Gene CG12091
CG12091
Species: D.melanogaster
Alias: CG12091
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of CG12091.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | CG12091.AA | PP2Cc | 57-317 | 10 | 2e-11 | 45.23 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 57-317
Range on HMM: 1-338/338
Sequence Identity: 10% (42 aa)
VSVVCGFAKDNLRHKY------KPGKYGEDSWFKASTASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFNP-------------------
.| ... .. .|. | . ...||... ..||.|| | . .... . . .|
HS-MGYNSG--WRYGYMESSMQGWRHPMEDAHVCRP-----FFGVFDG-----HGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMW
-----QRPVNLLAYSYCELMEQKKPILGSSTACVLILNRETSTVHTANIGDSGFVVVREGQ----------VVHKSEEQQH-------------------
. . ..| ... .. |. .||.|... .. ...||.||| |. | |. .. .|.. .
HDKWFEDWEDALRKAFLRMDEEI------CTAVVALIRGNK--LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPM
-------------YFNTP---FQLSLPP-------------------------PGHGPNVLSDSPESADTMSF----PVRDGDVILIATDGVFDNVPEDL
..| ..| ... . .. |. .. |. |.| .....||..|.....
HRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQE
MLQVLSEVE---GERDPV-------------------KLQMTANSLALMARTLSLNSEFLSPFALSARRNNIQARGGKPDDITVVLA
... . .. || ... |. |. .|. |..||..
VVDIVRKCLRKWHHK-PVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI---------------------------CDNMTVIVV
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| Phosphatase | CG12091.AA | Family.PPTC7.PD | 58-319 | 58 | 9.1e-128 | 415.0 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 58-319 Range on HMM: 1-262/262 Sequence Identity: 58% (153 aa) SVVCGFAKDNLRH-KYKPGKYGEDSWFKASTASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFNPQRPVNLLAYSYCELMEQKKPILGSS .|.||||||.|.. ..| .|.|||..| .|...|||.||||||||||.||.|...||| ||..|||||..|.|.|..| .||...|.||.|.|.|..||| avkcgfakdllkqkskkrskfGeDayFvssnkvadvlgvADgvggwreygvdssafsselmkkcerlvkeskfkplkpkkllkaayaelleekvpvvGss TACVLILNRETSTVHTANIGDSGFVVVREGQVVHKSEEQQHYFNTPFQLSLPPPGHGPNVLSDSPESADTMSFPVRDGDVILIATDGVFDNVPEDLMLQV ||||..|.||......||.|||||.|||||.|||.|.|||||||||.|||.||.... .|.|||||.||..||.|..||.||.||||||||..|| .|.. tAcvvvldredkklesanlGDsgflvvRegkvvhrskeqqhyFntPyqLsipPeerdgkvisdspeaAdstsfevkkgDiillatDGvfDnlsedqilee LSEVEGeRDPVKLQMTANSLALMARTLSLNSEFLSPFALSARRNNIQARGGKPDDITVVLATV |.|... ||...||..|||||..||.||..... |||| .|......|.||||||||||||.| lkelke-rdeeelqllanslaekareLsfdpkyespFaqkakkrglaasGGKpDDitvvlavv |
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| Phosphatase | CG12091.AA | Subfamily.PPTC7.PD | 58-319 | 58 | 1.7e-124 | 404.2 | In-house | 2-263 (263) | Show / Hide |
Range on Protein: 58-319 Range on HMM: 2-263/263 Sequence Identity: 58% (153 aa) SVVCGFAKDNLRH-KYKPGKYGEDSWFKASTASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFNPQRPVNLLAYSYCELMEQKKPILGSS |||||||||.|.. ..| .|.|||..| .|...|||.||||||||||.|||||.|||. ||..|||.|..|.|....| ..|...|.||.|.|.|..||| svvcgfakdllkqkskkrskfGeDayFvssnkvadvlgVADgvggwreygidpsefskelmkkcerivkeskfkerkpkkileaayqelleekvpvvGss TACVLILNRETSTVHTANIGDSGFVVVREGQVVHKSEEQQHYFNTPFQLSLPPPGHGPNVLSDSPESADTMSFPVRDGDVILIATDGVFDNVPEDLMLQV |||...|.||......||.|||||.|||.|.|||.|.|||||||||.|||.||.... .|..|.||.||..||.|..||.||.||||||||..|| .|.| tacivvldredkklesaNlGDSgflVvRngkvvhrskeqqhyFNtPyqLsipPeerdgkvildkpeaadstsfevkkgDlillatDGvfDNlsedeilev LSEVEGeRDPVKLQMTANSLALMARTLSLNSEFLSPFALSARRNNIQARGGKPDDITVVLATV |.|... ||. .||..||||| .||.|||.... |||| .|..|...|.||||||||||||.| lkelke-rdeeelqllanslaekarelsldpkyespFakkakknglaasGGKpDDitvvlalv |
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| Phosphatase | CG12091.AA | Group.PPM.PD | 76-194 | 20 | 3.5e-13 | 38.4 | In-house | 50-188 (459) | Show / Hide |
