• Phosphatome.Net

Gene Notch_PTP

Notch_PTP
Species: M.brevicollis
Alias: XP_001750093.1, Notch_PTP
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Classic_PTP
Subfamily: R_Choan_EGF
Protein domain

Protein domains of Notch_PTP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF Notch_PTP.AA EGF 8-43 33 1.5e-08 35.67 SMART 1-32 (32) Show / Hide 
Range on Protein: 8-43
Range on HMM: 1-32/32
Sequence Identity: 33% (14 aa)

PCDRLGQPCQNG-----ATCNDQTDGYSCSCA-FGYTGANCT
.|.    ||..|     .||     .|.| |.  |||| .| 
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF 9-41 38 2.5e-07 27.53 Pfam 1-36 (36) Show / Hide 
Range on Protein: 9-41
Range on HMM: 1-36/36
Sequence Identity: 38% (14 aa)

CDRLGQPCQNGATCNDQTDGYSCSCAFG---YTGAN
|.  . ||....||.|  .||.| |. |   ||| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF_CA 46-82 45 8.9e-07 29.37 SMART 2-34 (34) Show / Hide 
Range on Protein: 46-82
Range on HMM: 2-34/34
Sequence Identity: 45% (18 aa)

VDLCASNPCVNGG---TCSQSAAGSYECSCSTGWTGDDCE
.| |   || |||   ||     |||.| |  |.|   ||
IDEC---PCQNGGPTGTCIN--PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF_CA 84-121 43 3.2e-12 47.86 SMART 1-34 (34) Show / Hide 
Range on Protein: 84-121
Range on HMM: 1-34/34
Sequence Identity: 43% (18 aa)

DIDECASAPCKNGG---SCSQPVVGAFACACTAGYSGPTCE
|||||   || |||    |    .| . | | .||. ..||
DIDEC---PCQNGGPTGTCIN--PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 49-80 37 2e-09 34.56 Pfam 1-36 (36) Show / Hide 
Range on Protein: 49-80
Range on HMM: 1-36/36
Sequence Identity: 37% (14 aa)

CASN--PCVNGGTCSQSAAGSYECSCSTG---WTGDD
|..|  || ..||| ..  |.|.| |  |   .||..
CNPNNNPCHHHGTCVDTP-GGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF 48-82 41 7.7e-09 36.61 SMART 1-32 (32) Show / Hide 
Range on Protein: 48-82
Range on HMM: 1-32/32
Sequence Identity: 41% (17 aa)

LCASNPCVNG-----GTCSQSAAGSYECSCS-TGWTGDDCE
 ||  || .|     |||      ||.| |   |.||  ||
ECA--PCHHGGCEQHGTCI-----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF_2 49-81 37 7e-06 21.98 Pfam 1-29 (29) Show / Hide 
Range on Protein: 49-81
Range on HMM: 1-29/29
Sequence Identity: 37% (13 aa)

CASNPCVN-GGTCSQSAAGSYECSCSTG-WTGDDC
|    | . .|||  .  |   |.|. | |.||.|
C----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF Notch_PTP.AA EGF 88-119 29 3.4e-09 33.78 Pfam 1-36 (36) Show / Hide 
Range on Protein: 88-119
Range on HMM: 1-36/36
Sequence Identity: 29% (11 aa)

CASA--PCKNGGSCSQPVVGAFACACTAG---YSGPT
|..   ||...| | ..  | . | |. |   |.|..
CNPNNNPCHHHGTCVDTP-GGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF 87-121 36 5.3e-08 33.82 SMART 1-32 (32) Show / Hide 
Range on Protein: 87-121
Range on HMM: 1-32/32
Sequence Identity: 36% (15 aa)

ECASAPCKNG-----GSCSQPVVGAFACACT-AGYSGPTCE
|||  || .|     | |       . | |  .||.| .||
ECA--PCHHGGCEQHGTCI-----SYTC-CPGPGYTG-RCE
Furin Notch_PTP.AA FU 117-161 38 9.4e-08 33.01 SMART 1-48 (48) Show / Hide 
Range on Protein: 117-161
Range on HMM: 1-48/48
Sequence Identity: 38% (19 aa)

GPTCESECPDNCYE-CTL--DDVCTSCNDYYYLYE-GTCVASCPVGIPD
. .|  .| ..| . |.   .| ||||  .||| . ||||..|| |   
DGVC-KPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
EGF Notch_PTP.AA EGF 1115-1148 37 8.1e-07 29.89 SMART 1-32 (32) Show / Hide 
Range on Protein: 1115-1148
Range on HMM: 1-32/32
Sequence Identity: 37% (15 aa)

TCLDCPCEQG-----APCTQSGNGYQCECP-AGYTGVNCE
 |.  ||..|     . |.    .|.| || .|||| .||
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF_CA 1150-1186 40 2.3e-12 48.33 SMART 1-34 (34) Show / Hide 
Range on Protein: 1150-1186
Range on HMM: 1-34/34
Sequence Identity: 40% (16 aa)

DINECADVPCSFGS---TCVNLVANYSCVCWAGLSGPDCE
||.||   ||. |.   ||.| .  |.| | .| . . ||
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 1190-1233 30 5e-06 27.32 SMART 1-32 (32) Show / Hide 
Range on Protein: 1190-1233
Range on HMM: 1-32/32
Sequence Identity: 30% (15 aa)

DCNAYRYDIFVSTGLRIDPCMNG-----GSCQPSGSCSCA-MGYTGSACE
.|                || .|     | |. | .| |.  ||||  ||
ECA---------------PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF_CA 1235-1271 47 1.8e-15 58.66 SMART 1-34 (34) Show / Hide 
Range on Protein: 1235-1271
Range on HMM: 1-34/34
Sequence Identity: 47% (19 aa)

DIDECADEPCLNGG---QCEDGIGSYSCTCAEGFEGDDCE
|||||   || |||   .|.. .|||.| | .|..   ||
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 1239-1269 33 6.9e-11 39.43 Pfam 1-36 (36) Show / Hide 
Range on Protein: 1239-1269
Range on HMM: 1-36/36
Sequence Identity: 33% (12 aa)

CADE--PCLNGGQCEDGIGSYSCTCAEG---FEGDD
|...  ||...|.| |. |.|.| |..|   . |..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF_CA 1273-1309 40 7.7e-11 43.26 SMART 1-34 (34) Show / Hide 
Range on Protein: 1273-1309
Range on HMM: 1-34/34
Sequence Identity: 40% (16 aa)

