Gene mbre_PTEN-A
mbre_PTEN-A
Species: M.brevicollis
Alias: mbre_PTEN-A
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mbre_PTEN-A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PH | mbre_PTEN-A.AA | PH | 301-412 | 27 | 3e-22 | 82.86 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 301-412 Range on HMM: 1-92/92 Sequence Identity: 27% (31 aa) VIHQGWLFKEGGQIRSWRRRYFVLQSNGLLVYFPDAPQASGRNSTPINAIDVVGAEVTQSTSSKRPHGFIVASDQSAKRRSSATNKREKYVLAGSSDADR ||..|||.| | ...||..|.|||..| |. | .| ..| |.. ...|| ...||||.| . . . ..|... .|. .. VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR-----------RTYYFQAESEEEM DAWMARIRYCAA . ||. |..... NDWMQAIQSACR |
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| Phosphatase | mbre_PTEN-A.AA | Family.DSP.PD | 448-764 | 22 | 5e-34 | 108.5 | In-house | 76-377 (387) | Show / Hide |
Range on Protein: 448-764 Range on HMM: 76-377/387 Sequence Identity: 22% (71 aa) RQLVSKQKIRFQKDGFDLDlTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCseraYPPSRFHNRVGVY----PFDDHNPAPLPLV ........ . |||| || . |. |.| | .. .| . .. . . .. | .. ||. . ...|... |.. |.||||. || .. gakqaelngfidvhtfdld-tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl laCCADIHaWLAANP-ERNVAAIHCKAGKGRTGLIISCYLMYA-GICPDpdSAMTMFGAKRthngKGVTIPSQRrYIRYFHTMLQGDRTVpPATPLTLTG . .| .. .. ...|...||||||||.| .|..|||.. |.. . |.... || .||..|.|. ...... .. ..|... | .. --fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle--ealdwvrskR----pgvitpnqg-flkqlkdlekeklkv-ssevmelrf IRLHGVPNYDFSGGCQPYYQVYQegvlIFSSKPAELRQLQAyKRQTHRDIRFSCNMAIEGNIRIELWDCDRGFHSEEKMFAATFFTGMVEGTSLRMVRQE ..|.| . ... . .... . |. .| |. . | . | . . | ...||. .. .. | |.... || .|..||| vissivqnlgsvevsvsvlkkva----tekakldrlkiLvi-deqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkke LDGAHKKKHLKMFEPQFAMELTF .||.| ... ...| |. . ldelhkskifdvykdseaveise |
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| PH | mbre_PTEN-A.AA | PH | 301-414 | 20 | 1.5e-18 | 68.85 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 301-414 Range on HMM: 1-82/82 Sequence Identity: 20% (23 aa) VIHQGWLFKEGGQIRSWRRRYFVLQSNGLLVYFPDAPQASGRNSTPINAIDVVGAEVTQSTSSKRPHGFIVASDQSAKRRSSATNKREKYVLAGSSDADR ||..||| | . .|..|.||| . . |.|. | .|. |.. ...|. . .| . . . |... .|. .. VIKEGWLYKKS--K-RWKKRWFVLFN-DCLYYYKDK--------KPKGSIPLSDCTVRE-P------CFEIHH-DR------------TYYFQCESEEEM DAWMARIRYCAALD . ||. |. ... QEWMQAIQKAIHNN |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.PTEN.PD | 466-681 | 37 | 8.4e-64 | 206.0 | In-house | 1-213 (305) | Show / Hide |
Range on Protein: 466-681 Range on HMM: 1-213/305 Sequence Identity: 37% (78 aa) DLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAANPeRNVAAI |..|| .|.....||.| | .... .|.|..|. .. | .....|.... . | |..|| |||||||||..| |. .. |.. || ...||.|.|| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedk-snVvav HCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGKGVTIPSQRRYIRYFHTMLQGDrtVPP-ATPLTLTGIRLHGVPNYDFSGGCQPYYQVYQ ||||||||..|..||.. ||....| |..... |||...|||||||||||..||..... || | .. ||.. | . | .. . HCkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkss--vpyskvslnvceirfsesscvqnlgmvecsisvlh EGVlIFSSKPAELRQLQ || |. | dsa-tenakpdrlktlp |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.Tensin.PD | 524-752 | 30 | 1.8e-39 | 125.8 | In-house | 2-226 (237) | Show / Hide |
Range on Protein: 524-752 Range on HMM: 2-226/237 Sequence Identity: 30% (70 aa) HNRVGVYPFDDHNPAPLPLVLACCADIHAWLAANPErNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNG--KGVTIPSQRRYIRYF ...| . . |. || . . | ...|| |.|. || ..||| ||||.|..||.|. |. |. .|.|. .| || . .|||||||||..|| nekvldlGWPdllaPpleklcsickalesWlkadpq-nvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf HTMLQGDRTVpPATPLTLTGIRLHGVPNYDFSGGCQPYYQVYQEGVLIFSSKPAELRQlqayKRQTHRDIRFSCNMAIEGNIRIELWDCDRGFHSEEKMF .|.|. . . || | . |||.||.| .|||.|. ..|| |...| .. . . ... | . ..|.. .. . . . . .| sgllsgsikl-nssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvag----edterlcitiepalllkgdvlvkcyhkklrsttrdvvf AATFFTGMVEGTSLRMVRQELDGAHKKKHLK | || .....| . ...|| |.| . . rvqfhtgaikdlklvfekedldealkderfp |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.TPIP.PD | 523-764 | 28 | 5.8e-32 | 101.4 | In-house | 1-243 (245) | Show / Hide |
