Gene aux
aux
Species: D.melanogaster
Alias: aux
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of aux.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | aux.AA | GAK | 50-319 | 64 | 5.4e-228 | 763.72 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 50-319 Range on HMM: 1-277/277 Sequence Identity: 64% (180 aa) LRIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAP--STQLGAQYLLLTELCKGGSLVDCFR--T .|..|||||||.||||||||||||.||||||....||||..||||||...|.|.||||||.|...||... |.|..|.||||.|.||...||||.. . YRVRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRME NNAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNN ...||...|||||||||.|||...|||.|||.|||||||||||||.|.|||||||||.|....|...|||..|||.||.....||||||||||.|..||. CYKPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNW PIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANYM--LPP-DPQYQCFSDIIRGCLKVNPFERLDITMVLEGL |||.|.||||.||.|||.|||.||.|||.||||||.||| .|| |.||.||.|.||.||.|||.|||||.||.|.. PIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMCFHDLIRACLQVNPDERLDIAMVVEYM |
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| Kinase | aux.AA | NAK | 50-319 | 39 | 7.79999999999e-150 | 503.41 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 50-319 Range on HMM: 1-299/299 Sequence Identity: 39% (118 aa) LRIKCVIAEGGYAFVYVAQ---------DVQTGTEYALKRLIGA-DMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPS-TQLGAQYLLLTELCKGGS .......||||...||..| ....|..|||||.| |.|. |...||...|.|..|.||| ...|... .. .. . ...|| |.|..|| YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS LVDCF--RT--NNAPFNPTCVLRIFYQMARAVASLHSQSP--PIAHRDIKIENFLIG---NDKQIKLCDFGSASTEVLSPTFEWSANQRSMLEDQLNTVT |.| . |. .. .|. ..|.||......|. .|.. | ||.||||||||.|.. .|...|||||||..|....|. .|.|..|||..|. |. | LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT TPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYED------GGKLRIINANYM--LPPD-PQYQCFSDIIRGCLKVNPFERLDITMVLEGL |||||.|||.|..||.||. |||||||||.||..|...||.|| ..||.|.|.||. |.. ..|.. |.||..|...| .|..| .||. | TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | aux.AA | NAK-Unclassified | 50-321 | 22 | 2.2e-67 | 230.15 | In-house | 1-405 (405) | Show / Hide |
Range on Protein: 50-321 Range on HMM: 1-405/405 Sequence Identity: 22% (92 aa) LRIKCVIAEGGYAFVYVAQ--------D------VQTGTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYT-APSTQLGAQYLLLTELC .| .|||| .|||... | .. |.||| | | . . .||.. | . .|.||| ... . . . ...| |.| YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC KGGSLVDCFR---------TNNAPFNPTCVLRIFYQMARAVASLHSQSP--------------------------------------------PIAHRDI ..|||.| | | .|.|... ..... .|...| |..|||| SRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDI KIENFLIG----------------------------------------------------------NDKQIKLCDFGSASTEVLSPTFEWSANQRSMLED |||| |. .. |||||||.... .. . ... |.| KIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIE---NRQEMQYLQD QLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLR-------IIN--ANYMLPPDPQY-QCFSDIIRGCLKVNPFERLDIT |. ||| ||.|||.|. .. || |.||||||| || .|. | |..| | |.. ..| |. ..| . |. .| ..| .|. | WINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIY MVLEGLAA ||. . QVLNHICQ |
