Gene fig
fig
Species: D.melanogaster
Alias: fig
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of fig.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | fig.AA | PP2Cc | 52-307 | 12 | 3.2e-15 | 57.79 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 52-307
Range on HMM: 1-338/338
Sequence Identity: 12% (49 aa)
RSKKPRFPGERSNQ---------RFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDG---------------------
| . .| |. . .||.... ..||.|| | .. ... . . . . .. |
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP-----FFGVFDG-----HGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHD
---RSPRNMLIAGFQELSHREHPVVGSSTACLATMHRKDCTLYTANLGDSGFLVVRNGR----------VLHRSVEQTH---------------------
... . |. .|... . .||..| .. .. ||.||.||| . ||| .. ......
KWFEDWEDALRKAFLRMDEEI------CTAVVALIRGNK--LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPMHR
-----------DFNTP---YQLTVPPEDR-------------------------KESYYCDKPEMAVSTRHS----LLPGDLVLLATDGLFDNMPESMLL
.| ... |. ||.| |. . .... .|...|..|||.|.|.. .
QWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQEVV
SILNGLKERGEHDLLVG----------------ASRVVEKARELSMNASFQSPFAIKARQHNVSYSGGGKPDDITLILS
.|. .....|. |. .. . | |..| . | |..| |.
DIVRKCLRKWHHK-PVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI---------------------CDNMTVIVV
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| Phosphatase | fig.AA | Family.PPTC7.PD | 61-309 | 52 | 6.2e-118 | 382.7 | In-house | 15-262 (262) | Show / Hide |
Range on Protein: 61-309 Range on HMM: 15-262/262 Sequence Identity: 52% (129 aa) ERSNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDGRSPRNMLIAGFQELSHREHPVVGSSTACLATMHRKDCTL ......||||..||||...|.|.||||||||||..|||...|..|||..|. ... |.|. ..|...| |...||.....|||||||||.....|.|..| skkrskfGeDayFvssnkvadvlgvADgvggwreygvdssafsselmkkcerlvkeskfkplkpkkllkaayaelleekvpvvGsstAcvvvldredkkl YTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRKESYYCDKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLSILNGLKERGEHDLLV ..||||||||||||.|.|.||| ||.|.|||||||..|||.|......|.||.| ||.... ||..||||||.|||..|...|..|.||||.|..| . esanlGDsgflvvRegkvvhrskeqqhyFntPyqLsipPeerdgkvisdspeaAdstsfevkkgDiillatDGvfDnlsedqileelkelkerdeeelql GASRVVEKARELSMNASFQSPFAIKARQHNVSYSgGGKPDDITLILSSV |....|||||||......||||.||.......| ||||||||..|..| lanslaekareLsfdpkyespFaqkakkrglaas-GGKpDDitvvlavv |
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| Phosphatase | fig.AA | Subfamily.PPTC7.PD | 58-309 | 52 | 2.9e-115 | 373.9 | In-house | 7-263 (263) | Show / Hide |
Range on Protein: 58-309 Range on HMM: 7-263/263 Sequence Identity: 52% (135 aa) FPG------ERSNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDGRSPRNMLIAGFQELSHREHPVVGSSTACLA |. ......||||..||||.. |.|.||||||||||..|.|...|.||||..|. ... |.|. |.|...| |..|||.....|||||||||.. fakdllkqkskkrskfGeDayFvssnkvadvlgVADgvggwreygidpsefskelmkkcerivkeskfkerkpkkileaayqelleekvpvvGsstaciv TMHRKDCTLYTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRKESYYCDKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLSILNGLK ...|.|..|..||||||||||||||.|.||| ||.|.|||||||..|||.|......||||.| ||.... |||.||||||.|||..|...|..|. || vldredkklesaNlGDSgflVvRngkvvhrskeqqhyFNtPyqLsipPeerdgkvildkpeaadstsfevkkgDlillatDGvfDNlsedeilevlkelk ERGEHDLLVGASRVVEKARELSMNASFQSPFAIKARQHNVSYSgGGKPDDITLILSSV ||.|..| . |....|||||||......|||| ||.......| ||||||||..|..| erdeeelqllanslaekarelsldpkyespFakkakknglaas-GGKpDDitvvlalv |
