Gene Fcp1
Fcp1
Species: D.melanogaster
Alias: Fcp1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of Fcp1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | Fcp1.AA | Subfamily.FCP1.PD | 206-351 | 61 | 1.6e-68 | 218.7 | In-house | 1-149 (150) | Show / Hide |
Range on Protein: 206-351 Range on HMM: 1-149/150 Sequence Identity: 61% (92 aa) RKLVLLVDLDQTVIHTTND---TVPD-NIKGIYHFQLyGPHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILSRDE |||||.||||||.||||.| .|.. . |.| .|.| .. .|...|||...||||..|.||||||.|.|.|.||..||..||||.|.||.||||||| rklvLvvDlDqtlihttkdptievkeeklkdikkftl-peekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrde CFNATSKTDNLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPYHFFQHT ..||.|||..||.|||.|||||.||||||||||.|.|||.||||.||... llnassktkklkklfptgdsmvviiDDredvWnfaenlikvkpykfFkgv |
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| Phosphatase | Fcp1.AA | CPDc | 206-352 | 29 | 3.8e-61 | 210.37 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 206-352 Range on HMM: 1-173/173 Sequence Identity: 29% (51 aa) RKLVLLVDLDQTVIHT-----------TNDTVPDN-IKGIYHF----------QLYGPHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQ .|..| .|||.| .|. . ...... ... .. ...|. ......||. |||.|.|..||.|..| | |.||. ... KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD LLDPEGKFFSHRILSRDECFNATSKTDN--LKALFPN-GDSMVCIIDDREDVWNMAS-NLIQVKPYHFFQHTG .|||..|.|..|.|.||.|.. .||.. . |.. .|||.||||..|.|.. |.|..||...|.| . MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | Fcp1.AA | Family.FCP.PD | 206-346 | 33 | 4e-41 | 129.7 | In-house | 1-139 (164) | Show / Hide |
Range on Protein: 206-346 Range on HMM: 1-139/164 Sequence Identity: 33% (48 aa) RKLVLLVDLDQTVIHTTNDTVpDNIKGIYHFQLYGpHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILsRDECFNA .|..|..|||.|..|.. . . .. . . .... . .. ..... ||.. ||||..|.|||..| |.. |.||. .|..||||.|.|..|.| ||||.. kkklLVlDLdetLvhselkpk-nkpdfvvkveide-leetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrll-rdecvlv TSKT-DNLKALfPNGDSMVCIIDDREDVWNMAS-NLIQVKPYH ... .|..| ....|.|.||||..|.... |.|.||... kgnyvkdLskl-grdlskviiiDdspdsyklnpdnaikvksfk |
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| Phosphatase | Fcp1.AA | NIF | 208-348 | 26 | 3.5e-25 | 93.34 | Pfam | 1-153 (189) | Show / Hide |
Range on Protein: 208-348 Range on HMM: 1-153/189 Sequence Identity: 26% (42 aa) LVLLVDLDQTVIHTT--NDTVPDNIKGIYHFQLYGP---HSPWYHTRL-RPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPE-GKFF-SHRIL-- ..| ||| | .|.. . .. . |.. | . ..... ||. |||..||..||..|.| . ..|| . . .||. .|.| .|..| KTLVLDLDETLVHCNPWWEPPN-----WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLIC -SRDEC--FNAT-SK-T-DNLKALFPNG-D-SMVCIIDDREDVWNM-ASNLIQVKPYHFF .|..| . .. . .| |..| | | | |.|.. ..| . .|.|...|| .. WYREHCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPY-WY |
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| Phosphatase | Fcp1.AA | Group.HAD.PD | 208-347 | 21 | 1.2e-22 | 70.0 | In-house | 2-163 (190) | Show / Hide |
Range on Protein: 208-347 Range on HMM: 2-163/190 Sequence Identity: 21% (35 aa) LVLLVDLDQTVI---HTTNDTVPDNIKGIYHFQLY--GPHSPWYHTRLR----------PGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFF .|..|||.... . .. . . .. .| .. ... ||. |...|||||...||||...|.| |.||. .. .|....||. dtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeaf SHRILSRDECFNATskTDNL------KALFPNGDSM-VCIIDDREDVWNM---ASNLIQVKPYhF |.| .. .. ..| ... | . |.|||.. .|... .| . .... . syrklrdacvylkg--pgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdf-i |
