Gene mbre_PRL
mbre_PRL
Species: M.brevicollis
Alias: mbre_PRL
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mbre_PRL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | mbre_PRL.AA | Family.DSP.PD | 11-152 | 22 | 1.4e-21 | 68.8 | In-house | 112-246 (387) | Show / Hide |
Range on Protein: 11-152 Range on HMM: 112-246/387 Sequence Identity: 22% (33 aa) HknmrFLITDRPSDAtvEDyVRVLQQENVVALCRVCEPSYDVSKlkDNGIEVHDWAFQDGAPPPDEVIdnWLRLCRetFAQH---PNGFVAVHCVAGLGR . .|. ....| .. |.. .| . .... . .| ..||....... |. .|| | . . . .. | . ..| |.||| ||.|| p----hlylgsllaa--kn-lewlkelgvtkivnltddkpqftk--elgikylripidDhnapplenl--fekaid--fieegndskgvVlVHCkaGkgR APVLVALSLIEA-GMSSEDAVLFIREKRH--GAINRRQLQFLQDYKRR ..|.. |... |.. |.|. ..|.|| | ..|. |.|. . sgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdleke |
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| Phosphatase | mbre_PRL.AA | Subfamily.PRL.PD | 14-152 | 65 | 1.3e-70 | 227.2 | In-house | 1-139 (140) | Show / Hide |
Range on Protein: 14-152 Range on HMM: 1-139/140 Sequence Identity: 65% (91 aa) MRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVA .||||.|.|||.|||.....|..|||....||||||||..|||..||||.|.||.|||.||.||.|.||.|..|.|...|. .||||||||||||||||| lrflildepsdetvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlva LSLIEAGMSSEDAVLFIREKRHGAINRRQLQFLQDYKRR |.||||||..|||| ||||||.||||..||.||..||.. lalieaGmkyedavefirekrrgainskqlkflekykak |
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| Phosphatase | mbre_PRL.AA | Subfamily.CDC14.PD | 27-148 | 28 | 4.8e-23 | 73.7 | In-house | 136-253 (258) | Show / Hide |
Range on Protein: 27-148 Range on HMM: 136-253/258 Sequence Identity: 28% (34 aa) VEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETfaqhpNGFVAVHCVAGLGRAPVLVALSLIE-AGMSSED | ... ...|| .. |. . || .| .|.|.. .| | ||. |.|... ..|... .. .| .|||| ||||| .|.. ||... .... . PeklleyfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyrftaae AVLFIREKRHGAINRRQLQFLQD .| | | . | ..|.. tiawlriarPGsvigpqqtylve |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP23.PD | 39-150 | 27 | 2.6e-16 | 51.4 | In-house | 17-124 (128) | Show / Hide |
Range on Protein: 39-150 Range on HMM: 17-124/128 Sequence Identity: 27% (31 aa) VVALCRVCEPSYDVSklkdNGIEVHDWAFQDGAPPPDEVIDNWLRLCREtfAQHPNGFVAVHCVAGLGRAPVLVALSLIE-AGMSSEDAVLFIREKRHGA .|.| ..| ... ... .. .| || | .....|.. | |.. .. |.|||. ||||. |.| |.. |....||..|..|.|.|. lvslttegapyseaa----psltlrridipdfcPPaleqvarlvrivee--aekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGs IN-RRQLQFLQDYK ..| . ..||. ietveqekavkdye |
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| Phosphatase | mbre_PRL.AA | Subfamily.PTPDC1.PD | 49-150 | 31 | 1.2e-15 | 49.1 | In-house | 124-224 (229) | Show / Hide |
Range on Protein: 49-150 Range on HMM: 124-224/229 Sequence Identity: 31% (33 aa) SYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCreTFAQhPNGFVAVHCVAGLGRAPVLVALSLI-EAGMSSEDAVLFIREKRHGAIN-RRQLQFL ||| .|. .|| .. ....| .. | | . .. .|| .| .|||| ||||| ||.| |. ...|.|. ..|.|| .|. | |.... sYdpeelmrqgiyfynfglkDygvasleriLdivkvv--dfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelv QDYK .... eeFa |
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| Phosphatase | mbre_PRL.AA | Subfamily.RNGTT.PD | 48-152 | 25 | 6e-12 | 37.0 | In-house | 32-136 (140) | Show / Hide |
Range on Protein: 48-152 Range on HMM: 32-136/140 Sequence Identity: 25% (26 aa) PSYDVSKLKDNGIEVHDWAF-QDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLIEA-GMSSEDAVLFIREKRHGAINRRQlqF || ..|...|.. . | | | ......|..| . ..|. ..||| | |. |.. |.| .| |.|| . |.| ... .|... ryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarppGiyked--y LQDYKRR .| lkelfkr |
