Gene mbre_PTEN-B
mbre_PTEN-B
Species: M.brevicollis
Alias: mbre_PTEN-B
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mbre_PTEN-B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | mbre_PTEN-B.AA | Subfamily.PTEN.PD | 24-317 | 34 | 7.1e-76 | 246.9 | In-house | 1-304 (305) | Show / Hide |
Range on Protein: 24-317 Range on HMM: 1-304/305 Sequence Identity: 34% (104 aa) DLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVAVIH |...| |......|.| |..... . |. .... . |.......|....... .| ||||.|||||||.|.. |.....|||...|.||..||...| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYGRYVREQREFEPIPLIMKRIilhgipDFKDGTCVPQFTLRHGPQH ||||||||||||.|||.. | .....|||..|...|| ..|||||||| |||.|. ..|. . . | . | |. .|| .. . | CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvcei------rfsesscvqnlgmvecsis VLTFKSG------WYEGISR-EQGTATLELKPHTPVCGDVKLEFIHRkgsSGKEKMFHLWFNTFFIVNN----------RF--YAAQSEVDKANKDKKNK | . . . | . | .|| ||.||||.|. .. | . . |.|.||||. |.. ..||.| .|| ..| . | | | |.| vlhdsatenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkk---spdkiichfwlntffvrnyspcesdgtvnkyihtlskseiddvhkdsehk IYPEGFAIEILFD . rfseefkisivfe |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Family.DSP.PD | 26-317 | 23 | 2e-46 | 150.5 | In-house | 95-378 (387) | Show / Hide |
Range on Protein: 26-317 Range on HMM: 95-378/387 Sequence Identity: 23% (71 aa) TFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCserdYDPQKFYG-RVAKY---PFDDHNAPPFLLMqpFCEDVHqYLSE--DSRNV |. . |. | | | ....| .....| . . . . .. ||. .|...|. || |.|||||||. .. |.... ...| ||..| tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgv AVIHCKAGKGRTGVMISAYLMHCGLFEKTeEALEFYGHARtmngKGVTIPSQVrYVHYYGRYVREQREFEPIPLIMKRIILHGIPDFKDGTCVPQFtLRH ...||||||||.|..|.||||.. ... |||... .| .||..|.| ..... .. |... . ........| ........ .. |.. VlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsv-lkk GPQHVLTFKSGWYEGiSREQGTATLELKPHTPVCGDVKLEFIHRKG-SSGKEKMFHLWFNTFFIVNNRFYAAQSEVDKANKDKKNKIYPEGFAIEILFD . . .. || . .|. |. ||||.|. .. .. .. .. .|.| .| ... . |.|.. |.| ..|.. .| ||... vatekakldrlkiLv-ideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveisee |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.TPIP.PD | 81-317 | 34 | 1.2e-42 | 137.6 | In-house | 1-244 (245) | Show / Hide |
Range on Protein: 81-317 Range on HMM: 1-244/245 Sequence Identity: 34% (83 aa) FYGRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNG-----KGVTIPSQVRYV | || . |||| | . . |...|...|..| .|| .|||| |||||| .. |.|.. ..|...||.|...|. || . .||||| |||.| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv HYYGRyVREQREFEPIP---LIMKRIILHGIpdfKDGTCVPQFTLRHGPQHVLTFKSGWYEGISREQGTA--TLELKPHTPVCGDVKLEFIHRKGSSG-K . |.. ... | |..||.|.. | . | . . . |.. | | .. | ... |.|||..|. . . | gylaq-vkhlynwnlpprrilfikrfiiysi---rgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyyd EKMFHLWFNTFFIVNNRFYAAQSEVDKANKDKKNKIYPEGFAIEILFD .|||| || |||. ..|.|. .|.| |||| ||.|||| ncpfffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfg |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.Tensin.PD | 84-316 | 32 | 4.4e-36 | 115.9 | In-house | 4-235 (237) | Show / Hide |
Range on Protein: 84-316 Range on HMM: 4-235/237 Sequence Identity: 32% (75 aa) RVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNGK--GVTIPSQVRYVHYYGRY .| . . |. |||. . |. .. .|. | .|| |.||| ||||.||.||||. . . . ...||. . | .. | ||| ||||||.|. .. kvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgl VREQREFEPIPLIMKRIILHGIPDFKD-GTCVPQFTLRHGPQHVLTfkSGWYEGISREQGTATLELKPHTPVCGDVKLEFIHRKGSS-GKEKMFHLWFNT .. ... ||... .||||||.|. |.| | . . .. | | | || |. . .. .. ..| . ||| ..|.| | .. .| . | | | lsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvyt--sgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfht FFIVNNRFYAAQSEVDKANKDKKnkiYPEGFAIEILF . .. ....|.| ||.. .|| .|..