. .|  | 
aGvgRtGaflvidamleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavleal

Phosphatase Ptp4E.AA Subfamily.R_Sponge_2.PD 1339-1583 40 2.7e-78 254.3 In-house 11-259 (262) Show / Hide
Range on Protein: 1339-1583
Range on HMM: 11-259/262
Sequence Identity: 40% (98 aa)

VGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPvDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKC
.  .| |.|. | .||||..|||||.|| .|.. |.  .||||||... |....  .|.|||||..| |.|||| || ...|||||   |.|.||| .||
ketefslsiaklkenvgKnRfkeilpydmsRvrLrt-dgskdsDYinAsfvdgykrrkayiatqgPlketveDfWRmvweykvstivmltnleengkekc

DQYWPVD-RVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCE---SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAF-RDVIGTDMRPIIVHCSAGVGRSG
|     .. ||..||.|  .... |. | ....|.. .   .. ...|||..||. .||.   ||. ...   |.   .  ..|.|.||.||||.|||||
akYWPekvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtG

TFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
|| .|..... . .|.| ..  .| .|...||...||| ||. ||     
tfialdsvlerlkaeeeidvfevlktlrtkriglvqdaaqYvfihdalle

Phosphatase Ptp4E.AA Subfamily.RG.PD 1329-1584 39 1.2e-76 248.9 In-house 2-262 (264) Show / Hide
Range on Protein: 1329-1584
Range on HMM: 2-262/264
Sequence Identity: 39% (102 aa)

FSEEFEELKHVGR-DQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
..|.|||....   |  ..... ..|. ||| .||.....|| ||.|. . ||.|||||.|. |..  .|.|||||||..| |.|||| |||.. |||||
leeqfeeiqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrskeyivtqgplketiedFWrmiWehnaqiivml

TRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC----ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIV
   ||||...|.||| .  .. ....||.|.  ..  .  . .|..  .     ..| .|..|.|.||| |.||     . ||.    .  ... ||.||
tdldekgrrdedvyWPkkdeplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkkeeaankeeaGPivv

HCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
.||||||.||.|||| .||...| . |......  .|..| ..|.|| ||| |.. || . 
hdsaGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydallel

Phosphatase Ptp4E.AA Subfamily.RK.PD 1329-1585 40 1.5e-75 245.1 In-house 2-266 (267) Show / Hide
Range on Protein: 1329-1585
Range on HMM: 2-266/267
Sequence Identity: 40% (108 aa)

FSEEFEELK---HVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDdGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIV
. |||| |.     .. . |. | .. || |||...||.||.|. .|..||.|  ||||||... ... |..||||||||..| ..|||. .. |. .||
lkeefetlnsvtpelqsedcdiakkdrnreknrsmdilaydrslvflisvdgd-ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MLTRC-FEKGREKCDQYWPVDrVAMFYGDIKVQLIIDTHYHDWSISEFMVSR----NCESRIMRHFHFTTWPDF-GVPEPPQSLVRFVRAFRDVIGT-DM
|||    |.|| || .||| |   . ||||||.|.  .   |  .  | |..    . | |..|.|.|..||.. .||.  .||....|    .    . 
mlteldvevgrvkClkyWPed-tevrygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeee

RPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
 .|.|||.|| ||||||||.| .|. |.. . ||.| .| ..|...| ||.||.||. ...  |  |
GrivvhClaGaGrsGtfiaidivlemieregvvdvfnavktlrnrkvnmveteeqykfvydvileal

Phosphatase Ptp4E.AA Subfamily.N9.PD 1330-1582 37 1.6e-75 245.4 In-house 3-271 (275) Show / Hide
Range on Protein: 1330-1582
Range on HMM: 3-271/275
Sequence Identity: 37% (99 aa)

SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTR
|.|......         ..|..|  |||.|..| ||..| ||. .|.|. |||||||.. |.. .. || |||||. | ..|||| ||... ||| ||.
skeyadirnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkkafiatqGplkktvsdfwrmvweqevlvivmttr

