• Phosphatome.Net

Gene CG12078

CG12078
Species: D.melanogaster
Alias: CG12078
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: FCP
Subfamily: DULLARD
Protein domain

Protein domains of CG12078.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase CG12078.AA CPDc 69-220 33 5.7e-59 203.15 SMART 1-173 (173) Show / Hide 
Range on Protein: 69-220
Range on HMM: 1-173/173
Sequence Identity: 33% (58 aa)

ARKTLVLDMDNTMITS---------WFIKRGKKPKNIPRIAHD----------FKFYLPAYGATIYVYKRPYLDHFLDRVSKWYDLTVFTSGAEIYASPI
 .||||||.|.|.. |         .. .| .|. . . . .           ....   ..  .||.|||....||.|.||||.. |||.| ..||.|.
KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDG--HPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPV

LDFLDRGR-GILNSRLYRQHCIEQFGK-WSKS-VLLAC-PDLSNVVLLDNSSTECSFNAENAILIKSYEIGCRDE
||.||..| .... ||||.|| . .|| . |    | . .|||.|. .|.|.. .... |||| ||..   . | 
LDMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT
Phosphatase CG12078.AA Subfamily.DULLARD.PD 70-239 51 2.4e-73 234.3 In-house 2-172 (172) Show / Hide 
Range on Protein: 70-239
Range on HMM: 2-172/172
Sequence Identity: 51% (89 aa)

RKTLVLDMDNTMITSwFIKRGKKPKNIPRIAHDFKFYLPAYG--ATIYVYKRPYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDRGRGILNSRLYRQ
|||||||.|.|.|.| .... .| .. ...|.|||... ..   ...||||||..|.|||.|||||||..||...|.||....|.||.|||||..|.|||
rktlvldldetlihs-ahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrq

HCIEQFGKWSKSVLLACPDLSNVVLLDNSSTECSFNAENAILIKSYEIGCRDEALINLLPFLDALRFMKDVR
||....||..|.. | ..|||.|..||||..... |..||| |||. ....|.||.|||||||||||.||||
hCtlesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdvr
Phosphatase CG12078.AA NIF 71-239 30 1.5e-56 199.0 Pfam 1-189 (189) Show / Hide 
Range on Protein: 71-239
Range on HMM: 1-189/189
Sequence Identity: 30% (60 aa)

KTLVLDMDNTMITSW--FIKRGKKPKNIPRIAHDFKFYLP--AYGATIYVYK-RPYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDRG-RGIL--NS
||||||.|.| . .   . .            |||.. .|   .  ..|||| |||.|.||...||.|.. ..|.. . || |..|..|.  ...     
KTLVLDLDETLVHCNPWWEPPN---------WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHH

RL---YRQHCI-EQFG-KW-S-KSVLLA--CP-DLSNVVLLDNSSTECSFNAENAILIKS-YEI-----G-CRD--EALINLLPFL-DALR-FM-KDVR
||   ||.||. .. | .    |   .   .  |||.|...|||.  . .. .|.|.|.. .       .  .|  ..|..||||| ..|. .. .|||
RLICWYREHCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR
Phosphatase CG12078.AA Family.FCP.PD 70-239 37 7e-49 154.9 In-house 2-164 (164) Show / Hide 
Range on Protein: 70-239
Range on HMM: 2-164/164
Sequence Identity: 37% (64 aa)

RKTLVLDMDNTMITSwfikrGKKPKNIPRIAHdfKFYLPAYGATIYVYKRPYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDRGRGILNSRLYRQHC
.|.||||.|.|.. |      .|||| |.. .  |. .  .  |.||.|||.||.||..||..|....||.. . ||.|..|.||. ..... ||.|..|
kklLVlDLdetLvhs-----elkpknkpdfvv--kveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdec

IEQFGKWSKSVLLACPDLSNVVLLDNSSTECSFNAENAILIKSYEIGCRDEALINLLPFLDALRFMKDVR
. . |. .|..   . |||.|...|.|......| .||| .||..   .|..|..|||||..|....|||
vlvkgnyvkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedvr
Phosphatase CG12078.AA Subfamily.SCP.PD 70-238 32 8.1e-34 105.6 In-house 2-162 (163) Show / Hide 
Range on Protein: 70-238
Range on HMM: 2-162/163
Sequence Identity: 32% (54 aa)

