Gene mbre_DUSP19A
mbre_DUSP19A
Species: M.brevicollis
Alias: mbre_DUSP19A
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mbre_DUSP19A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | mbre_DUSP19A.AA | Family.DSP.PD | 33-162 | 25 | 1.2e-20 | 64.8 | In-house | 97-213 (387) | Show / Hide |
Range on Protein: 33-162 Range on HMM: 97-213/387 Sequence Identity: 25% (32 aa) RATETVVRSTLSFVVDqrqdlnvgyatdRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFP-EDLHYLKLELLDVPEASLLTILQPALDFVRNALDi | | . | . . .. || . | .. | .||||...|. . | | .. .||.. . | .. .| ... |.||. .. | . dhfervengkpseilp------------hlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegnd- dPANRVFIHCNAGVSRSASVAMAYLITDHES ..|..||.||..||... .|||. . -skgvVlVHCkaGkgRsgtliiaYlmksegl |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP19.PD | 55-174 | 50 | 1e-45 | 145.6 | In-house | 2-119 (139) | Show / Hide |
Range on Protein: 55-174 Range on HMM: 2-119/139 Sequence Identity: 50% (61 aa) VGYATDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIDpaNRVFIHCNAGVSRSASVAMA |. ...|...|||||||.. .|..|..||.|||.||.|..||.|..|...|.||.||..||..|. ||||...|.. | .||..||||||||||||..| vaevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskd--grvlvHCnAGvSRsasvvia YLITDHESDLERERERERED ||..|.|..||.. |. ||. ylmkdeelslekalekvrea |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP1.PD | 61-164 | 31 | 7.1e-23 | 71.8 | In-house | 8-109 (139) | Show / Hide |
Range on Protein: 61-164 Range on HMM: 8-109/139 Sequence Identity: 31% (32 aa) RVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYLITDH . .||. |... .|..|..|..||| .| |.| ..| .... | ..| ... ...|.||. .. . ||..||.||.||||...|||.. .. fLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkk--gGrvlvhCqaGisrsativlayLmkek ESDL | kvrl |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.Slingshot.PD | 60-168 | 35 | 2.4e-22 | 69.8 | In-house | 7-113 (139) | Show / Hide |
Range on Protein: 60-168 Range on HMM: 7-113/139 Sequence Identity: 35% (38 aa) DRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIDpaNRVFIHCNAGVSRSASVAMAYLITD | . .||. |. | . ||...||| | ||||...||.. . | .|..||. . . .|...| . . .|..|| |||||||. .|| . . dhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekg--skvlvhckmGvsrsastviayamke HESDLERER .| .||. yelsleeal |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP3.PD | 59-165 | 33 | 3e-22 | 69.7 | In-house | 6-120 (148) | Show / Hide |
Range on Protein: 59-165 Range on HMM: 6-120/148 Sequence Identity: 33% (39 aa) TDRVLFGSQDVAASRFTLDQLGVTHVLNVGVG--------IPCFFPE-DLHYLKLELLDVPEASLLTILQPALDFVRNALDIdPANRVFIHCNAGVSRSA ...| | ..|| . | .||.||||| | . |. . ...|| .| ||||. | . . | ||. .||. .|..||..|.|||| ypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsq-kngkvlvhcvvGisRsa SVAMAYLITDHESDLE ...|||. .. .|. tlvlayLmirrkltlk |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP10.PD | 62-160 | 37 | 4.1e-20 | 62.7 | In-house | 9-107 (141) | Show / Hide |
Range on Protein: 62-160 Range on HMM: 9-107/141 Sequence Identity: 37% (36 aa) VLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPE--DLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYLITD .|.|.. ||.. .||.||...|||| .|.|| | ...| .... | .. | . .. ||.|. .| .||..||.||.|||||..||.. lllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkr--gsrvlvhchaGisrsatvviayvmkh H l |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP12.PD | 60-165 | 32 | 1.1e-18 | 58.3 | In-house | 7-112 (143) | Show / Hide |