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| Kinase | aux.AA | S_TKc | 50-322 | 24 | 3.2e-61 | 210.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 50-322 Range on HMM: 1-231/231 Sequence Identity: 24% (69 aa) LRIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKG--GSLVDCFRTNN .| .| .|... || .... || ..|.|.. |..||.|.|. .|.||| . .. .. . . .|.| | |.| | . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG AP-----FNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTW . |.. . ...||...|.. .||. | |||.| || |. . .||.||||.| . || |..||.| RHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL--- SNNPIGP-KVDIWALGCILYFLCYRKHPYEDGGKLRIINANYMLPPDPQYQCFSDIIRGCLKVNPFERLDITMVLE-G-----LAAL . |. |.|.|..||||| ..... |.. .... . . |.||.||...| .|. . .|. . . ---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | aux.AA | BIKE | 50-291 | 34 | 4.3e-55 | 189.34 | In-house | 1-239 (267) | Show / Hide |
Range on Protein: 50-291 Range on HMM: 1-239/267 Sequence Identity: 34% (85 aa) LRIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLVDCF--RTNN . ..||||.| |....| . |. .|||| .. . |. | ||.||| ||| .| .. .. . . ..|.| |.. .|. | . VTVEEQLAEGGFAMVFLVRD-HKGNKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGNGV-WECMILMEYCRH-QVVNMMNQRLQQ A-PFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDK--QIKLCDFGSASTEVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSN | ||.|| .. ||. || || ||| |.|| |. . . ||||||| . .|.| . . | . .| || ||.||| | .| GQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQKH-GVN---YVKDEIEKYTTMCYRAPEMIDLYSG NPIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANYMLPPDPQY .|. | |||||||.|| ||. |.. .| | . |. .| ..| KEITTKADIWALGCMLYKLCFFCLPFGE-SQLAICDGNFTIPDNSKY |
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| Phosphatase | aux.AA | CAMK | 55-317 | 17 | 3.2e-46 | 146.52 | In-house | 1-421 (425) | Show / Hide |
Range on Protein: 55-317 Range on HMM: 1-421/425 Sequence Identity: 17% (73 aa) VIAEGGYAFVYVAQDVQTG------------TEYALKRLIGADMQAS----------------------------TAIINEINIHKQLSG------HENI .. .|... |. ... .|. ...| | . .. . . .||.|.|.|.| |.|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VAFVGSSYTAPSTQLGA--------------QYLLLT---ELCKGG----SLVDCFRTNNA--------------PFNPTCVLRIFYQMARAVASLHSQS . . .. . .. .. . . |.| || | | . . |. . |.| |.. ||. .||. IKLYEVYEDPHYFK-NTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN PPIAHRDIKIENFLIGNDK-----------------QIKLCDFGSA--STEVLSPTFEWSANQRSMLEDQ----------LNTVT-TPMYRS-PEMLDTW |.|||.| || |. ... .||..||| | .. . ... . .... . .. ..|. || | . ||.| --IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK S-----------NNPIGPKVDIWALGCILYFLCYRKHPYEDG-----------------GKLRIINANYMLPPDPQY----------------------- . . ..|||.|.|..|.|||.. . |... . .|....| ||.. GHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVS QCFSDIIRGCLKVNPFERLDITMVLE | | ||..|.|.| .|. |. .|. QECKDLIRKMLQVDPEKRMTIEQCLN |
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| Kinase | aux.AA | TKL | 56-319 | 18 | 2.8e-39 | 136.81 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 56-319
Range on HMM: 1-364/364
Sequence Identity: 18% (69 aa)
IAEGGYAFVYVAQDVQ--------TGTEYALKRLIG------------------------ADMQASTAIINEINIHKQLSG--HENIVAFVGSSYTAPST
| .||.. || .. . ||.. | |.. |. || . |.. ...| |.||| |.|.. |..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
Q-------LGAQYLLLTELCKGGSLVDCFRTNNAPFNPTCVLRIFYQMARAVASLHSQS------PPIAHRDIKIENFLIGNDKQ--------------I
. |. . .|.|.|||| . . . .|. ...||... |||. |||.|||.| .| |. .. . .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC
KLCDFGSAS-TEVLSPTFEWSANQR------SMLEDQLNTVTTPMYRSPEMLD---TWSN----------NPIGPKVDIWALGCILYFLCYRKHPYEDGG
|.|||| . . . .. ... . . . . || . .||.|. .. . .|.|... | .|. .. |..||.| .