NIDDCENNNCAMGS---TCVDGINSYTCACVPGYTGIFCD
.||.|   .|  |.   ||.. ..||.| | ||||   |.
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 1238-1271 40 2e-10 41.85 SMART 1-32 (32) Show / Hide 
Range on Protein: 1238-1271
Range on HMM: 1-32/32
Sequence Identity: 40% (16 aa)

ECADEPCLNG-----GQCEDGIGSYSCTCA-EGFEGDDCE
|||  || .|     |.|     ||.| |. .|..|  ||
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF_CA 1235-1270 32 6.7e-07 24.26 Pfam 1-53 (53) Show / Hide 
Range on Protein: 1235-1270
Range on HMM: 1-53/53
Sequence Identity: 32% (17 aa)

DIDECADEP---C---LNGGQCEDGIGSYSCT---CAEGFE--------GDDC
|.||||| .   |    ... |.  |||..|.   | .|.|        |. |
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC
EGF Notch_PTP.AA EGF_CA 1311-1347 37 2.6e-11 44.83 SMART 1-34 (34) Show / Hide 
Range on Protein: 1311-1347
Range on HMM: 1-34/34
Sequence Identity: 37% (15 aa)

DIDECEPVPCHNGA---TCTEGINTFTCTCASGFGGSLCD
|||||   ||.||.   ||.  .. ..| |  |.    |.
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 1277-1307 44 6e-09 32.97 Pfam 1-36 (36) Show / Hide 
Range on Protein: 1277-1307
Range on HMM: 1-36/36
Sequence Identity: 44% (16 aa)

CENN--NCAMGSTCVDGINSYTCACVPG---YTGIF
|  |  .|  . ||||. ..||| | ||   |||..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF 1276-1309 40 1.4e-07 32.42 SMART 1-32 (32) Show / Hide 
Range on Protein: 1276-1309
Range on HMM: 1-32/32
Sequence Identity: 40% (16 aa)

DCENNNCAMGS-----TCVDGINSYTCACV-PGYTGIFCD
.|.   |  |      ||.    |||| |  |||||  | 
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF 1315-1345 33 2.6e-09 34.15 Pfam 1-36 (36) Show / Hide 
Range on Protein: 1315-1345
Range on HMM: 1-36/36
Sequence Identity: 33% (12 aa)

CEPV--PCHNGATCTEGINTFTCTCASG---FGGSL
| |   |||...||... ...|| |. |   . |  
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF 1314-1347 35 8.1e-09 36.54 SMART 1-32 (32) Show / Hide 
Range on Protein: 1314-1347
Range on HMM: 1-32/32
Sequence Identity: 35% (14 aa)

ECEPVPCHNG-----ATCTEGINTFTCTCA-SGFGGSLCD
||.  |||.|     .||.    ..|| |.  |. |  | 
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF_2 1705-1747 26 1.6e-07 26.99 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1705-1747
Range on HMM: 1-29/29
Sequence Identity: 26% (12 aa)

CAAAMFDAFQRSGARISPCQN-GGTCLTS-SGLCQCTDS-YTGSAC
|                 |.. .||| ..  | |||.|. ..|  |
C-----------------CNGHHGTCNNQGCGKCQCDDGWWQGDHC
EGF Notch_PTP.AA EGF 3697-3730 42 2.8e-08 34.74 SMART 1-32 (32) Show / Hide 
Range on Protein: 3697-3730
Range on HMM: 1-32/32
Sequence Identity: 42% (17 aa)

YCALDPCLSG-----GSCIKEFFDYRCVCA-PGYLGANCE
 ||  ||  |     | ||     |.| |. ||| | .||
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF_CA 3732-3768 35 4.2e-09 37.49 SMART 1-34 (34) Show / Hide 
Range on Protein: 3732-3768
Range on HMM: 1-34/34
Sequence Identity: 35% (14 aa)

NADDCGGHDCQNGA---TCVDGVDGYYCACAPGFDGETCA
. |.|    ||||.   ||.. . .|.| | ||.   .| 
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 3698-3728 33 1.8e-07 27.99 Pfam 1-36 (36) Show / Hide 
Range on Protein: 3698-3728
Range on HMM: 1-36/36
Sequence Identity: 33% (12 aa)

CALD--PCLSGGSCIKEFFDYRCVCAPG---YLGAN
|. .  ||. .| |..   .|.| |.||   | | .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF_CA 3770-3806 37 4.9e-11 43.91 SMART 1-34 (34) Show / Hide 
Range on Protein: 3770-3806
Range on HMM: 1-34/34
Sequence Identity: 37% (15 aa)

NIDDCTESACAHGG---TCVDEVHGYSCECPTGYRGDFCQ
.||.|    | .||   ||.. . .|.| || ||.   |.
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 3736-3766 36 2e-09 34.57 Pfam 1-36 (36) Show / Hide 
Range on Protein: 3736-3766
Range on HMM: 1-36/36
Sequence Identity: 36% (13 aa)

CGGH--DCQNGATCVDGVDGYYCACAPG---FDGET
|  .   |....||||. .||.| |.||   ..|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF 3735-3768 30 2.1e-08 35.15 SMART 1-32 (32) Show / Hide 
Range on Protein: 3735-3768
Range on HMM: 1-32/32
Sequence Identity: 30% (12 aa)

DCGGHDCQNG-----ATCVDGVDGYYCACA-PGFDGETCA
.|   .|..|     .||.    .|.| |. ||. | .| 
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF Notch_PTP.AA EGF_CA 3891-3927 37 2.4e-11 44.91 SMART 1-34 (34) Show / Hide 
Range on Protein: 3891-3927
Range on HMM: 1-34/34
Sequence Identity: 37% (15 aa)

ELDECITTPCLHGG---TCLDKVNGFACTCPTTYFGDLCE
  |||   || .||   || . .... | ||  |    ||
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF Notch_PTP.AA EGF 3774-3804 44 3.4e-08 30.43 Pfam 1-36 (36) Show / Hide 
Range on Protein: 3774-3804
Range on HMM: 1-36/36
Sequence Identity: 44% (16 aa)

CTES--ACAHGGTCVDEVHGYSCECPTG---YRGDF
|..    | |.|||||  .||.|.|| |   | |..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF 3773-3806 37 3.7e-08 34.33 SMART 1-32 (32) Show / Hide 
Range on Protein: 3773-3806
Range on HMM: 1-32/32
Sequence Identity: 37% (15 aa)

DCTESACAHG-----GTCVDEVHGYSCECP-TGYRGDFCQ
.|    | ||     |||.    .|.| ||  ||.|  |.
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
Phosphatase Notch_PTP.AA PTPc 4031-4301 31 7.9e-88 299.01 SMART 1-308 (308) Show / Hide 
Range on Protein: 4031-4301
Range on HMM: 1-308/308
Sequence Identity: 31% (99 aa)

