Gene ssh
ssh
Species: D.melanogaster
Alias: ssh
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of ssh.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| DEK_C | ssh.AA | DEK_C | 326-379 | 33 | 1.4e-20 | 71.73 | Pfam | 1-56 (56) | Show / Hide |
Range on Protein: 326-379 Range on HMM: 1-56/56 Sequence Identity: 33% (19 aa) TESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEIL-DMDLG-EYKSFIDAEMLVILG |.. || ....|....||..||.| || .||. . ..|| ..|.||.......|. TDEQIKEEIREILRTADLMTVTMKQIRKQLEQRFPGCDLSKHRKAFIKEQIEEFLD |
|||||||||
| Phosphatase | ssh.AA | Family.DSP.PD | 382-532 | 31 | 3.3e-40 | 129.1 | In-house | 105-257 (387) | Show / Hide |
Range on Protein: 382-532 Range on HMM: 105-257/387 Sequence Identity: 31% (47 aa) DAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFP-GTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVI |..|..|.|||| .|.|||.|...|| .|.|.| . ..| . ..| .. . | ....| .... ...| .. ....||||||.|..||....||| gkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtlii AYAMKAYQWEFQQALEHVKKRRS-CIKPNKNFLNQLETYSGMLDAMKNKEKLQ ||........||..|...|. .|.||..|| ||. .. .. .... aYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevmel |
|||||||||
| Phosphatase | ssh.AA | Subfamily.Slingshot.PD | 384-521 | 68 | 5e-77 | 247.0 | In-house | 2-139 (139) | Show / Hide |
Range on Protein: 384-521 Range on HMM: 2-139/139 Sequence Identity: 68% (94 aa) PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYA ..|||.|.||||||||||||||..|||..|||||.|||||||..|.|.|.||||.|.|.|||.|..|...|..||..|||||||||||||||||.||||| askifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviaya MKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM ||.|......|||.||.|||.|||||.||.||..|.|. mkeyelsleealeyvkerrsiikpnkgflkqlkvyegi |
|||||||||
| Phosphatase | ssh.AA | DSPc | 383-521 | 29 | 1.4e-46 | 161.95 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 383-521 Range on HMM: 1-172/172 Sequence Identity: 29% (51 aa) APTKIFEHVYLGSEWNAS--NLEELQKNGVRHILNVTREIDN-----------------FFPGTFEYFNVR-VYD-------DEKTNLLKYWDDTFRYIT .|..| .|.||||. .. |...|.|... |..|||.|... ... |.|... . | ..||...|.. ....| GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH RAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHV-----KKRR-SCIKPNKNFLNQLETYSGM .....| ||||||..|.||||...||| || ... . |...| |.|| ..| || ||. || . . DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP1.PD | 384-518 | 39 | 6.2e-45 | 143.2 | In-house | 2-136 (139) | Show / Hide |
Range on Protein: 384-518 Range on HMM: 2-136/139 Sequence Identity: 39% (53 aa) PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYA |..| ...||||. .||||. |.. .. ..|||..|..| |. .|.| .. | |..|......... .| ..|..| .|||||..|.||||..|.|| pveildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayL MKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY || ......| |.||.|||.|.|| .|..|| .. mkekkvrleeafefvkqrrsiisPnfgfvgqLlef |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP19.PD | 386-519 | 43 | 1.1e-43 | 139.0 | In-house | 4-137 (139) | Show / Hide |
Range on Protein: 386-519 Range on HMM: 4-137/139 Sequence Identity: 43% (58 aa) KIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMK .. ...|||| |...|.|.|... |||||. ...|.|| |.| .. ..|...|.||.|..... .| |. .. |||||. |||||||||||| || evkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmk AYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS . ....|||.|.. | |||||. |..||..| deelslekalekvrearpcikPneGFikqLkeye |
|||||||||
| Phosphatase | ssh.AA | DSPc | 391-521 | 33 | 7e-41 | 144.07 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 391-521 Range on HMM: 1-151/151 Sequence Identity: 33% (51 aa) VYLGSEWNAS-NLEELQKNGVRHILNVTREIDN---FFPGTFEYFNVR-VYD---------DEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSA .||||. .. ... |||.|. |..|.|.|..| . .. |.|... | | . ||. .| . . .| .....| ||||||..|.|||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA SVVIAYAMKAYQWEFQQALEHV-----KKRR-SCIKPNKNFLNQLETYSGM ...||| || ... . |...| |.|| ..| || ||. || | . CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP6.PD | 384-518 | 40 | 1.4e-39 | 125.6 | In-house | 2-138 (141) | Show / Hide |