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| Phosphatase | fig.AA | Group.PPM.PD | 60-186 | 23 | 7.1e-12 | 34.1 | In-house | 47-190 (459) | Show / Hide |
Range on Protein: 60-186 Range on HMM: 47-190/459 Sequence Identity: 23% (34 aa) GERSNQrfgEDSWFVSSTPLA--EVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQL---------SDFDG--RSPRNMLIAGFQELSHR------EH |.|... ||.... ... ..|| || ||.. . | .. | |.. .. . .. .|.|. ..... | .|.|| .| . gwrkem---EDrhvivenfdnndsffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedlseeanek P---VVGSSTACLATMhRKDcTLYTANLGDSGFLVVRNGRVLHRSVEQT . .||. | . ... .||.||.||| ...|||.. . | . . eepgkdsGtTAvvali-ngk-klyvANaGDSravLcrngkavplskdHk |
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| Phosphatase | fig.AA | Group.PPM.PD | 223-308 | 21 | 5.1e-08 | 21.4 | In-house | 248-320 (459) | Show / Hide |
Range on Protein: 223-308 Range on HMM: 248-320/459 Sequence Identity: 21% (20 aa) PGD-LVLLATDGLFDNMPESMLLSILNGLKER----GEHDLLVGASRVVEKARELSmnasfqspfaikarqhnvSYSGGGKPDDITLILSS . | . ||.|||.| . . ...... | ..|| |.|.|..|.. . | |...|.|| |. . eedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakg------------------stgdgtscDNiTvivvt |
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| Phosphatase | fig.AA | Family.PPM.PD | 142-186 | 32 | 1.7e-07 | 19.6 | In-house | 120-162 (495) | Show / Hide |
Range on Protein: 142-186 Range on HMM: 120-162/495 Sequence Identity: 32% (14 aa) VVGSSTACLATMHRKDctLYTANLGDSGFLVVRNGRVLHRSVEQT . .||. . ...|. ||.||.||| ...|||.. . | . . kdsGtTAvvvlirgkk--lyvAnaGDsravLcrngkavelskdHk |
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| Phosphatase | fig.AA | Subfamily.PPM1E.PD | 224-271 | 34 | 1.1e-06 | 17.5 | In-house | 208-255 (269) | Show / Hide |
Range on Protein: 224-271 Range on HMM: 208-255/269 Sequence Identity: 34% (16 aa) GDLVLLATDGLFDNMPESMLLSILNGLKERGEHDLLVGASRVVEKARE |...||.|||.| ..|. ...... ..|..|| | .||.|.| edylilacDGlwDvvneeevvklveefladgaedlsevakllveaake |
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| Phosphatase | fig.AA | PP2C_SIG | 69-309 | 14 | 4e-06 | 12.61 | SMART | 1-250 (250) | Show / Hide |
Range on Protein: 69-309 Range on HMM: 1-250/250 Sequence Identity: 14% (42 aa) EDSWFVSSTPLAE--------------------VMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDGRSPRNMLIAGFQELSHR-EHPVVGSST .|.|... . .. .. ..|..| | |. |....... . .|.... || .| . . . .. ... .| DDHWDIYQYYEDATQVCGDWYDFWKIPEGQDRYFFVIGDVMG-WA-HGLPAALMMGMARTMM--RTFWHE----SPPQILERCNRWIYQNNHEECGMFTT ACLATM--HRKDCTLYTANLGDSGFLVVRNGRVLHRSVEQTHD-----------------------FNTPYQLTVPPEDRKESYYCDKPEMAVSTRHSLL .|.. . . .. ||. .. |.| ....|. .. ||.||| ..| . | . |. . . .. .. MCCCVYMPDFATHTLWYCHCGHSPPYLYRA--MDGGRVEHTHDHYLVQHYVMRIIDEEDAKHHPWHNWTGPPLGMEPDYM-----------YDVQEFQYE PGDLVLLATDGLFDNMPESM-------LLSILNGLKERGEHDLLVGASRVVEKARELSMNASFQSPFAIKARQHNVSYSGGGKPDDITLILSSV |||.....|||..... . |. || . .... ... | .. . |.. .. .||.|.|. | PGDRFVMCTDGVTEARNPQGEFFGEEWLQEILEEHQ--CCCPQEIAQ-RIMQELMEHMGDHNG--------------------HDDMTVIVVKV |
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