• Phosphatome.Net

Gene mbre_TNS1

mbre_TNS1
Species: M.brevicollis
Alias: mbre_TNS1
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: Tensin
Protein domain

Protein domains of mbre_TNS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1 mbre_TNS1.AA C1 71-118 18 3e-06 27.95 SMART 1-61 (61) Show / Hide 
Range on Protein: 71-118
Range on HMM: 1-61/61
Sequence Identity: 18% (11 aa)

HVFVEGQGFGKPCRICTDRVWRR--------AAMCTNCRYICHERCIGQARK-----HLDC
| ....   .. |..| ...|          . .|..|.| ||..|  .. .      ..|
HHWHWWRFKPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Phosphatase mbre_TNS1.AA Subfamily.Tensin.PD 207-401 40 6.5e-63 202.1 In-house 1-207 (237) Show / Hide 
Range on Protein: 207-401
Range on HMM: 1-207/237
Sequence Identity: 40% (84 aa)

FHNQVLDFGWPDHMAPSLERLASICNSIDSWIEADPNNVIAVHCKGGKGRTALS----------TNSPSFGADIISFTS--DKKSSGITNPSQRRYVLYF
....|||.||||..||.||.|.|||....||..|||.||...||||||||....          ..|.....|......  |.|.||.|.||||||| ||
lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf

EAVLAGQLKVYRKHLVLEHVYLQGIPAFDGSGGCRPYLSIMEDFRVVYQSPepIRTFR-RDDKFIQFDLDQGLHLAGDVVIECYHRPSRGAD-VLMFRIQ
...|.|..|.  . | | .| |.|||.|| .|||||.| | . ...|| |   . .    | . .   ....| | |||...|||.  |...  ..||.|
sgllsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsg--vynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvq

FPTCVVADR
| |. . | 
fhtgaikdl
Phosphatase mbre_TNS1.AA Subfamily.PTEN.PD 151-376 24 2.3e-34 108.9 In-house 1-238 (305) Show / Hide 
Range on Protein: 151-376
Range on HMM: 1-238/305
Sequence Identity: 24% (57 aa)

DLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNV-SDKKYDIEEFHNQVLDFGWPDHMAPSLERLASICNSIDSWIEADPNNVIAVH
|..|| . .|..| |.  ..  ...| .|.  .|.... ... . .. ......  .|...|  ..  ||..|.|| | .|....|.|...|.||.||||
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH

CKGGKGRTALST-------NSPSFGADIISF---TSDKKSSGITNPSQRRYVLYFEAVLAGQLKVYRKHLVLEHVYLQGIPAFDGSGGCRPYLSIMEDFR
| ||||| . .       .  . . . ...   .  |.. |.| ||||||| ||. ..   .   .  | .  . .    . .|     .|.. |  .  
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecsisvlhdsa

VVYQSPEPIRTFRRD-DKFIQFDLDQGLHLAGDVVIEC
  |. ..|.  | .| . . .   . ..||| .|    
tenakpdrlktlpidfqksfvltikpsipvsgdvkfel
Phosphatase mbre_TNS1.AA Family.DSP.PD 119-401 20 4.7e-29 91.6 In-house 73-346 (387) Show / Hide 
Range on Protein: 119-401
Range on HMM: 73-346/387
Sequence Identity: 20% (59 aa)

PGFYQKTSTLVRQIRKV-VTGNKVRYVTEVVDLDLTYITPriiamSLPATGLQAAyrNNlkdVAAFlnsKHGSNYMIFNVSDKKYDieeFHN----QVLD
.  ..| . | ..|.   .. ..   .. |   . ..|.|     .| . .|.||  .|     ..   |.    .| |..|.|     |....|.....
visgakqaelngfidvhtfdldtydhfervengkpseilp-----hlylgsllaa--kn---lewl---kelgvtkivnltddkpq---ftkelgikylr

FGWPDHMAPSLERLasICNSIDsWIEA--DPNNVIAVHCKGGKGRTAL-------STNSPSFGaDIISFTSDKKSsGITNPSQRrYVLYFEAVLAGQLKV
|| ||.||.|  ....|| .||   |...|..||||.||||..        . .  ..  . . . ..|.. |...|.|. .. .....  .||| .. .
ipidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskRp-gvitpnqg-flkqlkdlekeklkv

YRKHLVLEHVYLQGIPAFDGSGGCRPYLSIMEDFRVVYQSPEPIRTfrRDDKFIQFDLDQGLHLAGDVVIECYHR-PSRGADVLMFRIQFPTCVVADR
.|..|  .... ..  ... . |  .   ......   . .   . . .   . .|| | ||| .|.... . .  . ......| |  . |      
ssevmelrfvissivqnlgsvevsvsvlkkvatekakldrlkiLvi--deqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikde
Phosphatase mbre_TNS1.AA Subfamily.TPIP.PD 207-298 37 4.5e-18 55.5 In-house 1-107 (245) Show / Hide 
Range on Protein: 207-298
Range on HMM: 1-107/245
Sequence Identity: 37% (39 aa)