CFEKGREKCDQYWP-VDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGT----------
 |.|| || ||||  .  .. .||..|. . . ...|. .. . ..  .. ||| . || |..|||.|||.  .||. ....|.  ..            
vvergrlkcgqywpleeessaefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdesk

---DMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
 .  ||.||||||.||.||||.||  |..... . ||..  |  .|. | |..||..||.  ....|  
ghlsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl

Phosphatase Ptp4E.AA Subfamily.N12.PD 1331-1584 36 2.4e-75 244.4 In-house 4-268 (270) Show / Hide
Range on Protein: 1331-1584
Range on HMM: 4-268/270
Sequence Identity: 36% (96 aa)

EEFEELKHVGR----DQ--ACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAI
.||..||.. .    ..  . . .. . |. |||. .|||||.|| .|.  ....||||||||.. | ... |.| .|||| .| ..|||||| | . .|
kefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegkleyiaaqgPLpktlddfWrmiweknveiv

VMLTRCFEKGREKCDQYWPVD-RVAMFYGDIKVQLIIDTHYH-DWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPII
|. | .| |. ||..|||     .. .|...|.|. . . . |. |  . | .. |||... ||.| ||| |||. ..||.......|.. ...  |..|
vmaCrevelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhytaWPDhgvPssaksllelielvrelqesedaPlv

VHCSAGVGRSGTFIALDRILQHIHKS---DYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
|||||||| || ||.| . . ...    . .|.| .|  .||.|. .|||..||. ...... . 
vhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

Phosphatase Ptp4E.AA Subfamily.R_Ecdysozoa.PD 1329-1582 35 3e-70 227.7 In-house 2-265 (269) Show / Hide
Range on Protein: 1329-1582
Range on HMM: 2-265/269
Sequence Identity: 35% (95 aa)

FSEEFEELK-HVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
. ||.|.|. ..  .. .....   |  |||. .| ..|. | ||...  .. ||||||... |..  ..||. |.|. .| ..|||| .| ..  ||||
leeeyekLearleiskstkvsekkenalknryedikafDktrvkLkkingkedsdyinasfikgykekkkfiaaqdPveatigDfWrmiaeqevtlivml

TRCFEKGREkCDQYWPVDrVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC-----ESRIMRHFHFTTWP-DFGVPEPPQSLVRFVRAFRDVIGTD----
.   || |. |..|||..   . |||| |.|.   . .|. | |. ||..      .|| .  ...|.|. |. ||| ...|.....  |..  ..    
snlteknrk-cakyWpie-devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnklsg

-MRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
   ||.|||||||||||.|.||| .||.... | |||| .|  .|..|..||  .||| ... |. 
srsPivvhCsaGvgrsgifvaldlllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyrala

Phosphatase Ptp4E.AA Subfamily.N3.PD 1331-1584 37 1.8e-68 221.8 In-house 4-259 (261) Show / Hide
Range on Protein: 1331-1584
Range on HMM: 4-259/261
Sequence Identity: 37% (95 aa)

EEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQpvddDDGSDYINANYM----PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVM
.|||| .   . |.| |..| | .|||. .|||||. | ||.    .  .|||||||.    |...    .|.|||||..| ..||.| ||.|. |||||
aqfeelyrkkpglaisaarkpenlaknryrdilpydatrvklk----esetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivm

LTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC--ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVH
   |.|| || ||||     . .|...|..  . . . . . |......   |.| . .. .. ||| |||. ......||.|..  .. .|..||||||
lttlverGrvkChqyWPetedelefgefsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

CSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
.||.| .|.|.  |. | ... | .  ||  ||  |  .|||..||  . ...|..    
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtvsqykfvCeailka

Phosphatase Ptp4E.AA Subfamily.N_Choan_2.PD 1352-1582 36 7e-67 216.6 In-house 20-262 (266) Show / Hide
Range on Protein: 1352-1582
Range on HMM: 20-262/266
Sequence Identity: 36% (88 aa)

CNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPG-HNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV---DRV
|.  ||...|||  ..| .|.....|. . ||||||..| .......| ..||| .| ..|||| ||....||||.|   ||||.||..|||    ..|.
rnkrlnRyndiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

AMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQ------SLVRFVRAFRDVIGT-DM-RPIIVHCSAGVGRSGTFIALD
. .|.|||  . ... . . . .  . .. |.| ..||...|||| |||. ..      .|.. .|| ||    |   |..|||||||||.||.||.| .
kladgkikvlalseekeegyiltrlrlekkgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRtGtliaiD

RILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
.. ....  ||.  |. ..||.|. .||. .||  ... ..  
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykavv

Phosphatase Ptp4E.AA Subfamily.N13.PD 1330-1585 37 1.3e-66 216.0 In-house 3-258 (259) Show / Hide
Range on Protein: 1330-1585
Range on HMM: 3-258/259
Sequence Identity: 37% (98 aa)

SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQpvddDDGSdYINANYM--PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
.|||.||...   . |. ..   |. |||. |.||||..| ||.    |.|. ||||...  |  .   |.|..||||  | ..||.| ||... |.|.|
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg----degg-yinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TRCFEKGREKCDQYWPVD--RVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDvIGTDMRPIIV
   |||. ||..|||.   .  . .. ..|.|.  ............|.     ||| . |..|..||| |||  ...||.||.  |  . ||  ||.||
tlekekgkvkchrywPerknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrl-lqtdagPivv

HCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
||||.||||..|..| .|. |..   .|.  ||  .|. |  .|||..||. ... .| || 
hcsaGiGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

Phosphatase Ptp4E.AA Subfamily.N5_RR.PD 1349-1582 33 2e-64 208.8 In-house 19-261 (265) Show / Hide
Range on Protein: 1349-1582
Range on HMM: 19-261/265
Sequence Identity: 33% (81 aa)

NLPCNRPKNRFTNILPYDHSRFKLQPVD-DDDGSDYINANYMPGHNS-PREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDR
... .  |||...||| ..||  |.. . .|. |.||||||. |..   . .. ||||| .| ..|||| .. ... |||||.  |. |.|| .|.| ..
evfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPdae

V---AMFYGDIKVQLIIDTHYHDWSISEFMVSRNCE-SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI---GTDMRPIIVHCSAGVGRSGTFIALD
    .  |||....    .. .|.|. .....   . .| . |. .| |||  .|. ...|...|.  ..      .. |..||||||.|| | ||| . 
dyeiserygdveikveeiverndysvrklvlkylerversvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiais

RILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
 .......  ||...||  .| .|  ||||..||  ||. |  
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

Phosphatase Ptp4E.AA Subfamily.N1.PD 1343-1587 39 3.3e-62 201.6 In-house 18-266 (268) Show / Hide
Range on Protein: 1343-1587
Range on HMM: 18-266/268
Sequence Identity: 39% (99 aa)

QACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDddgsDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYW
.. |.|| ||..||. .. |||||| ||.  |     |||||. .   .  |..|.|||||  | . ||.| || ||.|..|| .. ||.. || |||| 
letreaklpenrglnryrdvspydhsrikleradv----dyinaslveleeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCaqyw

PVDRVA--MFYGD--IKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRD--VIGTDMRPIIVHCSAGVGRSGT
.. .  . . .  .||.||   ... .  . . .   .. |.| . |||.|||||||||| |.....|.   |.  .. .|.|...|||||.|||||.  
pqeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpavihCsagigrsgt

FIALDRILQHIHKSDY---VDIFGIVFAMRKERVFMVQTEQQyvcIHQCLLAVLEG
.| .| .| | .    |||   . ..|| || ..|| .|   ..   .|.|||   
lslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdq---LrFsyiaileg