GIDESDERRPKGETLQ---------RISLNMEPEIM--EMAEVP-NPEYANDDTLVHLQD--------EQNSYINANHVTFAEEGRTLWYIAAQGPLPGT
|. |  || .. .. .         ...    || .  ..   . .   ..|.| |.|..        | . |||||.. .   .|.  ||..|||||.|
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDI-PCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY--WRPKRYICTQGPLPHT

VGDFWRMVWEQGSQIVVMVTGEVEG--------GKVKCERYWPTETGEYDALVFGDLKISLVKSVSSG-NYTIRGLRVRNMSE--------DLMRTVWHL
. |||||||.|...|.|| . ..|.        |..||..||| |      ...|.... ... ..   .||.| ..|.|  .        .  |||.|.
IEDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE-----PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHY

QYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMG-----------VAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQRAKV
.||.||||.||..|.|.|||| ..|. . ....           .. . |  |.|||||||.||||.. ...  . ..|.   ... |.. ..|.||.. 
HYTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGM

VQTEEQYEFCLRTLLEVAR
||||||| || | .||...
VQTEEQYIFCYRCILEYIK
EGF Notch_PTP.AA EGF 3895-3925 38 2.6e-08 30.84 Pfam 1-36 (36) Show / Hide 
Range on Protein: 3895-3925
Range on HMM: 1-36/36
Sequence Identity: 38% (14 aa)

CITT--PCLHGGTCLDKVNGFACTCPTT---YFGDL
|  .  ||.|.|||.|. .|. | ||     | |. 
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Notch_PTP.AA EGF 3894-3927 40 2.9e-07 31.37 SMART 1-32 (32) Show / Hide 
Range on Protein: 3894-3927
Range on HMM: 1-32/32
Sequence Identity: 40% (16 aa)

ECITTPCLHG-----GTCLDKVNGFACTCP-TTYFGDLCE
||   || ||     |||.    .. | ||   | |  ||
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
Phosphatase Notch_PTP.AA Y_phosphatase 4068-4298 37 1.4e-88 305.4 Pfam 12-243 (243) Show / Hide 
Range on Protein: 4068-4298
Range on HMM: 12-243/243
Sequence Identity: 37% (92 aa)

ANDDTLVHLQ----DEQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGK-VK-CERYWPTETGEYDALVFGDLKI
..|.| |.||    ||.  |||||....   ..   ||..|||.| |..|||||||.|.....||.. ..|.|. .| |..|||. . | . ...||...
CYDHTRVKLQPIPGDEDSDYINANYIDG-PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPD-NKEGQPMTYGDFQV

SLVKSVSSGNYTIRGLRVRNMSE--DLMRTVWHLQYTAWPDHSVPKT-PSSLLDFIDEIREIRVRLMGVAVNNPPW------PTVVHCSAGVGRTGVLML
 .|.  .  .||.| ..|.|  .  .  |||.|..||.||||.||.. | |.||||...|. .            .      |.|||||||.||||....
TCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP-----------NPDHGCPPIVVHCSAGCGRTGTFCA

VESELIRLEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
..  . ..|..  ..  |.. ..|.||.  |||||||.|| ...||
IDIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE
Phosphatase Notch_PTP.AA Subfamily.N3.PD 4069-4299 40 1.1e-69 225.5 In-house 38-259 (261) Show / Hide 
Range on Protein: 4069-4299
Range on HMM: 38-259/261
Sequence Identity: 40% (93 aa)

NDDTLVHLQDEQNSYINANHVTFAEEGRTLW--YIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgEYDALVFGDLKISLVKS
|.| |.|..... |||||.| .  .. .|   |||.||||. |. |||.||||| |...||.|  || |.||| .|||.   . | | ||.... . |. 
ydatrvklkesetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlttlverGrvkChqyWPe---tedelefgefsvrceke

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
.. .| .| | ... ...  |.. .|||.|||||.||. ....|.|....|..|        .    |.|||||||.||||||.|.|  |  .|.    .
detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr--------sgkeePvvvhCsaGigrtGvlilletalalieaaepv

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
| . . ..|.||| .|||..||.|   ..|.. 
ypldivrtmrdqramlvqtvsqykfvCeailka
Phosphatase Notch_PTP.AA Subfamily.N13.PD 4070-4299 40 6.7e-66 213.4 In-house 39-257 (259) Show / Hide 
Range on Protein: 4070-4299
Range on HMM: 39-257/259
Sequence Identity: 40% (93 aa)

DDTLVHLQDEQNsYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDALVFGDLKISLVKSVSS
|.| |.|.|| . ||||...    .  .  |||.||||| || |||.||||| .....||| |.|.|||||.|||| ....    | . |...|.| .  
detrvklgdegg-yinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPerknk-klkvsnrlevellkvqkl

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMgvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
 ....| | |...     | | ||....||||.||... .|. |. |.|...             | |||||||.||.|||...  |  .|.    . ..
dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrllqtdag---------PivvhcsaGiGrsGvlitidvvlglierdkefdvk

QTLVELREQRAKVVQTEEQYEFCLRTLLEV
.. .|||||  ||||..|| |. ...||| 
eivrklreqrqgvvqtkdqyifvykailev
Phosphatase Notch_PTP.AA Subfamily.N14.PD 4073-4298 40 2.1e-65 211.7 In-house 45-272 (275) Show / Hide 
Range on Protein: 4073-4298
Range on HMM: 45-272/275
Sequence Identity: 40% (91 aa)

LVHLQDEQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNY
|.  ..... |||| ..  .  |... ||.|||||. || |||.|||||| |..||.| | |.|| |. .|.| .. . . . ||  |..| .|. .. .
lsptkenstgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmlteeeedgkeksfkylPkleskkktvefgkfkvttkfsedsdsv

TIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVA--VNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQ
||... .     ||||||||| |||| ||. ....|.|..|.. .| .       |..   | .|||||||||||||.|..  .  ||.. . . ...| 
ittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnsevesvkeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikk

TLVELREQRAKVVQTEEQYEFCLRTLLE
 ||.||  .|||  ||.|  ..|..   
vlarLrkqrmllvqtlaqykfvykvlik
Phosphatase Notch_PTP.AA Subfamily.RB.PD 4076-4300 40 2e-62 201.9 In-house 45-260 (261) Show / Hide 
Range on Protein: 4076-4300
Range on HMM: 45-260/261
Sequence Identity: 40% (92 aa)

