Gene Sbf
Sbf
Species: D.melanogaster
Alias: Sbf
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of Sbf.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| UDENN | Sbf.AA | uDENN | 1-92 | 36 | 7.1e-31 | 112.77 | Pfam | 1-95 (95) | Show / Hide |
Range on Protein: 1-92 Range on HMM: 1-95/95 Sequence Identity: 36% (36 aa) MSRLADYFVIVGYDSDKEKTASNVGGQPTCGKIVQRFPEKDW----PDTPFIEGIEWFCQPLGWSLSYEK---QEPKFFVSVLTDIDANKHYCACLSFH | ||.||||..||| | .. .| .|| ...|.||. .|.|| .....||.| ||.. ... ..|.||. ||||.| ...|..|. | MQRLFDYFVVCGYDKD----HMHPLGRSYKPKILDQYPPKDHMQMFWDPPFPDAVPMFCFPDGWDWVTWRDRHYDPQFFSFVLTDEDGSRWYGFCRTFY |
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| DENN | Sbf.AA | DENN | 142-325 | 37 | 2e-90 | 311.54 | Pfam | 1-207 (207) | Show / Hide |
Range on Protein: 142-325 Range on HMM: 1-207/207 Sequence Identity: 37% (77 aa) YAPKCLVLISRLDCAETF-KNCLGTIYTVYIENLA-------------YGLETLIGNILGCIQVPPAGGPQVRFS---IGAGDKQSLQPPQ-SSSL-PT- ..|||...|||... .|| ...|. ||..|.... .|..| |.. ....||.|..|| || .|.......| |. .|.| | WIPKCYCIISRWPWFNTFWRKWLDCIYRRYTSCPHPRIPPSSPRVGMWNPIERYIQNLCYEVPFPPPGRTQVLFSFIPLGVYEPILFQRPSPDSELHPVW TGSGVHFLFKQLGIKNVLILLCSVMTENKILFLSKCYWHLTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPFIMGIHSSLQT---EITDLLDVI ... .| ||..||..|.| |.|.|.||..|.|.|. |. ||. |.|.|||.|||...|.||||.|| | ..|..|.|||||.||.... ......||. EHIDFHPLFRCLGPENCLHLFCCVLTEHRIIFHSSHYAMLTLCCHAVVALLYPFQWQHIYIPICPARLLDYLCAPCPFIMGVHSRYFDSKLLYDPPDDVV VVDLDGG .||||.. CVDLDTN |
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| UDENN | Sbf.AA | uDENN | 1-92 | 29 | 2.4e-31 | 111.35 | SMART | 1-114 (114) | Show / Hide |
Range on Protein: 1-92 Range on HMM: 1-114/114 Sequence Identity: 29% (34 aa) MSRLADYFVIVGYDSDKEKT--------------------ASNVGGQPTCGKIVQRFPEKDWPDTPFIEGIEWFCQPLGWSL-----SYEKQEPKFFVSV ..||.|||...|...|.. . .. . .| .|....|||||.|.|| ..|. ||.| ||.. . . ..| ||. | PHRLFDYFCVCGCPKDPGWWPDMHYACYQWEAPGRTGCFCPLQRSYKP---EILYQYPEKDWWDFPFPDMIPMFCFPMGWDWCTWPRKTDRPDPQFFTFV LTDIDANKHYCACLSFH |||.| ...|..|. | LTDEDGSRRYGFCRRFY |
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| DENN | Sbf.AA | DENN | 142-325 | 31 | 4.3e-79 | 269.98 | SMART | 1-204 (204) | Show / Hide |
Range on Protein: 142-325 Range on HMM: 1-204/204 Sequence Identity: 31% (65 aa) YAPKCL-VLISRLDCAETFKNCLGTIYTVYI--ENLAYGLE-TLIGNILGCIQVPPAGGPQVR------FSIG-AGDKQ---SLQPPQSSSLPTTG--SG ..|||. ..||.... ..|...| ..|.... .| . .. ..| ... ....|| |...| |... .|. . .. | ...||... . WTPKCIHCIISHHPWFNWFRKWLNELYRYWQSDHNQHLFHHEFMIYLCHYPVPLPPPGKSIVFMSIVSYFQFHPPGNYYQPIEFCRPDDNRLPHIDENWD VHFLFKQLGIKNVLILLCSVMTENKILFLSKCYWHLTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPFIMGIHSSLQTEITDLLD----VIVVD .| ||..||..|.. |.|....|..|.|.|. |. |...|.|.|||.|||.. |.||||||| . ..|..|.|.|||.|||...|.....| |.||| LHELFECLGVENIMQLFCCILLERRIIFHSSNYQMLSMCCHAFVALLYPFQWQHIYIPILPASMLDYLCAPMPYIMGCHSSYFEEVKPEPDEEDDVVVVD LDGG .| . IDTN |
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| DDENN | Sbf.AA | dDENN | 383-452 | 35 | 7.1e-25 | 90.55 | Pfam | 1-77 (77) | Show / Hide |
Range on Protein: 383-452 Range on HMM: 1-77/77 Sequence Identity: 35% (27 aa) IDKELRAIFMRLFAQLLQGYRSCLTIIRIHPKP----VITFHKAGFLGA-RDLIESEFLFRVLDS--MFFTTFVNER .....|..|.|.||||...||..|..||.||.| ..||.|..|| . |. . .|| ..... ..|..|. || HNQQVREAFLRFFAQLFGHYRNFLRYIRQHPRPWTDQMYTFQKEAFLKSRRPKSHRPFLKQFMETQVQMFAQFIQER |
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| SBF2 | Sbf.AA | SBF2 | 562-787 | 52 | 2.7e-151 | 507.95 | Pfam | 1-233 (233) | Show / Hide |
