Gene MKP-4
MKP-4
Species: D.melanogaster
Alias: MKP-4
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of MKP-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | MKP-4.AA | DSPc | 38-179 | 26 | 6.9e-35 | 123.14 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 38-179 Range on HMM: 1-172/172 Sequence Identity: 26% (46 aa) SIDEVDTGLFLGNLTAAT--HMETLRSFKITHILTLD-SVPLPQHI-------------LEASFLTTKYIQ-IAD-------MPREDILQHLEGCVDFIS .. |. .|.||. .... . . | ..|||.. . ..|.. |. .. | . . |. | | .. ..|.|... ..|||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH SALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELV-----KAKR-RFVQPNAGFVSQLKLFRRM .. ...|.|||||. |.||| . .|||.||..|.. ||..| | .| ..||..|. ||....|. DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | MKP-4.AA | Subfamily.DSP12.PD | 39-181 | 45 | 1.6e-57 | 184.1 | In-house | 2-143 (143) | Show / Hide |
Range on Protein: 39-181 Range on HMM: 2-143/143 Sequence Identity: 45% (65 aa) IDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTtKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI ..|...||.||.|.|....|.|...||||.|.... .||.. |.. . |.|||.|.|.||.|.||. .|.||...|...|.|||||..|||||...|| vseilpglylggleavqerellkelkithvlsvikeelpelqkekgvks-kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtivi AYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRMGC ||.||...|.. |..|||.|.. ..||.||..|||||..|.. AYlmkkeklslekAlklvkekkkeiepNegFleQLklfekmkk |
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| Phosphatase | MKP-4.AA | Subfamily.DSP19.PD | 39-176 | 42 | 6.1e-39 | 123.6 | In-house | 2-136 (139) | Show / Hide |
Range on Protein: 39-176 Range on HMM: 2-136/139 Sequence Identity: 42% (58 aa) IDEVDTGLFLGNLTAATHMETLRSFKITHILTLdSVPLPQHIleASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI . || |.|| .|.. |.|.. |||||| . .| .|.. .. .|.| |.| | | ...|..|. ..||| .|. ..| ||||| |||||.| || vaevkprlylgsqdvaadkeilkklkitHilnv-avgvpnvf--pkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvvi AYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF ||.||...|.. |.| |...|. ..||.||. ||| . aylmkdeelslekalekvrearpcikPneGFikqLkey |
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| Phosphatase | MKP-4.AA | Subfamily.DSP15.PD | 38-177 | 38 | 1.5e-33 | 106.2 | In-house | 1-136 (138) | Show / Hide |
Range on Protein: 38-177 Range on HMM: 1-136/138 Sequence Identity: 38% (53 aa) SIDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPLPqhILEAsfLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTV ....| .||..||.. | . | |. .||||||.. . | .|| .. . |..|| | |. .... ..||| .. ..||||||||.||| . |.| gmnkvlpGlyvGnfrdakdkeqleenkithilsihdsakp--lled--ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlv IAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR |.| .|.. | . ||| | .||.|| .||. | vayimtvtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | MKP-4.AA | Subfamily.DSP1.PD | 45-176 | 37 | 3.5e-33 | 105.1 | In-house | 8-136 (139) | Show / Hide |
Range on Protein: 45-176 Range on HMM: 8-136/139 Sequence Identity: 37% (49 aa) GLFLGNLTAATHMETLRSFKITHILTLDSVpLPQHIleASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR |.|| . |.....|.. |||..| . . ||... .. .. | |.. | ...||....| .||| |. ...| ||||| |.|||..|.||.||... fLyLGsaehasnlqlLkelkitallnvsae-lpnvf--eelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmke HNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF . . |.| || .| ..|| ||| || | kkvrleeafefvkqrrsiisPnfgfvgqLlef |
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| Phosphatase | MKP-4.AA | DSPc | 46-179 | 28 | 4.1e-32 | 113.6 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 46-179 Range on HMM: 1-151/151 Sequence Identity: 28% (43 aa) LFLGNLTAAT-HMETLRSFKITHIL-TLDSVPLPQHILEASFLTTKYIQ-IAD---------MPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRS |.||. .... . | ..|||.. ...| . .. | . . |. . | .. ..| |... ..|||... ...|.|||||. |.||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN-WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRS SSTVIAYMMKRHNLDFLPAYELV-----KAKR-RFVQPNAGFVSQLKLFRRM . .|||.||..|.. ||..| | .| . ||..| || ..|. ACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | MKP-4.AA | Family.DSP.PD | 40-192 | 32 | 5.9e-32 | 101.9 | In-house | 108-259 (387) | Show / Hide |