L----QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGDLKISLVKSVSSGN
|    ..... |||||..   .  |   |||.|||||.|| ||||||||. |.|.||.|  ||.||.|||.|||..   ... ..||.|..|... .  .
Laalkdesdtdyinanyipgynspre--yiatqGPlpetvddfWrmvwekkssiivmltqlvEkgkekceeYWPad---eepvlyGdikvtllaekelde

YTIRGLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvAVNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
..|| ..... .|  .|.| ....|.||||.||.....||||. ..||   .    |...   |.||||||||||||. . ..| ..|.    .   ...
wvirefkiekgke--krkvrqyhftsWpdhgvPektktlldfvrtvreaiekk---askk---PivvHCsaGvGRtGtfialdrllqaieendyvdvfgv

LVELREQRAKVVQTEEQYEFCLRTLLEVA
||||.|...||||.|| |  ..||...  
vaelReeRnllvqtekqyifiheclldll
Phosphatase Notch_PTP.AA Subfamily.R_Anemone_2.PD 4075-4299 41 4.6e-62 200.9 In-house 45-260 (262) Show / Hide 
Range on Protein: 4075-4299
Range on HMM: 45-260/262
Sequence Identity: 41% (93 aa)

HLQ----DEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeyDALVFGDLKISLVKSVSSG
.||    .|.  |||||..   .. ..  |||.|.||| |. |||||||||.|...||.| |.| ||.|..|||| .    ...|.|.. | ..|....|
klqmlegeegsdyinanyidGyrrkka--yiatqaPlpetiedfWrmvWeqnsavivmltqeeergkakvhryWPsk----gsrsygklvvelkeevels

NYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQ
..| ..|... |.  |.|   .||.|||..||. ..||||.. .....  .       .   |.||||||||||||| . |.. | |...    .  ||.
dyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqe-------sgagpivvhcsaGvGrtGvfiavdillerikaealvdvfq

TLVELREQRAKVVQTEEQYEFCLRTLLEV
 .|||||  .|||..||||.  .|||   
tvkqlreqrnlmvqtkdqyefiydvllea
Phosphatase Notch_PTP.AA Subfamily.N9.PD 4077-4300 42 1.1e-61 199.7 In-house 50-274 (275) Show / Hide 
Range on Protein: 4077-4300
Range on HMM: 50-274/275
Sequence Identity: 42% (97 aa)

QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSSGNYTIRG
.||.  |||||.|   .. ..  .||.||||. || |||||||||   ..||.|  || |..|| .|||.|...  .  ||||..| |. ... .|..| 
edeasdyinanfvdGykqkka--fiatqGplkktvsdfwrmvweqevlvivmttrvvergrlkcgqywpleees--saefgdlsvsnveveveedykvrv

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIR---VRLMGVAVNNPP--WPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
| ..|. .. .|.| | |...|||. ||.. .||||.....|| .   |. .|   . ..   | |||||||.|||| .. ..| |||.    . ..|. 
leiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdeskghlsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvet

LVELREQRAKVVQTEEQYEFCLRTLLEVA
 ||.|||  .||.||||||  ..|| |  
vkllrtqrafsiqtpeqyefcylavleya
Phosphatase Notch_PTP.AA Subfamily.N12.PD 4077-4299 45 9.1e-59 189.7 In-house 56-268 (270) Show / Hide 
Range on Protein: 4077-4299
Range on HMM: 56-268/270
Sequence Identity: 45% (98 aa)

QDEQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSSG-NYTIR
..|...|||||..  .|.  .| ||||||||| |. |||||.||.  .||||.  ||| || ||||||| |..|  .| ||.....| ....|| |.|..
eeegsdyinanfikgveg--kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCeryWpeegee--elefgefevtleeekavdddflir

GLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP---RQTL
 .|   |.|  ..||||||| ||....|||..|...||..         .   | ||||||||||||... ..|.... |.     . ..|||.||| .|
tLkveaqke--srkvyqfhytaWPDhgvPssaksllelielvrelqe--------sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlv

VELREQRAKVVQTEEQYEFCLRTLLEV
||.||||.  ....|.           
lelrkqraalvqtkeqyelvykavael
Phosphatase Notch_PTP.AA Subfamily.N_Choan_1.PD 4070-4299 36 3.6e-58 188.0 In-house 39-260 (262) Show / Hide 
Range on Protein: 4070-4299
Range on HMM: 39-260/262
Sequence Identity: 36% (84 aa)

DDTLVHL----QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeydALVFGDLKISLVK
| | |..    ..... |||||.|   .. .   |||.|||.| .. .||.|||||  ...|||| |.|.||.|| |||| |..| .||.... ... ..
DatrvkvtpneenkntDyinanfvpgykgeke--yiatqgPvPaslvsfWqmvweqkvsaivmvtreieagklkChryWPdens---elklgdvtvksls

SVSSGNYTIRGLRVrNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGvavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
 .|  | ... ....   |.| .|.||||||| ||.|.. ||.| ....... .           ||.||||||||||. . ..  . ..|. . . ...
eeekktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktk-------aplvihCsaGvGrtGtyialDrlvkaveekae

P-NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
... |||..|  .|||  ||||  ...|..     
aldvkavvaelrkernlmvqtlvqyefvykavlda
Phosphatase Notch_PTP.AA Subfamily.N6.PD 4064-4295 35 7.6e-58 187.1 In-house 52-289 (295) Show / Hide 
Range on Protein: 4064-4295
Range on HMM: 52-289/295
Sequence Identity: 35% (86 aa)

NpeyanDDTLVHLQDE-----QNSYINANHVTF------AEEGRTLW-----YIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTE
|.| | |.|       . |||||....        |    .     |||.||.|. || |||||||.. |...||.| ||| || || ||||.|. . . 
f-----DhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvwqensrvivmttkevergknkCarYWPde

TGEYDalvFGDLKISLVKSVSSGNYTIRGLRVRNM-SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnNPPWPTVVHCSAGVGR
  .|..... ..  |  .||.| . | .  ... .|........|||||.||| |. .|.|...... . .|. . |.|||||||.|||| .....  | 
etkke---tGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqeel------ekagpivvhcsaGiGr

TGVLMLVESELIRLEQGMRPN---PRQTLVELREQRAKVVQTEEQYEFCLRT
 .|| .       .... ..|.||...||||.||.| ...            
tGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvyka
Phosphatase Notch_PTP.AA Subfamily.N23.PD 4065-4301 37 1.2e-57 186.5 In-house 110-350 (350) Show / Hide 
Range on Protein: 4065-4301
Range on HMM: 110-350/350
Sequence Identity: 37% (90 aa)