RKTLVLDMDNTMITSWFiKRGKKPKNIPRIAHDfkfylpAYGATIYVYKRPYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDRGrGILNSRLYRQHC
.|.||||.|.|.. | | |  .... .  .  |           .|| |||..|.||..|.. ... .||.  . ||.|..|.||.  ....||.|..|.
kkclvldldetlvhssf-kpvenadfvvpveid------gtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkk-nvikarlfresc

IEQFGKWSKSVLLACPDLSNVVLLDNSSTECSFNAENAILIKSYEIGCRDEALINLLPFLDALRFMKDV
 . |.. | .     ||..||..||| .   |...||. ..|.    .|. | .|||.|. |. ..|| 
vfhkgnyvkdlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedv
Phosphatase CG12078.AA Subfamily.HSPC129.PD 70-239 33 2.9e-33 103.9 In-house 2-164 (164) Show / Hide 
Range on Protein: 70-239
Range on HMM: 2-164/164
Sequence Identity: 33% (56 aa)

RKTLVLDMDNTMITSWFikrgkkpKNIPRIAHDFKFYLPAYGATIYVYKRPYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDRGRGILNSRLYRQHC
. .||||.|.|.. . .       ....  .. || .      ..||  ||.| .||.|||| ... .||.  ..||  .||.||  ... ||.|.||. 
efslvldldetlvhcsl-------akledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehc

IEQFGKWSKSVLLACPDLSNVVLLDNSSTECSFNAENAILIKSYEIGCRDEALINLLPFLDALRFMKDVR
  |.. | . .   |||. ...|||.   ... || | |.|.     |. |..|||||..|  ..|||  
vcvdgnyikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedvr
Phosphatase CG12078.AA Group.HAD.PD 70-239 30 3.1e-31 97.9 In-house 1-190 (190) Show / Hide 
Range on Protein: 70-239
Range on HMM: 1-190/190
Sequence Identity: 30% (58 aa)

RKTLVLDMDNTMI--TSWFIKRGKKPKNIPRIAHDFkfylPAYGATIYVYKR------------PYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDR
..|||||.| . .  .|.  ..|.. |.. .|         |.   .|..||            |.|| ||.||...|.|.|||.| . ||.|....| |
kdtlvlDldgvlwlhgspepleglrskgkvlifltn----natksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdv

GRGILNSRLYRQHCIEQFGKWSK------SVLLACPDLSNVVLLDNSSTECSF--NAENAILIKSYEIGCRDEALINLLPFLDAL--RFMKDVR
..... |..|..| .  |.  .       . . ..||..|| .||..  . |  | |||..|...     | .|..|.|.|...  || |||. 
gdeafsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrfgkdvg
Phosphatase CG12078.AA Subfamily.TIM50.PD 117-234 30 2.6e-21 65.2 In-house 27-143 (150) Show / Hide 
Range on Protein: 117-234
Range on HMM: 27-143/150
Sequence Identity: 30% (35 aa)

YKRPYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDRgRGILNSRLYRQHCIEQFGKWSKSVLLACPDLSNVVLLDNSSTECSFNAENAILIKSYEIG
||| .|.||..... ... ||||   ..|.|..| ||  ..... ||.|...  . |.  | .     ||| |...|  ...  .. |||. .| ..   
kkrPgvdafleelaelfeivvftseqgltaaplidkldP-kqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkwkGn

CRDEALINLLPFLDALRF
 |. |..||.||  .   
addrelldllaflktiat
Phosphatase CG12078.AA Subfamily.FCP1.PD 72-214 30 2.1e-17 52.8 In-house 4-144 (150) Show / Hide 
Range on Protein: 72-214
Range on HMM: 4-144/150
Sequence Identity: 30% (44 aa)

TLVLDMDNTMITSWFIKRGKKPK-NIPRIahdFKFYLPAYGATIYVYKRPYLDHFLDRVSKWYDLTVFTSGAEIYASPILDFLDRGRGILNSRL-YRQHC
.||.|.|.|.| .   .  . .. .   |    || ||    . || .||.| .||...|| |.| ..| |.  ||. |  .||  . . ..|.  |. .
vLvvDlDqtlihttkdptievkeeklkdi---kkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdel

IEQFGKWSKSVLLACPDLSNVVLLDNSSTECsFNAENAILIKSYE
.... | .|   |   . | ||..|. .     .||| | .|.|.
lnassktkklkklfptgdsmvviiDDredvW-nfaenlikvkpyk
Sequence
Name Sequence Type Origin Length Description Download
CG12078.AA Protein None 253 None Fasta, JSON
CG12078.NA RNA None 759 None Fasta, JSON
CG12078.AA.PD_69-239 Protein Phosphatase Domain None 171 None Fasta, JSON