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
KLR-----------IINANYMLPPDPQ------------YQC---FSDIIRGCLKVNPFERLDITMVLEGL
..... |.| . .| ..... | . .| .|. . .|. |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | aux.AA | Ciliate-E2 | 50-317 | 18 | 2e-35 | 119.06 | In-house | 1-361 (365) | Show / Hide |
Range on Protein: 50-317 Range on HMM: 1-361/365 Sequence Identity: 18% (69 aa) LRIKCVIAEGGYAFVYVAQDVQTGT-----------------------EYALKRLIGADMQASTA---IINEINIHK----------QLSGHENIVAFVG . .| .|... || ... ... .||.|... . .. |..|||. . .. | ||. .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE SSYT-APSTQLGAQYLLLTELCKGGSLVD--CFRTNNAPFNPT--------CVLRIFYQMAR---------------AVASLHSQSPPIAHRDIKIENFL . .. .. . | .|.|.||.| | . . ..... ...|..| .. |. .|||. . | ||||| || | CFQEKDDNN-----IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENIL IGNDKQIKLCDFGSASTEVLSPTFEWSANQRS-MLEDQLN--------------------TVTTPMYRSPEMLDTWS------NNPIGPKVDIWALGCIL . ||..||| . . . .|.. .. . | .. ||.| .||.| . .. . |.|||.||.|| F-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL YFLCYRKHPYEDGGKLRIINA-NYMLP-----------------PDPQYQCFSDIIRG----CLKVNPFERLD-ITMVLE |.... |.|. ...| .. .| .. | |.|. .|...| .|.. . .|. YEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| Kinase | aux.AA | Pkinase | 50-202 | 27 | 1.2e-31 | 113.03 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 50-202 Range on HMM: 1-159/293 Sequence Identity: 27% (47 aa) LRIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAIIN----EINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGG----SLVD ..|. .| .|... || .... || ..|.|.. . . ... || |.| | .|.||| . .. .. . . . .|.| || .| | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD CFR-TNNAPF--NPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQI----KLCDFGSA . .. .| . . ...||..|... .||. | |||.| ||.|| |. .| |.||||.| YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | aux.AA | TKL-ciliate1 | 124-319 | 23 | 1.7e-30 | 101.58 | In-house | 67-279 (279) | Show / Hide |
Range on Protein: 124-319
Range on HMM: 67-279/279
Sequence Identity: 23% (52 aa)
GAQY----LLLTELCKGGSLVD-CFRTNN--APFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSAN
...| . .|.| .|...| | |. . .|. . |. . ||. .|. |||.|..| | . . | | |.|.. . . .
ISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRI---RNC
QRSMLEDQLNTVTTPMYRSPEMLD--TWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANYMLPPDP------------QY-QCFSDIIRGC
. . ||.... || .| .| || |.||.|.| ..| || || |.. |. || . | . | | ... |
SFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQ--KMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRC
LKVNPFERLDITMVLEGL
. || | . ... |
WCQNPNKRPNFNEIIQIL
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| Kinase | aux.AA | STE | 50-309 | 21 | 4.2e-29 | 99.97 | In-house | 1-345 (359) | Show / Hide |
Range on Protein: 50-309
Range on HMM: 1-345/359
Sequence Identity: 21% (76 aa)
LRIKCVIAEGGYAFVYVAQDVQ---------------TGTEYALKRLIGADM-----------------QASTAIINEINIHKQLSG-HENIVAFVGSSY
... .| .|.. || | .. ||. .| |.. . . |..||.|.|... |.||| . |. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
TAPS-TQLGAQYLLLTELCKGGSLVDCFRTNNAPFNP-------------TCVLRIFYQMARA-VASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGS
.. . . . |.. |||| | ... ...| . . .| .| .. . |||. | ||||| | |. .||||||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV
