Gene PRL-1
PRL-1
Species: D.melanogaster
Alias: PRL-1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PRL-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PRL-1.AA | Subfamily.PRL.PD | 22-160 | 67 | 2.6e-72 | 232.7 | In-house | 1-139 (140) | Show / Hide |
Range on Protein: 22-160 Range on HMM: 1-139/140 Sequence Identity: 67% (94 aa) MKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVA ..|||.|.||| |....|.||||.||..|||||||||....|...||.|.||||.||..||..|||||.|.||.|....|...||||||||||||||||| lrflildepsdetvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlva LALIELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPK ||||| |.||| |||.||.|||||||.|||.||||||.| lalieaGmkyedavefirekrrgainskqlkflekykak |
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| Phosphatase | PRL-1.AA | Subfamily.CDC14.PD | 36-156 | 28 | 2.8e-22 | 71.1 | In-house | 137-253 (258) | Show / Hide |
Range on Protein: 36-156 Range on HMM: 137-253/258 Sequence Identity: 28% (35 aa) NHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKyqqnpEACVAVHCVAGLGRAPVLVALALI-ELGLKYEAA .... .||||.|.||. . |. . . .|. .|| |.||| |..... .. |.. . | .|||| ||||| .|.. ||. ... . .. eklleyfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyrftaaet VEMIRDKRRGAINAKQLSFLEK .| | | . ..| ..|.. iawlriarPGsvigpqqtylve |
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| Phosphatase | PRL-1.AA | Family.DSP.PD | 39-158 | 23 | 1.6e-21 | 68.6 | In-house | 125-244 (387) | Show / Hide |
Range on Protein: 39-158 Range on HMM: 125-244/387 Sequence Identity: 23% (29 aa) IMELKKNNVNTVVRVCEPSYNT-DeleTQGITVKDLAFEDG-TFPPQQVVDEWFEVLKDKYqqNPEACVAVHCVAGLGRAPVLVALALIEL-GLKYEAAV .||...|. .|.... . . ..||.. .....|. . |....... ....... ... .|.||| ||.|| ..|.. |.. ||..|.|... lewlkelgvtkivnltddkpqftk---elgikylripidDhnapplenlfekaidfieegn--dskgvVlVHCkaGkgRsgtliiaYlmksegltleeal EMIRDKRRGAINAKQL--SFLEKYK .|.||.| |. .| . |... dwvrskRpgvitpnqgflkqlkdle |
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| Phosphatase | PRL-1.AA | Subfamily.PTPDC1.PD | 57-157 | 31 | 5.5e-14 | 43.7 | In-house | 124-223 (229) | Show / Hide |
Range on Protein: 57-157 Range on HMM: 124-223/229 Sequence Identity: 31% (32 aa) SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYqqnPEACVAVHCVAGLGRAPVLVALALI-ELGLKYEAAVEMIRDKRRGAINAK-QLSFL ||. .|| |||.. ...| .. . . . |.. |. .|||| ||||| ||.| |. |. | |....|.|| .|... |. .. sYdpeelmrqgiyfynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelv EKY |.. eeF |
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| Phosphatase | PRL-1.AA | Subfamily.RNGTT.PD | 42-149 | 23 | 2.8e-12 | 38.0 | In-house | 16-127 (140) | Show / Hide |
Range on Protein: 42-149 Range on HMM: 16-127/140 Sequence Identity: 23% (26 aa) LKKNNVNTVVRVCEP--SYNTDELETQGITVKDLAF-EDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEM .|... |. . . |. .||| .|.. . | | | .. .... .. |. ....|. ..||| | |. |.. |.| .. ||||.. tlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaaval IRDKRRGAINAK | | . fakarppGiyke |
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| Phosphatase | PRL-1.AA | Subfamily.DSP23.PD | 49-150 | 23 | 8.8e-12 | 36.8 | In-house | 16-115 (128) | Show / Hide |
Range on Protein: 49-150 Range on HMM: 16-115/128 Sequence Identity: 23% (24 aa) TVVRVCEPSYNTDElETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAIN .| . . . . | ....|.. . .| . | . |......... .... |.|||. ||||. |.| |.. || . |. .| .|.|.|.. vlvslttegapyse-aapsltlrridipdfcPPaleqvarlvriveeaekke--eavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGsie AKQ .. tve |
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| Phosphatase | PRL-1.AA | Subfamily.PTPMT1.PD | 40-158 | 30 | 1.4e-11 | 35.9 | In-house | 18-144 (146) | Show / Hide |
