• Phosphatome.Net

Gene mbre_DUSP12

mbre_DUSP12
Species: M.brevicollis
Alias: mbre_DUSP12
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP12
Protein domain

Protein domains of mbre_DUSP12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase mbre_DUSP12.AA Subfamily.DSP12.PD 1-147 38 9.3e-51 162.5 In-house 2-143 (143) Show / Hide 
Range on Protein: 1-147
Range on HMM: 2-143/143
Sequence Identity: 38% (57 aa)

MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSwywFGHRLLPSTVRrqKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.|....|||.|.|| .|...|. || ...... .....     ..  .....  |.| ..||...|.||.|.||..|||......| |.|||.||||||.
vseilpglylggleavqerellkelkithvlsvikeel---pelqkekgvks--kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSv

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMKC
|.|.||||.. .|...||....|.... . || ||..||.||||||.
tiviAYlmkkeklslekAlklvkekkkeiepNegFleQLklfekmkk
Phosphatase mbre_DUSP12.AA Subfamily.DSP19.PD 3-144 40 2.2e-38 122.1 In-house 4-138 (139) Show / Hide 
Range on Protein: 3-144
Range on HMM: 4-138/139
Sequence Identity: 40% (57 aa)

RVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWfghrllPSTVrRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATV
.| . ||.|| .  .|.  . .|..  |   |      .      |. . . ||| ..|......||.|.|||||||.|||.||.|.|||.|||||||.|
evkprlylgsqdvaadkeilkklkitHilnvavgvpnvf------pkdf-tyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasv

VMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|.||||..  |...||......|.... || ||..||. .|.
viaylmkdeelslekalekvrearpcikPneGFikqLkeyea
Phosphatase mbre_DUSP12.AA DSPc 1-145 23 5.5e-32 113.51 SMART 2-172 (172) Show / Hide 
Range on Protein: 1-145
Range on HMM: 2-172/172
Sequence Identity: 23% (41 aa)

MSRVDDGLYIGSLELLQ--DHALMGELGVSSIAGSAHRRSWYWFGHRL----------LPSTVRRQKSIL-VFD-------EEQADILSWLPEALDFIES
.|..  .||.||    .  . ... ....  .   . ...|  .. .           ..   .. ..|  . |       .....|. ..||. |||..
PSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIHD

ARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRML----KAAHR-P-ALPNPGFQQQLRLFEKM
.|.. | |.||||||.|||||...||||.  ... . |....    .   | |  .|| .|..||...|..
CRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase mbre_DUSP12.AA DSPc 55-145 32 1.4e-30 108.25 Pfam 45-151 (151) Show / Hide 
Range on Protein: 55-145
Range on HMM: 45-151/151
Sequence Identity: 32% (35 aa)

KSIL-VFD---------EEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRML----KAAHR-P-ALPNPGFQQQ
..|  | |         .....|  ..|.| |||...|.. | |.||||||.||||....||||.  ... . |....    .   | |   ||..|. |
MWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQ

LRLFEKM
|. .|..
LCEYERQ
Phosphatase mbre_DUSP12.AA Subfamily.DSP1.PD 7-144 38 2.9e-28 89.5 In-house 8-138 (139) Show / Hide 
Range on Protein: 7-144
Range on HMM: 8-138/139
Sequence Identity: 38% (53 aa)

GLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWfghrllpSTVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAY
||.|| |   ...|. ||... .   . . . ..        .. . ||| | |...|||.|.. ||.|||.|.....| |.||||||.|||||.|.|||
fLyLGsaehasnlqlLkelkitallnvsaelpnvf-------eelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlay

LMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|..  .. ..||  .|       || || .||  ||| 
LmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek
Phosphatase mbre_DUSP12.AA Family.DSP.PD 2-153 27 9e-28 88.5 In-house 108-254 (387) Show / Hide 
Range on Protein: 2-153
Range on HMM: 108-254/387
Sequence Identity: 27% (44 aa)

SRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRS---WywfghrllpstvR---RQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAG
|.. ..||.|||.  ...  . ||||. |   .. ..   .            .   .   | . | .. .. ... .|.||||..... | |.|||.||
seilphlylgsllaaknlewlkelgvtkivnltddkpqftk------------elgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaG

VSRSATVVMAYLMRNLGLNCSKAFRMLKAAHR-PALPNPGFQQQLRLFEKMKCTLDDSN
..||.|...|||| . ||. ..|..... ...  . || || .||  .||.|...  . 
kgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssev
Phosphatase mbre_DUSP12.AA Subfamily.DSP6.PD 53-145 40 9.4e-26 81.0 In-house 49-141 (141) Show / Hide 
Range on Protein: 53-145
Range on HMM: 49-141/141
Sequence Identity: 40% (38 aa)

RQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
. | | . |. .... ...|||..||. |||..  | ||| |||||| ||..||||..| |   .|. ..|. .    ||  | .||  ||..
kykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkkksnisPnfnfmgqlldfers
Phosphatase mbre_DUSP12.AA Subfamily.DSP15.PD 1-144 36 3.2e-25 79.5 In-house 2-137 (138) Show / Hide 
Range on Protein: 1-144
Range on HMM: 2-137/138
Sequence Identity: 36% (52 aa)

