Gene mbre_TPIP
mbre_TPIP
Species: M.brevicollis
Alias: mbre_TPIP
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mbre_TPIP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Amidohydro_2 | mbre_TPIP.AA | Amidohydro_2 | 26-289 | 16 | 2.3e-21 | 75.8 | Pfam | 1-263 (286) | Show / Hide |
Range on Protein: 26-289 Range on HMM: 1-263/286 Sequence Identity: 16% (46 aa) IDLRAD------VDPYGMKLTGAIHIEAIADDALPGRFVLTRPPYHPNGAVLEMILLGEVDYVVQLAEQADIPLGIVGYANLADAQAPALVASMMEGNRG || .. . ... .... . ||.|. . ... ..|..... ... . ..|| .. | ...|.| ... .. || .. . IDCHHHFWWWRWPWWPW-WYPFMDRRGYDPYDASPADMRVLHEA-GWARWVIWQAS-CRGANNWYAAEWCKHPDRFFGWAAWPPPDPEDAVAEIERCVHE KYMRGIRMILNHNPSWPKVEHDEHLTSTEFARGYAELAKHKLSFDLQ------------ANPHQLERAAALAAKHPEVPMIVDHLGTLKLNVEGSAQRTE . ||.|. .......| .... . ........|.. .... . ..|.. .. .....|......||.| . AGFRGVRLHPHWHGDYPWDPRYWD-----WRPIWERCEEHGWPVQIHTGPWHWGWHQEPTRHTQPMYLDGVFRRFPDLKFVLDHMGWPWI--------GY ALANWRAGMHLLAAAGPHVYVKLSMLAYTESNWHEGSDATVDDLVHEVIALFGTDRCMLASNYPVDKAEFNVQPAQLWARVA ....||. |.||| |.|..|||. .|....||... .. . ..|..|| |||| .|..|... .. ..... .. HYWWWRWMMRLLARH-PNVWCKLSG-WYRMCRWHFWPPYADPPYLRRLIEWFGPDRCMWGSDWPHWPP-WWYAAWWWADLLD |
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| Ion_trans | mbre_TPIP.AA | Ion_trans | 442-509 | 22 | 5.8e-07 | 28.19 | Pfam | 1-79 (199) | Show / Hide |
Range on Protein: 442-509 Range on HMM: 1-79/199 Sequence Identity: 22% (18 aa) VSTIIVVYFMIELCARIYAIGP----RHFVRLPWEMFDALIVLVTFIFEFAFEAG----RVIILARLVR---IFLILRL . .. .| | .| . ...| |. .|..| .| .|| ..|....| ..|. . ||. . |..| .. ..|. FDYVFTVWFTFEMILKFWAFGFKFHPFHYFRDWWNWFDFFVVIPSYIDLIWFFFNWDWFRVLRVFRWLRVLRPLRLFRR |
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| Phosphatase | mbre_TPIP.AA | Subfamily.PTEN.PD | 539-753 | 27 | 3e-47 | 152.6 | In-house | 1-212 (305) | Show / Hide |
Range on Protein: 539-753 Range on HMM: 1-212/305 Sequence Identity: 27% (59 aa) DLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCCSERDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLAIH |.... .|..|.| .... . .. ....|.. . . . . ......... |.. |. .|||| |.|. . .|... . .|..|...| |.| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTDKGvgnmfQGVQTPSQYRFVGYVEDIIQKynRIPPPTKTLHISTIRV----CSLRPTYTRCPF || ||||||..||..||.||....|.|||....| || .. .|| ||| |.| | . ... .| .| . ||.| | . . CkaGkGRtGvmicayLlksgikksadealaiydekRtkdk-----kGVtiPSQrRYvqYfsklvks--svpyskvslnvceirfsesscvqnlgmvecsi ASVDPSGTNGIRSLRVKML | |. . |.| | svlhdsatenakpdrlktl |
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| Phosphatase | mbre_TPIP.AA | Subfamily.TPIP.PD | 596-826 | 42 | 1.3e-73 | 238.9 | In-house | 1-215 (245) | Show / Hide |
Range on Protein: 596-826 Range on HMM: 1-215/245 Sequence Identity: 42% (94 aa) FNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTDKGVGNMFQGVQTPSQYRFV |.|.|....||||||| |.|......|....|.||...|.||||||||||||||.|..|..|..|..|.|.||.|.|||||| ..|.||||.||||.|.| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv GYVEDIIQKYNRIPPPTKTLHISTIRVCSLRPTYtrCPFAsVDpsgtngiRSLRVKMLNPDTTVLETSDAKQVTVERsgVSIPAiefsCSGTAVRQDVKT ||...... || || . | | . . |.| | . |. . |.. |.. ..| ... ... . || . .||| |.| .|| gylaqvkhlynwnlpprrilfikrfiiysirgdv--cdlk-vq-------vvmekkvvfsstslgncsilhdietdk--ilinv----ydgpplyddvkv MFYSEDLPAYYDKCPFYFWFNTGFVPEDRFV |||.|||.||||| |. ..|.. qffssnlpkyydncpfffwfntsfiqnnrlc |
