Gene puc
puc
Species: D.melanogaster
Alias: puc
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of puc.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | puc.AA | Family.DSP.PD | 128-272 | 35 | 5.3e-38 | 122.2 | In-house | 101-249 (387) | Show / Hide |
Range on Protein: 128-272 Range on HMM: 101-249/387 Sequence Identity: 35% (53 aa) DIETHPASPVFPHLLLGNGRDADDPSSV---GANCVLNVTCQSPNESHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSA .| .. | ..||| ||. ..| . . | . ..|.|...|... .| ||..|| .|.. ... ..|..|.||||........|| ||.||..||.| rvengkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsg TIAIAYVMRYKSLSLLEAYKLVKVARP-IISPNLNFMGQLLELEQNLRK . ||| | .. |.| ||...|. .|| .| || .|. || .||....| tliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklk |
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| Phosphatase | puc.AA | Subfamily.DSP10.PD | 133-269 | 62 | 7.1e-68 | 217.8 | In-house | 1-141 (141) | Show / Hide |
Range on Protein: 133-269 Range on HMM: 1-141/141 Sequence Identity: 62% (88 aa) PASPVFPHLLLGNGRDADDPSSV---GANCVLNVTCQSPNESHLQGLK-YMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAI |||...|.|||||..||.| ... |...|||||...||... .||. |..||.||...||.||.|.||..|||.|||.|||||.|||||||||||..| passilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvi AYVMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQN ||||...|||| ||||.|| .||||||||||||||||.|.. ayvmkhlslslseaykfvkekrPiisPnlnfmGqllefeke |
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| Phosphatase | puc.AA | DSPc | 133-269 | 37 | 9.3e-44 | 152.61 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 133-269 Range on HMM: 1-172/172 Sequence Identity: 37% (65 aa) PASPVFPHLLLGNGRDAD--DPSSVGAN---CVLNVT--CQSPNE--------------SHLQGLKYMQIP-ASD-------TPHQNIKQYFQEAYDFIE . | . ||| ||. ... .| . .. |.||| | ... .| .. ||.|| .| .. .|| ||| |.||||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH DARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLV-----KVAR-PIISPNLNFMGQLLELEQN |.|. | .|| || ||||||||..||| |.|...|. .|| .| | .| |||.||.||..||.|.|. DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | puc.AA | Subfamily.DSP6.PD | 137-268 | 46 | 1.3e-42 | 135.7 | In-house | 5-140 (141) | Show / Hide |
Range on Protein: 137-268 Range on HMM: 5-140/141 Sequence Identity: 46% (63 aa) VFPHLLLGNGRDADDPSS---VGANCVLNVTCQSPNESHLQ-GLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVM . |.| ||. .|| . . .. . ||||| . || . . |||.|||..|. .||. ..| || .||..||.. | ||.||.||.||||...||.|. ilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylm RYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQ ...||| .||.||| .. ||||.|||||||. |. kklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | puc.AA | DSPc | 160-269 | 43 | 6.4e-42 | 147.69 | Pfam | 24-151 (151) | Show / Hide |
Range on Protein: 160-269
Range on HMM: 24-151/151
Sequence Identity: 43% (56 aa)
VLNVT--CQSPNESHLQGLKYMQIP-ASD---------TPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLV-
|.|.| | ....| . ||.|| | .. .|| |||..|.|||.|.|. | .|| || |||||||...||| |.|. .|. ||| .|
VINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVY
----KVAR-PIISPNLNFMGQLLELEQN
| | |.|||| ||..||.|.|..
