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Gene mbre_DUSP19B

mbre_DUSP19B
Species: M.brevicollis
Alias: mbre_DUSP19B
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Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP19
Protein domain

Protein domains of mbre_DUSP19B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase mbre_DUSP19B.AA Subfamily.DSP12.PD 1-88 46 1.3e-39 126.9 In-house 51-138 (143) Show / Hide 
Range on Protein: 1-88
Range on HMM: 51-138/143
Sequence Identity: 46% (41 aa)

KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLY
|.| ..||...|.||.|.||..|||......| |.|||.||||||.|.|.||||.. .|...||....|.... . || ||..||.|.
kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiepNegFleQLklf
Phosphatase mbre_DUSP19B.AA Subfamily.DSP19.PD 1-88 53 7.1e-38 120.9 In-house 49-136 (139) Show / Hide 
Range on Protein: 1-88
Range on HMM: 49-136/139
Sequence Identity: 53% (47 aa)

KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLY
||| ..|......||.|.|||||||.|||.||.|.|||.|||||||.||.||||..  |...||......|.... || ||..||. |
ksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpcikPneGFikqLkey
Phosphatase mbre_DUSP19B.AA Subfamily.DSP1.PD 1-85 49 7.4e-28 88.7 In-house 49-133 (139) Show / Hide 
Range on Protein: 1-85
Range on HMM: 49-133/139
Sequence Identity: 49% (42 aa)

KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQL
||| | |...|||.|.. ||.|||.|.....| |.||||||.|||||.|.||||..  .. ..||  .|       || || .||
ksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrsiisPnfgfvgqL
Phosphatase mbre_DUSP19B.AA DSPc 1-88 33 9.4e-28 98.43 Pfam 45-148 (151) Show / Hide 
Range on Protein: 1-88
Range on HMM: 45-148/151
Sequence Identity: 33% (35 aa)

KSIL-VFD---------EEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRML----KAAHR-P-ALPNPGFQQQ
..|  | |         .....|  ..|.| |||...|.. | |.||||||.||||....||||.  ... . |....    .   | |   ||..|. |
MWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQ

LRLY
|. |
LCEY
Phosphatase mbre_DUSP19B.AA Subfamily.DSP6.PD 2-86 42 4.1e-25 79.4 In-house 52-136 (141) Show / Hide 
Range on Protein: 2-86
Range on HMM: 52-136/141
Sequence Identity: 42% (35 aa)

SILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLR
| . |. .... ...|||..||. |||..  | ||| |||||| ||..||||..| |   .|. ..|. .    ||  | .||  
qipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkkksnisPnfnfmgqll
Phosphatase mbre_DUSP19B.AA Subfamily.DSP14.PD 3-88 40 8.3e-25 78.8 In-house 50-135 (138) Show / Hide 
Range on Protein: 3-88
Range on HMM: 50-135/138
Sequence Identity: 40% (35 aa)

ILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLY
| | |...|.. ... |. | ||......| . ||| |||||||..|.||||.   |.  .|....|.|     ||.|| .||. |
ikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidy
Phosphatase mbre_DUSP19B.AA Subfamily.DSP8.PD 4-85 44 2.2e-24 77.4 In-house 54-135 (143) Show / Hide 
Range on Protein: 4-85
Range on HMM: 54-135/143
Sequence Identity: 44% (36 aa)

LVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQL
| |. . ..| |...||.||. |||..| | ||| || ||||||..||.|..| ..  .|.| .|       ||  | .|| 
PvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqL
Phosphatase mbre_DUSP19B.AA Family.DSP.PD 5-88 34 2.5e-24 77.6 In-house 159-243 (387) Show / Hide 
Range on Protein: 5-88
Range on HMM: 159-243/387
Sequence Identity: 34% (29 aa)

VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHR-PALPNPGFQQQLRLY
. | .. .. ... .|.||||..... | |.|||.||..||.|...|||| . ||. ..|..... ...  . || || .||  .
idDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdl
Phosphatase mbre_DUSP19B.AA Subfamily.DSP10.PD 2-85 46 3.4e-24 76.7 In-house 52-135 (141) Show / Hide 
Range on Protein: 2-85
Range on HMM: 52-135/141
Sequence Identity: 46% (39 aa)

SILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAhRPA-LPNPGFQQQL
| | |... ..   . |||.||| ||.... | |||.||.|||||||.||.|. |.|  |.|....| . ||.  || .|  || 
ripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvkek-rPiisPnlnfmGql
Phosphatase mbre_DUSP19B.AA Subfamily.Slingshot.PD 2-88 41 4.6e-24 76.1 In-house 50-136 (139) Show / Hide 
Range on Protein: 2-88
Range on HMM: 50-136/139
Sequence Identity: 41% (36 aa)

SILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLY
.| |.|||..|.|..  |. .||| |....  | |||. ||||||..|.|| |.. .|.  .|.. .|   . . || || .||. |
nirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnkgflkqlkvy
Phosphatase mbre_DUSP19B.AA Subfamily.DSP15.PD 2-87 42 2.4e-23 74.0 In-house 49-134 (138) Show / Hide 
Range on Protein: 2-87
Range on HMM: 49-134/138
Sequence Identity: 42% (36 aa)

SILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRL
| . |  . |. ... |. ||| ..| |.| |.||| ||.||| |.|.||.|    |.  .|....|||   | || ||..||.  
cikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqe
Phosphatase mbre_DUSP19B.AA Subfamily.DSP3.PD 5-86 43 2.3e-22 70.8 In-house 62-143 (148) Show / Hide 
Range on Protein: 5-86
Range on HMM: 62-143/148
Sequence Identity: 43% (36 aa)

VFDEEQADILSWLPEALDFIESARSE-DGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKaAHRPALPNPGFQQQLR
| |  ..|. ..  || |||..| |. .| |.|||..|.|||||.|.|||| .  |.  .| .. .  .|  ||| || .||.
vsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvr-kkreilPneGflkqLl
Phosphatase mbre_DUSP19B.AA Subfamily.LRR-DSP.PD 3-88 39 1.4e-20 64.8 In-house 50-134 (137) Show / Hide 
Range on Protein: 3-88
Range on HMM: 50-134/137
Sequence Identity: 39% (34 aa)

ILVFDEEQADILSWLPEALDFIESARSEDGiVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLY
| . | ..|||  .. |   ||.. | . | | .||.||||||||.|.||||..  |.  .|. . .       ||.||..||. .
idiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkknslkfkealdlvikkrpriypnrgfldqlkkf
Phosphatase mbre_DUSP19B.AA Subfamily.STYXL1.PD 3-86 40 3.8e-18 57.4 In-house 55-138 (143) Show / Hide 
Range on Protein: 3-86
Range on HMM: 55-138/143
Sequence Identity: 40% (34 aa)

ILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLR
| | ||..||.|. | |. .|||. . |. .| |  . |.||||.|..|||| .  ..  ||.  ||  .    || .| .||.
iavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkckenvkPnrafveqls
Phosphatase mbre_DUSP19B.AA Subfamily.STYX.PD 5-88 38 3.9e-18 57.0 In-house 60-143 (146) Show / Hide 
Range on Protein: 5-88
Range on HMM: 60-143/146
Sequence Identity: 38% (32 aa)

VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLY
| |.   .|. .||.. .||... .. | | || .||.||||..|.||.|   ||.  .||....       || || .||. |
vadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey
Phosphatase mbre_DUSP19B.AA Subfamily.PTPMT1.PD 7-72 43 2.3e-17 54.5 In-house 62-127 (146) Show / Hide 
Range on Protein: 7-72
Range on HMM: 62-127/146
Sequence Identity: 43% (28 aa)

DEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAH
|  .|  |  | |...|||. .|.   |||||.|| .||||.| .|||..  |.  .| ..||.  
DfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkR
Phosphatase mbre_DUSP19B.AA Subfamily.Laforin.PD 15-75 38 1.2e-10 32.7 In-house 88-147 (165) Show / Hide 
Range on Protein: 15-75
Range on HMM: 88-147/165
Sequence Identity: 38% (23 aa)

SWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLkAAHRPA
||.|. .. .   .  ||||||.||| ||...|  .|.  || . .|   .|  |.||.  
enlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfl-lakrpv
Phosphatase mbre_DUSP19B.AA Subfamily.CDC14.PD 22-74 30 4.1e-10 31.1 In-house 189-240 (258) Show / Hide 
Range on Protein: 22-74
Range on HMM: 189-240/258
Sequence Identity: 30% (16 aa)

DFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAhRP
|.| . . .| . |||.||. | .|.. .||... ... . .   |. | || 
kfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlria-rP
Phosphatase mbre_DUSP19B.AA Subfamily.DSP11.PD 13-71 23 5.1e-09 27.4 In-house 63-121 (141) Show / Hide 
Range on Protein: 13-71
Range on HMM: 63-121/141
Sequence Identity: 23% (14 aa)

ILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAA
. ..  .  .|.|.   .| .. |||  || |.  ..  ||.   |.. ..| .... |
vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeea
Phosphatase mbre_DUSP19B.AA DSPc 1-88 21 2.3e-08 35.04 SMART 15-169 (172) Show / Hide 
Range on Protein: 1-88
Range on HMM: 15-169/172
Sequence Identity: 21% (33 aa)