| gaikdlklvfekedldealkder---fpeyakvelvf |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | PTEN_C2 | 188-318 | 35 | 1.1e-31 | 115.46 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 188-318 Range on HMM: 1-141/141 Sequence Identity: 35% (50 aa) FEPIPLIMKRIIL-HGIPDF-KDGTC-VPQFTLRHGPQHVLTFKSGWYEGISRE-QGTATLELKP-HTPVCGDVKLEFIHRK-G---SSGKEKMFHLWFN . | || ..||. ||||.| ..|.| |... . | |. ....|.. . | ... | ||.||||....|.. . .. .|.||..||| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVF-YTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFN TFFIV--NNRFYAAQSEVDKANKDKKNKIYPEGFAIEILFDN |.|| ||| . .| |||.||||.|..|..|..|..|. TCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.PRL.PD | 68-160 | 29 | 3.3e-11 | 34.6 | In-house | 29-122 (140) | Show / Hide |
Range on Protein: 68-160 Range on HMM: 29-122/140 Sequence Identity: 29% (27 aa) YNLCSERDYDPQKF---YGRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLfeKTEEALEFYGHART . | || .|. .| ..||| ..|| ... . | ... .|.. .. .|| || ||. |... |. .|. |.|.|.|| .| vvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kyedavefirekrr |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.PTPDC1.PD | 88-182 | 25 | 2.6e-10 | 31.5 | In-house | 140-227 (229) | Show / Hide |
Range on Protein: 88-182 Range on HMM: 140-227/229 Sequence Identity: 25% (24 aa) YPFDDHNAPPFLLMQPFCEDVHQYLseDSRNVAvIHCKAGKGRTGVMISAYLMHCGLFEkTEEALEFYghaRTMNGKGVTIPSQVRYVHYYGRYV ....|..... . | . | ..| .|| ||.|||||.|..||.. .. .|||... | | . .||. |.. ... fglkDygvasleriLdivkvvdfal--eegkia-vHCHAGlGRtGvliacylvyakrlt-aeeaiklv---rskrpksiqtreqvelveeFalfl |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.CDC14.PD | 90-149 | 33 | 2.8e-10 | 31.7 | In-house | 176-230 (258) | Show / Hide |
Range on Protein: 90-149 Range on HMM: 176-230/258 Sequence Identity: 33% (20 aa) FDDHNAPPFLLMQPFCEdvhqyLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTE | | |. ... | | ..|... ...||||| ||||..|..||.. |. .| fiDGtvPsdailkkfle-----itekaeGaiavhCkaGLGrtgtligcylikhyrftaae |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.DSP11.PD | 73-160 | 26 | 1.2e-09 | 29.6 | In-house | 32-123 (141) | Show / Hide |
Range on Protein: 73-160 Range on HMM: 32-123/141 Sequence Identity: 26% (24 aa) ERDYDPQKFYGRV---AKYPFDDHNAPPFLLMQPFCEDVHQYL--SEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGHART .| |..... . | |. | .. |.| |...| ..|. .. .|| | ||| .| ||... . ..|.|.| . .|| dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegy-spedaieafeearG |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.PTPMT1.PD | 117-157 | 31 | 8.5e-08 | 23.6 | In-house | 86-125 (146) | Show / Hide |
Range on Protein: 117-157 Range on HMM: 86-125/146 Sequence Identity: 31% (13 aa) RNVAVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGH .. .|||||..| . ....|||. . ..||| .| . gssvYvHCkAGrtRsatlvacylmkkkkl-speeavkflkk |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.RNGTT.PD | 102-160 | 31 | 2.3e-07 | 22.0 | In-house | 64-121 (140) | Show / Hide |
Range on Protein: 102-160 Range on HMM: 64-121/140 Sequence Identity: 31% (18 aa) QPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGHART . | . |...|.. .| .|| | ||| .| |||.. . . |.|.. . .|| klfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedw-sveaavalfakarp |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.N5_RR.PD | 60-139 | 22 | 1.6e-06 | 19.1 | In-house | 137-219 (265) | Show / Hide |
Range on Protein: 60-139 Range on HMM: 137-219/265 Sequence Identity: 22% (19 aa) RCKDHYRVYNLCSERDYD-PQKFYGRV-AKYPfdDHNAPP-FLLMQPFCEDVHQYLSEDSRN--VAVIHCKAGKGRTGVMISAYL ...|.| .| . . ... . ...| ||..| . ....|.. .|.. . |.|| || ||||..|.. . verndysvrklvlkylerversvkhywytdWP--dhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisi |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.RB.PD | 100-140 | 31 | 1.7e-06 | 19.0 | In-house | 175-216 (261) | Show / Hide |