Range on Protein: 523-764 Range on HMM: 1-243/245 Sequence Identity: 28% (70 aa) FHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAANPErNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNG-----KGVTIPSQRRY ||||| |||| | .. . ... |||...| || ||||| |||||| |. ..|....|. . .. || .|| . .|||||.||. fhnrvsrimiddhnvPtleelvvftkevkewlakdle-nvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnry IRYFHTMLQG-DRTVPPATPLTLTGIRLHGVPnydfSGGCQPYYQVYQEGVLIFSSKPAELRQLQAYKRQTHRDIRFSCNMAIEGNIRIELWDCDRGFHS |. . . . .|| | . . .. . . |. || | ..||| . . | ........ .. . .. vgylaqvkhlynwnlpprrilfikrfiiysir----gdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyy EEKMFAATFFTGMVEGTSLRMVRQELDGAHKKKHLKMFEPQFAMELTF | | | ... | . |.||| ||.| |.. |.||.|. | dncpfffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilf |
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| Phosphatase | mbre_PTEN-A.AA | PTEN_C2 | 632-766 | 31 | 2.9e-19 | 71.08 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 632-766 Range on HMM: 1-141/141 Sequence Identity: 31% (46 aa) PPATPLTLTGIRL-HGVPNYDFSGGC-QPYYQVYQEGVLIFSSKPAELRQLQAYKRQTHRDIRFSCNMAIEGNIRIELWDCDRG-----FHSEEKMFAAT || ||.|..|.. ||.|| . ||| || |.||. . .| ... . .. ||.| . . | .. ..| ..|. ..| .||.|| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVF-YTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQC--YHKGPSDLPWMYEECMFRFW FFTGMVE--GTSLRMVRQELDGAHKKKHLKMFEPQFAMELTFKS | |...| .. |. ..|||.|.| | | | |.|..|. |. FNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.PTPDC1.PD | 561-604 | 43 | 3e-12 | 36.7 | In-house | 167-209 (229) | Show / Hide |
Range on Protein: 561-604 Range on HMM: 167-209/229 Sequence Identity: 43% (18 aa) NVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTH |.|| ||.||||..|.|||.|| ... |... .||.. gkiavHCHAGlGRtGvliacylvyakrl-taeeaiklvrskrpk |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.PTPMT1.PD | 560-604 | 31 | 1.2e-09 | 28.4 | In-house | 86-129 (146) | Show / Hide |
Range on Protein: 560-604 Range on HMM: 86-129/146 Sequence Identity: 31% (14 aa) RNVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTH .. .|||||..| . ...||||. . |..|.... .|| . gssvYvHCkAGrtRsatlvacylmkkkkl-speeavkflkkkRpq |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.CDC14.PD | 562-584 | 63 | 3.5e-09 | 26.9 | In-house | 200-222 (258) | Show / Hide |
Range on Protein: 562-584 Range on HMM: 200-222/258 Sequence Identity: 63% (14 aa) VAAIHCKAGKGRTGLIISCYLMY .|.||||| |||| .|.|||.. aiavhCkaGLGrtgtligcylik |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.DSP23.PD | 554-585 | 39 | 1.2e-07 | 22.1 | In-house | 60-91 (128) | Show / Hide |
Range on Protein: 554-585 Range on HMM: 60-91/128 Sequence Identity: 39% (11 aa) LAANPERNVAAIHCKAGKGRTGLIISCYLMYA |. . . ..|| | |||| ...|||. eeaekkeeavgvhcalGlGrtGtllacylvke |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.RNGTT.PD | 554-603 | 30 | 5.5e-07 | 19.6 | In-house | 74-121 (140) | Show / Hide |
Range on Protein: 554-603 Range on HMM: 74-121/140 Sequence Identity: 30% (15 aa) LAANPERnVAAIHCKAGKGRTGLIISCYLMYAgICPDPDSAMTMFGAKRT | .|.. | ..|| | |||..| .||. . . ..|...| | lkkkPde-vigvhCthGfnrtGflivayLvek-edwsveaavalfakarp |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.PRL.PD | 527-602 | 27 | 2.3e-06 | 17.7 | In-house | 49-121 (140) | Show / Hide |
Range on Protein: 527-602 Range on HMM: 49-121/140 Sequence Identity: 27% (21 aa) VGVYPFDDHNPAPLPLVLACCADIHAWLAANPERNVaAIHCKAGKGRTGLIISCYLMYAGICPdpDSAMTMFGAKR | ..||| .. | .| . ... . .|. | |.|| || ||. .... |. ||. . . |. . || vldlafddGavPpkevvdeWlellkekfkeepkstv-avhcvaGlGraPvlvalalieaGmky--edavefirekr |
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| Phosphatase | mbre_PTEN-A.AA | Subfamily.DSP11.PD | 551-605 | 26 | 7.2e-06 | 16.1 | In-house | 71-125 (141) | Show / Hide |
Range on Protein: 551-605 Range on HMM: 71-125/141 Sequence Identity: 26% (15 aa) HAWLAA-NPERNVAAIHCKAGKGRTGLIISCYLMyAGICPDPDSAMTMFGAKRTHN . .| . . .. ..|| | ||| .| ||. .|. |. .| | |. kefleknkdndkligvhCthGvnrtGyliCryli-dvegyspedaieafeearGhs |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| mbre_PTEN-A.AA | Protein | None | 766 | None | Fasta, JSON |
| mbre_PTEN-A.NA | RNA | None | 2298 | None | Fasta, JSON |
| mbre_PTEN-A.AA.PD_523-626 | Protein Phosphatase Domain | None | 104 | None | Fasta, JSON |