Gene 28189
28189
Species: M.brevicollis
Alias: 28189
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of 28189.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Abhydrolase_1 | 28189.AA | Abhydrolase_1 | 102-280 | 15 | 3e-09 | 34.53 | Pfam | 50-236 (236) | Show / Hide |
Range on Protein: 102-280 Range on HMM: 50-236/236 Sequence Identity: 15% (31 aa) VLIGHSYGTSLVVQLYQSLPTSFQSQVVGLVCCNAVTQDASCLLQASMRAL-----SLVPTPVLG-LIRRWQARRGSES---QSVARMVAADATNETK-- ...|||.|. .. .... |.. | ..|.|... ..|.|.. ... ... .. . . .. .. .| |.. | .| .. . HVVGHSWGGMICWYYAAQHPDK---RVKAMVLCGPP---HPCGLWWPVWPMCWWWFTQFWDWFFNWMYDQFEHFWGMWPKQFQHYHRHFVNDFLKWMEHW VMQLHW---NTWTPTHVL--QAMAAGLQVVSLADYARVTIPVLLLAGAEDTVVPPEHTYSIYDTVPRVHGPHIAPNAKHNL-IEEASELVNALLTT |. . ..|.... . ..| .| . .|...|.|.. | .| ..||.|.. . ...|. . |. ... | . ... . .|.|. YCQYWRFGMMDWFMGMFWYYYQMWYWWQWDCT-WLKRIDCPTLIIWGMQDHIFPPQHMWKMAQWFPN-AQYHVFDDCGHWAFQWWHPDEFNHLI-K |
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| Phosphatase | 28189.AA | Subfamily.DSP11.PD | 357-471 | 28 | 3.1e-20 | 62.9 | In-house | 18-134 (141) | Show / Hide |
Range on Protein: 357-471 Range on HMM: 18-134/141 Sequence Identity: 28% (33 aa) KFTNVGLVIDVSREPPPYLTNAP-DV-PPYVKIATVSKREPEAESVAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHA | ...|||||.. | ... | |.|. .. .. || | | |.......| . .. | . .|| | ||.|.. | ||... |. . .|..| knkklGLvidltntdryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaiea FRKARPPGIKHEHFRAE | .|| . .|.. . feearGhslerenyled |
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| Phosphatase | 28189.AA | Subfamily.RNGTT.PD | 361-478 | 30 | 2.5e-21 | 66.3 | In-house | 21-139 (140) | Show / Hide |
Range on Protein: 361-478 Range on HMM: 21-139/140 Sequence Identity: 30% (36 aa) VGLVIDVSREPPPYLTNAPDV--PPYVKIATVSK-REPEAESVAKLHKVLDNFWANpdNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK .|||||. . | .. . |.|. . |. | . .. |. ..|. . . . . .|| .|||| ||. ..|||.. ...|.. | ||| lglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkk--kPdevigvhCthGfnrtGflivayLvekedwsveaavalfak ARPPGIKHEHFRAEFLRRYAS |||| |.. |. .||.. arppGiykedylkelfkryed |
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| Phosphatase | 28189.AA | Family.DSP.PD | 358-465 | 27 | 1.2e-17 | 54.8 | In-house | 130-231 (387) | Show / Hide |
Range on Protein: 358-465 Range on HMM: 130-231/387 Sequence Identity: 27% (28 aa) FTNVGLVIDVSREpPPYLTNAPDVPpYVKIATVSKREPEAESVakLHKVLDnFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK .| ..... . .| |. .. |..|. .| |.. . |..| | . ......| .||. | .||| . . ||.|..|. . |||..|..|| elgvtkivnltdd-kpqftkelgik-ylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrs ARPpGIKH |. kRp-gvit |
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| Phosphatase | 28189.AA | Subfamily.DSP23.PD | 363-464 | 29 | 1.1e-12 | 38.6 | In-house | 16-112 (128) | Show / Hide |
Range on Protein: 363-464 Range on HMM: 16-112/128 Sequence Identity: 29% (29 aa) LVIDVSREPPPYLTNAPDVPpYVKIATVSKREPEAESVAKLHKVLDNfwAnpDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPG ..... |..|| ||.. ...| | | ||.| ..... | .. . | .|| |. |.| . |||| .|. | .|.|| |. | vlvslttegapyseaapslt-lrridipdfcPPaleqvarlvrivee--a--ekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGs IK ie |
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| Phosphatase | 28189.AA | Subfamily.PTPDC1.PD | 420-465 | 36 | 1.5e-09 | 28.0 | In-house | 168-213 (229) | Show / Hide |
