Gene mbre_MKP_s3
mbre_MKP_s3
Species: M.brevicollis
Alias: mbre_MKP_s3
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mbre_MKP_s3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | mbre_MKP_s3.AA | DSPc | 66-205 | 25 | 1.1e-33 | 119.15 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 66-205 Range on HMM: 1-172/172 Sequence Identity: 25% (44 aa) FPSEIWPAFLFLGNKHHAL--DWSVVHDMGLTHIVNCSKEHPNAFADR----------------GIRYFNVR-VAD--------EKFALSCPFETIPTST |||| | |.||.. |.. . . ||..|...| |..| ...|... . | .. ..| |. GPSEITPH-LYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFI DEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALV-----KDKR-QGVRPNHGFLKQLADWEQR ......||..|||| .|.||| . . |||.... .|...| ..| |..| ....|| .|..|| .||.. HDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP1.PD | 67-204 | 40 | 8.2e-38 | 120.1 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 67-204 Range on HMM: 2-138/139 Sequence Identity: 40% (56 aa) PSEIWpAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRgIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLA |.|| ||.|| ..|| . ........|...|.|.| ||.|.. .| .. | |.| .|. ||.. |.||..||| |||| .|.|||.. ||| pveil-dfLyLGsaehasnlqlLkelkitallnvsaelpnvfeel-fkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativla YLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ ||...|. .|.|| ||..|. . || ||..|| .|. yLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP14.PD | 74-205 | 39 | 2.8e-34 | 108.7 | In-house | 8-138 (138) | Show / Hide |
Range on Protein: 74-205 Range on HMM: 8-138/138 Sequence Identity: 39% (52 aa) FLFLGnKHHALDWSVVHDMGLTHIVNCSKEHPNAFaDRGIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKR |.|. ||. .... ..|.||| . | |. ..... ...|.|.. |. |... .|||..||..||||..||||| . |||||.. ... sLyls-gaaalkkeklkkkkitlivnvttelpetk-ledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyek KSLREAAALVKDKRQGVRPNHGFLKQLADWEQR ||||| |||..|. .||| || ||| |.|.. lsLreayklvksaRpiirPnvGFwkqlidyEkk |
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| Phosphatase | mbre_MKP_s3.AA | DSPc | 75-205 | 29 | 8.9e-34 | 119.37 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 75-205 Range on HMM: 1-151/151 Sequence Identity: 29% (44 aa) LFLGNKHHAL-DWSVVHDMGLTHIVNCSKEHPN--AFADRGIRYFNVR-VAD----------EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRST |.||.. |.. | | ||..||..| || .... ...|... | | . ..| |. . | ....||..||||..|.||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA ACVLAYLIRTKRKSLREAAALV-----KDKR-QGVRPNHGFLKQLADWEQR . ..|||..... |..|| ..| |..| ....|| .|..|| ..|.. CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.Slingshot.PD | 68-203 | 37 | 1.1e-31 | 100.0 | In-house | 3-137 (139) | Show / Hide |
Range on Protein: 68-203 Range on HMM: 3-137/139 Sequence Identity: 37% (51 aa) SEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRgIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAY |.|. .|.|| . | .. ....|...|.| .|| | |... ..|.|.|| ||. | ... . ...|..| ..||||||||||.. |.|| skifd-hlylGsewnasnleelkengveyilnvtkeidnffpek-fkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviay LIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWE ... . || || . ||..|. ..||.|||||| .| amkeyelsleealeyvkerrsiikpnkgflkqlkvye |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP6.PD | 67-204 | 33 | 6.8e-31 | 97.4 | In-house | 2-140 (141) | Show / Hide |
Range on Protein: 67-204 Range on HMM: 2-140/141 Sequence Identity: 33% (47 aa) PSEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRG-IRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVL | || | .|.||....| . |...... ...| ... ||.|.. | ..| .. . |. |. | . || . . .|||| ||||| . .| pveilp-llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtl AYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ |||.... || .| .|||.|. . || |..|| |.|. aylmkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP3.PD | 69-204 | 34 | 1.2e-30 | 96.9 | In-house | 4-147 (148) | Show / Hide |
Range on Protein: 69-204 Range on HMM: 4-147/148 Sequence Identity: 34% (50 aa) EIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKE--------HPNAFADRGIRYFNVRVADE-KFALSCPFETIPTSTDE-VKAQGGRCLVHCTMGVSR |..| ...|... | | . .. .|.||..|.... ..... | .|.| | | | .| || ||. || .. ..|. ||||..|.|| evypk-vyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisR STACVLAYLIRTKRKSLREAAALVKDKRQgVRPNHGFLKQLADWEQ |...|||||. ... .|.|| |..||. . ||.||||||.. .. satlvlayLmirrkltlkeaiktvrkkre-ilPneGflkqLlelde |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP10.PD | 73-204 | 36 | 3.5e-30 | 95.2 | In-house | 7-140 (141) | Show / Hide |