Phosphatase Ptp4E.AA Subfamily.RC.PD 1329-1582 29 8.1e-60 193.7 In-house 2-284 (288) Show / Hide
Range on Protein: 1329-1582
Range on HMM: 2-284/288
Sequence Identity: 29% (85 aa)

FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKL-------------------QPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTR
.  ||..| .|   ..   |. . |. |||....||||. | .|                   . .| ..||.|||| .. ..  |. .| .||||. | 
leaefqrlpsvrskrtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykkpekyiaaqGplketv

EEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWpvDRVAMFYGDIKVQLIIDTHYHDWSISEFMV--SRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFV
..|||| .|   . |||||.. |  |||| .||  .     |||..|.|    .  |. .  . .  ... .|| . .. .|.|.. ..|| |. |....
ddfwrmiferkvkvivmltelkeGdrekcaeyw--eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkli

RAFRD-------VIG---TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
.  ..       . .       |..|||..|..|.|.||||. .|. .   . ||.|..| ..||.|  ||..|.||. ... | 
qvvkqklpqkrsseafknfkstpllvhcrdGsqrtGifiallallesleaeekvdvfqvvkklrkarplmvsveeqyillydvlv

Phosphatase Ptp4E.AA Subfamily.N14.PD 1331-1585 32 1.5e-52 169.8 In-house 4-274 (275) Show / Hide
Range on Protein: 1331-1585
Range on HMM: 4-274/275
Sequence Identity: 32% (87 aa)

EEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDdGSDYINANYMPG--HNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT
|.|....   |  .| |.|| | .|||| ..|||...| .|.|  ..  ..||||  .      . |..||.||||. | ..||.| ||.. . |||||.
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken-stgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmlt

RCFEKGREKCDQYWPVD---RVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG--TDMR--
  |.|.||. .|.| .   .  . .|  ||.    .. .    . . .      | | . |. .| ||| |||| .....|.. .. |    ....    
eeeedgkeksfkylPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnseves

------PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
    |..|||||||||.|  |  | ... ... . .||  ..  .|| | ..|||  ||  ... |.  |  
vkeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLrkqrmllvqtlaqykfvykvlikyl

Phosphatase Ptp4E.AA Subfamily.N_Nematode_1.PD 1330-1583 31 2.7e-52 168.9 In-house 3-262 (265) Show / Hide
Range on Protein: 1330-1583
Range on HMM: 3-262/265
Sequence Identity: 31% (82 aa)

SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQpvDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTR
.||..||.  . .  .  .   .. |||....   |..| ||.  ..   |||| |||.     |. || .|.||..| ..|| |.   .  ||||| ..
rdefralkkfndeekvkafkeaqeadknrykdvgcldknrvkla--eeplpsdyihanyvgtptnpkrficaqaPldktiadfwymvlqekveaivmlck

CFEKGREKCDQYWPVDRVA-MFYGD----IKV--QLIIDTHYHDW---SISEFMVSR-NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRdvigTDM
 |||. || .|.|. .   . . .    | |  .| ...  .|     . .. |.   ...|..|...| ||| |||.   . . .. | |    ..  |
liekgkkkcaeyfpakegeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavr----gsk

RPIIVHCSAGVGRSGTFIALDRILQHIHKSDYV-DIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
|.||||||.||.|| .|.. ||... ... . |.  .| ..|..| . .||..||. .|. ||   
gPivvhCsaGiGrtGtivaieyildkllegkqiedmeklvkkireqrnysiqtdaqylfvhrvlln

Phosphatase Ptp4E.AA Subfamily.N23.PD 1366-1582 35 3.9e-50 162.1 In-house 115-346 (350) Show / Hide
Range on Protein: 1366-1582
Range on HMM: 115-346/350
Sequence Identity: 35% (83 aa)