AS--TEVLSPTFEWSANQRSM----LED-QLNTVT-TPMYRSPEMLDTWS---NNPIGPKVDIWALGCILYFLCYRKHPYEDGGKL----RIINANYML-
.. |. .. . |.| . . ||.. || . .||... . ... . |.||| ||| . .. |.|. |. . .|.. ..|
CGQLTDSMANI-Q-SNN-I-IDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ
------------PPDPQY---------------------QCFSDIIRGCLKVNPFER
|| |. ..| | |. ||. .| .|
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKR
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| Kinase | aux.AA | CAMKL | 50-202 | 26 | 4.8e-23 | 70.25 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 50-202 Range on HMM: 1-176/297 Sequence Identity: 26% (47 aa) LRIKCVIAEGGYAFVYVAQD-VQTGTEYALKRLI--GADMQASTA-------------IINEINIHKQLS--GHENIVAFVGSSYTAPS-TQLGAQYLLL || .. .|... | |.. ||...| | . .. . . | ||.|.|.|. .|.||. . .| . .. | YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV TELCKGGS--LVDCFRTNN---APFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDK--QIKLCDFGSA .|.| ||. | | . . .. . |.| |. ||. .||. |.||||| || |. ... .||..||| . MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Phosphatase | aux.AA | Subfamily.PTEN.PD | 413-575 | 25 | 9.1e-16 | 46.0 | In-house | 1-160 (305) | Show / Hide |
Range on Protein: 413-575 Range on HMM: 1-160/305 Sequence Identity: 25% (42 aa) DISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPppvrtVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKS |||.| . ..|. | . .| .. | .|..| | .|| |.|. .. | . .||.. ..|.|. | .. |. ..|..| . disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdf-----dgrvavypfdDhnpptleLleeivedvdkwLkedksn VVIVQTGDSGGCTaATVICALLMYADLLREPEDAVQVFAVKRHTIN---LRPSEFRYLYYFGDILR ||.| | | ..||| |.. .....|..... || . . || ||..|| ... VvavHCkaGkGRt-GvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvk |
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| Kinase | aux.AA | Pkinase | 230-319 | 21 | 3e-14 | 51.47 | Pfam | 174-293 (293) | Show / Hide |
Range on Protein: 230-319 Range on HMM: 174-293/293 Sequence Identity: 21% (26 aa) TPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDG------GKLRIINANYMLPPDPQY------------------------QCFSDIIR || |..|| . .....|||||.|..||||| .. .. |. . .. .|. . . |.. .. . . |.|. TPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK GCLKVNPFERLDITMVLEG--L .||...| .|. .. .|. . WCLCKDPKKRPTAEQILQHPWF |
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| Kinase | aux.AA | TyrKc | 50-319 | 18 | 4.3e-10 | -59.5 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 50-319
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)
LRIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAIINEINIHKQL-SGHENIVAFVGSSYTAPSTQLG------AQYLLLTELCKGGSLVDC
.. . .. || . || .. .. | | | ....|..| ..| |.|||...| . | ......|....|.| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQ-----GRNFMYIEPLMIVMEYMPHGDLKDY
FRTNNAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSANQRSMLED-------QLNTVTT-PMYR
| . ... | . .| |. . |||. .. |||. | |.|.....| .||| || | .| . .... .
LRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFG------LS---------RDIYDDDQQGESKDYYRKKEHKGGK
--------SPEMLDTWSNNPIGPKVDIWALGCILY-FLCYRKHPYED------GGKL---RIINANYMLPPDP---------QYQCFSDIIRGCLKVNPF
.|| . . .| |.|. | .. . | . ||.. . .. . ..| .|. .. |.. | . .|
TMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPE
ERLDITMVLEGL
.| . . | .