PEYANDDTLVHLQ-----DEQNSYINANHVtFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDL
|.  .| . |.||      .|. |||| ..       .  .||.|||.. |..||| ||||| |...||.| ||||.| ||..|||...||. .||||..
pdsrhdpnrvklqqstqpgqqddyinatyl-keltpmsPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidege--tnlfgdl

KISLVKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIR-VRLMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELI
|| .  || ..  | |...    . .|.| ||..|.|... ||| |..||.|..|....  ..    . ...  | ..||||||||||.. .| | .. |
rvslkslrssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysair

RLEQGMR-PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
..|   .|  . . .||.||  .||........ .  || ||  
eltagngiiniprvvrrlrqqRkymvqkkvilkklyeavleaar
Phosphatase Notch_PTP.AA Subfamily.N_Choan_2.PD 4077-4299 36 6.5e-57 183.7 In-house 45-264 (266) Show / Hide 
Range on Protein: 4077-4299
Range on HMM: 45-264/266
Sequence Identity: 36% (82 aa)

QDEQNSYINANHVTFA-EEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
.|.. .|||||.|  . .| ..  ||||.|||| |. .||||.||. .. .||.|| .| |. |||||||.|..|  .|  |..|.  .... .  | ..
edsataYinAnyvrGfdgekkk--YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkladgkikvlalseekeegyilt

GLRVRNmsEDLMRTVWHLQYTAWPDHSVPKTPSSL---LDFIDEIREIRVRLMgvAVNNPPwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
 ||...  .. .|.. | .|..||||.||... |     . .. .|..|       ...   |..|||||||||||.|....  .  ||. .. .. . .
rlrlek--kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrk--eldkae-PllvHcsaGvgRtGtliaiDiavrlLeetkkvdvlaii

VELREQRAKVVQTEEQYEFCLRTLLEV
 |||..| ..||. ||||.  ....| 
eelRkdRmalvqhpeqyellykavvey
Phosphatase Notch_PTP.AA Subfamily.N5_RR.PD 4076-4298 35 7.8e-56 180.3 In-house 47-262 (265) Show / Hide 
Range on Protein: 4076-4298
Range on HMM: 47-262/265
Sequence Identity: 35% (79 aa)

LQDEQNSYINANHVTFAEeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
.||. ||||||..   . ...  |.|.||||| |. |||||.... .|..||.|   |  . ||..|.|....   .  .||..|  .. |.  .|..| 
sededssyinanyikGyd-eeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPdaedyeiserygdveikveeiverndysvr

GLRVRNMSEdLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGV-AvnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVE
| ...... ..|.| |  ||.|||| .|. ...|||...|..| | .     |      | |||||||.||||. ...  . .|.. .  .  .. ..||
klvlkyler-versvkhywytdWPdhksPddintlldlvleveesreeenakla------PvvvhcsaGiGrtGcfiaisiavrqlreeivvdvlkivcn

LREQRAKVVQTEEQYEFCLRTLLE
 .|  .|||.||||.  |.| .  
lrldrGGmvqtseqyelihralcl
Phosphatase Notch_PTP.AA Subfamily.R_Sponge_2.PD 4070-4299 34 4.9e-55 177.8 In-house 38-260 (262) Show / Hide 
Range on Protein: 4070-4299
Range on HMM: 38-260/262
Sequence Identity: 34% (81 aa)

DDTLVHLQD---EQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDAlvFGDLKISLVKS
|.. |.|.    ..  ||||..|   ..     |||.||||. ||.||||||||. ....||.|  .| || ||..|||....|.   .|. |. |... 
dmsRvrLrtdgskdsDYinAsfvdgykr--rkayiatqgPlketveDfWRmvweykvstivmltnleengkekcakYWPekvdeeve--ygkfkvtlkee

VSSGNYTIRGLRVRNMSE-DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
 . .|.|| |.. . .. .  ..| . ...|||.|.|||. .|||..|..... .        .. .. .|.||.||||||  . ..| | ||..    .
ekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqk-------ksgnkaitvvCsdgvgrtGtfialdsvlerlkaeee

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
  ..| .|| .|  .||...||.|.   |||.  
idvfevlktlrtkriglvqdaaqYvfihdalley
Phosphatase Notch_PTP.AA Subfamily.R_Ecdysozoa.PD 4077-4299 34 1.2e-53 173.0 In-house 51-267 (269) Show / Hide 
Range on Protein: 4077-4299
Range on HMM: 51-267/269
Sequence Identity: 34% (78 aa)

QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVkCERYWPTEtgeyDALVFGDLKISLVKSVSSGNYTIRG
.|. .||||...   .| ..  .||||.|. .|.||||||..|| ....||.. . |  .  |..||| |    |   .||.. ||.. . ..|.|| | 
gkedsdyinasfikgykekkk--fiaaqdPveatigDfWrmiaeqevtlivmlsnlteknrk-cakyWpie----devqygdilvklvseekhsdyiire

LRVRNMS---EDLMRTVWHLQYTAWP-DHSVPKTPSSLLDFIDEIREIRVRLMGVAVNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
| ..    ..  | |   .||.|. |  ||... .||..|...||.      .  .    | ||||||||||.|... ... | .|..  . .  .|  .
ldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnklsgsrs---PivvhCsaGvgrsgifvaldlllqqlkaedkvdifetv

VELREQRAKVVQTEEQYEFCLRTLLEV
||.||. .||  |||.|. | |..   
kkLrsqrnllvqsleqyvflyralady
Phosphatase Notch_PTP.AA Subfamily.R_Anemone_1.PD 4077-4298 35 1.9e-53 172.8 In-house 49-255 (258) Show / Hide 
Range on Protein: 4077-4298
Range on HMM: 49-255/258
Sequence Identity: 35% (78 aa)

QDEQNSYINANHVTFAEEGrtLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdalvfGDLKISLVKSVSSGNYTIRG
.||.  |||| ..   ..     .||.|.||. ||.|||||||.. ....||.|. .|| | ||..|||..| .|     |.|..|| |.   ..|.|| 
ndeesdYinasylrasdkt--rafiatqapleetvedFWrmvwqekigviVmLtnliegekkkchqYwPdsteky-----gelrvslrkkevfadyiirt

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIrvrlmgVAVNNPPWptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
| . . .|   |.| ....| |||..||..  ..|.. .....          .. |.  ||||||||||||. . ... | .. .    . ....  .|
lvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqks------slagarpv--vvhCsaGvgRtGaflvidamleqakkekvvDifnyvkair