DHSRFKLQ-PVDDDDGSDYINANYMPGHN--SPrEFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRV-AMFYGDIKVQLIID
|..| |||   .    .||||| |.      || .||.||||..||  .|| | ||  |. |||||.  |... ||||||| |.  .. .||..| |   
dpnrvklqqstqpgqqddyinatylkeltpmsP-pfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvslksl

THYHDWSISEFMVSRNCES--RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI---------GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK-SD
.. . |.   . .. |  |  | . |.|.|||...|||. |..|..|. . . .          |   .|||.||||||||.|||  .  ... ...   
rssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltagng

YVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
 ..|  .|  .|..| .|||.....  . .  |
iiniprvvrrlrqqRkymvqkkvilkklyeavl

Phosphatase Ptp4E.AA Subfamily.RN.PD 1329-1580 35 2.8e-49 159.0 In-house 2-258 (264) Show / Hide
Range on Protein: 1329-1580
Range on HMM: 2-258/264
Sequence Identity: 35% (91 aa)

FSEEFEELKHVGRDQA-CSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNsPRE--FIVTQGPLHSTREEFWRMCWESNSRAIV
...|.| |..   ... .. |. . |  ||| ...||||||| ||.    .. ||||||  .  |. ||.  .| ||||| ||  .||.| ||. .  ||
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd-prapayiatqgplsstiadfwqmvweqGvvviv

MLTRCFEKGREKCDQYWPvDRVAMFYGDIKVQLIIDTH-YHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPII
.|||  |.| ..|..||| |  .  |.  .|.|. .    .|. .  | .   .. |.| .  ||| .||. |||  ..||. ||           ||.|
nltrleeegvkqckrywp-deGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpiv

VHCSAGVGRSGTFIALDRILQHIHKS-DYVDIFGIVFAMRKERVFMVQTEQQYVCIHQC
|||.|.||.|..|..| .|... |    .||   .  .| .|  .|.|..|.  . .. 
vhcsdGaGrtGvyilidlvlerllkGvkeidiaatlehlrdqrpglvktkdqfefalta

Phosphatase Ptp4E.AA Subfamily.N_Nematode_6.PD 1351-1585 35 5.2e-49 158.2 In-house 22-252 (253) Show / Hide
Range on Protein: 1351-1585
Range on HMM: 22-252/253
Sequence Identity: 35% (85 aa)

PCNRPKNRFTNILPYDHSRFKLQpvddDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPvDRV--A
.. .||.|||  .| .|.||.    ||   || ||..  .  || .|.||.||..| ||||.|   | .  ||||    |||.||. .| . |.|  |. 
lkfkdrnrytniqCcdagrlkla----ddedfyihanlvkistkprrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeyls-dkvGda

MFYGDIKVQLIIDTHYHDWSI--SEFMVSRNCE-SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDvigtDMRPIIVHCSAGVGRSGTFIALDRILQHI
....  .. |. .  |  .  |   .... . . |..|.|.  ||| |||.  .| .|.. ....    | .||.||||||||| ||.. .  ||. . .
rkitklctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvkk----dkkPivvhCsaGvGrtGtlaliliileal

HKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
 |. ..  ..  .|.||.  |||| ||.  ..|.|  |  
rlpdfqgvkdllvklreerfravqtevqylyalrcvleyl

Phosphatase Ptp4E.AA Subfamily.N20.PD 1347-1585 38 8.4e-46 147.9 In-house 20-256 (257) Show / Hide
Range on Protein: 1347-1585
Range on HMM: 20-256/257
Sequence Identity: 38% (93 aa)

FANLPCNRPKNRFTNILPYDHSRFKLQpvdddDGSDYINANYMPGHNSPREF--IVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV
| |.|| |||. .||||| .|  |         |||||.|.   |   |.  | ||||| || ..||.|  | ||  | |.||  | ||| .|||.    
sgnqpsnreknryrdilpydstrvplg-----kskdyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpi

DR-VAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTdmRPIIVHCSAGVGRSGTFIALDRI
 .    ..| |      . . |  | |  .    |. .....|| |||.| |   .|.....|  |    |   |..||||||.||.| |...| ..  |
slkkplelkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryarkshlt--gpmvvhcsagigrtgvflcvdvv

LQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
 |   ..|. ||  ||..|  ||||..||   .. .| ||    
fcaivkncsfnimdivaqmreqrsgmvqtkeqyhfcydivlevl

Phosphatase Ptp4E.AA PTPc_motif 1482-1583 44 4.7e-45 156.91 SMART 1-92 (92) Show / Hide
Range on Protein: 1482-1583
Range on HMM: 1-92/92
Sequence Identity: 44% (48 aa)

IMRHFHFTTWPDF-----GVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVC
...|.|.|.|||.     ||||  .|...|.|..|.       ||.||||||.||.|||.|.| ..|.      ||||..| .|||.| .|||||.||. 
TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQYIF

IHQCLLA
...|.| 
CYRCILE

Phosphatase Ptp4E.AA Subfamily.N_Nematode_4.PD 1343-1582 27 8.1e-45 144.5 In-house 16-260 (264) Show / Hide
Range on Protein: 1343-1582
Range on HMM: 16-260/264
Sequence Identity: 27% (67 aa)

QACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDdgSDYINANYMPGHnSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYW
..       |  |||...||  |..|  |.  | |   ||| |..|       ..| |||||. | ..|| | ..    ..|||   .|.| ||| .|.|
pnvtasaseknsdknryadilcidetrvvlknrdpd--ndyihaswmrmP-dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcaryy

PVDRVA-MFYGDIKVQLI-------IDTHYHDWSISEFMVSRNCES--RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDviGTDMRPIIVHCSAGVGRS
 .    . .|. ...|.        |. ..   ...   .... |   ...|.... |.||. ....... .| ..   .  .||.|||||||||. |..
peksekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk--kkkekPivvhcsaGvGrt

GTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
 .|   ..|.    ...  ||  .|. |.  ||.. |.. ..|.      
atlvGidyatirirenseievldivrelramrlkavqshlqflfllvvli

Phosphatase Ptp4E.AA Subfamily.R_Nematode_2.PD 1353-1583 26 8.4e-44 141.0 In-house 29-258 (261) Show / Hide
Range on Protein: 1353-1583
Range on HMM: 29-258/261
Sequence Identity: 26% (60 aa)

NRPKNRFTNILPYDHSRFKLqpVDDDDGSDyINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAM-FY
.. |.|. ..   .... .   . |.  .. | ||..| .. |. ||.|||||. |.|.|| |.   .   ||||... ||.|||..|.|..       |
pkdkhRypdvPCkpetavev--ivdgkrvp-ihanwvptagnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkldl

GDIKVQLIIDTHY-----HDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVrfvrAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIH
 ....     .      .  ..     . . ..| ..|. .. ||| |||.  . |...  . .||.||||||.||...||. . . ... . . . .  
grfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelf----eLlelvkksekPivvhCsaGiGRtmafigteylareve

KSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
 .  .|. |   .|||.|.  ..  .|          
adptieltealkelrehRwkgiqtesqlywltlgaly

Phosphatase Ptp4E.AA Subfamily.N_Nematode_5.PD 1330-1582 23 5.2e-34 108.9 In-house 3-254 (258) Show / Hide
Range on Protein: 1330-1582
Range on HMM: 3-254/258
Sequence Identity: 23% (60 aa)

SEEFEELKHVGRDQAcSFANLPCNRPKNRFTNILPYDHSRFKLQpvdDDDgSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTR
..|||.|. .  ..  .. .   |  ||| ...  .|..| ||.   |.| ..||||...   .. ...|.|| || .| |.||||  . .  ..|.|..
ktefeklaslkpnke-tckafeknlkknrskdvkilDetrVklt---ded-dsYinaskiklddlekkliltQlPlpdteedFWrmvyqekitsvvllve