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| Phosphatase | mbre_TPIP.AA | Family.DSP.PD | 581-707 | 32 | 3.9e-27 | 86.7 | In-house | 135-249 (387) | Show / Hide |
Range on Protein: 581-707
Range on HMM: 135-249/387
Sequence Identity: 32% (42 aa)
LIVNCCSERDYdhaF-FNNSVK--NCRIDDHNVPPLNEIfsICREFQdFLSK--DEKRVLAIHCKGGKGRTGTIICSWLLYS-GMFTQaqEALDFFAERR
|||.. ... | .....| .. |||||.|||... ... .. |... |.| | ..|||.||||.||.|. .|..| |. . ||||.....|
kivnltddkpq---ftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle--ealdwvrskR
tdkgvgnmfQGVQTPSQYrFVGYVEDIIQKYNR
.|| ||.| |. ...| ...
---------pgvitpnqg-flkqlkdlekeklk
|
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| Phosphatase | mbre_TPIP.AA | Subfamily.Tensin.PD | 596-719 | 33 | 1.1e-23 | 75.1 | In-house | 1-121 (237) | Show / Hide |
Range on Protein: 596-719 Range on HMM: 1-121/237 Sequence Identity: 33% (41 aa) FNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTdkgVGNMFQGVQTPSQYRFV .|. |.. |. |||. . |||.. . .|. | ..|...||||||||.| .|.... || . . |..||| || .| . . .||. ||| |.| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrf---yddkvsgvtqPsqrryv GYVEDIIQKYNRIPPPTKTLHIST |...... .. || eyfsgllsgsiklnssplflhyvi |
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| LIM | mbre_TPIP.AA | LIM | 850-902 | 41 | 4.6e-16 | 60.62 | SMART | 1-52 (52) | Show / Hide |
Range on Protein: 850-902 Range on HMM: 1-52/52 Sequence Identity: 41% (22 aa) KCPSCGKSVYFAEKHTALGKDWHKMCLKCEKCKKILANGSFLEHGGKPYCQKP || |.| .| .. .|.|| ||. |..|..|.| |.. | |..|||||.. KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGG-TFYEKDGKPYCKHC |
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| Phosphatase | mbre_TPIP.AA | Subfamily.PTPDC1.PD | 600-676 | 31 | 3.4e-13 | 40.8 | In-house | 137-209 (229) | Show / Hide |
Range on Protein: 600-676 Range on HMM: 137-209/229 Sequence Identity: 31% (24 aa) VKNCRIDDHNVPPLNEIFSICREFQDFLskDEKRvLAIHCKGGKGRTGTIICSWLLYSGMFTqAQEALDFFAERRTD . |. ..|..|..|..| | . . | | . .|.|| |.|||| .|...|.|. .| |.||... ..|.. fynfglkDygvasleriLdivkvvdfal--eegk-iavHCHAGlGRtGvliacylvyakrlt-aeeaiklvrskrpk |
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| Phosphatase | mbre_TPIP.AA | Subfamily.DSP11.PD | 588-674 | 26 | 1.1e-10 | 32.7 | In-house | 32-122 (141) | Show / Hide |
Range on Protein: 588-674 Range on HMM: 32-122/141 Sequence Identity: 26% (24 aa) ERDYDHAFFNNS-VK--NCRIDDHNVPPLNEIFSICREFQDFL--SKDEKRVLAIHCKGGKGRTGTIICSWLLYSgMFTQAQEALDFFAERR .| |.. .... || .. |.|| ... . ... ..|| .||.......|| | ||| .|| .|. . ....|.. | || dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidv-egyspedaieafeear |