EQRAKVVQTEEQYEFCLRTLLE
|.|...|||.||| |. ...||
edrphmvqtkeqyvfihlavle
Phosphatase Notch_PTP.AA Subfamily.N1.PD 4070-4298 35 2.5e-53 172.2 In-house 41-265 (268) Show / Hide 
Range on Protein: 4070-4298
Range on HMM: 41-265/268
Sequence Identity: 35% (83 aa)

DDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdALVFGD--LKISLVKSV
| . ..|..... ||||. | . | .|   || .||||| |.. ||.||||| |. |.|.   || ...||  |||.|. |  .|.. .  ||. |..  
dhsrikleradvdyinaslveleeakrr--YiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCaqywpqeeeea-ellleetklkvklisee

SSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVAvnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMR--
 . ... | |........ .|.. | .|| ||| .||..|...|.|. ..||  .    |.      |.|.|||||.||.| |.||.. |...|.     
rksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvg------pavihCsagigrsgtlslvdtclveiektgdln

-PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
  . .. |.|||..|  ..|| .| .|    .||
avdikkvLlelRkyRvGLiqtpdqLrFsyiaile
Phosphatase Notch_PTP.AA Subfamily.RA.PD 4078-4298 34 1.3e-49 159.9 In-house 52-263 (266) Show / Hide 
Range on Protein: 4078-4298
Range on HMM: 52-263/266
Sequence Identity: 34% (77 aa)

DEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeydALVFGDLKISLVKSVSSGNYTIRGL
|.  |||| ..   .|  .  .||||||.  || |||||.||| |. .||.|   | .. || .|||.|     .. .|...... ... ..||.| . |
eeesdyinasfidGyrekdk--fiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqywpdeG----lvtyGeirvevkdetvledytvrdf

RVRN----MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGvavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLV
..    . |.  | |  . .|.||.  || ..  .|... ...... .  .        | |||||||||||| .. ... ||..   . .  ... .||
lvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsan-------hpivvhcsaGvGrtGtfivldavlervkaerkldvfeavk

ELREQRAKVVQTEEQYEFCLRTLLE
 ||...|||.|||||. ..|||   
rlrlqrpqmvqtleqyefiykvlle
Phosphatase Notch_PTP.AA Subfamily.RC.PD 4046-4298 33 4.6e-49 158.1 In-house 41-285 (288) Show / Hide 
Range on Protein: 4046-4298
Range on HMM: 41-285/288
Sequence Identity: 33% (81 aa)

QRISLNMEPEIMEMAEVPNPEYANDDTlvhLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWp
|. |. | |. . .|  . | ..||.     .|   |||| ..    . .   ||||||||  ||.|||||..|.  ...||.|   || .|| .||   
nrvelkhelemskesehdsdessdddi---dseegskyinasfidsykkpek--yiaaqGplketvddfwrmiferkvkvivmltelkeGdrekcaeyw-

tetgEYDALVFGDLKISLVKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRL--MGVAVNNPPWPTVVHCSAG
  |     .||... | .   | .|..| | ..|  .   |.| ..|||.|... .|. |  ||..|. ...   .|    | .|||..|..|||. . .
----eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkliqvvkqklpqkrsseafknfkstpllvhcrdG

VGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
.. |  ||   . .  | ...|| .|. .|..|||| .   .| |          
sqrtGifiallallesleaeekvdvfqvvkklrkarplmvsveeqyillydvlve
Phosphatase Notch_PTP.AA Subfamily.RK.PD 4072-4299 31 2.1e-47 152.5 In-house 47-265 (267) Show / Hide 
Range on Protein: 4072-4299
Range on HMM: 47-265/267
Sequence Identity: 31% (72 aa)

TLVHLQDEQNSYINANHVtfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGE-VEGGKVKCERYWPTETgeydALVFGDLKISLVKSVSSG
.|. ...... ||||. .      |.  .|..||||. || ||||.|.....  .||.|   || |.||| .||| .|       .||.|.||..    .
flisvdgdssdyinaali--dsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClkyWPedt----evrygdikvelveaelda

NYTIRGLRVRN--MSEDLMRTVWHLQYTAWPDH-SVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPN
. .| .||..   . . .|.| ..|...||..  ||.   |||..| .. . .         .   ..||||.|| ||.|. .... |  .|.    .  
dlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqee-------eeeGrivvhClaGaGrsGtfiaidivlemieregvvd

PRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
..  .||.... .|.|||||.|.    ||   
vfnavktlrnrkvnmveteeqykfvydvilea
Phosphatase Notch_PTP.AA Subfamily.RG.PD 4079-4299 35 3.3e-45 145.5 In-house 53-262 (264) Show / Hide 
Range on Protein: 4079-4299
Range on HMM: 53-262/264
Sequence Identity: 35% (77 aa)

EQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGDLKISLVKSVSSGNYTIRGLR
... ||||....  .  |.  ||..||||. |. |||||.||. .||.||.|  .| |. ....|||..    ..| ...||. |...||.| . ..|. 
dgkDYinAsyidGyr--rskeyivtqgplketiedFWrmiWehnaqiivmltdldekgrrdedvyWPkk---deplelealkvtllskeklskytvrdfv

VRNMSEDLMRT--VWHLQYTAWPDHSVPKTPSSLLDFIDEIreirvrlmGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
 |  ..  | ...|| |||...|.     | |.             | ..   |.|||.||||||.|... ... | .||.    |  |.|  .| .| .
lkntkddkekervvrqyhytkWPdmgsPestlfvlifvkke--------eaankeeaGPivvhdsaGvgragtyialdtllqqlekeeavnvyqvlklir

EQRAKVVQTEEQYEFCLRTLLEV
.|.||||| |   .|||.     
akRpglvtteEqyvfiydallel
Phosphatase Notch_PTP.AA Subfamily.RN.PD 4072-4297 36 3.8e-45 145.1 In-house 42-260 (264) Show / Hide 
Range on Protein: 4072-4297
Range on HMM: 42-260/264
Sequence Identity: 36% (84 aa)

TLVHLQ----DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydalVFGDLKISLVK-S
. |.|.    .|.. ||||  ..  .. |.  |||.||||. |. |||.||||||. ..|..|   | |  .|.|||| |  |    |.... ||   . 
srvklkeeasaeksdyinasail-dhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse----vyhiyevhlvseh

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIdeiREIRVRLMGVAVnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
. .| .| . ..|.  .  |||  . . .||...|| .. |||.|    | .     | .      | |||||.|.|||||.|..  | || .|..    
iwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr---rkvnksyrGrsc-----pivvhcsdGaGrtGvyilidlvlerllkGvke