Range on Protein: 384-518 Range on HMM: 2-138/141 Sequence Identity: 40% (56 aa) PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFP--GTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIA | .| ...||||. .||||| |.| .....|||| ...|.| | ..| .. . | ..|| |.. .....| |. . ||||||| ||||| .|..| pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtla YAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY | || .. ...| . |||..| | || ||..|| . ylmkklalslndaydlvkkkksnisPnfnfmgqlldf |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP12.PD | 385-521 | 31 | 2.3e-37 | 118.8 | In-house | 3-141 (143) | Show / Hide |
Range on Protein: 385-521 Range on HMM: 3-141/143 Sequence Identity: 31% (44 aa) TKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREI-DNFFP-GTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAY ..| . .|||. .. . |.|.. . |.| |..| ... .. .. ..|.....||.. |...|.| . ... .|||||..|||||...|||| seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAY AMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM || .......||. ||. .. |.||..||.|| . | lmkkeklslekAlklvkekkkeiepNegFleQLklfekm |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP10.PD | 385-518 | 38 | 9.5e-37 | 116.6 | In-house | 3-138 (141) | Show / Hide |
Range on Protein: 385-518 Range on HMM: 3-138/141 Sequence Identity: 38% (53 aa) TKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFP--GTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAY ..|. ...||.| .|.. . |.. |....|||| .. ||| |...| .. | | .|.|| ....... .| |. .||.|||||. |.|||| ||||| ssilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviay AMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY || . ...| . ||..| | || ||. || . vmkhlslslseaykfvkekrPiisPnlnfmGqllef |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP8.PD | 384-519 | 36 | 2.5e-34 | 108.9 | In-house | 2-139 (143) | Show / Hide |
Range on Protein: 384-519 Range on HMM: 2-139/143 Sequence Identity: 36% (50 aa) PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDN--FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIA ||.| ...||||. .. . | |.|.|. ..||.... . . . ... . | |. . .|| ..| .. .| .|... .|||||| | ||||.|.|| ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia YAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS | || . ....| ..||..|. |.|| |||.|| | yimktlemsldeayrfvkekrptispnlnflgqLleye |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP14.PD | 386-518 | 36 | 2.7e-34 | 108.7 | In-house | 4-135 (138) | Show / Hide |
Range on Protein: 386-518 Range on HMM: 4-135/138 Sequence Identity: 36% (48 aa) KIFEHVYLGsEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMK .| |..||. |.. |.|.|... .|.|||.|. . ... ...| |.....| ...| . | .|..| |.||||..|||||||.|.|| || eitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmk AYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY . ..| ..||..|. |.||. | .|| .| yeklsLreayklvksaRpiirPnvGFwkqlidy |
|||||||||
| Phosphatase | ssh.AA | Subfamily.LRR-DSP.PD | 384-518 | 36 | 4.3e-34 | 107.9 | In-house | 2-134 (137) | Show / Hide |
Range on Protein: 384-518 Range on HMM: 2-134/137 Sequence Identity: 36% (49 aa) PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTrEIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSkVLVHCKMGVSRSASVVIAYA | .| ...|||. | | |..|.| ||| |. ... ..| .| |. . . | ..... ...... .| . .| ||.||. ||||||..|||| pdliidklylgcresamnksilkdnnvthilava-dfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviayl MKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY || . .|..||. |.|.|. |.||. ||.|| . mkknslkfkealdlvikkrpriypnrgfldqlkkf |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP3.PD | 386-518 | 33 | 9e-31 | 97.3 | In-house | 4-145 (148) | Show / Hide |
Range on Protein: 386-518 Range on HMM: 4-145/148 Sequence Identity: 33% (48 aa) KIFEHVYLGSEWNASNLEELQKNGVRHILNVTRE--------IDNFFPG-TFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKA-EGSKVLVHCKMGVSRS ....||.| | |.. |.|.| |. |.|| ... ..|. . .| | | | ...| ||.. . .| .| . ...||||||..|.|||| evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRs ASVVIAYAMKAYQWEFQQALEHVKKRRsCIKPNKNFLNQLETY .|.|| | . . ..|...|.|.| .| ||. ||.|| .. atlvlayLmirrkltlkeaiktvrkkr-eilPneGflkqLlel |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP15.PD | 385-519 | 30 | 9.1e-30 | 94.0 | In-house | 3-136 (138) | Show / Hide |
Range on Protein: 385-519 Range on HMM: 3-136/138 Sequence Identity: 30% (41 aa) TKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGtFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAM .|. . .|.|. .|.. | |..| . ||| . . . .... ..| ... | ...| |..... .| ... ||..||||| |.|||..|.|| | nkvlpGlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayim KAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS . ......||. || ||. .|| | .||. .. tvtelswedalkavkaarsvanPnvGfrrqlqefe |
