Gene 33235
33235
Species: M.brevicollis
Alias: 33235
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of 33235.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | 33235.AA | DSPc | 76-219 | 23 | 1.3e-27 | 99.02 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 76-219 Range on HMM: 1-172/172 Sequence Identity: 23% (40 aa) GPADILPQLCLGDASHAL--DVEQLRRAGVSGVVNCAESATLSSRS-------------DYPAEWEYLGFDAQDH-------SHYDMLGNHFEQVAAFID || |.| | || ..|.. ....| .. |.|.... .... . . . .|.. . | .|.. . ..|..|..||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH AAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHC-----ARQR-PCILRNVGFIEQLVVFAHE .... . |||.|||||..||| ...||.| . . .. .|... ..| |.|..|..|. || .. DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | 33235.AA | Subfamily.DSP1.PD | 77-217 | 31 | 2.4e-31 | 99.7 | In-house | 2-137 (139) | Show / Hide |
Range on Protein: 77-217 Range on HMM: 2-137/139 Sequence Identity: 31% (44 aa) PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESatlsSRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI |..||..| || |.|| . ..|.. ... ..|.... .. ..| .|... |.. ..||... |||.. ... .||.|||||. ||| | pveildfLyLGsaehasnlqlLkelkitallnvsae----lpnvfeelfkyksipvednkkadis-slfeeaidfidsvkkkgGrvlvhCqaGisrsati VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA |.|| | ... | | ... ..| .| |.||..||. | vlayLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefe |
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| Phosphatase | 33235.AA | Subfamily.DSP3.PD | 79-217 | 33 | 2.7e-30 | 96.3 | In-house | 4-146 (148) | Show / Hide |
Range on Protein: 79-217 Range on HMM: 4-146/148 Sequence Identity: 33% (49 aa) DILPQLCLGDASHALDVEQLRRAGVSGVVNCAESAT----LSSRSDYPA-EWEYLGFDAQDHSHYDMlGNHFEQVAAFIDAAAAA-KRKVLIHCQAGVNR .. |.. .||.. | | |.|.. |. |.|.||. . .. | | .|||....| . |. ..||. | ||| | . . |||.||..|. | evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdl-skyfeeaadfidealsqkngkvlvhcvvGisR SAMIVVAYYMLSTHTPLLAALDHCARQRpCILRNVGFIEQLVVFA || .|.|| |.. . | |. . ..| .|| | ||..||. .. satlvlayLmirrkltlkeaiktvrkkr-eilPneGflkqLleld |
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| Phosphatase | 33235.AA | Family.DSP.PD | 76-220 | 33 | 5.7e-30 | 95.9 | In-house | 106-247 (387) | Show / Hide |
Range on Protein: 76-220 Range on HMM: 106-247/387 Sequence Identity: 33% (48 aa) GPADILPQLCLGDASHALDVEQLRRAGVSGVVNCAesaTLSSRSDYPAEWEYLGFDAQDHSHYDMLGnHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAM .| |||.| || ...| . |.|...||. .||.. . ... .. .. .|| . ||. .. .||.. ||. . .| .||.||.||..||.. kpseilphlylgsllaaknlewlkelgvtkivnlt---ddkpqftkelgikylripidDhnapplen-lfekaidfieegndskgvVlVHCkaGkgRsgt IVVAYYMLSTHTPLLAALDHCARQRP-CILRNVGFIEQLVVFAHEH ...|| | | . | .|||. . .|| .| | ||..|| . .| liiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekek |
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| Phosphatase | 33235.AA | Subfamily.DSP19.PD | 79-215 | 32 | 5.3e-28 | 88.7 | In-house | 4-135 (139) | Show / Hide |
Range on Protein: 79-215 Range on HMM: 4-135/139 Sequence Identity: 32% (44 aa) DILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSsrsdYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV . |.| || . | | |.|.. .. ..| | .| ...|. . |.. ..| ...... ||. | .. ||.||.||| ||| .|.| evkprlylgsqdvaadkeilkklkitHilnvavgvpnv----fpkdftyksieilDlpetkll-sylkealdFieearskdgrvlvHCnAGvSRsasvvi AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVV | | .... | ||... .|||| | |||.|| aylmkdeelslekalekvrearpcikPneGFikqLke |
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| Phosphatase | 33235.AA | Subfamily.DSP10.PD | 78-217 | 32 | 5.3e-27 | 85.5 | In-house | 3-139 (141) | Show / Hide |