N-PRQTLVELREQRAKVVQTEEQYEFCLRTLL
  ||  ||.||...|.|..|.||.| ..    
idiaatlehlrdqrpglvktkdqfefaltava
Phosphatase Notch_PTP.AA Subfamily.N20.PD 4070-4301 38 4.4e-43 138.7 In-house 39-257 (257) Show / Hide 
Range on Protein: 4070-4301
Range on HMM: 39-257/257
Sequence Identity: 38% (89 aa)

DDTLVHLQDeQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVSS
| | | |    . ||||...   . |   .|||.||||  |. |||.|| |. |... |.| |.||| .|| .|||        | .  ... | .    
dstrvplgk-skdyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpislk--kplelkhfrvflenyqil

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSlldFIDEIREIRVR-LMGvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
  . || ..| . |    ..| .||.| ||||  | .  |   ||  ||  |   | |        | |||||||.|||||.. |.  .  . .    | 
qyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasads---fikyiryarkshltg--------pmvvhcsagigrtgvflcvdvvfcaivkncsfni

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
 . . ..||||. .|||.||| ||   .||| |
mdivaqmreqrsgmvqtkeqyhfcydivlevlr
Phosphatase Notch_PTP.AA Subfamily.N_Nematode_6.PD 4070-4298 36 3.2e-41 132.4 In-house 37-250 (253) Show / Hide 
Range on Protein: 4070-4298
Range on HMM: 37-250/253
Sequence Identity: 36% (81 aa)

DDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLK-ISLVKSVS
| ....|.|... || || |  . . |   .| .|.|| ||. .||.|.  .|.. .||. . || || |. .| . . ||| ....|  .  .. ..  
dagrlkladdedfyihanlvkistkprr--lictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvG--darkitklctvikigrkd

SGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLdfideireirvRLMGVaVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
  . | |..   . |    | |... .|||| || .  | |           ||. | | .| |||||||||||| | |... |  | .    . .. ||
idkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsal-----------rllsv-vkkdkkPivvhCsaGvGrtGtlaliliilealrlpdfqgv

RQTLVELREQRAKVVQTEEQYEFCLRTLLE
 |||.|.. |||| || . || .||     
kdllvklreerfravqtevqylyalrcvle
Phosphatase Notch_PTP.AA Subfamily.N_Nematode_1.PD 4070-4298 33 1.6e-39 126.7 In-house 39-262 (265) Show / Hide 
Range on Protein: 4070-4298
Range on HMM: 39-262/265
Sequence Identity: 33% (81 aa)

DDTLVHL--QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISL----
|.. | |  .   . || ||.|. . . .   .| ||.||  |. ||| ||  .  . .||.   .| ||.||. |.|...||   .  .. ||..    
dknrvklaeeplpsdyihanyvgtptnpkr--ficaqaPldktiadfwymvlqekveaivmlckliekgkkkcaeyfpakegeklefkekgqkitvensl

-VKSVSSGNYTIR--GLRVRnMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLdfideireirvRLMgVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRL
 || ... . .|.   |.|  .. .  |.| |.|.| |||. ||..  . |            |.  ||..   |.|||||||.|||| .. .|  | .|
gvkkleedeevikvtvleve-gaGektrkvthyqWtdWPdrGvPpadlaal-----------ell-eavrgskgPivvhCsaGiGrtGtivaieyildkl

EQGMRPNPRQTLV-ELREQRAKVVQTEEQYEFCLRTLLE
 .| . .. . || ..||||.  .||. || |  | ||.
legkqiedmeklvkkireqrnysiqtdaqylfvhrvlln
Phosphatase Notch_PTP.AA Subfamily.R_Nematode_2.PD 4074-4293 34 7.4e-38 121.2 In-house 46-253 (261) Show / Hide 
Range on Protein: 4074-4293
Range on HMM: 46-253/261
Sequence Identity: 34% (74 aa)

VH-LQDEQNSYINANHVTFaeEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNY
|. ..|.. . | ||.|    .|..  .||.||||  |. ||| ||  .  . .||..  ||  | |||.|.|.||..   |..|.  .... . . . |
vevivdgkrvpihanwvpt--agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkldlgrfsiktvsaekilkdei

TIRGLRVRNMSEDL-MRTVWHLQYTAWPDHSVPKTPSSLLdfideireirvRLMGVAvNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
 |.| . . ..  ||| |.||. |||. |||.   |             |. ..  .   ||||||||.|||. .. .|    ..|.    .  ..| ||
ekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelf-----------eLlelv-kksekPivvhCsaGiGRtmafigteylareveadptieltea

LVELREQRAKVVQTEEQYEFCL
||.| | .|||.|. .      
lkelrehRwkgiqtesqlywlt
Phosphatase Notch_PTP.AA PTPc_motif 4189-4298 40 2.6e-37 131.22 SMART 1-92 (92) Show / Hide 
Range on Protein: 4189-4298
Range on HMM: 1-92/92
Sequence Identity: 40% (46 aa)

TVWHLQYTAWPDH-----SVPKTPSSLLDFIDEIREIRVRLMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQRAKVV
||.|..||.||||     .||.  .|.|.||...|.               |.|||||||.||||....... . .      ..  ||. |.|.||.  |
TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK---------------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMV

QTEEQYEFCLRTLLE
|||||| || | .||
QTEEQYIFCYRCILE
Phosphatase Notch_PTP.AA Subfamily.N_Nematode_4.PD 4069-4298 31 3.4e-35 112.6 In-house 38-261 (264) Show / Hide 
Range on Protein: 4069-4298
Range on HMM: 38-261/264
Sequence Identity: 31% (72 aa)

NDDTLVHLQDE--QNSYINANHVTFAeegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKS
|.| | |..   .| || |. ..         ||..||||. |. ||| ||...  ..|||.   .|.|  ||.||.| ....  . .||. .| ||.  
idetrvvlknrdpdndyihaswmrmP---dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcaryypeksek--vvkfGkyritlvek

VSS--GNYTIRGLRVRNMSE--DLMR---TVWHLQYTAWPDHSVPKTPSSLLDFIDEIREiRVRlmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIR
     .  .. |.| |. .  |       | |.|.. |.|.  |... ......  ... . .. | |||||||||||  |. ..   ||. .    .  
keeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk-kkk---------ekPivvhcsaGvGrtatlvGidyatir

LEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
. . |||. | | ||.. |. | |  |.|          
irenseievldivrelramrlkavqshlqflfllvvlie
Phosphatase Notch_PTP.AA Subfamily.N_Nematode_5.PD 4068-4297 30 1.2e-32 104.2 In-house 36-254 (258) Show / Hide 
Range on Protein: 4068-4297
Range on HMM: 36-254/258
Sequence Identity: 30% (69 aa)