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| Phosphatase | mbre_TPIP.AA | Subfamily.PRL.PD | 577-675 | 26 | 1.8e-09 | 28.7 | In-house | 24-122 (140) | Show / Hide |
Range on Protein: 577-675 Range on HMM: 24-122/140 Sequence Identity: 26% (26 aa) PNAYLIVNCCsERDYDHAFFN---NSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAER |. .| .| | || . .. .|.. || .||| . . . . .. ....| ..|.|| | ||. ... |. .|| . ..|..| |.| envkevvrvc-epsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kyedavefirek RT rr |
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| Phosphatase | mbre_TPIP.AA | Subfamily.RNGTT.PD | 588-678 | 24 | 3.9e-09 | 27.5 | In-house | 31-123 (140) | Show / Hide |
Range on Protein: 588-678 Range on HMM: 31-123/140 Sequence Identity: 24% (23 aa) ERDYDHAFFNNS-VKNCRIDD--HNVPPL-NEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSgMFTQAQEALDFFAERRtDKG .| ||. .... || ... . . | ... . . ..||.| ..|...|| | ||| .|...|. . . ..|.. ||. |..| sryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvek-edwsveaavalfakar-ppG |
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| Phosphatase | mbre_TPIP.AA | Subfamily.PTPMT1.PD | 605-675 | 21 | 1.3e-08 | 26.0 | In-house | 61-128 (146) | Show / Hide |
Range on Protein: 605-675 Range on HMM: 61-128/146 Sequence Identity: 21% (15 aa) IDDHNVPPLNEIFSICREFQDFLsKDEKRVlAIHCKGGKGRTGTIICSWLLYSGMFTqAQEALDFFAERRT .| ..| |.... . ... .....| .||| |..| .|.. ..|... .. ..|| .|....| vDfteapslekleegvefiekva-skgssv-YvHCkAGrtRsatlvacylmkkkkls-peeavkflkkkRp |
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| Phosphatase | mbre_TPIP.AA | Subfamily.DSP23.PD | 589-667 | 25 | 1.8e-08 | 25.8 | In-house | 25-100 (128) | Show / Hide |
Range on Protein: 589-667 Range on HMM: 25-100/128 Sequence Identity: 25% (20 aa) RDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEkrVLAIHCKGGKGRTGTIICSWLLYSGMFTqAQEAL . | .| . ... .|.|. | |. . . | .. |.| ...|| | |||||.. .|. . .. |..|. apyseaapsltlrridipdfcPPaleqvarlvriveeaekkee--avgvhcalGlGrtGtllacylvkeegla-addai |
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| Phosphatase | mbre_TPIP.AA | Family.DSP.PD | 786-826 | 19 | 4e-08 | 24.2 | In-house | 309-349 (387) | Show / Hide |
Range on Protein: 786-826 Range on HMM: 309-349/387 Sequence Identity: 19% (8 aa) GTAVRQDVKTMFYSEDLPAYYDKCPFYFWFNTGFVPEDRFV | . ||| ... |. ....... ..|.|....... | glplsgDVkvelfkknldkiirdiilntfFvtnyikdeslv |
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| Phosphatase | mbre_TPIP.AA | Subfamily.DSP1.PD | 582-675 | 24 | 5.1e-08 | 24.3 | In-house | 31-121 (139) | Show / Hide |
Range on Protein: 582-675 Range on HMM: 31-121/139 Sequence Identity: 24% (23 aa) IVNCCSERDyDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLaIHCKGGKGRTGTIICSWLLYSGMFTqAQEALDFFAERRT ..|...| . .. . |. ..|.. . . |. .| | . | . ||| .||. | |. ||. .|. . .. .|| .| .||. llnvsaelp-nvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvl-vhCqaGisrsativlayLmkekkvr-leeafefvkqrrs |
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| Phosphatase | mbre_TPIP.AA | Subfamily.N12.PD | 606-695 | 29 | 5.7e-08 | 23.4 | In-house | 173-261 (270) | Show / Hide |