Range on Protein: 562-787 Range on HMM: 1-233/233 Sequence Identity: 52% (126 aa) PMGPRLP-------EALDVRPNVQ-NSA---RRLEVLRICVSYIFENRITDARKLLPAVMRTLMHRDARLILCREFFGYVHGNKA-VLDHQQFELVVRFM ||||... .... ..... ||| ||||||| |.||||.|.|..|.|..|||.|.| .|.||..||||.......|.. ||||||| .|||.| PMGPPVNTIVPGSMSIMEKHSGMFHNSALMLRRLEVLRNCISYIFDNKILEAKKMFPAVLRALKGRAARICLCRELNLHCQQNRHFVLDHQQFDMVVRMM NKALQKSSGIDEYTVAAALLPMSTIFCRKLSTGVVQFAYTEIQDHAIWKNLQFWESTFFQDVQGQIKALYLLHRRQNEHQKEANCVLDEVPLEEPTALEI |.||| ... |||.|||||||.||.|||||..||.|||||..||| .|||.||||..|.|||| .|..||| |.|..|.....|... .||.|.|| NCALQDCCSMDEYGVAAALLPLSTAFCRKLCPGVHQFAYTCVQDHPVWKNQQFWEACFYQDVQNHIRELYL-----NMHHDEQKTWSDWCHKQEPCAMEI TAEQLRKSPNIEEEKKAELAKSEESTLYSQAIHFANRM .|||.|..| ...||..||...||||.||||||.|||| AAEQMRLWPTMDKEKQQELVQKEESTVYSQAIHYANRM |
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| DDENN | Sbf.AA | dDENN | 383-452 | 32 | 9.2e-25 | 89.5 | SMART | 1-84 (84) | Show / Hide |
Range on Protein: 383-452 Range on HMM: 1-84/84 Sequence Identity: 32% (27 aa) IDKELR-AIFMRLF--AQLLQG--YRSCLT--------IIRIHPKPVITFHKAGFLGARDLIE-SEFLFRVLDSMFFTTFVNER .....| |.|.|.| .||... ||..|. .|.||.|.|||.|..||..|. . .|| .......|..|. || LNDQIREACFLRFFNYVQLFGHVDYRNYLRHHMIQQAYTWRKHPEPHITFNKESFLKSRPSHHMRPFLKMFCETQMFSQFIEER |
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| GRAM | Sbf.AA | GRAM | 902-982 | 16 | 6.4e-17 | 63.54 | Pfam | 1-78 (78) | Show / Hide |
Range on Protein: 902-982 Range on HMM: 1-78/78 Sequence Identity: 16% (14 aa) PKIQTPCL--LPGEDLVTDH----LRCFLMPDGREDETQCLIPAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKIS .|..... ||... . .. .| |. .. ..||. |....||..|.|......... ......|.... . .|.. EKFRKHFKDPLPPNEKLIMDCNVTYSCCLWRPF------TKIPVQGRMYITNHHVCFYSDKFGWET---YYKMVIPWNDITRVEKMQ |
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| Myotub-related | Sbf.AA | Myotub-related | 1168-1254 | 20 | 3.7e-25 | 94.71 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 1168-1254 Range on HMM: 1-121/121 Sequence Identity: 20% (26 aa) YATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH-ANGALLIRGGQP-----------------------------------NSKSVIGMLKN |. |..|||..| |...||.............|.|. .||| .|||...| .|| .... . ...| YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN -TTGSTTNAHHDVTHYPEQDKYFL ..| ..... |||.....|. RAKG---GGYENEEHYPNWEFVFM |
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| GRAM | Sbf.AA | GRAM | 902-982 | 17 | 7.5e-17 | 63.23 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 902-982 Range on HMM: 1-80/80 Sequence Identity: 17% (15 aa) PKIQTPCLLPGEDLVTDH------LRCFLMPDGREDETQCLIPAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKIS |..... || .. . .. .| |. .. ||. | ....|....|...... . |.|......|.|.. . .|.. EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTY-------DIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT |
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| Phosphatase | Sbf.AA | Subfamily.MTMR1.PD | 1391-1524 | 42 | 1.9e-39 | 123.1 | In-house | 10-142 (149) | Show / Hide |
Range on Protein: 1391-1524 Range on HMM: 10-142/149 Sequence Identity: 42% (56 aa) ADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKpSHANT | . . . .|.. ||..| .... . ..| .. ...||.. || | ||||.|.| | ||.|||.. || ||.|||||.|||.||.| . .. ideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighg-dknha NIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLR .| ||||.|.| |..||||.|||||. .| dadrspvflqfidcvwqvtrqfptafefneefli |
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| Phosphatase | Sbf.AA | Family.Myotubularin.PD | 1392-1529 | 42 | 2.5e-47 | 148.4 | In-house | 3-139 (141) | Show / Hide |