Range on Protein: 60-165 Range on HMM: 7-112/143 Sequence Identity: 32% (35 aa) DRVLFGSQDVAASRFTLDQLGVTHVLNVGVGI-PCFFPE-DLHYLKLELLDVPEASLLTILQPALDFVRNALdiDPANRVFIHCNAGVSRSASVAMAYLI .....|. . ...| .|..| .|||| | | . | . ... ...|| ||. ||. |. |..|. ..| . . |..||.||||||... .|||. pglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieegl--ekegavlvHClagvSRSvtiviAYlm TDHESDLE .. .|| kkeklsle |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP14.PD | 62-164 | 30 | 3.1e-18 | 56.7 | In-house | 8-108 (138) | Show / Hide |
Range on Protein: 62-164 Range on HMM: 8-108/138 Sequence Identity: 30% (31 aa) VLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYLITDHE |. | .| .. .|.. ..|...|| . .| ||....|... | |||.| . .... | .... . ....|| ||||||||...|||. .. sLylsgaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkk--kgGktlvhCvaGvsRsAslvlaylmkyek SDL | lsL |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP6.PD | 62-164 | 31 | 9.3e-18 | 54.8 | In-house | 9-111 (141) | Show / Hide |
Range on Protein: 62-164 Range on HMM: 9-111/141 Sequence Identity: 31% (33 aa) VLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPE--DLHYLKLELLDVPEASLLTILQPALDFVRNALDIDpaNRVFIHCNAGVSRSASVAMAYLITD . .||.. |. . .|..|.. .|||| .| .| | .|.|... . |. .. | . . |..|. .| . . |..|| |||||| .|..|||. lylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskk--skvlvhclaGvsrsvtvtlaylmkk HESDL .. | lalsl |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP8.PD | 59-159 | 31 | 1.2e-17 | 54.8 | In-house | 6-106 (143) | Show / Hide |
Range on Protein: 59-159 Range on HMM: 6-106/143 Sequence Identity: 31% (32 aa) TDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPC--FFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYL .. . .||| .. .. .|..||...|||. | . .. ..|.. . | | || ... ||.|. | .|..|| || ||||.||.||. lpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsa--ngkvlvhclaGisrsatvaiayi ITD . mkt |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.LRR-DSP.PD | 60-160 | 31 | 2e-17 | 53.9 | In-house | 7-103 (137) | Show / Hide |
Range on Protein: 60-160 Range on HMM: 7-103/137 Sequence Identity: 31% (32 aa) DRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPcFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDidpANRVFIHCNAGVSRSASVAMAYLITD |.. .|... | . | ...|||.| |. | ..|. ..|| ... ||.|| . .. |. . . |.||| |||||||....|||. dklylgcresamnksilkdnnvthilavadfkp-lypdlfkyliidiedvdeadiyqhfkemnafidegre---kggvlihcragvsrsatlviaylmkk H . n |
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| Phosphatase | mbre_DUSP19A.AA | DSPc | 62-157 | 24 | 9.1e-15 | 53.28 | Pfam | 1-108 (151) | Show / Hide |
Range on Protein: 62-157 Range on HMM: 1-108/151 Sequence Identity: 24% (27 aa) VLFGSQDVAA-SRFTLDQLGVTHVLNVGVGIPC---FFPEDLHYLKLE-LLD---------VPEASLLTILQPALDFVRNALDIDPANRVFIHCNAGVSR . .||. .. . |...|.|||.|.. .| . ... ||... ..| ... . .. | ||.... . .| .||.||.|| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDC--RQKGGKVLVHCQAGISR SASVAMAYLI ||....|||. SACLCIAYLM |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.DSP15.PD | 71-160 | 26 | 1.6e-14 | 44.6 | In-house | 18-104 (138) | Show / Hide |