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| Phosphatase | mbre_PRL.AA | Subfamily.PTPMT1.PD | 35-151 | 27 | 5.1e-11 | 34.2 | In-house | 22-145 (146) | Show / Hide |
Range on Protein: 35-151 Range on HMM: 22-145/146 Sequence Identity: 27% (34 aa) QQENVVALCRVCEP------SYDVSKLKDNGIEVHDWAFQDGAP-PPDEVIDNWLRLCRETFAQhpNGFVAVHCVAGLGRAPVLVALSLI-EAGMSSEDA ..||| |. ..| . . . |..|.| | | . | | . . ... .. . . | ||| || .|. ||| |.. .|.|.|| ekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekleegvefiekvask--gssvYvHCkAGrtRsatlvacylmkkkklspeea VLFIREKRHGA-INRRQLQFLQDYKR |...||. .. .|.. || .|. vkflkkkRpqirlkskqwralqefke |
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| Phosphatase | mbre_PRL.AA | Subfamily.PTEN.PD | 47-134 | 25 | 2.1e-09 | 28.7 | In-house | 50-136 (305) | Show / Hide |
Range on Protein: 47-134 Range on HMM: 50-136/305 Sequence Identity: 25% (23 aa) EPSYDVSKLkdnGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLIEAGMSS--EDAVLFIREKR . ... |.. |. |.| ||. |.. . . . . . ||||| || ||. |... |.. |. . ..|. . ||| rgekedsdf---dgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekR |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP3.PD | 91-150 | 29 | 1.3e-08 | 26.4 | In-house | 86-146 (148) | Show / Hide |
Range on Protein: 91-150 Range on HMM: 86-146/148 Sequence Identity: 29% (18 aa) QHPNGFVAVHCVAGLGRA-PVLVALSLIEAGMSSEDAVLFIREKRHGAINRRQLQFLQDYK .. || | ||||.|. |. . .| .| .. ..|. .|.||. |. |. | ... sqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkreilPneGflkqLleld |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP11.PD | 47-142 | 23 | 3.9e-08 | 24.8 | In-house | 32-130 (141) | Show / Hide |
Range on Protein: 47-142 Range on HMM: 32-130/141 Sequence Identity: 23% (23 aa) EPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETF--AQHPNGFVAVHCVAGLGRAPVLVALSLIE-AGMSSEDAVLFIREKRHGAINRRQ . |. ..|.|.|.. . | .|..... . .| .. . ...||| |. |. |. ||. |.|.|||. | |...| . dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhsleren |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP8.PD | 90-146 | 37 | 1.9e-07 | 22.7 | In-house | 77-132 (143) | Show / Hide |
Range on Protein: 90-146 Range on HMM: 77-132/143 Sequence Identity: 37% (22 aa) AQHPNGFVAVHCVAGLGRAPV-LVALSLIEAGMSSEDAVLFIREKRhGAINrRQLQFL |.. || | ||| || |.. .| . . ||...| |..||| .|. ..|.|| arsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekr-ptis-pnlnfl |
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| Phosphatase | mbre_PRL.AA | Subfamily.RB.PD | 69-127 | 27 | 4e-07 | 21.2 | In-house | 167-226 (261) | Show / Hide |
Range on Protein: 69-127 Range on HMM: 167-226/261 Sequence Identity: 27% (16 aa) DGAPPPDEVIDNWLRLCRETFAQH-PNGFVAVHCVAGLGRAPVLVALSLIEAGMSSEDAV | | . . ...| ||. .. .. . ||| ||.||. . .|| . ....| | hgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqaieendyv |
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| Phosphatase | mbre_PRL.AA | Subfamily.N13.PD | 91-149 | 29 | 5.8e-07 | 20.8 | In-house | 188-251 (259) | Show / Hide |
Range on Protein: 91-149 Range on HMM: 188-251/259 Sequence Identity: 29% (19 aa) QHPNGFVAVHCVAGLGRAPVLVALSLI----E--AGMSSEDAVLFIREKRHGAINRRQlQFLQDY |. .| ..||| ||.||. ||... . | . .. | .||.|.| . .. |.. | qtdagPivvhcsaGiGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkd-qyifvy |
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| Phosphatase | mbre_PRL.AA | PTPc_motif | 56-154 | 19 | 1e-06 | 25.06 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 56-154 Range on HMM: 1-92/92 Sequence Identity: 19% (20 aa) KDNGIEVHDWAFQ----DGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLIEAGMSSEDAVLFIREKRHGAINRRQLQFLQDYKR . . ...| . .|.| . | ..|..|. . ||| || ||. ...|.... .. .. | .|. |.|.. |.. |. TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQVDIFQTVKEMRKQRPGMV-QTEEQYIFCYRC RGK . ILE |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP10.PD | 16-135 | 25 | 1.3e-06 | 20.0 | In-house | 8-123 (141) | Show / Hide |