IYHMKQRRCPMISPNMNFWRQLCEYERQ
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| Phosphatase | puc.AA | Subfamily.DSP8.PD | 153-270 | 46 | 6.1e-40 | 127.4 | In-house | 24-142 (143) | Show / Hide |
Range on Protein: 153-270 Range on HMM: 24-142/143 Sequence Identity: 46% (55 aa) SSVGANCVLNVTCQSPN-ESHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARP . .| . |||.... | . |. ....|| |. . .. ..|..|..||. ||.. ..||.||.||||||||.||||.|.. ..|| |||. || || kklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrp IISPNLNFMGQLLELEQNL |||||||.||||| |..| tispnlnflgqLleyekel |
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| Phosphatase | puc.AA | Subfamily.DSP14.PD | 137-269 | 39 | 1.1e-39 | 126.6 | In-house | 5-138 (138) | Show / Hide |
Range on Protein: 137-269 Range on HMM: 5-138/138 Sequence Identity: 39% (54 aa) VFPHLLLGnGRDADDPSSVGA---NCVLNVTCQSPNEShLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMR . ..| |. |. | ... . . ....||| . |. . |...|...|. .|.|.......|.|..| ||...|.| ..|.|| ||.||||....||.|. itesLyls-gaaalkkeklkkkkitlivnvttelpetk-ledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmk YKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQN |..||| ||||||| ||||| || | || ..|.. yeklsLreayklvksaRpiirPnvGFwkqlidyEkk |
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| Phosphatase | puc.AA | Subfamily.DSP1.PD | 137-268 | 43 | 3.2e-39 | 125.1 | In-house | 5-138 (139) | Show / Hide |
Range on Protein: 137-268 Range on HMM: 5-138/139 Sequence Identity: 43% (59 aa) VFPHLLLGNGRDADDPS---SVGANCVLNVTCQSPNEsHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMR . ..| || .| . . ... .|||. . || . . .||..|| .|.....|...|.|| |||....|.| |||.||.||||||||| .||.|. ildfLyLGsaehasnlqlLkelkitallnvsaelpnv-feelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmk YKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQ | ..| ||.. || | |||||..|.||||| |. ekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | puc.AA | Subfamily.DSP19.PD | 141-268 | 41 | 7e-35 | 110.8 | In-house | 9-138 (139) | Show / Hide |
Range on Protein: 141-268 Range on HMM: 9-138/139 Sequence Identity: 41% (54 aa) LLLGNGRDADDPSSVGA---NCVLNVTCQSPNEsHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSL |.|| | | ... .|||. . || . . ..|..|. |.| ... .|..|| ||||.||... |||.||.||.||||...|||.|. ..| lylgsqdvaadkeilkklkitHilnvavgvpnv-fpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeel SLLEAYKLVKVARPIISPNLNFMGQLLELEQ || .|.. |. ||| |.|| |. || |.|. slekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | puc.AA | Subfamily.DSP15.PD | 137-268 | 40 | 8.8e-33 | 104.1 | In-house | 5-137 (138) | Show / Hide |
Range on Protein: 137-268 Range on HMM: 5-137/138 Sequence Identity: 40% (54 aa) VFPHLLLGNGRDADDPSSVGANCVLNVT-CQSPNESHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYK | | | .|| ||| | . .. | . . . . .|...||. |.|.|.|.|.....|.|. ||| .| |. ||.|| |||||| |...||.| vlpGlyvGnfrdakdkeqleenkithilsihdsakplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvt SLSLLEAYKLVKVARPIISPNLNFMGQLLELEQ .|| .| | ||.||.. ||. | || | |. elswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | puc.AA | Subfamily.DSP12.PD | 137-263 | 35 | 1.8e-32 | 103.3 | In-house | 5-135 (143) | Show / Hide |
Range on Protein: 137-263 Range on HMM: 5-135/143 Sequence Identity: 35% (47 aa) VFPHLLLGNGRDADDPS---SVGANCVLNVTCQS-PNESHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVM . | |.||. ... ... .. . || |. .. |. .. .| |. .|.. |.|.... ....|| .|||...... || ||.||.|||.|| |||.| ilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlm RYKSLSLLEAYKLVKVARPIISPNLNFMGQL ... ||| .|.|||| ... |.|| .|. || kkeklslekAlklvkekkkeiepNegFleQL |