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| Phosphatase | Fcp1.AA | Subfamily.DULLARD.PD | 208-345 | 24 | 1.9e-15 | 45.8 | In-house | 3-146 (172) | Show / Hide |
Range on Protein: 208-345 Range on HMM: 3-146/172 Sequence Identity: 24% (35 aa) LVLLVDLDQTVIHTT-----NDTVPDNIKGIYHFQLYGPHSP-WYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILsRDE .|..|||.|.||.. . || .... ...... ..| .. || .||...|. |.| | | ....||. ... || . ....| |..| ktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryy-rqh CFNAT-SKTDNLKALFPNGDSmVCIIDDREDV-WNMASNLIQVKPY . . | .| .. .. .| |.|.|. . . | |..| . Ctlesgkytkdlslvsedlss-viilDnspvayrknpdnaipiksw |
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| Phosphatase | Fcp1.AA | Subfamily.HSPC129.PD | 208-306 | 35 | 3e-15 | 45.3 | In-house | 3-98 (164) | Show / Hide |
Range on Protein: 208-306 Range on HMM: 3-98/164 Sequence Identity: 35% (34 aa) LVLLVDLDQTVIHTTNDTVPDNIkgIYHFQLYGPHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRiLSRDECFNAT |..|||.|..|.. ..| . . | . . |||| |||||.|.|.|. . | . ||. . .||||| |.. ||| |. | . fslvldldetlvhcslakledat--lsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhr-lfrehcvcvd |
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| Phosphatase | Fcp1.AA | Subfamily.SCP.PD | 207-318 | 27 | 1.1e-13 | 40.1 | In-house | 2-110 (163) | Show / Hide |
Range on Protein: 207-318 Range on HMM: 2-110/163 Sequence Identity: 27% (31 aa) KLVLLVDLDQTVIHTTNDTVPdNIKGIYHFQLYGPHSPWYHTRlRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKfFSHRiLSRDECFNAT | |..|||.|..|.. |. | . . .. | . | .. || |||.....|.|. . | .||. .|.|||.... ...| | |..|.. . kkclvldldetlvhssfkpve-nadfvvpveidgtvhqvyvlk-rpfvdeflkkvgelfevvlftaslakyadpvadlldkknv-ikar-lfrescvfhk S-KTDNLKALFPN . .| | . gnyvkdlsrlGrd |
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| Phosphatase | Fcp1.AA | Subfamily.TIM50.PD | 246-346 | 21 | 8.3e-09 | 24.6 | In-house | 24-123 (150) | Show / Hide |
Range on Protein: 246-346 Range on HMM: 24-123/150 Sequence Identity: 21% (21 aa) YHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGkFFSHRILSRDECFNATSKTDNLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPY . .. ||| . |||....|.|. . | .|. . . |||.. . ..|.. . ... .|. | . . .. . |.| |.| ...|... wrfkkrPgvdafleelaelfeivvftseqgltaaplidkldPkq-limyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkw H k |
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| BRCT | Fcp1.AA | BRCT | 586-666 | 17 | 1.1e-07 | 31.16 | Pfam | 1-84 (84) | Show / Hide |
Range on Protein: 586-666 Range on HMM: 1-84/84 Sequence Identity: 17% (16 aa) IRSEVLRGKNLVFSGLVPTQMKLEQSRA--YFIAKSLGAEVKPNIDKEITHLV--AVNA---GTYK-VNAAKKEPAIKVVNANWLWTCA . ...|. ... . ..... . ......|..| ....|..||.. . . .| | ...| ||. |..|. |.| | H-EKPFKGCTFCI---TGGFDNMNRDEIHWQEMIEKHGGKVTDSVSKQTTHVIPWVGEPHCTRTKKFYWKA-KEWNIPIVHPDWIWDCI |
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| BRCT | Fcp1.AA | BRCT | 588-669 | 13 | 1.3e-08 | 35.89 | SMART | 1-93 (93) | Show / Hide |
Range on Protein: 588-669 Range on HMM: 1-93/93 Sequence Identity: 13% (13 aa) SEVLRGKNLVFSG--LVPTQMKLEQSRAYFIAKSLGAEVKPNIDK----EITHLVAVNAGTYKVNA---------AKKEPAIKVVNANWLWTCAERW .....|. ...| . . . . ......|..| ... ..||... .... |. .... |..|. |.| | ..| MKPFKGCTFCITGDDIEGNFD-M-RDELKEMIEMHGGKVT-SVSRKRCPDTTHVIC-SPENPKYETWNRMMTKYMKAIAWGIWIVHPDWIWDCIKKW |
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