|||||||||
| Phosphatase | ssh.AA | Subfamily.STYX.PD | 388-519 | 34 | 9.4e-27 | 84.3 | In-house | 6-144 (146) | Show / Hide |
Range on Protein: 388-519 Range on HMM: 6-144/146 Sequence Identity: 34% (48 aa) FEHVYLGSE--WNASNLEELQKNGVRHILNVTREID-----NFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVI . ..|| |.|| |...|. ||. . ..|. || .| |. . | |. |...| . .| . .| ||||| . |.||||..|| lpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalvi AYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS || |..| ....| .|..|| ||.||. | .||. | ayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
|||||||||
| Phosphatase | ssh.AA | Subfamily.STYXL1.PD | 389-518 | 29 | 4.6e-25 | 79.1 | In-house | 8-140 (143) | Show / Hide |
Range on Protein: 389-518 Range on HMM: 8-140/143 Sequence Identity: 29% (39 aa) EHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFE---YFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMK ...||| . .| | . . |. .||. . .... |. . ....| |.....||. .. ..| . | ||. ||| . |.||||.|.||| | gklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmy AYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY .......|....|| .. .|||..|..||. . skkitlkkaykylkkckenvkPnrafveqlseW |
|||||||||
| Phosphatase | ssh.AA | Subfamily.PTPMT1.PD | 389-518 | 25 | 7.8e-18 | 55.3 | In-house | 4-143 (146) | Show / Hide |
Range on Protein: 389-518 Range on HMM: 4-143/146 Sequence Identity: 25% (35 aa) EHVYLGSEWNASNLEEL-QKNGVRHILNVTREID---------NFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASV |.|.||. |. .|| .|. |. ..... | . .. |.... . | .. |.. .. ..| . . .||.| |||| | .|||.. etvilGalPfrsltkeLvekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatl VIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY |..| || ... ..| ...||.|. |. ... .. |. . vacylmkkkklspeeavkflkkkRpqirlkskqwralqef |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP23.PD | 404-503 | 23 | 5e-08 | 23.7 | In-house | 8-108 (128) | Show / Hide |
Range on Protein: 404-503 Range on HMM: 8-108/128 Sequence Identity: 23% (23 aa) ELQKNGVRHILNVTREIDNFFPGTFEYFNVRV-YDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRR | .|.|.....| | .. . . .|. .| |. . .| . |.... | ||| .|. |. ... | .| . ..|. |.||| fladqGirvlvslttegapyseaapsltlrridipdfcPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrr S k |
|||||||||
| Phosphatase | ssh.AA | Subfamily.CDC14.PD | 458-513 | 31 | 1.8e-07 | 21.7 | In-house | 196-252 (258) | Show / Hide |
Range on Protein: 458-513 Range on HMM: 196-252/258 Sequence Identity: 31% (18 aa) KAEGsKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRR--SCIKPNKNFLN |||| .. |||| |. | .... .| .| |. . .... ... | | | | ...| kaeG-aiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPGsvigpqqtylv |
|||||||||
| Phosphatase | ssh.AA | Subfamily.DSP11.PD | 443-517 | 20 | 1.5e-06 | 18.7 | In-house | 63-137 (141) | Show / Hide |
Range on Protein: 443-517 Range on HMM: 63-137/141 Sequence Identity: 20% (15 aa) LLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLET . |. . ... . | ... . ||| || |. .. | .. .. ..|.| .. | .|.|..|.. vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhslerenyledLkk |
|||||||||
| Phosphatase | ssh.AA | Subfamily.R_Nematode_3.PD | 458-500 | 22 | 1.7e-06 | 18.2 | In-house | 195-243 (267) | Show / Hide |
Range on Protein: 458-500 Range on HMM: 195-243/267 Sequence Identity: 22% (11 aa) KAEGSKVLVHCKMGVSRSASVVI---AYAMKAY---QWEFQQALEHVKK .. . |.|||. |.||||. . .| . . . .. . .....| eksktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrk |
|||||||||
| Phosphatase | ssh.AA | Subfamily.PTPDC1.PD | 451-516 | 21 | 2.1e-06 | 17.9 | In-house | 157-221 (229) | Show / Hide |
Range on Protein: 451-516 Range on HMM: 157-221/229 Sequence Identity: 21% (14 aa) FRYITRAKaEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLE . .. | | .|. ||| | | ... .| . | . . ..|.. |...|. .. .. .| vkvvdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelve |
|||||||||
| Phosphatase | ssh.AA | Subfamily.Laforin.PD | 460-502 | 27 | 4.9e-06 | 16.9 | In-house | 103-145 (165) | Show / Hide |
Range on Protein: 460-502 Range on HMM: 103-145/165 Sequence Identity: 27% (12 aa) EGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRR .| .| |||. || ||...| . . .|.... .. .| kghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr |
|||||||||