Range on Protein: 78-217 Range on HMM: 3-139/141 Sequence Identity: 32% (45 aa) ADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSSRSDypAEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIV ..||| | ||. | | . |.| |.. |.| . |. . .. . .| ...| .. . | ..||. .||. | .||.||.||. ||| .| ssilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeek--glvrykripvsdsgkqn-lkqkfeealefieearkrgsrvlvhchaGisrsatvv VAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA .|| | .. | | .|| | |..|. ||. | iayvmkhlslslseaykfvkekrPiisPnlnfmGqllefe |
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| Phosphatase | 33235.AA | Subfamily.DSP12.PD | 79-217 | 29 | 6.4e-27 | 85.5 | In-house | 4-139 (143) | Show / Hide |
Range on Protein: 79-217 Range on HMM: 4-139/143 Sequence Identity: 29% (40 aa) DILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATlSSRSDYPAEWEyLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV |||.| ||..... . |.|. . .. |. .. .. .. .. . . . . .. |. . |.| .|.... .||. . . ...||.||.||| ||. ||.| eilpglylggleavqerellkelkithvlsvikeel-pelqkekgvks-kliqilDepeedlL-shldeavrFieeglekegavlvHClagvSRSvtivi AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA | | ... .| ||. .... | | ||.||| .| AYlmkkeklslekAlklvkekkkeiepNegFleQLklfe |
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| Phosphatase | 33235.AA | DSPc | 84-219 | 26 | 9.9e-27 | 94.87 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 84-219 Range on HMM: 1-151/151 Sequence Identity: 26% (41 aa) LCLGDASHAL-DVEQLRRAGVSGVVNCAESATLSSRSDYPAEWEYLGFD-AQDH--------SHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRS | || ..|.. | ..| |.. |.||... . . . . . .|.. || .|.. . ..|... .|||.... . |||.|||||..|| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN-WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRS AMIVVAYYMLSTHTPLLAALDHC-----ARQR-PCILRNVGFIEQLVVFAHE | ...||.| . . .. |.|. .| |.| .|..|. || . ACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | 33235.AA | Subfamily.DSP6.PD | 77-217 | 32 | 2.8e-26 | 82.9 | In-house | 2-139 (141) | Show / Hide |
Range on Protein: 77-217 Range on HMM: 2-139/141 Sequence Identity: 32% (46 aa) PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESatLSSRSDYPAEWEYLGFDAQDHSHYDMlGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI |..|||.| || | .| ..| |.. ... |.| .. | . . | .|. ..|| . .. ..| . .||| | .| |||.|| ||| || . pveilpllylGsakdasnlevlkklkikyvlnvtsn--lpnkfeesgelkykqipiedhlsqnl-akffPeaiefidearskkskvlvhclaGvsrsvtv VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA ..|| | ... | | | .... | | |..||. | tlaylmkklalslndaydlvkkkksnisPnfnfmgqlldfe |
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| Phosphatase | 33235.AA | Subfamily.DSP14.PD | 79-216 | 29 | 7.9e-25 | 78.6 | In-house | 4-135 (138) | Show / Hide |
Range on Protein: 79-216 Range on HMM: 4-135/138 Sequence Identity: 29% (41 aa) DILPQLCLGdASHALDVEQLRRAGVSGVVNCAEsatlSSRSDYPAEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV .| ..| |. .. ||. |.|...... .|| . . . . ... .|... . | .||..||. |... ... |.|.|| ||| ||| .|. eitesLyls-gaaalkkeklkkkkitlivnvtt----elpetkledvktvkikveDkpeak-laehfdevadkieevkkkgGktlvhCvaGvsRsAslvl AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF || | .. | | . .|| | |||| .||. . aylmkyeklsLreayklvksaRpiirPnvGFwkqlidy |
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| Phosphatase | 33235.AA | Subfamily.LRR-DSP.PD | 77-217 | 36 | 4.1e-24 | 76.0 | In-house | 2-135 (137) | Show / Hide |