Range on Protein: 40-158 Range on HMM: 18-144/146 Sequence Identity: 30% (39 aa) MEL-KKNNVNTVVRVCEPSY------NTDELETQGITVKDLAFEDGTF-PPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALI-ELGLK || .|.||..|| ..| .|.| . .|.. || | | | .. . | |..... .. . .| ||| || .|. ||||. . |. | keLvekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekleegvefiekv--askgssvYvHCkAGrtRsatlvacylmkkkkls YEAAVEMIRDKRRGA-INAKQLSFLEKYK ||.....||. .. ||.. |...| peeavkflkkkRpqirlkskqwralqefk |
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| Phosphatase | PRL-1.AA | Subfamily.DSP11.PD | 57-146 | 25 | 2.8e-09 | 28.4 | In-house | 34-126 (141) | Show / Hide |
Range on Protein: 57-146 Range on HMM: 34-126/141 Sequence Identity: 25% (23 aa) SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKY--QQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAI |...||. .|.. | | ..| ...|... |..|. ... .. ..||| |. |. |. ||. |.. | |.|. . |.. yykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhsl |
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| Phosphatase | PRL-1.AA | Subfamily.DSP19.PD | 40-145 | 22 | 9.9e-09 | 26.7 | In-house | 21-123 (139) | Show / Hide |
Range on Protein: 40-145 Range on HMM: 21-123/139 Sequence Identity: 22% (24 aa) MELKKNNVNTVVRVCE--PSYNTDELETQGITVKDLAFEDGTfppqQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAP-VLVALALIELGLKYEAAVE .|||... .. | | ....... | . || .. . .. .| .. ... ... .| ||| || |.. | .| . .|..| |.|..| eilkklkitHilnvavgvpnvfpkdftyksieilDlpetkll----sylkealdFieearskd--grvlvHCnAGvSRsasvviaylmkdeelslekale MIRDKRRGA ..|. . kvrearpci |
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| Phosphatase | PRL-1.AA | Subfamily.PTEN.PD | 56-142 | 26 | 2.4e-08 | 25.2 | In-house | 51-136 (305) | Show / Hide |
Range on Protein: 56-142 Range on HMM: 51-136/305 Sequence Identity: 26% (23 aa) PSYNTDELetqGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEA--AVEMIRDKR .... .. |. |.| . |. ... | | .. ... . ||||| || ||. |... |.. | | .| |... .|| gekedsdf---dgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekR |
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| Phosphatase | PRL-1.AA | Subfamily.DSP3.PD | 49-152 | 23 | 1.5e-07 | 22.9 | In-house | 41-140 (148) | Show / Hide |
Range on Protein: 49-152 Range on HMM: 41-140/148 Sequence Identity: 23% (25 aa) TVVRVCEPSYNTDELETQGITVKDLAfedgTFPPQQVVDEWFEVLKDKYQQnPEACVAVHCVAGLGRAP-VLVALALIELGLKYEAAVEMIRDKRRGAIN . |. . |. |.. |. |.|. .| .. .| .. ... .| .. | ||||.|. |.. . .| .| |. . |....|.|| | lkvdtdaefYkdleikylGvevsDvp----efdlskyfeeaadfidealsq-kngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkreilPn AKQLS |. eGflk |
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| Phosphatase | PRL-1.AA | Subfamily.DSP12.PD | 43-147 | 20 | 1.8e-07 | 22.8 | In-house | 24-128 (143) | Show / Hide |
Range on Protein: 43-147 Range on HMM: 24-128/143 Sequence Identity: 20% (22 aa) KKNNVNTVVRVCEPSYnTDELETQGITVKDLAFEDG-TFPPQQVVDEWFEVLKDKYqqNPEACVAVHCVAGLGRA-PVLVALALIELGLKYEAAVEMIRD |. ... |. | . . .. ...| . | . | . . . .|| .. ... . | | ||| ||. | . .| . . .|.| |......| kelkithvlsvikeel-pelqkekgvkskliqilDepeedlLshldeavrFieegl--ekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvke KRRGA-IN .. . | kkkeiepN |
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| Phosphatase | PRL-1.AA | Subfamily.Slingshot.PD | 40-145 | 24 | 2.5e-07 | 22.1 | In-house | 21-123 (139) | Show / Hide |
Range on Protein: 40-145 Range on HMM: 21-123/139 Sequence Identity: 24% (26 aa) MELKKNNVNTVVRVCE--PSYNTDELETQGITVKDLAFEDgtFppQQVVDEWFEVLKDKYQQnpEACVAVHCVAGLGR-APVLVALALIELGLKYEAAVE |||.|.|. .. |.. .. .... . | | | .| . . .| .. .. .. .. | ||| |. | | ...| |. | .|..| |.| eelkengveyilnvtkeidnffpekfkylnirvydeeetd--l--lkhwnetykfiekakek--gskvlvhckmGvsrsastviayamkeyelsleeale MIRDKRRGA ....|. . yvkerrsii |