Range on Protein: 420-465 Range on HMM: 168-213/229 Sequence Identity: 36% (16 aa) DVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPGIKH . .||| | | | . ..||| . ..| ||.. |. || |. kiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqt |
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| Phosphatase | 28189.AA | Subfamily.PTEN.PD | 411-459 | 34 | 5.8e-09 | 26.1 | In-house | 88-136 (305) | Show / Hide |
Range on Protein: 411-459 Range on HMM: 88-136/305 Sequence Identity: 34% (17 aa) WANPDNaRKDVIIHCHYGFNRSGFMACSYLVKRRGFGAR-EALHAFRKAR | . |. .. |..||. | |.| | |.||.|. . |||. . ..| wLkedk-snVvavHCkaGkGRtGvmicayLlksgikksadealaiydekR |
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| Phosphatase | 28189.AA | Subfamily.CDC14.PD | 405-462 | 32 | 2.3e-08 | 24.4 | In-house | 185-242 (258) | Show / Hide |
Range on Protein: 405-462 Range on HMM: 185-242/258 Sequence Identity: 32% (18 aa) KVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPG ..| .| ..|. ...||. | | | . .||.|. .| | |.. .| ||| ailkkfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPGs |
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| Phosphatase | 28189.AA | Subfamily.DSP19.PD | 395-461 | 29 | 2.6e-08 | 24.3 | In-house | 57-122 (139) | Show / Hide |
Range on Protein: 395-461 Range on HMM: 57-122/139 Sequence Identity: 29% (20 aa) PEAESVAKLHKVLdNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPP ||.. .. |...| .| . .. |..||. | || .. .||.|.. ..||. |.|||. petkllsylkeal-dFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpc |
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| Phosphatase | 28189.AA | Subfamily.PTPMT1.PD | 398-476 | 25 | 3.7e-08 | 23.7 | In-house | 67-143 (146) | Show / Hide |
Range on Protein: 398-476 Range on HMM: 67-143/146 Sequence Identity: 25% (20 aa) ESVAKLHKVLdNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPgIKHEHFRAEFLRRY |..||.. . .| . . .. | .|| | ||. .. .||.|.. . . || ....| || |. .. . . |... pslekleegv-efiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpq-irlkskqwralqef |
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| Phosphatase | 28189.AA | Subfamily.DSP12.PD | 410-468 | 23 | 6.5e-08 | 23.2 | In-house | 73-131 (143) | Show / Hide |
Range on Protein: 410-468 Range on HMM: 73-131/143 Sequence Identity: 23% (14 aa) FWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPGIKHEHF | . . .. |..||..| || . ||.|.... ..||.. ..... | | FieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiepNegF |
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| Phosphatase | 28189.AA | DSPc | 416-460 | 27 | 1.1e-07 | 28.67 | Pfam | 83-133 (151) | Show / Hide |
Range on Protein: 416-460 Range on HMM: 83-133/151 Sequence Identity: 27% (14 aa) NARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAF-----RKAR-P . . | .|| | .||. ... || |.|.. ..||.. . .. | | QKGGKVLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCP |
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| Phosphatase | 28189.AA | Subfamily.DSP3.PD | 418-459 | 35 | 1.2e-07 | 22.2 | In-house | 89-130 (148) | Show / Hide |
Range on Protein: 418-459 Range on HMM: 89-130/148 Sequence Identity: 35% (15 aa) RKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKAR . |..||. |. || .. .||. || . ..||... || | ngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkr |
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| Phosphatase | 28189.AA | Subfamily.DSP10.PD | 358-460 | 20 | 1.6e-07 | 21.7 | In-house | 25-123 (141) | Show / Hide |