Range on Protein: 40-192 Range on HMM: 108-259/387 Sequence Identity: 32% (51 aa) DEVDTGLFLGNLTAATHMETLRSFKITHILTLDsVPLPQhileAS-FLTTKY--IQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSST |. ..|.||.| ||.. | |. ..|.|. | || . | || |.| | ..... ...| ..|||... ..|.|||||. |..|| . . seilphlylgsllaaknlewlkelgvtkivnlt-ddkpq----ftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtl VIAYMMKRHNLDFLPAYELVKAKRR-FVQPNAGFVSQLKLFRRMGCKIDPNCQRYKI |||.||...| . |...|. ||. ..|| ||..||| .. . .| . .. iiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevmelrf |
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| Phosphatase | MKP-4.AA | Subfamily.DSP14.PD | 39-174 | 37 | 2.8e-31 | 98.9 | In-house | 2-133 (138) | Show / Hide |
Range on Protein: 39-174 Range on HMM: 2-133/138 Sequence Identity: 37% (51 aa) IDEVDTGLFLGnLTAATHMETLRSFKITHILTLDSvPLPQHILEAsfLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI . |. |.|. .||.. |.|.. |||.|. . ||. || . | |...|.|.... .|.. .| | .. ...|..||||. ||||| | |. lseitesLyls-gaaalkkeklkkkkitlivnvtt-elpetkled--vktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvl AYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLK ||.|| ..| ||.|||..| ..|| || .|| aylmkyeklsLreayklvksaRpiirPnvGFwkqli |
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| Phosphatase | MKP-4.AA | Subfamily.DSP10.PD | 45-176 | 35 | 3.1e-31 | 98.7 | In-house | 8-138 (141) | Show / Hide |
Range on Protein: 45-176 Range on HMM: 8-138/141 Sequence Identity: 35% (46 aa) GLFLGNLTAATHMETLRSFKITHILTLDSVpLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR |.||| . |.....|. . |...| . .. .|.. |.. .. | |.. | ..... |..| ..|| | ....||||| |.|||.||||.|| .| flllGnekdaadkdaldrlgikyvlnvtts-vPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkh HNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF . ||..|| || . || .|. || | lslslseaykfvkekrPiisPnlnfmGqllef |
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| Phosphatase | MKP-4.AA | Subfamily.Slingshot.PD | 45-177 | 36 | 4.2e-30 | 94.9 | In-house | 8-137 (139) | Show / Hide |
Range on Protein: 45-177 Range on HMM: 8-137/139 Sequence Identity: 36% (48 aa) GLFLGNLTAATHMETLRSFKITHILTLDSvPLPQHiLEASFlTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR |.|| |. .| |. ....|| . . .. . .| . . |.. | ...|.|.| . .||. | ... .||||| |||||.|||||| ||.. hlylGsewnasnleelkengveyilnvtk-eidnf-fpekf-kylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamke HNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR .|.. |.| || .|. ..||.||..||| .. yelsleealeyvkerrsiikpnkgflkqlkvye |
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| Phosphatase | MKP-4.AA | Subfamily.LRR-DSP.PD | 40-177 | 37 | 5.9e-30 | 94.4 | In-house | 3-135 (137) | Show / Hide |
Range on Protein: 40-177 Range on HMM: 3-135/137 Sequence Identity: 37% (51 aa) DEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVplpQHILEASFlTTKYIQIADMPREDILQHLEGCVDFISSAlAQQGNVLVHCYFGVSRSSSTVIA |.. .|.|| . .|. |.. ..||||.. . . . | |.| |... || ||.. || . ..| ||.|||||||.. ||||. dliidklylgcresamnksilkdnnvthilavadf---kplypdlf-kyliidiedvdeadiyqhfkemnafideg-rekggvlihcragvsrsatlvia YMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR ||...| | |..||. || ..|| ||. ||| | ylmkknslkfkealdlvikkrpriypnrgfldqlkkfe |
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| Phosphatase | MKP-4.AA | Subfamily.DSP6.PD | 45-178 | 37 | 1.1e-29 | 93.5 | In-house | 8-140 (141) | Show / Hide |
Range on Protein: 45-178 Range on HMM: 8-140/141 Sequence Identity: 37% (49 aa) GLFLGNLTAATHMETLRSFKITHILTLDSvPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR |.||. ..|. .|.|. .|| ..| . | ||. |. |. | | | | ... ... ..|| | .. .|||||. ||||| ...||.||... llylGsakdasnlevlkklkikyvlnvts-nlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkk HNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR | . ||.|||.|. . || |. ||. | | lalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | MKP-4.AA | Subfamily.DSP3.PD | 39-174 | 35 | 5.1e-29 | 91.6 | In-house | 2-143 (148) | Show / Hide |
Range on Protein: 39-174 Range on HMM: 2-143/148 Sequence Identity: 35% (51 aa) IDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPL-PQHILEASFLTT---KY--IQIADMPREDILQHLEGCVDFISSALAQ-QGNVLVHCYFGVS .||| ....|. ..|.. | |. . |||.| . .|.| . || ... |.|. |. .. | .||| .||.| .| ||||| |.| vdevypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGis RSSSTVIAYMMKRHNLDFLPAYELVKAKrRFVQPNAGFVSQLK ||. |.||.| |..|. | . |. | | ..|| ||..|| RsatlvlayLmirrkltlkeaiktvrkk-reilPneGflkqLl |
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| Phosphatase | MKP-4.AA | Subfamily.STYX.PD | 40-177 | 36 | 5.2e-26 | 81.8 | In-house | 3-144 (146) | Show / Hide |