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| Phosphatase | PRL-1.AA | Subfamily.DSP8.PD | 86-156 | 29 | 1.2e-06 | 20.1 | In-house | 67-134 (143) | Show / Hide |
Range on Protein: 86-156 Range on HMM: 67-134/143 Sequence Identity: 29% (21 aa) VDEWFEVLkDKYQQNpEACVAVHCVAGLGRAP-VLVALALIELGLKYEAAVEMIRDKRrGAINaKQLSFLEK |. .| . || ... ...| ||| || |.. | .| . .| .... | . ...|| .|. ..| ||.. fdkalefi-dkarsa-ngkvlvhclaGisrsatvaiayimktlemsldeayrfvkekr-ptis-pnlnflgq |
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| Phosphatase | PRL-1.AA | Subfamily.DSP10.PD | 42-153 | 25 | 1.4e-06 | 19.7 | In-house | 23-131 (141) | Show / Hide |
Range on Protein: 42-153 Range on HMM: 23-131/141 Sequence Identity: 25% (28 aa) LKKNNVNTVVRVCEPSYNTDELETQgITVKDLAFED-GTFPPQQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRA-PVLVALALIELGLKYEAAVEMIR |.. ... |. | . |. | . . .. | . .| |. .| .| .| ... ... . | ||| ||. |. | .| . |.|. | .....| ldrlgikyvlnvttsvPnffeekgl-vrykripvsdsgkqnlkqkfeealefieearkrg--srvlvhchaGisrsatvviayvmkhlslslseaykfvk DKRRgaINAKQLSF | | . |.| ekrP--iisPnlnf |
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| Phosphatase | PRL-1.AA | Subfamily.DSP6.PD | 41-143 | 25 | 1.6e-06 | 19.4 | In-house | 22-123 (141) | Show / Hide |
Range on Protein: 41-143 Range on HMM: 22-123/141 Sequence Identity: 25% (26 aa) ELKKNNVNTVVRVCEPSYNTDElETQGITVKDLAFEDGTFP-PQQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRA-PVLVALALIELGLKYEAAVEMI ||| ... |. | . |. | |.. .. |... || .. . | .| ... ... . | ||| ||. |. | .| . .| |. | .....| vlkklkikyvlnvtsnlpnkfe-esgelkykqipiedhlsqnlakffPeaiefidearskk--skvlvhclaGvsrsvtvtlaylmkklalslndaydlv RDKRR . kkkks |
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| Phosphatase | PRL-1.AA | Subfamily.R_Nematode_3.PD | 98-153 | 28 | 1.9e-06 | 18.9 | In-house | 194-257 (267) | Show / Hide |
Range on Protein: 98-153 Range on HMM: 194-257/267 Sequence Identity: 28% (18 aa) QQNPEACVAVHCVAGLGRAPVLVALAL-IEL------GLKYEAAVEMIRDKRRGAINA-KQLSF .. .. | |||..| .|. .|.| | ..| |.. . .. .| .| |||. ..|.| veksktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqRagaiqtelelaf |
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| Phosphatase | PRL-1.AA | Subfamily.N13.PD | 99-150 | 27 | 2.2e-06 | 18.9 | In-house | 188-245 (259) | Show / Hide |
Range on Protein: 99-150 Range on HMM: 188-245/259 Sequence Identity: 27% (16 aa) QNPEACVAVHCVAGLGRAPVLVALALI----E--LGLKYEAAVEMIRDKRRGAINAKQ |. .. ..||| ||.||. ||... . | .. . |. .|..|.| . .|. qtdagPivvhcsaGiGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkd |
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| Phosphatase | PRL-1.AA | Subfamily.N5_RR.PD | 82-138 | 29 | 3.1e-06 | 18.2 | In-house | 176-233 (265) | Show / Hide |
Range on Protein: 82-138 Range on HMM: 176-233/265 Sequence Identity: 29% (17 aa) PQQVVDEWFEVLKDKYQQNPE-ACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMI .....| || ... ..| . | | ||| ||.||. . .| . |. | |... intlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisiavrqlreeivvdvl |
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| Phosphatase | PRL-1.AA | Subfamily.DSP15.PD | 42-145 | 21 | 3.7e-06 | 18.5 | In-house | 23-122 (138) | Show / Hide |
Range on Protein: 42-145 Range on HMM: 23-122/138 Sequence Identity: 21% (23 aa) LKKNNVNTVVRVCEpsyNTDELeTQGITVKDLAFEDGtfpPQQVVDEWFEVLKDKYQQ--NPEACVAVHCVAGLGRAPVLVALA-LIELGLKYEAAVEMI |..|.. .. . . ... | ..|. . . .| |.| . ..|.. | . . | |||.||. |. ||. . |..| |.... leenkithilsihd---sakpl-ledikylcikaads---PdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkav RDKRRGA . | | kaarsva |