Range on Protein: 16-135 Range on HMM: 8-123/141 Sequence Identity: 25% (30 aa) FLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSKLK-DNGIEVHDWAFQDGAPPPDEVIDnwlrLCREtfAQHPNGFVAVHCVAGLGRA-PVLVA ||. ||. .| .. |. . |. . .. .. .|. |.|.| |. .| .. | |.. .. | ||| ||.|. | .| flllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeeale----fiee--arkrgsrvlvhchaGisrsatvvia LSLIEAGMSSEDAVLFIREKRH . ..| ..| |..||| yvmkhlslslseaykfvkekrP |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP19.PD | 80-136 | 29 | 2.2e-06 | 19.1 | In-house | 63-122 (139) | Show / Hide |
Range on Protein: 80-136 Range on HMM: 63-122/139 Sequence Identity: 29% (17 aa) NWLRLCRETF--AQHPNGFVAVHCVAGLGRAPVL-VALSLIEAGMSSEDAVLFIREKRHG ..|. . . |.. .| | ||| || |.. . .| . . .| |.|. .||.| sylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpc |
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| Phosphatase | mbre_PRL.AA | Subfamily.N_Nematode_1.PD | 64-138 | 31 | 2.3e-06 | 18.7 | In-house | 172-247 (265) | Show / Hide |
Range on Protein: 64-138 Range on HMM: 172-247/265 Sequence Identity: 31% (26 aa) DWAfQDGAPPPDEVIDNWLRLCRETfaqhpNGFVAVHCVAGLGRAPVLVALSLIEAGMSS-------EDAVLFIREKRHGAI || |.|| | . . | |. .| ..||| ||.||. .||...| . . |. | |||.|. .| dWP-drGvPpadlaalelleavrgs-----kgPivvhCsaGiGrtGtivaieyildkllegkqiedmeklvkkireqrnysi |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP1.PD | 91-135 | 32 | 2.3e-06 | 19.3 | In-house | 76-121 (139) | Show / Hide |
Range on Protein: 91-135 Range on HMM: 76-121/139 Sequence Identity: 32% (15 aa) QHPNGFVAVHCVAGLGRAPVLVALSLI-EAGMSSEDAVLFIREKRH .. .| | ||| ||. |. .| . |. | .. |.| |....|. kkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrs |
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| Phosphatase | mbre_PRL.AA | Subfamily.R_Nematode_3.PD | 96-145 | 28 | 3.1e-06 | 18.3 | In-house | 200-257 (267) | Show / Hide |
Range on Protein: 96-145 Range on HMM: 200-257/267 Sequence Identity: 28% (16 aa) FVAVHCVAGLGRAPVLVALSLIEA-------GMSSEDAVLFIREKRHGAINRR-QLQF | |||..| .|. .|.| | .. . . .|..|.|||. .| | pvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqRagaiqtelelaf |
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| Phosphatase | mbre_PRL.AA | Subfamily.N20.PD | 36-141 | 23 | 3.8e-06 | 18.2 | In-house | 136-242 (257) | Show / Hide |
Range on Protein: 36-141 Range on HMM: 136-242/257 Sequence Identity: 23% (26 aa) QENVVALCRVCEPSYDVSKLKdNGIEVHDWAfQDGAPPPDeviDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLIEA------GMSSEDAVLF | .. . .| | | |. . ... | . |.| |.... | . | | . ||| ||.||. |.... .. . .| | .|| qyfiirmfqvvekstgtshsv-kqlqftkwp-dhgtpasa---dsfikyiryarkshltgpmvvhcsagigrtgvflcvdvvfcaivkncsfnimdivaq IREKRHGAINRR .| | .. . mreqrsgmvqtk |
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| Phosphatase | mbre_PRL.AA | Subfamily.DSP12.PD | 92-137 | 29 | 5.3e-06 | 18.1 | In-house | 79-125 (143) | Show / Hide |
Range on Protein: 92-137 Range on HMM: 79-125/143 Sequence Identity: 29% (14 aa) HPNGFVAVHCVAGLGRA-PVLVALSLIEAGMSSEDAVLFIREKRHGA . .| | ||| ||. | . .| . . ..| |.|. ...||.. . ekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkei |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| mbre_PRL.AA | Protein | None | 161 | None | Fasta, JSON |
| mbre_PRL.NA | RNA | None | 483 | None | Fasta, JSON |
| mbre_PRL.AA.PD_14-154 | Protein Phosphatase Domain | None | 141 | None | Fasta, JSON |