Range on Protein: 73-204 Range on HMM: 7-140/141 Sequence Identity: 36% (48 aa) AFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIR-YFNVRVADE-KFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRT .||.|||.. | | .... .|.....| .. || | ..|. | .. | |. | |. || .|.. .|.| ||||. |.|||..|.||... . pflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkh KRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ . ||.|| .||.|| . || .|. || ..|. lslslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP19.PD | 74-204 | 33 | 9.6e-30 | 93.8 | In-house | 8-138 (139) | Show / Hide |
Range on Protein: 74-204 Range on HMM: 8-138/139 Sequence Identity: 33% (44 aa) FLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRgIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKR .|.|| . | | .... ..|||.| . . ||.|.. ..| .. . |.. | .... .|.. ..|| |||| |||||.. |.|||..... rlylgsqdvaadkeilkklkitHilnvavgvpnvfpkd-ftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdee KSLREAAALVKDKRQGVRPNHGFLKQLADWEQ .||..| |...|. ..||.||.||| ..|. lslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | mbre_MKP_s3.AA | Family.DSP.PD | 66-210 | 33 | 1.2e-29 | 94.2 | In-house | 106-251 (387) | Show / Hide |
Range on Protein: 66-210 Range on HMM: 106-251/387 Sequence Identity: 33% (50 aa) FPSEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVADE---KFALsCpFETIPTSTDEVKAQGGRCLVHCTMGVSRSTAC ||||.| .|.||. ..| . ... | |.|||.....|. . ||.| .. . | .... . || . ..|.. ..|. ||||..|..||. . kpseilp-hlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplen-l-fekaidfieegndskgvVlVHCkaGkgRsgtl VLAYLIRTKRKSLREAAALVKDKRQ-GVRPNHGFLKQLADWEQRELGSR |||. .. .| || ..|..||. ..|| |||||| |.|.. | . iiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvs |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP12.PD | 75-204 | 31 | 2.1e-26 | 83.2 | In-house | 9-140 (143) | Show / Hide |
Range on Protein: 75-204 Range on HMM: 9-140/143 Sequence Identity: 31% (42 aa) LFLGNKHHALDWSVVHDMGLTHIVNCSKEH-PNAFADRGIRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKR |.||. ... . . ... .||.. ||. |. ...| . .. ..|| . | .... . .| ...| ||||..||||| . |.|||..... lylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkek KSLREAAALVKDKRQGVRPNHGFLKQLADWEQ ||..| |||.|.. ..||.|||.|| .|. lslekAlklvkekkkeiepNegFleQLklfek |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP8.PD | 73-204 | 31 | 1.8e-25 | 80.1 | In-house | 7-140 (143) | Show / Hide |
Range on Protein: 73-204 Range on HMM: 7-140/143 Sequence Identity: 31% (42 aa) AFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPN-AFADRGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRT .|.|| ....|| ......|.....| |.. | . |.. . | |. |. |.. | .... |..|||| | |||....||...| . pnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimkt KRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ || || ||.||. . || || || ..|. lemsldeayrfvkekrptispnlnflgqLleyek |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.STYXL1.PD | 66-204 | 29 | 2.5e-24 | 76.6 | In-house | 1-142 (143) | Show / Hide |
Range on Protein: 66-204 Range on HMM: 1-142/143 Sequence Identity: 29% (41 aa) FPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAF-ADRG-IRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTAC .|.|. | .|.||| ..| . .. .|. . || |.. . . .. . . ....| ||. | | .. . .. | .| ||. |.|||.| .. yPvevlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaav VLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ |||. |. .|..| . .|. .. |.||..|..|| .||. iiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.LRR-DSP.PD | 67-204 | 32 | 2.8e-24 | 76.0 | In-house | 2-136 (137) | Show / Hide |
Range on Protein: 67-204 Range on HMM: 2-136/137 Sequence Identity: 32% (45 aa) PSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPnaFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGrCLVHCTMGVSRSTACVLA |..| . |.|| .. | . |...| ..|||. .. .| . ..|. . . | ... .. |. . . || . .|| |.|||||||.. |.||| pdliidk-lylgcresamnksilkdnnvthilavadfkp--lypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlvia YLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ .. .. ..|| ||..|| ..||.|||.|| .|. ylmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP15.PD | 75-204 | 31 | 3.2e-20 | 63.0 | In-house | 9-137 (138) | Show / Hide |