CFEKGREKCdQYWP-VDRVAMFYGDIKVQLIIDTHY----HDWSIsEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVR-FVRAFRDVIGTDMRPIIV
  |  . .. ...|      . .|.. ..    ..     . ... | ..  . || .... |.|||..  ||.  . ...  .  . .    .  |..|
deelketav-sffpletgdylnlgkmfinnrkvevkedekkeytv-evlpegcsesvfakvyhlttWkkkkvPdkvkkvikraiekvlskkqgknapvvv

HCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
....|.||.|||..|. . . ...   ..|  |. ..|..|. .|.. .||. .....|
vsdlGlgRagtflllsvaieqlnngkepnideilkkirsqRpgavesliqyasvyaavl

Phosphatase Ptp4E.AA Subfamily.R_Nematode_3.PD 1364-1583 24 3.4e-31 99.8 In-house 34-264 (267) Show / Hide
Range on Protein: 1364-1583
Range on HMM: 34-264/267
Sequence Identity: 24% (57 aa)

PYDHSRFKLQPVDDDDGSDYINANYMPGHNSpREFIVTQGPL--------HSTREEFWRMCWESNSRAIVMLTRCFE---KGREKCDQYWPVDR-VAMFY
. ..| .|.       .|.|.||..   |.  ..|.||.|.        .|| | || |  . .. ..|||    |   ..||| .|.| .    .  ..
llektrvvLkgygkrfkddfihAnvvecpng-lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfveedgeeeekcseYypekvdgelkf

GDIKVQL-IIDTHYH-DWSISEFMVSRN-CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIgtdmRPIIVHCSAGVGRSGTFIALDRILQHIHKS
..|.   |..... |    ...|. .  .   ..| ... |.. ..|| |....  ... ..      |..||||.|..||.|. | .   | | ||.  
egvsvkctdikkelsedvekrtlvvtfekkkeftvthllykgWkelnapeepkealelikfveksk----tpvvVHCsdGisRsatlaaielgyqliiks

D-YVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
.|.  .. ..|| |   .|||...  .  ..|    
kgkldllslikelrkqRagaiqtelelafvilgilk

Phosphatase Ptp4E.AA Subfamily.N_Nematode_egg.PD 1329-1583 23 2e-26 84.2 In-house 2-254 (257) Show / Hide
Range on Protein: 1329-1583
Range on HMM: 2-254/257
Sequence Identity: 23% (60 aa)

FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT
. ..|| |...  ... . |    .. | |   .   . || ||.        |.| ||.. |.    |||..| ||  ||.|||| .. . . ||||| 
lerrfeilersvdeislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvedfwrmvfqekvqyivmlt

RCFEKgrEKCDQYWPV---DRVAMFYGDIKVQLIIDTHYHD--WSISEF-MVSRNCESRIMRHFHFtTWPDFGVPEPPqslVRFVRAFRDVigtdMRPII
  |   |.|. |||    . . .  | .... .   .  |  . .... .|  . | .. |.    .   .    |   .| .|  |..     .|..|.
sakes--erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgddeelflehwqg-dvnylsdvysp---lrvlrklrnl----skpvv

VHCSAGVGRSGTFIALDRILQHIHKSDY--VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
.  || ...|..|..  | .. .       .   |  .|..| . |..  .|. ... .|   
vqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

Phosphatase Ptp4E.AA Subfamily.N_Fungi_PTP1.PD 1356-1446 38 2.9e-25 80.2 In-house 48-152 (343) Show / Hide
Range on Protein: 1356-1446
Range on HMM: 48-152/343
Sequence Identity: 38% (39 aa)

KNRFTNILPYDHSRFKLQ----PVD----DDDGSDYINANYMPGH------NSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQY
|||..|||||.||| ||.    . |       ..|||||||.         |.   .| ||.|| || ..|.... . . .|..||  .| ..|||..||
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPVDR
.    
Wqegs