MSRVDDGLYIGSLELLQDHALMGELGVSSIAgSAHRRSwywfgHRLLPStvRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
|..|  |||.|...  .|.....|  .. |  | |  .     ..||.    . . | . |  . |. ... |. ||| ..| |.| |.||| ||.||| 
mnkvlpGlyvGnfrdakdkeqleenkithil-sihdsa-----kplled--ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsv

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|.|.||.|    |.  .|....|||   | || ||..||. |||
tlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefek
Phosphatase mbre_DUSP12.AA Subfamily.DSP14.PD 2-144 28 7.6e-25 78.4 In-house 3-137 (138) Show / Hide 
Range on Protein: 2-144
Range on HMM: 3-137/138
Sequence Identity: 28% (41 aa)

SRVDDGLYIGSLELLQdHALMGELGVSSIAGSAHRRSWYWFGHRLlpstvrrQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSAT
|.. . ||...   |. .. . . ... |   . . .   . .         .  | | |...|.. ... |. | ||......| . ||||||||||..
seitesLylsgaaalk-keklkkkkitlivnvttelpetkledvk-------tvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAs

VVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|.||||.   |.  .|....|.|     ||.|| .||. .|| 
lvlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidyEk
Phosphatase mbre_DUSP12.AA Subfamily.DSP8.PD 4-144 36 1.5e-24 77.4 In-house 5-140 (143) Show / Hide 
Range on Protein: 4-144
Range on HMM: 5-140/143
Sequence Identity: 36% (52 aa)

VDDGLYIGSLELLQDHALMGELGVSSIAG-SAHRRSWYwfghRLLpsTVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATV
. . ||.|| .   |. |. .||.| .   | .          ||  .  |   | | |. . ..| |...||.||. |||..| | ||| || ||||||
ilpnlylGsqkdsldeellkklgisyvlnisescpkdv----ell--kesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatv

VMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
..||.|..| ..  .|.| .|       ||  | .||  .||
aiayimktlemsldeayrfvkekrptispnlnflgqLleyek
Phosphatase mbre_DUSP12.AA Subfamily.DSP10.PD 52-144 48 2e-24 76.9 In-house 48-140 (141) Show / Hide 
Range on Protein: 52-144
Range on HMM: 48-140/141
Sequence Identity: 48% (44 aa)

RRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAhRPA-LPNPGFQQQLRLFEK
| | | | |... ..   . |||.||| ||.... | |||.||.|||||||.||.|. |.|  |.|....| . ||.  || .|  |||||   
vrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvkek-rPiisPnlnfmGqllefek
Phosphatase mbre_DUSP12.AA Subfamily.DSP3.PD 4-143 30 1.2e-23 74.4 In-house 5-146 (148) Show / Hide 
Range on Protein: 4-143
Range on HMM: 5-146/148
Sequence Identity: 30% (43 aa)

VDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSW--YWFGHRLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESARSE-DGIVYVHCQAGVSRSA
| ...|.|  .  .|.  . .||.  .  .|. ..      ..    ..  .   . | |  ..|. ..  || |||..| |. .| |.|||..|.||||
vypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsa

TVVMAYLMRNLGLNCSKAFRMLKaAHRPALPNPGFQQQLRLFE
|.|.|||| .  |.  .| .. .  .|  ||| || .||. ..
tlvlayLmirrkltlkeaiktvr-kkreilPneGflkqLleld
Phosphatase mbre_DUSP12.AA Subfamily.Slingshot.PD 55-144 40 3.5e-23 72.8 In-house 49-138 (139) Show / Hide 
Range on Protein: 55-144
Range on HMM: 49-138/139
Sequence Identity: 40% (36 aa)

KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
..| |.|||..|.|..  |. .||| |....  | |||. ||||||..|.|| |.. .|.  .|.. .|   . . || || .||..|  
lnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnkgflkqlkvyeg
Phosphatase mbre_DUSP12.AA Subfamily.LRR-DSP.PD 4-144 33 2.4e-22 70.1 In-house 5-136 (137) Show / Hide 
Range on Protein: 4-144
Range on HMM: 5-136/137
Sequence Identity: 33% (47 aa)

VDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYwfghrllPSTVRrQKSILVFDEEQADILSWLPEALDFIESARSEDGiVYVHCQAGVSRSATVV
. |.||.|..|  ...... ...|. |   |. .  |       | . .   .| . | ..|||  .. |   ||.. | . | | .||.||||||||.|
iidklylgcresamnksilkdnnvthilavadfkply-------pdlfk-yliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlv

MAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
.||||..  |.  .|. . .       ||.||..||. |||
iaylmkknslkfkealdlvikkrpriypnrgfldqlkkfek
Phosphatase mbre_DUSP12.AA Subfamily.STYXL1.PD 54-145 40 2.9e-18 57.3 In-house 52-143 (143) Show / Hide 
Range on Protein: 54-145
Range on HMM: 52-143/143
Sequence Identity: 40% (36 aa)

QKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
| | ||..||.|. | |. .|||. . |. .| |  . |.||||.|..|||| .  ..  ||.  ||  .    || .| .||. .||.   
llhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkckenvkPnrafveqlseWekq
Phosphatase mbre_DUSP12.AA Subfamily.STYX.PD 59-144 37 1.8e-17 54.4 In-house 60-145 (146) Show / Hide 
Range on Protein: 59-144
Range on HMM: 60-145/146
Sequence Identity: 37% (32 aa)

VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
| |.   .|. .||.. .||... .. | | || .||.||||..|.||.|   ||.  .||....       || || .||. .| 
vadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
Phosphatase mbre_DUSP12.AA Subfamily.PTPMT1.PD 60-129 41 2.3e-16 50.7 In-house 61-130 (146) Show / Hide 
Range on Protein: 60-129
Range on HMM: 61-130/146
Sequence Identity: 41% (28 aa)

FDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPA
|  .|  |  | |...|||. .|.   |||||.|| .||||.| .|||..  |.  .| ..||.  .   
vDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqi
Phosphatase mbre_DUSP12.AA Subfamily.Laforin.PD 69-129 38 1.8e-09 28.4 In-house 88-147 (165) Show / Hide 
Range on Protein: 69-129
Range on HMM: 88-147/165
Sequence Identity: 38% (23 aa)

SWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLkAAHRPA
||.|. .. .   .  ||||||.||| ||...|  .|.  || . .|   .|  |.||.  
enlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfl-lakrpv
Phosphatase mbre_DUSP12.AA Subfamily.CDC14.PD 76-128 30 4.6e-09 27.1 In-house 189-240 (258) Show / Hide 
Range on Protein: 76-128
Range on HMM: 189-240/258
Sequence Identity: 30% (16 aa)

DFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAhRP
|.| . . .| . |||.||. | .|.. .||... ... . .   |. | || 
kfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlria-rP
Phosphatase mbre_DUSP12.AA Subfamily.DSP11.PD 67-126 23 7e-08 23.2 In-house 63-122 (141) Show / Hide 
Range on Protein: 67-126
Range on HMM: 63-122/141
Sequence Identity: 23% (14 aa)

ILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAH
. ..  .  .|.|.   .| .. |||  || |.  ..  ||.   |.. ..| .... | 
vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeear
Phosphatase mbre_DUSP12.AA Subfamily.N_Nematode_1.PD 74-111 38 3.6e-07 20.6 In-house 185-223 (265) Show / Hide 
Range on Protein: 74-111
Range on HMM: 185-223/265
Sequence Identity: 38% (15 aa)

ALDFIESARSEDGIVYVHCQAGVSRSATVVMA-YLMRNL
||...|..|.. | . ||| ||. |. |.|.  |.. .|
alelleavrgskgPivvhCsaGiGrtGtivaieyildkl
Phosphatase mbre_DUSP12.AA Subfamily.PTPDC1.PD 81-125 29 7.4e-07 19.7 In-house 163-206 (229) Show / Hide 
Range on Protein: 81-125
Range on HMM: 163-206/229
Sequence Identity: 29% (13 aa)

ARsEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAA
|  |.| . ||| ||  |   .. .||. .  |. ..| ..... 
al-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrsk
Phosphatase mbre_DUSP12.AA Subfamily.PTEN.PD 83-113 34 8.1e-07 19.5 In-house 92-122 (305) Show / Hide 
Range on Protein: 83-113
Range on HMM: 92-122/305
Sequence Identity: 34% (10 aa)

SEDGIVYVHCQAGVSRSATVVMAYLMRNLGL
... .| |||.||  |. ....|||. ..  
dksnVvavHCkaGkGRtGvmicayLlksgik
Phosphatase mbre_DUSP12.AA Subfamily.DSP23.PD 76-119 34 1e-06 19.7 In-house 57-100 (128) Show / Hide 
Range on Protein: 76-119
Range on HMM: 57-100/128
Sequence Identity: 34% (14 aa)

DFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAF
.| |  ... | |||  |. |. |..  ||... ||  ..|   
riveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddai
Phosphatase mbre_DUSP12.AA Subfamily.R_Nematode_3.PD 73-107 42 1.1e-06 19.0 In-house 186-220 (267) Show / Hide 
Range on Protein: 73-107
Range on HMM: 186-220/267
Sequence Identity: 42% (15 aa)

EALDFIESARSEDGIVYVHCQAGVSRSATVVMAYL
|||. |. ...    | ||| .|.||||| ... |
ealelikfveksktpvvVHCsdGisRsatlaaiel
Sequence
Name Sequence Type Origin Length Description Download
mbre_DUSP12.AA Protein None 356 None Fasta, JSON
mbre_DUSP12.NA RNA None 1068 None Fasta, JSON
mbre_DUSP12.AA.PD_1-150 Protein Phosphatase Domain None 150 None Fasta, JSON