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| Phosphatase | puc.AA | Subfamily.Slingshot.PD | 134-265 | 39 | 5e-31 | 98.3 | In-house | 2-135 (139) | Show / Hide |
Range on Protein: 134-265 Range on HMM: 2-135/139 Sequence Identity: 39% (53 aa) ASPVFPHLLLGNG---RDADDPSSVGANCVLNVTCQSPNeSHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAY || .| || || . .. . | . .||||.. | . . .||..| |...... ....|.|.||| |...||.||.|||.||||.. ||| | askifdhlylGsewnasnleelkengveyilnvtkeidn-ffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviay VMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLE . .||| ||.. || | || || .|. || . amkeyelsleealeyvkerrsiikpnkgflkqlkv |
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| Phosphatase | puc.AA | Subfamily.DSP3.PD | 169-268 | 44 | 3.5e-30 | 95.8 | In-house | 47-147 (148) | Show / Hide |
Range on Protein: 169-268 Range on HMM: 47-147/148 Sequence Identity: 44% (44 aa) NESHL-QGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKT-GSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIiSPNLNFMGQLLEL .| . ..||. ...||.|. ....||.|| |||..| .. ...||.||..|||||||...||.| ...|.| || | |. | | |||. |||||.. aefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkrei-lPneGflkqLlel EQ de |
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| Phosphatase | puc.AA | Subfamily.LRR-DSP.PD | 172-268 | 43 | 2.3e-28 | 89.7 | In-house | 41-136 (137) | Show / Hide |
Range on Protein: 172-268 Range on HMM: 41-136/137 Sequence Identity: 43% (42 aa) HLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSrVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQ . . .||. | ..|... .| |.|.| ||.. |. | ||.|| ||.|||||..|||.|...|| . ||. ||. || | || |.||. |. ypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | puc.AA | Subfamily.STYXL1.PD | 141-268 | 32 | 1.2e-21 | 68.3 | In-house | 10-142 (143) | Show / Hide |
Range on Protein: 141-268 Range on HMM: 10-142/143 Sequence Identity: 32% (43 aa) LLLGNGRDADDPS---SVGANCVLNVTCQS-PNESHLQG-LKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYK | ||| ..| .|. . ..||. .. . . |.. | ..|. .|... .. . ..|. .|||. .|.|. ||. . ||||||...|||.| .| lylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmysk SLSLLEAYKLVKVARPIISPNLNFMGQLLELEQ ..| .||| .| .. . || .|. || | |. kitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | puc.AA | Subfamily.STYX.PD | 174-267 | 38 | 5.2e-20 | 62.7 | In-house | 51-144 (146) | Show / Hide |
Range on Protein: 174-267 Range on HMM: 51-144/146 Sequence Identity: 38% (36 aa) QGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELE . ..|. . .|.. .|| .|. .. .||.|. ..| .||.| |||||||.. |||.| | ||.. |. | |.|| |. || || drfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | puc.AA | Subfamily.PTPMT1.PD | 162-254 | 34 | 1.5e-18 | 58.0 | In-house | 39-131 (146) | Show / Hide |
Range on Protein: 162-254 Range on HMM: 39-131/146 Sequence Identity: 34% (32 aa) NVTCQSPNESHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIIS . ..| .| . .|....|.. | . ... .|. .|||. .. ||.| .|| || .||||....|.|. | || || |..| ||.| kalansteewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqir |
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| Phosphatase | puc.AA | Subfamily.CDC14.PD | 200-260 | 25 | 1.9e-08 | 25.2 | In-house | 189-251 (258) | Show / Hide |
Range on Protein: 200-260 Range on HMM: 189-251/258 Sequence Identity: 25% (16 aa) DFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARP--IISPNLNFM |.| . |. . .||.||. | .|. .|.... .. |. ...||| .|.| ... kfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPGsvigpqqtyl |
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| Phosphatase | puc.AA | Subfamily.R_Nematode_3.PD | 187-237 | 35 | 2.3e-08 | 24.7 | In-house | 176-229 (267) | Show / Hide |
Range on Protein: 187-237 Range on HMM: 176-229/267 Sequence Identity: 35% (19 aa) PHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAI---AYVMRYKSL ...|... .|| . |. ..| . |. ||..|||||||.| .| . || kelnapeepkealelikfveksktpvvVHCsdGisRsatlaaielgyqliiksk |
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| Phosphatase | puc.AA | Subfamily.R_Nematode_2.PD | 172-233 | 24 | 4.5e-08 | 23.6 | In-house | 161-218 (261) | Show / Hide |
Range on Protein: 172-233 Range on HMM: 161-218/261 Sequence Identity: 24% (15 aa) HLQGLKYMQIPASDTPHQNikqyfQEAYDFIEDARKTGSRVLLHCHAGISRSAT-IAIAYVMR .. ..| . |. ..|. . .| .. .| ..| .. || ||| |. . |...|. | tvthyqyeeWpdrgvPksh-----aelfeLlelvkksekPivvhCsaGiGRtmafigteylar |
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| Phosphatase | puc.AA | Subfamily.Laforin.PD | 174-252 | 24 | 9.6e-07 | 19.6 | In-house | 69-147 (165) | Show / Hide |
Range on Protein: 174-252 Range on HMM: 69-147/165 Sequence Identity: 24% (19 aa) QGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPI .|| |. .| | .. . . .| .. . | .| .|| ||. ||..| ... || . ||. eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv |
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| Phosphatase | puc.AA | Subfamily.DSP23.PD | 165-250 | 22 | 1.4e-06 | 19.3 | In-house | 24-107 (128) | Show / Hide |
Range on Protein: 165-250 Range on HMM: 24-107/128 Sequence Identity: 22% (19 aa) CQSPNEShLQGLKYMQIPASDTPHQNIKQyFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVAR .....|. ..| . .| | ..| .. . .|.| | . | .|| |. |. |. |... . |. .| |. | gapysea-apsltlrridipdfcPPaleq-varlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrr |
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| Phosphatase | puc.AA | Subfamily.DSP11.PD | 179-252 | 19 | 1.6e-06 | 19.0 | In-house | 50-124 (141) | Show / Hide |
Range on Protein: 179-252 Range on HMM: 50-124/141 Sequence Identity: 19% (14 aa) MQIPASDTPHQNI-KQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPI ...| ..|.... |.. .. .|.|. .... . .|| |. |. . |.. ...| .| . . || lncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGh |
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| Phosphatase | puc.AA | Subfamily.N_Nematode_1.PD | 159-232 | 24 | 2.3e-06 | 18.0 | In-house | 151-220 (265) | Show / Hide |
Range on Protein: 159-232 Range on HMM: 151-220/265 Sequence Identity: 24% (18 aa) CVLNVTCQSPNESHLQGLKYMQIPASDTPHQNIKQYfqeayDFIEDARKTGSRVLLHCHAGISRSATI-AIAYVM ||.|. .. ... ..... | |. .. ...|..|. . ...|| ||| |. || ||.|.. tvlevegaGektrkvthyqWtdWPdrGvPpadlaal-----elleavrgskgPivvhCsaGiGrtGtivaieyil |
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| Phosphatase | puc.AA | Subfamily.PTPDC1.PD | 209-251 | 38 | 6.6e-06 | 16.6 | In-house | 166-208 (229) | Show / Hide |
Range on Protein: 209-251 Range on HMM: 166-208/229 Sequence Identity: 38% (16 aa) GSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARP ... .||||| | . .|.. | |. || |||. || egkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrp |
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| Phosphatase | puc.AA | Subfamily.N12.PD | 161-233 | 25 | 8.3e-06 | 16.0 | In-house | 153-224 (270) | Show / Hide |
Range on Protein: 161-233 Range on HMM: 153-224/270 Sequence Identity: 25% (19 aa) LNVTCQsPNESHLQGLKYMQIPASDTPHQnIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATI-AIAYVMR |.|..| .. ... ..|.. | ..|.. .|. .. .. | .. . ...|| ||. | || || || . Lkveaq-kesrkvyqfhytaWPDhgvPss-aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvre |
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