Range on Protein: 100-140 Range on HMM: 175-216/261 Sequence Identity: 31% (13 aa) LMQPFCEDVHQYLSED-SRNVAVIHCKAGKGRTGVMISAYLM . |.. |....... |.. |.|| || ||||. |. . tlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrl |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.DSP23.PD | 114-142 | 35 | 2.2e-06 | 19.2 | In-house | 63-91 (128) | Show / Hide |
Range on Protein: 114-142 Range on HMM: 63-91/128 Sequence Identity: 35% (10 aa) EDSRNVAVIHCKAGKGRTGVMISAYLMHC |.. . .|| | |||| ... ||.. ekkeeavgvhcalGlGrtGtllacylvke |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.N_Fungi_PTP1.PD | 109-150 | 25 | 2.4e-06 | 18.2 | In-house | 252-295 (343) | Show / Hide |
Range on Protein: 109-150 Range on HMM: 252-295/343 Sequence Identity: 25% (11 aa) HQYLSEDSRNVAVIHCKAGKGRTGVMISA-YLMH-CGLFEKTEE ...| .. . ..|| || ||||.... .|.. .|.... eshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.N12.PD | 104-161 | 25 | 3.2e-06 | 17.9 | In-house | 187-244 (270) | Show / Hide |
Range on Protein: 104-161 Range on HMM: 187-244/270 Sequence Identity: 25% (15 aa) FCEDVHQYLSEDSrNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTE-EALEFYGHARTM . |.|... .... . |.|| || ||||..|. ... | ... | |. . .. lielvrelqesed-aPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlel |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.N3.PD | 101-150 | 36 | 3.4e-06 | 17.9 | In-house | 178-225 (261) | Show / Hide |
Range on Protein: 101-150 Range on HMM: 178-225/261 Sequence Identity: 36% (18 aa) MQPFCEDVHQYLSEDSrNVAVIHCKAGKGRTGVMISAYLMHCgLFEKTEE . | | |... | .. . |.|| || |||||.| . . | |..|. flefvervrklrsgke-ePvvvhCsaGigrtGvlilletala-lieaaep |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.DSP19.PD | 109-153 | 33 | 3.4e-06 | 18.4 | In-house | 73-114 (139) | Show / Hide |
Range on Protein: 109-153 Range on HMM: 73-114/139 Sequence Identity: 33% (15 aa) HQYLSEDsrNVAVIHCKAGKGRTGVMISAYLMHcGLFEKTEEALE .. .|.| .. ..||.|| |. .. ||||. ..|.||| eearskd--grvlvHCnAGvSRsasvviaylmk-deelslekale |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.N14.PD | 114-143 | 44 | 3.9e-06 | 17.7 | In-house | 204-233 (275) | Show / Hide |
Range on Protein: 114-143 Range on HMM: 204-233/275 Sequence Identity: 44% (12 aa) EDSRNVAVIHCKAGKGRTGVMISAYLMHCG ..|. ..|| || |||||.| . |. keskPPvlvhCsaGvGrtGvlilsdlliat |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.R_Sponge_2.PD | 91-168 | 20 | 4.6e-06 | 17.7 | In-house | 167-243 (262) | Show / Hide |
Range on Protein: 91-168 Range on HMM: 167-243/262 Sequence Identity: 20% (16 aa) DDHNAPPFL-LMQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLfeKTEEALEFYGHARTMNGKGVTI .|. | . . . ..|.. .. .. ...|..| |||| | . . | |.|| .. . .|. | . . pehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialdsvlerl--kaeeeidvfevlktlrtkrigl |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.N_Nematode_4.PD | 101-176 | 23 | 5e-06 | 17.5 | In-house | 180-254 (264) | Show / Hide |
Range on Protein: 101-176 Range on HMM: 180-254/264 Sequence Identity: 23% (18 aa) MQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTE-EALEFYGHARTMNGKGVTipSQVRYVH .| . ... . |.|| || ||| .. .. . . |..| | |. . |.| | | |...... aapviklykavkkkkkekPivvhcsaGvGrtatlvGidyatirirenseievldivrelramrlkavq--shlqflf |
|||||||||
| Phosphatase | mbre_PTEN-B.AA | Subfamily.N_Choan_1.PD | 103-136 | 39 | 8.4e-06 | 16.8 | In-house | 179-212 (262) | Show / Hide |
Range on Protein: 103-136 Range on HMM: 179-212/262 Sequence Identity: 39% (13 aa) PFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMIS | ..|... .... |||| || ||||. |. efrkavlkatkkktkaplvihCsaGvGrtGtyia |
|||||||||
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| mbre_PTEN-B.AA | Protein | None | 422 | None | Fasta, JSON |
| mbre_PTEN-B.NA | RNA | None | 1266 | None | Fasta, JSON |
| mbre_PTEN-B.AA.PD_84-181 | Protein Phosphatase Domain | None | 98 | None | Fasta, JSON |