Range on Protein: 358-460 Range on HMM: 25-123/141 Sequence Identity: 20% (20 aa) FTNVGLVIDVSREPPPYLTNAPDVpPYVKIATvskREPEAESVAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK .. |..| . | . ... .| | .| .. . . . . . .| . . . |..||| | || .. .|..| ..|| . ...|| rlgikyvlnvttsvPnffeekglv-rykripv---sdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvke ARP krP |
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| Phosphatase | 28189.AA | Subfamily.DSP1.PD | 396-459 | 21 | 4.3e-07 | 20.5 | In-house | 58-120 (139) | Show / Hide |
Range on Protein: 396-459 Range on HMM: 58-120/139 Sequence Identity: 21% (14 aa) EAESVAKLHKVlDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKAR .|. ...... .| . ... |..||. | || . ||.|.. . .|| . .. | kadisslfeea-idfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrr |
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| Phosphatase | 28189.AA | Subfamily.DSP8.PD | 362-465 | 19 | 5.2e-07 | 20.2 | In-house | 29-127 (143) | Show / Hide |
Range on Protein: 362-465 Range on HMM: 29-127/143 Sequence Identity: 19% (20 aa) GLVIDVSREPPpyltNAPDVPPYVKIATVSKREPEAESVAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARpP . |...|.. | ... . ... . .. | . .. .| .| . |..||. | || .| .|..|. .. || ... | | | syvlnisescp----kdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekr-p GIKH . tisp |
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| Phosphatase | 28189.AA | Subfamily.DSP14.PD | 361-460 | 28 | 5.4e-07 | 20.2 | In-house | 27-120 (138) | Show / Hide |
Range on Protein: 361-460 Range on HMM: 27-120/138 Sequence Identity: 28% (28 aa) VGLVIDVSREPPPYLtnAPDVPpYVKIATvsKREPEAESVAKLHKVLDNFwANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARP . |...|..| | ..|| .|||. . .|||. . . .| |. . ... ...|| | || .. ||.| . |||.. ..||| itlivnvttelpetk--ledvk-tvkikv--eDkpeaklaehfdevadki-eevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRp |
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| Phosphatase | 28189.AA | Subfamily.DSP15.PD | 400-461 | 24 | 2.6e-06 | 17.9 | In-house | 60-121 (138) | Show / Hide |
Range on Protein: 400-461 Range on HMM: 60-121/138 Sequence Identity: 24% (15 aa) VAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPP . | |. .| . ..|..|| | || .. .|.. .. ..||.| . ||. lskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsv |
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| Phosphatase | 28189.AA | Subfamily.TPIP.PD | 398-459 | 30 | 3.1e-06 | 17.4 | In-house | 19-79 (245) | Show / Hide |
Range on Protein: 398-459 Range on HMM: 19-79/245 Sequence Identity: 30% (19 aa) ESVAKLHKVLDNFWAnPDNaRKDVIIHCHYGFNRSGFMACSYLVKRRGF-GAREALHAFRKAR | . .. | .... | |. .. |.||| | .| | . |..|.. | |.|.|. | . | eelvvftkevkewla-kdl-envvaihckGGkgrtGtivcalliaseifltaeesldyfgerr |
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| Phosphatase | 28189.AA | Subfamily.LRR-DSP.PD | 400-463 | 29 | 4.5e-06 | 17.0 | In-house | 60-122 (137) | Show / Hide |
Range on Protein: 400-463 Range on HMM: 60-122/137 Sequence Identity: 29% (18 aa) VAKLHKVLDNFWaNPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPGI . . | .. | . . |.||| | || .. .||.|.. . .||| | || iyqhfkemnafi-degrekggvlihcragvsrsatlviaylmkknslkfkealdlvikkrpriy |
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| Phosphatase | 28189.AA | Subfamily.DSP6.PD | 409-457 | 24 | 6e-06 | 16.4 | In-house | 72-120 (141) | Show / Hide |
Range on Protein: 409-457 Range on HMM: 72-120/141 Sequence Identity: 24% (12 aa) NFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK .| . .. . |..||. | || .. .||.|.. . .| . .| efidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkk |
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