Pp1-Y1
Species: D.melanogaster
Alias: Pp1-Y1
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: PPP
Family: PPP
Subfamily: PPP1C
Protein domain

Protein domains of Pp1-Y1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase Pp1-Y1.AA Subfamily.PPP5C.PD 18-209 37 1.5e-48 155.3 In-house 54-250 (346) Show / Hide
Range on Protein: 18-209
Range on HMM: 54-250/346
Sequence Identity: 37% (74 aa)

DEMIASLLSWKIDRKMmVPESDIIKLLKQARQVLMSEPMLLTVEAP----VNVLGDIHGQYNDLLRYFETSGHPP-KKRYLMLGDYVDRGKYSVETLTLL
|..  ||..  ..|. ...  ..|.|..| ..| ..| |. .. |    . | ||||||. |||  ||  |.|  .. ||. ||.||||.|||.. .||.
kefvkellelfkkqkk-lhkkyalkilleakellkklpslveitipetkkitvCgdihgqfyDllnifelnGlpseenpylfngDfvdrGsfsveviltl

LAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSP-SLHNLNDIQHLQRPAEVDRNGLLCDL
.|. || ...| ||||||  .|. ||| .|.| ..| ..  .| . .. ||.| .||.|.. .||||       |.|.....| |.  ..|||..|  
lgfkllypnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeeglllel

Phosphatase Pp1-Y1.AA Subfamily.PPP1C.PD 36-209 61 2.2e-94 305.9 In-house 2-175 (271) Show / Hide
Range on Protein: 36-209
Range on HMM: 2-175/271
Sequence Identity: 61% (107 aa)

PESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAI
|..| ||...||....|.|.||..|||....|||||||.||||.||..|.||...||.||||||||| |.||..||||||..||....|||||||.|.||
keaeirklclkareiflsqpilleleaplkivGdihGqyadllrlfekggfppesnylflGdyvdrGkqsletivlllaykikypenffllrGnhecasi

NRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|.||||||||||..|.||..||||..|||||||...|||..||||||.|..|..|....||..|. .|||||| 
nriygfydeckrryniklwktfvdcfnclpvaaivdekifcvhGGlspdlksleqirriarptdvpdkGllcdl

Phosphatase Pp1-Y1.AA Family.PPP.PD 21-209 46 3.1e-79 256.6 In-house 55-245 (349) Show / Hide
Range on Protein: 21-209
Range on HMM: 55-245/349
Sequence Identity: 46% (90 aa)

IASLLSWkIDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKK-RYLMLGDYVDRGKYSVETLTLLLAYKVRY
. .|. . . .|  ........||..|...|..||.|| ||||..| ||||||..|||| |...| ||.. .||.|||||||||.|||...||.|.|..|
vkelvea-fkekkqleakevlelleeakellkkepnlleveapitvcGDihGqfdDLlrlfdinglppaenkylFlGDyVDRGkfsvEvilllfalklly

PTSIHLLRGNHESAAINRYYGFYDECKRRF--TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|. ..||||||||. .|..||||.|.|...  . .....| .....||.||.|..||. .||||||.|..|..|....|| |. ..||||||
psrffllRGnhEsrsvnkvygfyeevkskykkgeeiyelfqevFnwLPlaalidekilcvhGGlspeltsldqirkierpleppkegllcdl

Phosphatase Pp1-Y1.AA Group.PPP.PD 21-209 46 3.1e-79 256.6 In-house 55-245 (349) Show / Hide
Range on Protein: 21-209
Range on HMM: 55-245/349
Sequence Identity: 46% (90 aa)

IASLLSWkIDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKK-RYLMLGDYVDRGKYSVETLTLLLAYKVRY
. .|. . . .|  ........||..|...|..||.|| ||||..| ||||||..|||| |...| ||.. .||.|||||||||.|||...||.|.|..|
vkelvea-fkekkqleakevlelleeakellkkepnlleveapitvcGDihGqfdDLlrlfdinglppaenkylFlGDyVDRGkfsvEvilllfalklly

PTSIHLLRGNHESAAINRYYGFYDECKRRF--TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|. ..||||||||. .|..||||.|.|...  . .....| .....||.||.|..||. .||||||.|..|..|....|| |. ..||||||
psrffllRGnhEsrsvnkvygfyeevkskykkgeeiyelfqevFnwLPlaalidekilcvhGGlspeltsldqirkierpleppkegllcdl

