Phlpp
Species: D.melanogaster
Alias: Phlpp
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: PPM
Family: PPM
Subfamily: PHLPP
Protein domain

Protein domains of Phlpp.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase Phlpp.AA Subfamily.PHLPP.PD 429-522 25 5.6e-08 20.8 In-house 3-92 (257) Show / Hide
Range on Protein: 429-522
Range on HMM: 3-92/257
Sequence Identity: 25% (24 aa)

QNKTSGPWTMGFAETpgSGDCRKLSVYQLRAANYGGSDEALYGMFEalegrGRAAQEMSHLVPDLMK---QEQMVKDSAVRDYMKFTLLAAQQQCGS
.. .|  . .|..|.  .|   || | .|.  |.  . ||.||...     |   .|...|.   |    .|.. ||     |.. .|| .... | 
aslasavfshGlsea--aGvknklCvaalavenfaenveavyGlid-----GdrnselpsllqctmadvlkeevqkdkneevyianillvshrklGe

Phosphatase Phlpp.AA Family.PPM.PD 579-662 22 3e-10 27.7 In-house 204-293 (495) Show / Hide
Range on Protein: 579-662
Range on HMM: 204-293/495
Sequence Identity: 22% (19 aa)

KDQIHSMPDPHVLELILS-NDDEYLVVGNAQLWSVMDIDRAAREIRKEE-----NSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDV
..|..  ..|..  . |. ..||.||.    || |.. . ... .|..      .   .|..||| | .    .  .|.|| . .     
eeqaivsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvalyenikqq

Phosphatase Phlpp.AA Subfamily.PHLPP.PD 585-653 49 4e-28 86.9 In-house 189-257 (257) Show / Hide
Range on Protein: 585-653
Range on HMM: 189-257/257
Sequence Identity: 49% (34 aa)

MPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVV
.|.||| ...|...||.|..||..||.|..||.|....|..|..|.|||.|||.|||..||.|.|..||
lPkphvrsvlLteqdEllilGnkalWevlsideaveavrnvedplvaAkklvdlaqsygaadsvsalvv

Phosphatase Phlpp.AA Group.PPM.PD 584-675 20 2e-08 21.8 In-house 235-341 (459) Show / Hide
Range on Protein: 584-675
Range on HMM: 235-341/459
Sequence Identity: 20% (21 aa)

SMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS---------LLAAKRLVDIAQSFAAA------ESLSVIVVRFRHLGTDVDHLIRE
..|.|  . |...||.||..   || |.. . ... .|.. ..           .|.|||| | .   .         .||||.. .     ..... ..
vsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTvivvtlndamrrqleivkk

LKQSVRK
  ..   
eevleee

Phosphatase Phlpp.AA Subfamily.LRR-PP2C.PD 585-655 26 1.2e-06 16.7 In-house 186-257 (257) Show / Hide
Range on Protein: 585-655
Range on HMM: 186-257/257
Sequence Identity: 26% (19 aa)

MPDPHVL-ELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRF
.|||..  .|  |..|..|..    .| ..  ..|   . . ...  ||..| | | |  . . .||||...
vpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivikl

Phosphatase Phlpp.AA Subfamily.PPM1A.PD 579-657 23 3.1e-06 15.2 In-house 199-280 (309) Show / Hide
Range on Protein: 579-657
Range on HMM: 199-280/309
Sequence Identity: 23% (19 aa)

KDQIhSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKE----ENSLLAAKRLVDIAQSFAAAESLSVIVVRFRH
..|.  .|.|.|  .  ...||.||.    .| ||. . .|. ....    ..   .|..|.| . .  . . .|||.| .  
teql-vspepevtvierdeedeflvlacDGiwDvmsneevaefvksrlevtddleevanelldtcLekgsrDNmsvilvllpg

Sequence
Name Sequence Type Origin Length Description Download
Phlpp.AA Protein None 954 None Fasta, JSON
Phlpp.NA RNA None 2862 None Fasta, JSON
Phlpp.AA.PD_586-648 Protein Phosphatase Domain None 63 None Fasta, JSON