Range on Protein: 1392-1529 Range on HMM: 3-139/141 Sequence Identity: 42% (59 aa) DGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHaNTN . ... . .|.. ||..|..|.. . .|. .. ...||.. || | ||||.|.|||.||||||...||.||.|||||.|||.||.| . .. ... eekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdks-ese IAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYH .| ||||.|.|.||..|||.|||||. .| .. | eersPvflqfidcvyqltkqfptafefnesflikildh |
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| Phosphatase | Sbf.AA | Subfamily.MTMR3.PD | 1399-1530 | 46 | 4.7e-44 | 137.9 | In-house | 4-134 (135) | Show / Hide |
Range on Protein: 1399-1530 Range on HMM: 4-134/135 Sequence Identity: 46% (60 aa) MVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAfAPTF .|.. |||..| |.. . ||. .| .. |.. || | |.|. ..|.|.||||||.|.||.||||.||| |||.|| |. .. ...| .| ||| alektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlner-cpvf LQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHS .||.||||..||| .||||. .| |. |. lqwldcvhqlkkqfptsfefneaflvklvqht |
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| Phosphatase | Sbf.AA | Subfamily.C2-MTMR1.PD | 1398-1530 | 44 | 2.6e-37 | 116.3 | In-house | 8-136 (137) | Show / Hide |
Range on Protein: 1398-1530 Range on HMM: 8-136/137 Sequence Identity: 44% (55 aa) KMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSnlkpSHANTNIAFAPT .|...|| |..... . |. .. | .. || | |.|| ..||| ||||||..||. ||.|||||||||.| .|.|.. .| ||||||.. sqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderl----ggadsvserspi FLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHS .|...||| |||.. .| .|| .| flqfldclyqvtkqfpsafeytarlllkladys |
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| C1 | Sbf.AA | C1 | 1771-1818 | 29 | 6.5e-12 | 46.82 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 1771-1818 Range on HMM: 1-61/61 Sequence Identity: 29% (18 aa) HRFEKHPYTTPTNCNHCTKLLWG-------PVGYRCMDCGNSYHEKCTEHSMK-------NC |....... .||.|.|| |..|| . |||| .|. .|.|| .. . .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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| PH | Sbf.AA | PH | 1870-1973 | 29 | 2e-16 | 61.87 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1870-1973 Range on HMM: 1-92/92 Sequence Identity: 29% (31 aa) RTHEGHLYKRGALLKGWKQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVQSVTAAQPAQIGAKGVDEKGFFDLKTSKR-IYNFYAINANLAQEWIEKL ..||.|.|.| .|.||.||||| . .| ||. . |||.| | .. .|| . . ... | ..| | | |.| .. ...|.. . VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN-------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAI QACLQ |... QSACR |
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| C1 | Sbf.AA | C1_1 | 1771-1821 | 27 | 2.3e-09 | 38.03 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 1771-1821 Range on HMM: 1-55/55 Sequence Identity: 27% (15 aa) HRFEKH-PYTTPTNCNHCTKLLWG---PVGYRCMDCGNSYHEKCTEHSMKNCTKY |... | . || |.|| ...|| |..| .|. .|..| .. ..| HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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| PH | Sbf.AA | PH | 1870-1973 | 27 | 5.2e-16 | 60.44 | SMART | 1-80 (82) | Show / Hide |
Range on Protein: 1870-1973 Range on HMM: 1-80/82 Sequence Identity: 27% (29 aa) RTHEGHLYKRGALLKGWKQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVQSVTAAQPAQIGAKGVDEKGFFDLKTSKRIYNFYAINANLAQEWIEKLQ ..||.|||.. . .||.|||||.. ..| ||. . .|||.| | .. .|. | ... .| | |.. .. .|||.. .| VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDC-TVRE-P-------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQ ACLQ .... KAIH |
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