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_6.PD 37-209 49 6.4e-68 218.7 In-house 3-176 (272) Show / Hide
Range on Protein: 37-209
Range on HMM: 3-176/272
Sequence Identity: 49% (86 aa)

ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAIN
|....|||..|..|......|. ||||..| |||||||.|||| |. .|.||.. ||.||||||||..|.|...|||||||..|. . ||||||| .|||
eeellkllelakkvfkkqkslveveapikvcGdihGqysdllrlfdkggfppdanylflGdyvdrGrqslevillllaykvkfpnnffllrGnheceain

RYYGFYDECKRRFT-IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
| ||||||..||..  ||. .| .... ||..|.. ..|.  |||||..|..|.....|.|| .. . |  || 
rvyGfydevqrrykstrlyaafqevfnalpltalvsgrilcmhGGlskklksldqlrelkrpldskeeslaidl

Phosphatase Pp1-Y1.AA Subfamily.PPP4C.PD 36-209 51 2.2e-65 210.5 In-house 2-176 (271) Show / Hide
Range on Protein: 36-209
Range on HMM: 2-176/271
Sequence Identity: 51% (90 aa)

PESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAI
|... .| ..||..|. |  . .|..|| | ||||||..|||. |. .|. |...||.|||.||||.|||||. ||||.|||||  |.|.||||||  | 
keeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqi

NRYYGFYDECKRRF-TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
. ||||||| |.. ....||. .. .| |..||||. |||  |||||||...|..|. ..|  || ..| |||| 
tqvygfydeclrkygsaevwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdl

Phosphatase Pp1-Y1.AA Subfamily.PPP3C.PD 37-209 44 5.3e-63 202.8 In-house 3-175 (292) Show / Hide
Range on Protein: 37-209
Range on HMM: 3-175/292
Sequence Identity: 44% (77 aa)

ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAIN
|....|....| ..| .|. ||.||||. |.||||||. |||. || .|.| ...||.|||||||| .|.|..  |.| |. ||....|||||||.  . 
eesalkiieeaakllkkeetlleveapitviGdihGqfydllklfevgGkpastkylflGdyvdrGyfsiecvlylyalkiaypsrlfllrGnhecrhlt

RYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
 |. | .|.| ... ... ......|.||.||..| | . .|||||| ...|.||..|.|  |.. .| ||||
eyftfkeevkikyseevyealmesfdslplaallnqkflcvhGGlspeikslddikkldrfkeppasGplcdl

Phosphatase Pp1-Y1.AA Subfamily.PPP2C.PD 37-209 49 1.5e-61 198.0 In-house 3-176 (271) Show / Hide
Range on Protein: 37-209
Range on HMM: 3-176/271
Sequence Identity: 49% (86 aa)

ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAIN
|... || ..|...|  |  .  |..|| | ||.|||. |||  |   |. |.  ||..||||||| |||||.|||.| ||||.  | .|||||||  | 
eeevkklcekakeilskesnvkevkcpvtvcgdvhgqfhdllelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqit

RYYGFYDECKRRFT-IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
. ||||||| |...   .|..| | .|.||..|.....||  |||||||.. |..|..|.|  ||  .| .|||
qvygfydeclrkygnanvwkyftdlfdylpltalvdnqifclhgglspsidtldkiraldrlqevphegpmcdl

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_5.PD 37-208 44 1.2e-60 194.7 In-house 3-176 (274) Show / Hide
Range on Protein: 37-208
Range on HMM: 3-176/274
Sequence Identity: 44% (75 aa)

ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAIN
..||...|......|   . || ||||....||||||..||||.|.  |..|| .||.||||||||  |.|   ||...|..|| ..||||||||  .||
dkdilevlekikstlkplaalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrgnhevkkin

RYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDR--NGLLCD
. |||..| |...  .|...| | .  ||. |... .|.  |||.|| |. |.... |..|.||  |       
klygfkeelkkkrqeslykkfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvd

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_4.PD 38-209 44 2.9e-59 190.5 In-house 4-175 (271) Show / Hide
Range on Protein: 38-209
Range on HMM: 4-175/271
Sequence Identity: 44% (74 aa)

SDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINR
.||.....|......|  |  .|||. |.||.|.|..|| | |.  | .|......||||||||. ..|.| ||...|.||.  | ||||||| | .|. 
eeiisvireaeaifsdekalveieapikvvgdlhaqfqdlirlfdllgrvpeeklvflgdyvdrgpqgievlillfclkiryrdrivllrgnheiasvnk

YYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
||||.||. .. . ||  |  |.. ||..|.|  |..  ||||||.| .|....   .| |||| ||     
kygfyeecvtkygeelwadfqrcfnrlpisaliakkvlcmhgglspelisldelrnipkpienldrgllidl

Phosphatase Pp1-Y1.AA Subfamily.PPP6C.PD 36-209 44 4.2e-58 186.6 In-house 2-176 (271) Show / Hide
Range on Protein: 36-209
Range on HMM: 2-176/271
Sequence Identity: 44% (78 aa)

PESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAI
||... || ..  ..|. |  . .|..|| | ||||||. ||.  | |.|. |...|..|||.|||| ||.||.|.||. |..||  | ||||||||  |
penelkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqi

NRYYGFYDECKRRFT-IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
 . |||||||....     |. ... .| |..||||. ...  |||||| .. |..|. ..|  |. ..| .|||
tqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhgglspdvktldqirvieraqeiphkgafcdl

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_2.PD 43-209 45 5.2e-57 182.8 In-house 9-181 (281) Show / Hide
Range on Protein: 43-209
Range on HMM: 9-181/281
Sequence Identity: 45% (77 aa)

LLKQARQVLMSEPMLLTVEA---PVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYY
. . |.. ... . || |.    ||.|..|.|||. |||| | . . |....||.||||||||. |||.. |||||| .||. |||||||       |||
isnyakkaflefsallrvdeeclpvtvvadlhgqsidllriflineapgiskylflgdyvdrgrqsvevvllllaykhlypdhlfllrgnhedvnttlty

GFYDECKRRFT---IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
.|||. ...    . |.|..|....||.||.|  |..  |||.|| |..|.||....||  ||| |||     
gffdeclekyndkgekvwlmiidafnhlplaalildkvlcahggisphlekledidkierplvvpsyglacdl

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_3.PD 89-209 46 9.7e-46 146.2 In-house 92-212 (308) Show / Hide
Range on Protein: 89-209
Range on HMM: 92-212/308
Sequence Identity: 46% (56 aa)

KKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNL
.|.||.|||||||| .|.| ..||.|.|..||  ..|||||||| ..|. |||| |.|.|.  .|. .|   . .||..|..|.||.  |||.| .| .|
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

NDIQHLQRPAEVDRNGLLCDL
. ...|.|| ..   |.|.||
kqldklkrpldipdvGvladl

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_7.PD 37-202 35 2e-44 141.7 In-house 3-183 (296) Show / Hide
Range on Protein: 37-202
Range on HMM: 3-183/296
Sequence Identity: 35% (64 aa)

ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYF----------ETSGHP-PKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHL
......|.... ... .| .|... .|| ..|||||||.|| |            . |. .  .|... ||||||||..|.|..|..|.|. ||| . ||
knellslidavkelfkkektlaeispPvtivGdihGqyeDLvriLnarvskeeakqksalsfvrkkfvfLGdYvdrGsksieCisLvfalkilyptkyil

LRGNHESAAINRYYGFYDECKRRFTIR----LWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDR
|||||. |||  |.|  | . |.       ..  | ...  .|.||.. .||.  |||.|| |. |.||....||   .  
lrGnhetkainfayefreelenrlskidgkeiyekfnevfsfmplaalvgekilcvhggispklesledinsierPlaevt

Phosphatase Pp1-Y1.AA PP2Ac 35-209 27 6.8e-39 136.46 SMART 1-296 (321) Show / Hide
Range on Protein: 35-209
Range on HMM: 1-296/321
Sequence Identity: 27% (81 aa)

VPESDIIKLLKQARQVLMSEPMLLTVE----APVNVLGDIHGQYNDLLRYF---ETSG-HPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLL
.....| .|. ... ....||... ||    .|| | ||||||..|||| |   .  |  || ..|..||||||||..|.|...||..||..||  ..||
MHKHEIYQLCHEVKEIFRQEPNMVEVEETPTPPVTVCGDIHGQFDDLLRLFKKEDKNGKPPPYTNYVFLGDYVDRGPWSIECICLLFCYKICYPNNFFLL