Range on Protein: 77-217 Range on HMM: 2-135/137 Sequence Identity: 36% (51 aa) PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLssrsdYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAaAAKRKVLIHCQAGVNRSAMI | |...| || | . |. .|. .. |. | || . || |..| ..|. .||... |||| | |||||.||| ||| . pdliidklylgcresamnksilkdnnvthilavadfkpl-----ypdlfkyliidiedvdeadiy-qhfkemnafideg-rekggvlihcragvsrsatl VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA |.|| | . . ||| ..|| | | ||..|| | viaylmkknslkfkealdlvikkrpriypnrgfldqlkkfe |
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| Phosphatase | 33235.AA | Subfamily.Slingshot.PD | 77-216 | 32 | 7.3e-24 | 75.2 | In-house | 2-136 (139) | Show / Hide |
Range on Protein: 77-216 Range on HMM: 2-136/139 Sequence Identity: 32% (45 aa) PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESAtlssRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI .. | | || | ..|.|.. ||. ..| .. . .| ...|| |... |.| .|... ||..| ... |||.||. || ||| . askifdhlylGsewnasnleelkengveyilnvtkei----dnffpekfkylnirvydeeetdll-khwnetykfiekakekgskvlvhckmGvsrsast VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF |.|| | . .. | ||.. ..| .| | ||..|| |. viayamkeyelsleealeyvkerrsiikpnkgflkqlkvy |
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| Phosphatase | 33235.AA | Subfamily.DSP8.PD | 77-218 | 34 | 9.5e-23 | 71.8 | In-house | 2-140 (143) | Show / Hide |
Range on Protein: 77-218 Range on HMM: 2-140/143 Sequence Identity: 34% (49 aa) PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSsrSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI | |||.| || ..|| | |.. |.| |.| .|| . . | ..| .|. . ..| ..|.. ||| | .|. |||.|| || ||| . ptrilpnlylGsqkdsldeellkklgisyvlnisescpkd--vellkesrflriPvkDkyeekll-pwfdkalefidkarsangkvlvhclaGisrsatv VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH ..|| | . | | . .|| | .|. |..||. . . aiayimktlemsldeayrfvkekrptispnlnflgqLleyek |
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| Phosphatase | 33235.AA | Subfamily.DSP15.PD | 79-217 | 31 | 2.6e-21 | 67.1 | In-house | 4-136 (138) | Show / Hide |
Range on Protein: 79-217 Range on HMM: 4-136/138 Sequence Identity: 31% (44 aa) DILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSSrsdypAEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV ..|| | .|. | | |||.. .. .. .|| . .|| . |.| . | | ..|.. || .. . .||.|| ||. || .|| kvlpGlyvGnfrdakdkeqleenkithilsihdsakpll-----edikylcikaadsPdqd-lskffkesidfihkcrleggnvlvhclaGisrsvtlvv AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA || | |. || |.. |||| .|| | ayimtvtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | 33235.AA | Subfamily.STYX.PD | 79-216 | 31 | 1.9e-19 | 61.0 | In-house | 4-143 (146) | Show / Hide |
Range on Protein: 79-216 Range on HMM: 4-143/146 Sequence Identity: 31% (45 aa) DILPQLCLGDASHAL--DVEQLRRAGVSGVVNCAES--ATLsSRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSA .||| | || | |. .|.|.. |.. .| .. |.| . ..| .. || .| | . ... .. .| .||| . |||.|.||. ||| eilpglflgpysaamksklevlkehgithivcirqnieanl-ikpnfpdrfrylvldvadntvenii-rylptvkefiddslqkggkvlvhgnagisrsa MIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF .|.|| | . | . ..| || | ||..|| .. alviayimetyglkyreafayvqerrfcinpnegfvsqlkey |
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| Phosphatase | 33235.AA | Subfamily.STYXL1.PD | 77-214 | 25 | 2e-17 | 54.8 | In-house | 2-138 (143) | Show / Hide |
Range on Protein: 77-214 Range on HMM: 2-138/143 Sequence Identity: 25% (35 aa) PADILP-QLCLGDASHALDVEQLRRAGVSGVVNCAESATLSSRSdYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAM | ..|| .| ||. ..| . . . | ..|| . | . . . | . .|... |.| .....| ||. .. ||.. |. ||| .. PvevlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliag-ladvakllhiavedeneadll-erlkevvqfiekhkkegevvlvfsnkGisrsaa IVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLV .|| | | .. | |... . .. . | .|.||| viiaylmyskkitlkkaykylkkckenvkPnrafveqls |