DRPTFSEIHECF
|
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| Kinase | aux.AA | CAMKL | 248-317 | 31 | 2.1e-09 | 26.03 | In-house | 214-293 (297) | Show / Hide |
Range on Protein: 248-317 Range on HMM: 214-293/297 Sequence Identity: 31% (26 aa) GPKVDIWALGCILYFLCYRKHPYEDGG-----------KLRIINANYMLPPDPQY-QCFSDIIRGCLKVNPFERLDITMVLE |||||||..| |||.. . . | .| ...|. |. |. .. .| |.||. |.||| .| | ... GPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVSDC-RDLIRKMLQVNPEKRPTIHQIMN |
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| Kinase | aux.AA | Pkinase_Tyr | 83-200 | 28 | 2e-06 | 22.34 | Pfam | 39-156 (270) | Show / Hide |
Range on Protein: 83-200 Range on HMM: 39-156/270 Sequence Identity: 28% (35 aa) GADMQA--STAIINEINIHKQLSGHENIVAFVGSSY--TAPSTQLGAQYLLLTELCKGGSLVDCFRTN---NAPFNPTCVLRIFYQMARAVASLHSQSPP ||. .. . . ..|..| ||| |.||| ..| . |. |... .|....|.| | |.. . |... | . .| |.. . |.|. GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-- IAHRDIKIENFLIGNDKQIKLCDFG . |||. | |.......| |||| CIHRDLAARNCLVTENNVVKICDFG |
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| Phosphatase | aux.AA | PTEN_C2 | 581-715 | 23 | 8.4e-35 | 126.63 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 581-715 Range on HMM: 1-141/141 Sequence Identity: 23% (33 aa) PHYKNTTLVSLSC-QPVPRMTKARDGC-RIYMEVYCNGNLLLSTLQDYEKMRLY-QAGPGKIVLPINLTACGDVTVVLFHAR-KGMVRPQGLKICQFQFN |. | .|... . ...|.. |...|| |.|...|.| . ...|...|.... | |.. .....|.... .||| . .| . . . . ....|.|| PPPKPLFLHCIIMDHGIPNF-KQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFN TGFIPEPETLITFTNQDLDDLPDP---EQVTPRFCVSLSLAV |.||.. ....||. ..||.. .. .. .| |.| . . TCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | aux.AA | Subfamily.Tensin.PD | 482-698 | 25 | 1.9e-17 | 51.5 | In-house | 8-220 (237) | Show / Hide |
Range on Protein: 482-698 Range on HMM: 8-220/237 Sequence Identity: 25% (56 aa) YGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTaATVICALLMYADLLREPEDAVQVFAVKR-----HTINLRPSEFRYLYYFGDILRP .| |. .|| |. | .. . .|.|||. ||.. . . | . . ||.| . |... .. |.. ||.|| . ..|| ||. || ..| lGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGri-gvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgllsg TPLLpHYKNTTLVSLSCQPVPRMtKARDGCRIYMEVYCNGNLLlSTLQDYEkmrLYQAGPGKIVLPI--NLTACGDVTVVLFHarKGMVRPQGLKICQFQ . | . | . .| . ... ||| .. .| .|. | |. . . .. .... | | ||| |.| | . .. . . || sikl-nssplflhyvilhgipnf-dskggcrpflkiyqalqlv-ytsgvyn---vagedterlcitiepalllkgdvlvkcyh--kklrsttrdvvfrvq FNTGFIPEPEtlITFTNQDLDDLP || | . . ..| .|||. fhtgaikdlk--lvfekedldeal |
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| Phosphatase | aux.AA | Subfamily.TPIP.PD | 489-573 | 22 | 1.8e-09 | 25.6 | In-house | 15-106 (245) | Show / Hide |
Range on Protein: 489-573 Range on HMM: 15-106/245 Sequence Identity: 22% (21 aa) APNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGcTAATVICALLMYADLLREPEDAVQVFAVKRHTINL--------RPSEFRYLYYFGDI |.|. |.... .. ..|..|.. ||.. | . |..||||........ |.... |. .| . || ||. |. .. vPtleelvvftkevkewlakdlenvvaihckGGkg-rtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgylaqv |
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| DnaJ | aux.AA | DnaJ | 1110-1150 | 41 | 4.6e-08 | 32.88 | Pfam | 13-52 (65) | Show / Hide |
Range on Protein: 1110-1150 Range on HMM: 13-52/65 Sequence Identity: 41% (17 aa) TPTEVKKAYRRACLAVHPDKHNGTENEEIAKLIFMELNNAW .. |.|||||. .| .||||. . . | |. |.|.|.|. SDEEIKKAYRKLALKYHPDKNPDDPE-EEAEEKFKEINEAY |
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