ANDDTLVHLQDEQNSYINANHVTFAEEGRtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCeRYWPTETGEYDAlvFGDLKIS--LVK
.|.|.|.|.||..|||||..... .  .   .| .| ||| |. |||||| ..  . ||..... |  . ..  ..|.|||.|    .|.. |    |..
ilDetrVkltdeddsYinaskiklddlek--kliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffpletgdyln--lgkmfinnrkve

SVSSG--NYTIRGLrVRNMSEDLMRTVWHlqYTAWPDHSVPKTPSSLLDfideiREIRVRLMGVAVNNppWPTVVHCSAGVGRTGVLMLVESELIRLEQG
..    .||.  | . . || .. .| |  .| |....||.  . ..      |.|   |..|   |.||....|.||.| ..|..     |..|  || 
vkedekkeytvevl-pegcsesvfakvyh--lttWkkkkvPdkvkkvik-----raiekvlskkqgkn--apvvvvsdlGlgRagtflllsvaieqlnng

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLL
 ..| ..|.||...|..  || .  ...|     
kepnideilkkirsqRpgavesliqyasvyaavl
Phosphatase Notch_PTP.AA Subfamily.R_Nematode_3.PD 4073-4297 24 4.1e-31 99.3 In-house 39-263 (267) Show / Hide 
Range on Protein: 4073-4297
Range on HMM: 39-263/267
Sequence Identity: 24% (60 aa)

LVHLQD----EQNSYINANHVTFAEEGRtlwYIAAQGPL--------PGTVGDFWRMVWEQGSQIVVMVTGEVE---GGKVKCERYWPTETGEydALVFG
| |..     .. .|.|| |..... .    | .|.|.          |.  || |. ......|||.   ||   ... || .|.|.. ..   | |..
rvvLkgygkrfkddfihAnvvecpnglk---lIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfveedgeeeekcseYypekvdg--elkfe

DLKISL--VKSVSSGNYTIRGLRVrNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnnppwPTVVHCSAGVGRTGVLMLVES
....   .|.  | .   | |.| .. .    || ||.|..|.....|..| ..|. |. ....             | |||||.|..|...|  .|   
gvsvkctdikkelsedvekrtlvv-tfekkkeftvthllykgWkelnapeepkealelikfvekskt------------pvvVHCsdGisRsatlaaiel

ELIRLEQGM-RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLL
  . . .   . .. . |||.|||. .|||... | .  .|  
gyqliikskgkldllslikelrkqRagaiqtelelafvilgil
Phosphatase Notch_PTP.AA Subfamily.N_Nematode_egg.PD 4066-4297 28 7.7e-21 65.6 In-house 51-253 (257) Show / Hide 
Range on Protein: 4066-4297
Range on HMM: 51-253/257
Sequence Identity: 28% (66 aa)

EYANddtlvhlqdeqnSYINANHVTfaeeGRTL--WYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGgkVKCERYWPTETGEYDALVFGDLKISL
|..             .| ||.|     |. |   .| || ||  || ||||||...  | .||.|  .|    .|| |||    |   .| | |.|  .
qyld------------dfihanrvk----Gkpllnefilaqaplkntvedfwrmvfqekvqyivmltsakes--erceyywpkaeseslvtvpGslrien

VKSVSS--GNYTIRGLRVrNMSEDLMRTVWHLQYTaWPDHSVPKTPSSLLdfideiREIRvrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLE
|  |     ...  |..   ..|  . . | |.  .   |   .|  .|      | .||   |.||..  || ....|. .|  |..| .|   .   .
lkvdskadplfrvtklkl-vGgddeelflehwqgd-vnylsdvysplrvl------rklr---------nlskpvvvqdilGvskaatlvaieiallsll

QGM--RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLL
.. | || .|   |..  .| |  | .|          
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
Phosphatase Notch_PTP.AA Subfamily.N_Nematode_eak.PD 4070-4297 25 5.8e-18 56.1 In-house 42-277 (281) Show / Hide 
Range on Protein: 4070-4297
Range on HMM: 42-277/281
Sequence Identity: 25% (60 aa)

DDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeyDALVFGDLKISLVKS-VS
|   | ... ||||  . |.| ||   || .  .    |  ||.|| || |  .|..  .|| .  | ..|.| .|. | .| |..   .  |  ...  
lvrltssqlnrdGyinaslaefsevGrk--yiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfpdkt---evlkyGildverkeyavk

SGNYTIRGLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTpSSLLDFIDEIREIRVRLMGVAVNN-------------PPWPTVVHCSAGVGRTGVLMLVEs
| | .|   |     | | ..  | . ..||    .| . . ..|. | |. |..             |    .. .. |  |.||.....  |||| ..
rniletrllilrkGne--thrvlhykvfGwtettlpky-edflalrkvmkevGvlllivmksallrstlkkyihtppsfapiiqsarGsaraGvfvvid-

ELIRLEQGMRPNP---RQTLVELREQRAKVVQTEEQYEFCLRTLL
 . |     . ..  ...| . | .. |. |.|            
llirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivl
Phosphatase Notch_PTP.AA Subfamily.N_Fungi_PTP1.PD 4079-4147 36 3e-17 53.5 In-house 79-151 (343) Show / Hide 
Range on Protein: 4079-4147
Range on HMM: 79-151/343
Sequence Identity: 36% (26 aa)

EQNSYINANHVTFA---EEGRTLW-YIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTE
. | |||||..  .    |  . . |||.|.||| || ||.... . . ......| .|| .  ||.|||.  
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
Phosphatase Notch_PTP.AA Subfamily.N_Fungi_PTP1.PD 4188-4297 31 4.8e-13 39.7 In-house 213-339 (343) Show / Hide 
Range on Protein: 4188-4297
Range on HMM: 213-339/343
Sequence Identity: 31% (38 aa)

RTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMG--VAVNNPPWPTVVHCSAGVGRTGVLMLVESELI---RL-------EQGMRPN-----PRQ
.|..||.  |.| |.   | |.|  ..   ..   |.      |.   | .|||||||||||.|. ..| |     |..  ...       ... |||.|
yevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

TLVELREQRAKVVQTEEQYEFCLRTLL
| ..||. .|. |.  .||        
ivnelrkqrismvqnldqfifiYeall
Sequence
Name Sequence Type Origin Length Description Download
Notch_PTP.AA Protein None 4310 None Fasta, JSON
Notch_PTP.NA RNA None 12930 None Fasta, JSON
Notch_PTP.AA.PD_4031-4301 Protein Phosphatase Domain None 271 None Fasta, JSON