Range on Protein: 75-204 Range on HMM: 9-137/138 Sequence Identity: 31% (41 aa) LFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADrgIRYFNVRVADE-KFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRK |..|| . | | . ... .|||. . . | |.| ...|| . || |. ... .|| .|||| |.|||.. |||.. | lyvGnfrdakdkeqleenkithilsihdsakplled--ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtel SLREAAALVKDKRQGVRPNHGFLKQLADWEQ ..| || | || || .|| ..|. swedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.STYX.PD | 70-203 | 34 | 1.7e-18 | 57.4 | In-house | 5-144 (146) | Show / Hide |
Range on Protein: 70-203 Range on HMM: 5-144/146 Sequence Identity: 34% (47 aa) IWPAfLFLGNKHHALD--WSVVHDMGLTHIVNCSKEHPNAFA----DRGIRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTAC | | |||| |. |... |.|||| .. .. . .||. . |||. . . |. . |. .||. ||||.|||.| |.| ilpg-lflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal VLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWE |.. | ||| | |...| . ||.|| .|| ..| viayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.PTPMT1.PD | 90-202 | 23 | 3.1e-12 | 37.0 | In-house | 34-143 (146) | Show / Hide |
Range on Protein: 90-202 Range on HMM: 34-143/146 Sequence Identity: 23% (27 aa) HDMGLTHIVNCSKEhpnaFADRGIRYFNVRVADekFALSCPFETIPTS---TDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKR . |....| ..| . . |...... . | |. . .|.. . ..|. .| . ||| | .||.. | .||...|. ||| ..|.||. . eeyelkalanstee----wkklGveqlqlatvD--fteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkR QGVRPNHGFLKQLADW | .. .. | . pqirlkskqwralqef |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP23.PD | 91-189 | 20 | 2.8e-08 | 24.4 | In-house | 11-110 (128) | Show / Hide |
Range on Protein: 91-189 Range on HMM: 11-110/128 Sequence Identity: 20% (20 aa) DMGLTHIVNCSKEH-PNAFADRGIRYFNVRVADEKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGV | |. ..|. ..| |. | .. . ... | . . .| ..... ||| .|. |. . . ||..... . .| ||. .|.| dqGirvlvslttegapyseaapsltlrridipdfcPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGs |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.PTPDC1.PD | 105-188 | 26 | 5.2e-07 | 19.8 | In-house | 127-209 (229) | Show / Hide |
Range on Protein: 105-188 Range on HMM: 127-209/229 Sequence Identity: 26% (22 aa) PNAFADRGIRYFNVRVADEK-FALSCPFETIPTSTDEVkaQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQG |... .|| ..|. .| . ..| . . . . . |. ||| | | . .||. .|| . || ||..|| peelmrqgiyfynfglkDygvasleriLdivkvvdfal--eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpk |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.Laforin.PD | 143-187 | 37 | 1.2e-06 | 18.8 | In-house | 102-146 (165) | Show / Hide |
Range on Protein: 143-187 Range on HMM: 102-146/165 Sequence Identity: 37% (16 aa) AQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ .| . ||| || |||| | .| ||. . || ekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.CDC14.PD | 95-188 | 25 | 1.8e-06 | 18.3 | In-house | 149-241 (258) | Show / Hide |
Range on Protein: 95-188 Range on HMM: 149-241/258 Sequence Identity: 25% (25 aa) THIVNCSKE--HPNAFADRGIRYFNVRVADEkfalSCPFETIPTSTDEV-KAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQG |.|| |. . . | | |. . .. .| ..| ..| . |. | ||| |. | .. . .|||.. | . |. | .. | | ttivrLnkklYdakkftdaGfahlDlffiDG----tvPsdailkkfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPG |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.RNGTT.PD | 150-201 | 32 | 2.1e-06 | 18.0 | In-house | 84-135 (140) | Show / Hide |
Range on Protein: 150-201 Range on HMM: 84-135/140 Sequence Identity: 32% (17 aa) VHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLAD |||| | | ..|||. .. |. .| || |. ...||.|.. vhCthGfnrtGflivayLvekedwsveaavalfakarppGiykedylkelfk |
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| Phosphatase | mbre_MKP_s3.AA | Subfamily.DSP11.PD | 105-187 | 20 | 3.4e-06 | 17.4 | In-house | 37-123 (141) | Show / Hide |
Range on Protein: 105-187 Range on HMM: 37-123/141 Sequence Identity: 20% (18 aa) PNAFADRGIRYFNVRVADEKFALSC----PFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ .....|.|..| .... ... . |.. ... | .. |||| || |. . ||| .. | .| .. | kkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearG |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| mbre_MKP_s3.AA | Protein | None | 219 | None | Fasta, JSON |
| mbre_MKP_s3.NA | RNA | None | 657 | None | Fasta, JSON |
| mbre_MKP_s3.AA.PD2_66-205 | Protein Phosphatase Domain | None | 140 | None | Fasta, JSON |