Range on Protein: 606-695 Range on HMM: 173-261/270 Sequence Identity: 29% (28 aa) DDHNVPP-LNEIFSICREFQDFLSkDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQ-EALDFFA---ERRTDKgvgnmFQGVQTPSQYRFV ||.|| ...... ...... . .|. |..|| | ||||||| . .. . .. | || | | |... ||| ||..| PDhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqr-----aalvqtkeqyelv |
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| Phosphatase | mbre_TPIP.AA | Subfamily.CDC14.PD | 618-668 | 38 | 6.1e-08 | 23.8 | In-house | 185-233 (258) | Show / Hide |
Range on Protein: 618-668 Range on HMM: 185-233/258 Sequence Identity: 38% (19 aa) SICREFQDFLSKDeKRVLAIHCKGGKGRTGTIICSWLLYSGMFTqAQEALD .| ..| . . | . .|.||| | |||||.| ..|.. || |.|.. ailkkfleiteka-eGaiavhCkaGLGrtgtligcylikhyrft-aaetia |
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| Phosphatase | mbre_TPIP.AA | PTEN_C2 | 792-824 | 36 | 9.7e-07 | 26.36 | Pfam | 72-109 (141) | Show / Hide |
Range on Protein: 792-824 Range on HMM: 72-109/141 Sequence Identity: 36% (14 aa) DVKTMFYSED-LP--AYYDKCPFYFWFNTGFVP--EDR ||| ..|. . .. .|..|.|.|||||.|.. . | DVKIQCYHKGPSDLPWMYEECMFRFWFNTCFIEHNNNR |
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| Phosphatase | mbre_TPIP.AA | Subfamily.DSP8.PD | 583-675 | 21 | 1.1e-06 | 19.9 | In-house | 32-123 (143) | Show / Hide |
Range on Protein: 583-675 Range on HMM: 32-123/143 Sequence Identity: 21% (20 aa) VNCCSERDYDHAFF-NNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLaIHCKGGKGRTGTIICSWLLYSgMFTQAQEALDFFAERRT .| .. . | . .. . . . |.. | ..| . || | . ...|| .|| |. |. |.. .... . . .|| | |.|. lnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvl-vhclaGisrsatvaiayimkt-lemsldeayrfvkekrp |
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| Phosphatase | mbre_TPIP.AA | Subfamily.N14.PD | 613-695 | 30 | 1.7e-06 | 18.7 | In-house | 186-266 (275) | Show / Hide |
Range on Protein: 613-695 Range on HMM: 186-266/275 Sequence Identity: 30% (26 aa) LNEIFSICREFQDFLS--KDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAERRTDKGvgNMFQGVQTPSQYRFV |.|. |..|.... . |..| . .|| | |||| .| | || . . . .| .| .. . ||| .||.|| LeevqsvrrktnsevesvkeskPPvlvhCsaGvGrtGvlilsdlliatl--ehneeidikkvlarLrk--qrmllvqtlaqykfv |
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| Phosphatase | mbre_TPIP.AA | Subfamily.DSP19.PD | 600-670 | 16 | 3.5e-06 | 18.1 | In-house | 46-116 (139) | Show / Hide |
Range on Protein: 600-670 Range on HMM: 46-116/139 Sequence Identity: 16% (12 aa) V--KNCRIDDHNVPPLNEIFSICREFQDFLSKDEKrVLAIHCKGGKGRTGTIICSWLLYsGMFTQAQEALDFF . |. | |.. | .... . .| . . . .. .||. | |. ... ..|. .. ..||. ftyksieilDlpetkllsylkealdFieearskdg-rvlvHCnAGvSRsasvviaylmk-deelslekalekv |
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| Phosphatase | mbre_TPIP.AA | Subfamily.RK.PD | 608-695 | 26 | 5.3e-06 | 17.0 | In-house | 173-258 (267) | Show / Hide |