Range on Protein: 71-160 Range on HMM: 18-104/138 Sequence Identity: 26% (23 aa) ASRFTLDQLGVTHVLNVGVGIPCFFPEdLHYLKLELLDVPEASLLTILQPALDFVRNAlDIDPANrVFIHCNAGVSRSASVAMAYLITDH . |.. .||.| . .... ..|| .. | |. | . .. . ||. .. .. | |..|| ||.||| ....||..| kdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkc-rleggn-vlvhclaGisrsvtlvvayimtvt |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.PTPMT1.PD | 99-164 | 28 | 1.2e-11 | 35.2 | In-house | 53-116 (146) | Show / Hide |
Range on Protein: 99-164 Range on HMM: 53-116/146 Sequence Identity: 28% (18 aa) LHYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYLITDHESDL ...|.| |. ||. | |. ...|. . . ..|..|| || .|||... .||.. .. veqlqlatvDfteapslekleegvefiekvas--kgssvYvHCkAGrtRsatlvacylmkkkklsp |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.STYXL1.PD | 79-165 | 26 | 3.2e-11 | 34.2 | In-house | 27-114 (143) | Show / Hide |
Range on Protein: 79-165 Range on HMM: 27-114/143 Sequence Identity: 26% (24 aa) LGVTHVLNVGVGIPCFF---PEDLHYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYLITDHESDLE | | ..|| .. .. . |.... |..|| ||. |. . .|. . . |.. | |.||||.|..|||. .. |. lkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkk--egevvlvfsnkGisrsaaviiaylmyskkitlk |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.STYX.PD | 76-158 | 28 | 7.9e-11 | 32.6 | In-house | 25-110 (146) | Show / Hide |
Range on Protein: 76-158 Range on HMM: 25-110/146 Sequence Identity: 28% (25 aa) LDQLGVTHVLNVGVGI-----PCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYLIT | . |.||.. . | ||....|| |.. | . .. | . .|. ..|. .|..| |||.||||.. .||.. lkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqk--ggkvlvhgnagisrsaalviayime |
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.PTEN.PD | 114-165 | 29 | 3.9e-08 | 23.5 | In-house | 74-125 (305) | Show / Hide |
Range on Protein: 114-165 Range on HMM: 74-125/305 Sequence Identity: 29% (15 aa) LLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASVAMAYLITDHESDLE | .|.. . | . |. | | | .|| || |. . .|||.. . . tleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksa |
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| Phosphatase | mbre_DUSP19A.AA | DSPc | 59-175 | 16 | 8.3e-07 | 17.85 | SMART | 6-172 (172) | Show / Hide |
Range on Protein: 59-175
Range on HMM: 6-172/172
Sequence Identity: 16% (28 aa)
TDRVLFGSQDVAA--SRFTLDQLGVTHVLNVGVGIPC-----------------FFPEDLHYLKLE-LLD-------VPEASLLTILQPALDFVRNALDI
| .. .||. .. . |.....|||.||. ..| .. . .|. . . | ... .. . . ||. .. .
TPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIHDC--R
DPANRVFIHCNAGVSRSASVAMAYLITDHESD-------L-----ERER-E--RER----------EDL
.|..|| ||.||||....|||. . . . . | . .. |.
QKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
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| Phosphatase | mbre_DUSP19A.AA | Subfamily.Laforin.PD | 97-157 | 31 | 8.9e-07 | 19.3 | In-house | 69-127 (165) | Show / Hide |
Range on Protein: 97-157 Range on HMM: 69-127/165 Sequence Identity: 31% (19 aa) EDLHYLKLELLDVPEASLLTILQPALDFVRNALdiDPANRVFIHCNAGVSRSASVAMAYLI | | |. | . |. | . | |. .. | . .|..|||||| ||... .| eglayiwlptedlstesrvenlpqavyllhall--ekghivyvhcnagvgrstaivcgflq |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| mbre_DUSP19A.AA | Protein | None | 177 | None | Fasta, JSON |
| mbre_DUSP19A.NA | RNA | None | 531 | None | Fasta, JSON |
| mbre_DUSP19A.AA.PD_59-175 | Protein Phosphatase Domain | None | 117 | None | Fasta, JSON |