Range on Protein: 40-177 Range on HMM: 3-144/146 Sequence Identity: 36% (51 aa) DEVDTGLFLGNLTAAT--HMETLRSFKITHILTLDSVPLPQhILEASFL-TTKY--IQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSS .|. ||||| .|| ..|.|.. ||||. . . . .. | . .| ...|| . |.|...| .|| ..| . |.|||||.|||.. | qeilpglflgpysaamksklevlkehgithivcirqniean-likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa STVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR |||.|. . | . |. |. .| ..||.||||||| .. alviayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | MKP-4.AA | Subfamily.DSP8.PD | 42-176 | 32 | 1.6e-24 | 77.0 | In-house | 5-138 (143) | Show / Hide |
Range on Protein: 42-176 Range on HMM: 5-138/143 Sequence Identity: 32% (45 aa) VDTGLFLGNLTAATHMETLRSFKITHILTL-DSVPL-PQHILEASFLTtkyIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIA . |.|| . . . |.|. |...| . | | .. . |. || | . | |..|.... ...|| | ...|.|||||. | |||.. .|| ilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflr---iPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia YMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF |.||. .... ||. || || ..|| |. || . yimktlemsldeayrfvkekrptispnlnflgqLley |
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| Phosphatase | MKP-4.AA | Subfamily.STYXL1.PD | 44-176 | 27 | 1.3e-19 | 61.3 | In-house | 8-140 (143) | Show / Hide |
Range on Protein: 44-176 Range on HMM: 8-140/143 Sequence Identity: 27% (37 aa) TGLFLGNLTAATHMETLRSFKITHIL--TLDSVPLPQHILEASflTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYM . |.||| |.. . . .|. . . |. .| . . ... |.. | .. |.|..|. |.|| . .. ||| |.||| . .|||. gklylGnykqaqnpaikkdlkvkahvnvssdaekliagladva--kllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiayl MKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF | ... . ||. .| . |.|| .||.||. . myskkitlkkaykylkkckenvkPnrafveqlseW |
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| Phosphatase | MKP-4.AA | Subfamily.PTPMT1.PD | 91-178 | 28 | 2.3e-13 | 40.7 | In-house | 58-145 (146) | Show / Hide |
Range on Protein: 91-178 Range on HMM: 58-145/146 Sequence Identity: 28% (25 aa) IQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR . . |. |..|| |.||.. .. .| ||| | .||.. |..|.||...| | ...|.||. .. . .. |. |.. latvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke |
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| Phosphatase | MKP-4.AA | Subfamily.Laforin.PD | 89-145 | 26 | 1.1e-06 | 18.9 | In-house | 74-130 (165) | Show / Hide |
Range on Protein: 89-145 Range on HMM: 74-130/165 Sequence Identity: 26% (14 aa) KYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRH .. . |. | .. | .| .. . | . | ||| || ||.. | ... iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvl |
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| Phosphatase | MKP-4.AA | Subfamily.PTPDC1.PD | 108-161 | 30 | 1.2e-06 | 18.6 | In-house | 156-208 (229) | Show / Hide |
Range on Protein: 108-161 Range on HMM: 156-208/229 Sequence Identity: 30% (16 aa) CVDFISSALaQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRR | ...|| ..|.. |||. | | . . .|.. ..|. | .||..|| ivkvvdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrp |
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| Phosphatase | MKP-4.AA | Subfamily.DSP23.PD | 57-148 | 24 | 1.4e-06 | 18.9 | In-house | 6-95 (128) | Show / Hide |
Range on Protein: 57-148 Range on HMM: 6-95/128 Sequence Identity: 24% (22 aa) METLRSFKITHILTLDSVPLPqHILEASFLTTKYIQIADMPREdILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLD .. | | ....| . | . | || . |.| | |. .. | . | .... | ||| |. |. . . |..| ..| vqfladqGirvlvslttegap-yseaapsltlrridipdfcPP-aleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeegla |
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| Phosphatase | MKP-4.AA | Subfamily.CDC14.PD | 110-147 | 24 | 2.9e-06 | 17.6 | In-house | 189-226 (258) | Show / Hide |
Range on Protein: 110-147 Range on HMM: 189-226/258 Sequence Identity: 24% (9 aa) DFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNL |.. . .|.. ||| |. | .. . .|..|.... kfleitekaeGaiavhCkaGLGrtgtligcylikhyrf |
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| Phosphatase | MKP-4.AA | Subfamily.R_Nematode_3.PD | 90-140 | 19 | 5.8e-06 | 16.3 | In-house | 169-222 (267) | Show / Hide |
Range on Protein: 90-140 Range on HMM: 169-222/267 Sequence Identity: 19% (10 aa) YIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI---AY .. . . . . .. . .. | . . . .|.|||. |.||| . . .| hllykgWkelnapeepkealelikfveksktpvvVHCsdGisRsatlaaielgy |
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