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| Phosphatase | 33235.AA | Subfamily.PTPMT1.PD | 96-211 | 25 | 4.6e-16 | 50.0 | In-house | 18-138 (146) | Show / Hide |
Range on Protein: 96-211 Range on HMM: 18-138/146 Sequence Identity: 25% (30 aa) EQL-RRAGVSGVVNCAESATLSSRSDYPAEWEYLGFDAQDHSHYDMLG----NHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLL ..| . | .||...| | .. ||. || . . |. . .. |. ||. | . .| .||.|| ||| .| .|| .... keLvekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspe AALDHCARQRPCILRNVGFIE | .. ...|| |. . .. eavkflkkkRpqirlkskqwr |
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| Phosphatase | 33235.AA | Subfamily.PTEN.PD | 118-195 | 23 | 8.4e-08 | 22.9 | In-house | 55-131 (305) | Show / Hide |
Range on Protein: 118-195 Range on HMM: 55-131/305 Sequence Identity: 23% (18 aa) RSDYPAEWEYLGFDAQDHSHYDMLGNHFEQVAAFIDAAAaaKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLL-AALDH ||. .|| . ..| . |.| .... .. | .||.|| |. ....|| . |.... ||.. dsdfdgrvavypfdDhnpptleLleeivedvdkwLkedk--snVvavHCkaGkGRtGvmicayLlksgikksadealai |
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| Phosphatase | 33235.AA | Subfamily.CDC14.PD | 124-183 | 20 | 1.9e-07 | 22.1 | In-house | 163-222 (258) | Show / Hide |
Range on Protein: 124-183 Range on HMM: 163-222/258 Sequence Identity: 20% (12 aa) EWEYLGFDAQDHSHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYML ... ||. .| | . . . |.... |. .. .||.||. | .... .| . kftdaGfahlDlffiDGtvPsdailkkfleitekaeGaiavhCkaGLGrtgtligcylik |
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| Phosphatase | 33235.AA | Subfamily.PTPDC1.PD | 152-218 | 22 | 2.6e-07 | 21.3 | In-house | 160-225 (229) | Show / Hide |
Range on Protein: 152-218 Range on HMM: 160-225/229 Sequence Identity: 22% (15 aa) IDAAAaAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH .| | . |. .|| || | ... .| . ... |.. .|| .. . .| . ||. vdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelveeFal |
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| Phosphatase | 33235.AA | Subfamily.R_Nematode_3.PD | 148-182 | 26 | 7.6e-07 | 19.8 | In-house | 187-221 (267) | Show / Hide |
Range on Protein: 148-182 Range on HMM: 187-221/267 Sequence Identity: 26% (9 aa) VAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYM . . |... . | |..|| .|. ||| .... . alelikfveksktpvvVHCsdGisRsatlaaielg |
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| Phosphatase | 33235.AA | Subfamily.RNGTT.PD | 158-214 | 25 | 7.6e-07 | 20.0 | In-house | 78-134 (140) | Show / Hide |
Range on Protein: 158-214 Range on HMM: 78-134/140 Sequence Identity: 25% (14 aa) AKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLV .. . .|| | || ...||| . . . ||.. |. || . .....|. PdevigvhCthGfnrtGflivayLvekedwsveaavalfakarppGiykedylkelf |
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| Phosphatase | 33235.AA | Subfamily.DSP11.PD | 141-185 | 22 | 2.2e-06 | 18.6 | In-house | 63-106 (141) | Show / Hide |
Range on Protein: 141-185 Range on HMM: 63-106/141 Sequence Identity: 22% (10 aa) LGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVaYYMLST . . |.| |.. . .. . .|| ||||. .. .|.... vkkfkeavkefleknkdndkligvhCthGvnrtGyliC-rylidv |
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| Phosphatase | 33235.AA | Subfamily.Laforin.PD | 147-202 | 26 | 6.3e-06 | 17.0 | In-house | 92-147 (165) | Show / Hide |
Range on Protein: 147-202 Range on HMM: 92-147/165 Sequence Identity: 26% (15 aa) QVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPC | .. | .| .||.||| ||. ||. . . . | . .||. qavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv |
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