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| Phosphatase | PRL-1.AA | Subfamily.N3.PD | 95-147 | 36 | 3.8e-06 | 17.8 | In-house | 186-244 (261) | Show / Hide |
Range on Protein: 95-147 Range on HMM: 186-244/261 Sequence Identity: 36% (21 aa) DKYQQNPEACVAVHCVAGLGRAPVLVA----LALIELGL--KYEAAVEMIRDKRRGAIN |... | | ||| ||.||. ||.. ||||| . | ..||.| .. rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvq |
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| Phosphatase | PRL-1.AA | Subfamily.DSP1.PD | 43-153 | 21 | 4e-06 | 18.4 | In-house | 24-129 (139) | Show / Hide |
Range on Protein: 43-153 Range on HMM: 24-129/139 Sequence Identity: 21% (24 aa) KKNNVNTVVRVCEpsyNTDELETQGITVKDLAFEDGTfppQQVVDEWFEVLKDKYQ--QNPEACVAVHCVAGLGRAPVLVALALI-ELGLKYEAAVEMIR |. .. .. |.. .... . . | . || . .. . ..|| | . .. . | ||| ||. |. .| . |. | ...| | | .. kelkitallnvsa---elpnvfeelfkyksipvednk---kadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvk DKRrGAINAkQLSF ..| |. ..| qrr-siisP-nfgf |
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| Phosphatase | PRL-1.AA | Subfamily.R_Ecdysozoa.PD | 91-138 | 34 | 4e-06 | 17.7 | In-house | 186-237 (269) | Show / Hide |
Range on Protein: 91-138 Range on HMM: 186-237/269 Sequence Identity: 34% (18 aa) EVLKDKYQQN----PEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMI | ... |..| .. . ||| || ||. ..|||.|. || | |... eqvrelyklnklsgsrsPivvhCsaGvgrsgifvaldlllqqlkaedkvdif |
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| Phosphatase | PRL-1.AA | Subfamily.N12.PD | 95-134 | 35 | 5e-06 | 17.3 | In-house | 192-231 (270) | Show / Hide |
Range on Protein: 95-134 Range on HMM: 192-231/270 Sequence Identity: 35% (13 aa) DKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAA ..|.. .| ..||| || ||. ...|. .. || | relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaeki |
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| Phosphatase | PRL-1.AA | Subfamily.R_Anemone_2.PD | 97-138 | 33 | 6.8e-06 | 17.3 | In-house | 188-230 (262) | Show / Hide |
Range on Protein: 97-138 Range on HMM: 188-230/262 Sequence Identity: 33% (14 aa) Y-QQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMI . |.. . ...||| ||.||. | .|. . .| || |.. aqqesgagpivvhcsaGvGrtGvfiavdillerikaealvdvf |
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| Phosphatase | PRL-1.AA | Subfamily.N_Choan_2.PD | 77-137 | 22 | 7.4e-06 | 16.8 | In-house | 173-233 (266) | Show / Hide |
Range on Protein: 77-137 Range on HMM: 173-233/266 Sequence Identity: 22% (14 aa) DGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEM |.. ..|... .| . . ... . . ||| ||.||. .|.|. . |. . |.. dsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRtGtliaiDiavrlLeetkkvdv |
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| Phosphatase | PRL-1.AA | Subfamily.DSP14.PD | 41-126 | 26 | 7.7e-06 | 17.5 | In-house | 21-102 (138) | Show / Hide |
Range on Protein: 41-126 Range on HMM: 21-102/138 Sequence Identity: 26% (23 aa) ELKKNNVNTVVRVCEpsyNTDELETQGITVKDLAFEDGtfpPQQVVDEWFEVLKDKYQQ--NPEACVAVHCVAGLGRAPVLVALALIE .|||......| | .. | ..... . .. || |.. . |.|.. || .. . . .. |||||| |. || |. klkkkkitlivnvtt---elpetkledvktvkikveDk---peaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmk |
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| Phosphatase | PRL-1.AA | Subfamily.N_Nematode_4.PD | 89-139 | 26 | 8.4e-06 | 16.8 | In-house | 186-233 (264) | Show / Hide |
Range on Protein: 89-139 Range on HMM: 186-233/264 Sequence Identity: 26% (13 aa) WFEVLKDKYQQNPeacVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMIR . ..|.| ...| . ||| ||.||. || . . .. .. . .|.. lykavkkkkkekP---ivvhcsaGvGrtatlvGidyatirirenseievld |
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