Range on Protein: 76-194 Range on HMM: 50-188/459 Sequence Identity: 20% (28 aa) KYGEDSWF-KASTASA-DVMGVADGVGGWRSYGIDPGEFSSFLMRTCERL---V---------------QCSHFNPQRPVNLLAYSYCELMEQKK--PIL |. ||... . . ...|| || ||.. . .....|.. ... | . . . . | ..| ..|... . kemEDrhvivenfdnndsffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedlseeanekeepgkd GSSTACVLILNREtsTVHTANIGDSGFVVVREGQVVHKSEE .||.|...| ....||.||| |..|.|..|. |.. sGtTAvvalingk--klyvANaGDSravLcrngkavplskd |
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| Phosphatase | CG12091.AA | Group.PPM.PD | 225-319 | 17 | 9.7e-10 | 27.1 | In-house | 240-321 (459) | Show / Hide |
Range on Protein: 225-319 Range on HMM: 240-321/459 Sequence Identity: 17% (17 aa) DTMSFPVRDGD-VILIATDGVFDNVPEDLMLQVLSEVEGE---RDPVKLQMTANSLALMARTLSlnseflspfalsarrnNIqARGGKPDDITVVLATV |...... . | .. .|.||..| . .. ..... | . .. .|...|..|. |. . . .|...|.|||..|. dvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakg----------------st-gdgtscDNiTvivvtl |
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| Phosphatase | CG12091.AA | Family.PPM.PD | 143-194 | 28 | 6.5e-09 | 24.2 | In-house | 110-160 (495) | Show / Hide |
Range on Protein: 143-194 Range on HMM: 110-160/495 Sequence Identity: 28% (15 aa) CELMEQKK-PILGSSTACVLILNRETstVHTANIGDSGFVVVREGQVVHKSEE .| ..|. . . .||.|....... ...||.||| |..|.|..|. |.. seelneksagkdsGtTAvvvlirgkk--lyvAnaGDsravLcrngkavelskd |
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| Phosphatase | CG12091.AA | PP2C_SIG | 63-319 | 13 | 2.2e-07 | 30.75 | SMART | 1-250 (250) | Show / Hide |
Range on Protein: 63-319 Range on HMM: 1-250/250 Sequence Identity: 13% (38 aa) FAKDNLRHKYKPGKY-GEDSWFKASTASAD----VMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFNPQRPVNLLAYSYCELMEQK--KPILGS .. . .. |.... . | |. . . .. .. ..|..| | |. ..... . . ... .. . .....|. . DDHWDIYQYYEDATQVCGD-WYDFWKIPEGQDRYFFVIGDVMG-WA-HGLPAALMMGMARTMMRTFWHE-------SPPQILERCNRWIYQNNHEECGMF STACVLIL--NRETSTVHTANIGDSGFVVVR--EGQVVHKSEE--------------QQHYFNTPFQLSLPPPGHGPNVLSDSPESADTMSFPVRDGDVI .|.|.... . .|.|.. ...|.| . ..| .|. |.. .. .... . . || |..|.. .|. .|.. ||.. TTMCCCVYMPDFATHTLWYCHCGHSPPYLYRAMDGGRVEHTHDHYLVQHYVMRIIDEEDAKHHPWHNWTGPPLGMEPDYM------YDVQEFQYEPGDRF LIATDGVFDNVPE--------DLMLQVLSEVEGERDPVKLQMTA-NSLALMARTLSLNSEFLSPFALSARRNNIQARGGKPDDITVVLATV ...||||.... . .|.. . . . . . .... . ||.... | .||.||.. | VMCTDGVTEARNPQGEFFGEEWLQEILEEHQ----CCCPQEIAQRIMQELMEHMGDHNG---------------------HDDMTVIVVKV |
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| Phosphatase | CG12091.AA | Subfamily.ILKAP.PD | 147-197 | 28 | 4.6e-06 | 15.6 | In-house | 109-158 (298) | Show / Hide |
Range on Protein: 147-197 Range on HMM: 109-158/298 Sequence Identity: 28% (15 aa) EQKKPIL--GSSTACVLILNretSTVHTANIGDSGFVVVREGQVVHKSEEQQH ...||. || ...||... ....||.||| |..| . .|..|... skakPvWkdGstavvvlvvd---nvlyvanlGDskavlaRakeegdkagesti |
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| Phosphatase | CG12091.AA | Subfamily.PPM1E.PD | 224-280 | 24 | 1e-05 | 14.4 | In-house | 197-253 (269) | Show / Hide |
Range on Protein: 224-280 Range on HMM: 197-253/269 Sequence Identity: 24% (14 aa) ADTMSFPVRD-GDVILIATDGVFDNVPEDLMLQVLSEVEGErDPVKLQMTANSLALMA ||...... . |....|.||..| |.|. ......| . . .|.. |..| .| advaeveldgsedylilacDGlwDvvneeevvklveeflad-gaedlsevakllveaa |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| CG12091.AA | Protein | None | 321 | None | Fasta, JSON |
| CG12091.NA | RNA | None | 963 | None | Fasta, JSON |
| CG12091.AA.PD_57-319 | Protein Phosphatase Domain | None | 263 | None | Fasta, JSON |