FHNQVLDFGWPDHMAPSLERLASICNSIDSWIEADPNNVIAVHCKGGKGRTA-----LSTNSPS----------FGADIISFTSDKKSSGITNPSQRRYV
|||.|      ||  | ||.| .... .. |...|..||.|.|||||||||      |  .|            ||      |  .|  |.|||.||| |
fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv

LYFEAVL
.. |   
gylaqvk
Phosphatase mbre_TNS1.AA PTEN_C2 304-396 31 3.7e-17 63.6 Pfam 1-101 (141) Show / Hide 
Range on Protein: 304-396
Range on HMM: 1-101/141
Sequence Identity: 31% (32 aa)

VYRKHLVLEHVYL-QGIPAFDGSGGC-RPYLS-IMEDFRV--VYQSPEPIRTFRRDDKFIQFDLDQGLHLAGDVVIECYHRP-S---RGADVLMFRIQFP
 ..| | | .... .||| |.. ||| |||.  ...|  |   ... .. .   ...| . |...|.....|||.|.|||.  |      ...|||..| 
PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKY-KQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFN

TC
||
TC
Phosphatase mbre_TNS1.AA Subfamily.PTPDC1.PD 195-258 36 7.9e-09 25.1 In-house 118-181 (229) Show / Hide 
Range on Protein: 195-258
Range on HMM: 118-181/229
Sequence Identity: 36% (24 aa)

FNVSDKKYDIEEFHNQ---VLDFGWPDHMAPSLERLASICNSIDSWIeadPNNVIAVHCKGGKGRTA
. |   || ||. .|   .  ||..|. ..||||.  |   .|. .    .  |||||  |.|||  
leesGfsYdpeelmrqgiyfynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtG
Phosphatase mbre_TNS1.AA Subfamily.PRL.PD 189-258 25 4.4e-06 16.4 In-house 24-96 (140) Show / Hide 
Range on Protein: 189-258
Range on HMM: 24-96/140
Sequence Identity: 25% (18 aa)

GSNYMIFNVSDKKYDIEEFHN---QVLDFGWPDHMAPSLERLASICNSIDSWIEADPNNVIAVHCKGGKGRTA
.   .  | . .|| |....   .|||. . |  .|. | . .  . . .  . .|....||||  | ||.  
envkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraP
Phosphatase mbre_TNS1.AA Subfamily.Tensin.PD 432-459 53 7.3e-06 15.4 In-house 209-236 (237) Show / Hide 
Range on Protein: 432-459
Range on HMM: 209-236/237
Sequence Identity: 53% (14 aa)

YTFEKHQLDEAYKDARFPEETNISCMFR
.|||..||||.||.|||| ...  .|  
lvfekedldealkderfpeyakvelvfs
Phosphatase mbre_TNS1.AA Subfamily.N12.PD 196-258 25 8.7e-06 14.8 In-house 152-214 (270) Show / Hide 
Range on Protein: 196-258
Range on HMM: 152-214/270
Sequence Identity: 25% (16 aa)

NVSDKKYDIEEFHNQVLDFGWPDHMAPS-LERLASICNSIDSWIEaDPNNVIAVHCKGGKGRTA
.  .. . ..  .|     ||||  ||  ..| .. ... .  | . .. ..|||  | |||  
tLkveaqkesrkvyqfhytaWPDhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtG
SH2 mbre_TNS1.AA SH2 687-773 23 4.7e-08 33.99 SMART 1-87 (87) Show / Hide 
Range on Protein: 687-773
Range on HMM: 1-87/87
Sequence Identity: 23% (21 aa)

CAWYFADFTKEATDRLLLEK-GQPGEFVVRR-DPLDSHTFYLSVRCPESVVVHLLVQWVPRQQQFELDH--RACFADMQQLIKFYSSNTVA
. ||. . ..|  ..||.   ...| |.||  .. .   . ||||.  . | | ...  .   .. .|   | .| .  .|. .|. |   
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES-NPGDYVLSVRWK-GKVKHYRIRRNDD-GKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 mbre_TNS1.AA SH2 689-767 25 3e-06 20.24 Pfam 1-81 (81) Show / Hide 
Range on Protein: 689-767
Range on HMM: 1-81/81
Sequence Identity: 25% (22 aa)

WYFADFTKEATDRLLLE-KGQPGEFVVRRDPLDSHT----FYLSVRCPE--SVVVHLLVQWVPRQQQFELDHRACFADMQQLIKFY
||. . ...   |||..  ...| |.||    .| .    . ||||.    ..| |  .|. ..  .. .  | .|.. |.|. .|
WYHGKISRQEAERLLMNPGNPDGTFLVR----ESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNG-GYYITGRHKFCSLQELVEHY
Sequence
Name Sequence Type Origin Length Description Download
mbre_TNS1.AA Protein None 843 None Fasta, JSON
mbre_TNS1.NA RNA None 2529 None Fasta, JSON
mbre_TNS1.AA.PD_207-299 Protein Phosphatase Domain None 93 None Fasta, JSON