RGNHESAAIN---RYYGFYDECKRRF-TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSP------SLHNLNDIQHLQR--------------------
|||||.  .|   .||||||||||.    |.| .| .|....|..|.||.||.  ||||||      ..|.|.||  . |                    
RGNHECRHMNMWVQYYGFYDECKRKYYHKRIWKIFQECFSWMPLCALINNKILCMHGGLSPRECQTDHIHTLDDIRNIDRPQHPPQEPPDWGLMCDLLWS

-P----------------AEV-------------------------DRNGLLCD-----------------------------------------L
 |                .                            |.  ...                                         .
DPVDFQWFHDDQWVPGWQPNCMRGMSYYFGPDVVDEFCKKNNLDLIIRAHQCVQYQMMDGYEFWHDRDTRVHKLITIFSAPNYCDQCDNHAAVMKV

Phosphatase Pp1-Y1.AA Subfamily.PPP7C.PD 31-196 33 4.6e-37 117.4 In-house 33-205 (338) Show / Hide
Range on Protein: 31-196
Range on HMM: 33-205/338
Sequence Identity: 33% (58 aa)

RKMMVPESDIIKLLKQARQVLMSEPMLLTVEA----PVNVLGDIHGQYNDLLRYFETSGHPPK-KRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHL
| ..    ....|.....|| . |.. .|..     |.| ||.||. .|||  .   | | . . |.. ||.||||| ||| | .|.|.. ||....| |
lkkllhakyvllilretkkvlkqlpnisrvstaiskevtvcgdlhgklddlllilyknGlpsaenpyvfnGdfvdrGkesveillilfalllvypkevyl

LRGNHESAAINRYYGFYDECKRRF---TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSlHNLNDIQHLQR
||||   .|  |||  | . ..   . .. |.. | .  ||.|..|..||. .|||.| .  .|. .....|  
nrGnhedyilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk-tdlelldkier

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_1.PD 45-195 30 5.3e-30 94.5 In-house 10-166 (273) Show / Hide
Range on Protein: 45-195
Range on HMM: 10-166/273
Sequence Identity: 30% (48 aa)

KQARQVLMSEPMLLT-VEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYD
..    .. |. ||  .||.|.|.||| ..| |||......| |.....|.||. .| ||.|.|.| .||  |. ||  . .|||..|   .     .. 
ledalkiaeetslleyieadvtviGdirsryadlldilkltGwPfeqkilflGnlldsGkssleellillcskkcyPknvvilrGeyetelvksdrrlig

ECKRRFT-IRLWRMFVDCY----DCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQ
| . ||     ||    .       |||||..| |..  ..|.|. ... .... ..
elrvrfpdsnkwralnaiikrllkrlPvaavlnkkllavysgvssnikekknvvavk

Phosphatase Pp1-Y1.AA Metallophos 62-201 33 8e-29 106.88 Pfam 1-114 (124) Show / Hide
Range on Protein: 62-201
Range on HMM: 1-114/124
Sequence Identity: 33% (47 aa)

APVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCY
... ..|||||||.||.| ||   . .   .. .|||||||..| |.. ||..||..||  ....||||... .|..|||| |       ..| |. ...
MRILHCGDIHGQYDDLNRLFEII-E-KPDFVIFTGDYVDRGPWSDECIWLLFCYKMNYPGPVYWVRGNHDYMHGNDFYGFY-E-------NDW-MWWWWF

DCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVD
 ..| | ... ||. .||..            ...  .||
-WMPLA-LDDWKILCMHGPP------------FCK-NGVD

Phosphatase Pp1-Y1.AA Subfamily.PPP_Nematode_3.PD 37-87 45 7.1e-15 44.9 In-house 3-53 (308) Show / Hide
Range on Protein: 37-87
Range on HMM: 3-53/308
Sequence Identity: 45% (23 aa)

ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHP
|...|.|  .||... .||. | .|||| ..||||||..|||  ..  |.|
ekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp

Sequence
Name Sequence Type Origin Length Description Download
Pp1-Y1.AA Protein None 209 None Fasta, JSON
Pp1-Y1.NA RNA None 627 None Fasta, JSON
Pp1-Y1.AA.PD_35-209 Protein Phosphatase Domain None 175 None Fasta, JSON