KSIL------------------------------------------------------VFD-------EEQADILSWLPEALDFIESARSEDGIVYVHCQ
....                                                      . |       .....|. ..||. |||...|.. | |.||||
PHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIHDCRQKGGKVLVHCQ

AGVSRSATVVMAYLMRNLGLNCSKAFRML----KAAHR-P-ALPNPGFQQQLRLY
||.|||||...||||.  ... . |....    .   | |  .|| .|..||...
AGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEW
Phosphatase mbre_DUSP19B.AA Subfamily.N_Nematode_1.PD 20-57 38 3.4e-08 24.4 In-house 185-223 (265) Show / Hide 
Range on Protein: 20-57
Range on HMM: 185-223/265
Sequence Identity: 38% (15 aa)

ALDFIESARSEDGIVYVHCQAGVSRSATVVMA-YLMRNL
||...|..|.. | . ||| ||. |. |.|.  |.. .|
alelleavrgskgPivvhCsaGiGrtGtivaieyildkl
Phosphatase mbre_DUSP19B.AA Subfamily.PTPDC1.PD 26-70 28 7.9e-08 23.3 In-house 162-205 (229) Show / Hide 
Range on Protein: 26-70
Range on HMM: 162-205/229
Sequence Identity: 28% (13 aa)

SARsEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKA
.|  |.| . ||| ||  |   .. .||. .  |. ..| .....
fal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrs
Phosphatase mbre_DUSP19B.AA Subfamily.DSP23.PD 21-65 31 9.5e-08 23.5 In-house 56-100 (128) Show / Hide 
Range on Protein: 21-65
Range on HMM: 56-100/128
Sequence Identity: 31% (14 aa)

LDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAF
.  .| |  ... | |||  |. |. |..  ||... ||  ..| 
vriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddai
Phosphatase mbre_DUSP19B.AA Subfamily.R_Nematode_3.PD 19-53 42 1.1e-07 22.8 In-house 186-220 (267) Show / Hide 
Range on Protein: 19-53
Range on HMM: 186-220/267
Sequence Identity: 42% (15 aa)

EALDFIESARSEDGIVYVHCQAGVSRSATVVMAYL
|||. |. ...    | ||| .|.||||| ... |
ealelikfveksktpvvVHCsdGisRsatlaaiel
Phosphatase mbre_DUSP19B.AA Subfamily.PTEN.PD 29-59 34 1.1e-07 22.8 In-house 92-122 (305) Show / Hide 
Range on Protein: 29-59
Range on HMM: 92-122/305
Sequence Identity: 34% (10 aa)

SEDGIVYVHCQAGVSRSATVVMAYLMRNLGL
... .| |||.||  |. ....|||. ..  
dksnVvavHCkaGkGRtGvmicayLlksgik
Phosphatase mbre_DUSP19B.AA Subfamily.PRL.PD 28-77 26 2.1e-06 18.9 In-house 78-126 (140) Show / Hide 
Range on Protein: 28-77
Range on HMM: 78-126/140
Sequence Identity: 26% (13 aa)

RSEDGIVYVHCQAGVSRSATVVMAYLMrNLGLNCSKAFRMLKAAHRPALP
.... .| ||| ||. |.  .|   |. . |..  .|  ...   | |. 
eepkstvavhcvaGlGraPvlvalali-eaGmkyedavefirekrrgain
Phosphatase mbre_DUSP19B.AA Subfamily.RNGTT.PD 29-76 25 3e-06 18.3 In-house 77-124 (140) Show / Hide 
Range on Protein: 29-76
Range on HMM: 77-124/140
Sequence Identity: 25% (12 aa)

SEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPAL
. | .. |||  |  |   ...|||. ..  . ..|  ..  |  | .
kPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarppGi
Phosphatase mbre_DUSP19B.AA Subfamily.TPIP.PD 19-55 27 9.5e-06 16.7 In-house 27-61 (245) Show / Hide 
Range on Protein: 19-55
Range on HMM: 27-61/245
Sequence Identity: 27% (10 aa)

EALDFIEsaRSEDGIVYVHCQAGVSRSATVVMAYLMR
|. ....  . .. .| .||. |  |  |.| |.|. 
evkewla--kdlenvvaihckGGkgrtGtivcallia
Sequence
Name Sequence Type Origin Length Description Download
mbre_DUSP19B.AA Protein None 88 None Fasta, JSON
mbre_DUSP19B.NA RNA None 264 None Fasta, JSON
mbre_DUSP19B.AA.PD_1-88 Protein Phosphatase Domain None 88 None Fasta, JSON