Phosphatase Ptp4E.AA Subfamily.N_Fungi_PTP1.PD 1477-1583 31 4.1e-20 63.3 In-house 209-340 (343) Show / Hide
Range on Protein: 1477-1583
Range on HMM: 209-340/343
Sequence Identity: 31% (38 aa)

NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGT----------DMRPIIVHCSAGVGRSGTFIALDRILQ----------HIHKSDYVD----
.|  .. ....  |.| ..   |.|... .    |.| .             ||.||||||||| ||...|| .|.. .|.|.       |. ||  .||
vsepyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

-IFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
.|. |||. .|.. |...||            
lisiivnelrkqrismvqnldqfifiYeallf

Phosphatase Ptp4E.AA Subfamily.N_Nematode_eak.PD 1356-1512 22 7.4e-17 52.8 In-house 29-184 (281) Show / Hide
Range on Protein: 1356-1512
Range on HMM: 29-184/281
Sequence Identity: 22% (35 aa)

KNRFTNILPYDHSRFKLQPVDDDdGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIK
.||  .|.|.|.   .| .   .    ||||  .   .  |..|.|  . ..    ||.|  | .| |||.|    |..|| |.|.| .   . || ..|
rnrvvkivpqdrylvrltssqln-rdGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfpdktevlkyGild

VQLIID-THYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPpQSLVRFVRAFRD
.      .        .....  |.  . |...  | .. .|   . .. . ..... 
verkeyavkrniletrllilrkGnethrvlhykvfGwtettlpky-edflalrkvmke

Phosphatase Ptp4E.AA Family.DSP.PD 1474-1555 21 1.3e-08 25.8 In-house 148-223 (387) Show / Hide
Range on Protein: 1474-1555
Range on HMM: 148-223/387
Sequence Identity: 21% (17 aa)

VsrnceSRIMRHFHFtTWPDFGVPEPPQSlvrFVRAFRdVIGT---DMRPIIVHCSAGVGRSGTFIALDRILQ-HIHKSDYVDIFG
.  ... ..  ..|...| . .    |..|.. .| .   .   . ||| ||.||||| |.  .. . .. ... .| .       
k-----elgikylri-pidDhnapplenl---fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvr

Phosphatase Ptp4E.AA Subfamily.PTPDC1.PD 1486-1579 22 4.1e-08 24.2 In-house 137-222 (229) Show / Hide
Range on Protein: 1486-1579
Range on HMM: 137-222/229
Sequence Identity: 22% (21 aa)

FHFTTWPDFGVPePPQSLVRFVRAFRDVIgtDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDyvdifGIVFAMRKERVFMVQTEQQYVCIHQ
|.  ...|.||. . ....  |.    ..      | ||| || || |  ||   . ..  ...       .  .|..|   .|| .|....  
fynfglkDygva-sleriLdivkvvdfal--eegkiavHCHAGlGRtGvliacylvyakrltae-----eaiklvrskrpksiqtreqvelvee

Phosphatase Ptp4E.AA Subfamily.DSP23.PD 1490-1573 28 6.1e-06 17.6 In-house 40-116 (128) Show / Hide
Range on Protein: 1490-1573
Range on HMM: 40-116/128
Sequence Identity: 28% (23 aa)

TWPDFGVPEPPQsLVRFVRAFrDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDyvdifGIVFAMRKERVFMVQTEQQ
|||  | . | ..|.||   ..      .. |||  |.||.||..|   . ..   .|       .  .||.|   ..| .|  
dipdfcPPaleq-varlvriv-eeaekkeeavgvhcalGlGrtGtllacylvkeeglaad-----daiaevrkrrkGsietveq

Sequence
Name Sequence Type Origin Length Description Download
Ptp4E.AA Protein None 1767 None Fasta, JSON
Ptp4E.NA RNA None 5301 None Fasta, JSON
Ptp4E.AA.PD_1328-1586 Protein Phosphatase Domain None 259 None Fasta, JSON