Range on Protein: 608-695 Range on HMM: 173-258/267 Sequence Identity: 26% (24 aa) H-NVPPLN-EIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYsGMFtQAQEALDFFAERRTDKG-VGNMfqgVQTPSQYRFV . .|| . .... |. . ...|. . .|| | ||.|| | . | . .. .| | .| . || |.| ||.|| yrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivl-emi-eregvvdvfnavktlrnrkvnm---veteeqykfv |
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| Phosphatase | mbre_TPIP.AA | Subfamily.N_Choan_1.PD | 607-695 | 35 | 6.7e-06 | 16.9 | In-house | 167-253 (262) | Show / Hide |
Range on Protein: 607-695 Range on HMM: 167-253/262 Sequence Identity: 35% (32 aa) DHNVPP-LNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRTDKGVGNMFqgVQTPSQYRFV || || .|... .. . . .|..| | ||| | ||||| | | . . . .|||| | . . |.. ||| ||.|| dhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyialDrlvkave-ekaealdvkavvaelrkernlm--vqtlvqyefv |
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| Phosphatase | mbre_TPIP.AA | Subfamily.R_Anemone_2.PD | 608-695 | 24 | 7.1e-06 | 17.0 | In-house | 169-253 (262) | Show / Hide |
Range on Protein: 608-695 Range on HMM: 169-253/262 Sequence Identity: 24% (22 aa) HNVPP-LNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAERRTDKGVGNMFqgVQTPSQYRFV ..|| ..... |. . . .......|| .| ||||. | | . .|.. .| | .. . |. ||| .|| |. egvpesgaslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiavdilleri--kaealvdvfqtvkqlreqrnlm--vqtkdqyefi |
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| Phosphatase | mbre_TPIP.AA | Subfamily.RB.PD | 607-671 | 28 | 9.2e-06 | 16.5 | In-house | 166-230 (261) | Show / Hide |
Range on Protein: 607-671 Range on HMM: 166-230/261 Sequence Identity: 28% (19 aa) DHNVPPL-NEIFSICREFQDFLSKD-EKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFA ||.|| . . ...|.... ..|. .|. . .|| | ||||| | | . .... .| |. dhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqai--eendyvdvfg |
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| Phosphatase | mbre_TPIP.AA | Subfamily.R_Sponge_2.PD | 608-696 | 25 | 1e-05 | 16.4 | In-house | 169-254 (262) | Show / Hide |
Range on Protein: 608-696 Range on HMM: 169-254/262 Sequence Identity: 25% (22 aa) HNVPPLN-EIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAERRTDKGVGNMFqgVQTPSQYRFVG |.|| . . .. .. . |...... ..|. | ||||| |. . . . .| | .| | .| . ... ||. .|||. hevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialdsvlerl--kaeeeidvfevlktlrtkrigl--vqdaaqYvfih |
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| LIM | mbre_TPIP.AA | LIM | 851-908 | 39 | 2.3e-17 | 64.37 | Pfam | 1-60 (60) | Show / Hide |
Range on Protein: 851-908 Range on HMM: 1-60/60 Sequence Identity: 39% (24 aa) CPSCGKSVYFAEKHT-ALGKDWHKMCLKCEKCKKILANGS-FLEHGG-KPYCQKPCYEALF | .|.| .| ... . |..| || |..| |.| |..|. . || | |.||.. || || CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKH-CYHKLF |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| mbre_TPIP.AA | Protein | None | 934 | None | Fasta, JSON |
| mbre_TPIP.NA | RNA | None | 2802 | None | Fasta, JSON |
| mbre_TPIP.AA.PD_596-703 | Protein Phosphatase Domain | None | 108 | None | Fasta, JSON |