• Phosphatome.Net

Gene Nvec_PTPN3

Nvec_PTPN3
Species: N.vectensis
Alias: Nvec_182236, Nvec_PTPN3
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Classic_PTP
Subfamily: N3
Protein domain

Protein domains of Nvec_PTPN3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FERM Nvec_PTPN3.AA B41 31-234 32 3.7e-74 253.61 SMART 1-232 (232) Show / Hide 
Range on Protein: 31-234
Range on HMM: 1-232/232
Sequence Identity: 32% (77 aa)

NPQKIRCVVELLDDSEFIIDVDKNAKGTVLLNEVFRHLDI--QEKHYFGLQYVSDSPDNMVGGAKEQWLQDDKIIRKQKKG---TPPYIFYFCVRFFVSD
.|. ..| | ..|..   . ||....| .|...|.||..|  .|..||||.| ..  |         ||. .| |.||..    ..|. ..| |.|...|
SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHED-------RHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPD

----PSKLVEDLTRY-YFYLQIKRDILTGRLPCL-YDTAAELSSYILQAELGDYDPK--------LHLDGYVSEFRFIPDQ---------------TDDF
    |..| || ||| |||||...|||.||.||  ......| ....|.|.|||||.         |. .|.|..||.|.|               ....
WHGFPNQLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMHHKEW

EERAAEFHKHHIGQTPADAEFNFLEVAKTLD-LYGVDLH
..| .|.|| |.|.||..|....|....... .|||...
RKRIMEWHKNHCGMTPEEAKLKYLQICQRWPPMYGVEHF
FERM_C Nvec_PTPN3.AA FERM_C 238-328 47 1.4e-43 155.9 Pfam 1-99 (99) Show / Hide 
Range on Protein: 238-328
Range on HMM: 1-99/99
Sequence Identity: 47% (47 aa)

DHDGTD-LFLGVSALGLTVY--HNKCKI---NFFPWSKIVKVCFKRKRFFIQIR--PDWNEWTDNIIGFQMLTYRSCKNLWKVCVEYHSFYRTHYPKAT
|..||| ..|||.|.|. ||  ... ||   |.|||..|.|. ||||.|||..|  ||..|. . ...|.| .|| ||.|||.|||.|.|.|.  |  |
DKKGTDTWWLGVCAKGINVYQVQDNNKITPMNTFPWPEIRKISFKRKKFFIKLRDDPDEGEKYEHTHTFYMPNYRACKYLWKCCVEHHQFFRLRRPPDT
FERM Nvec_PTPN3.AA FERM_M 125-234 24 1.2e-42 147.44 Pfam 1-171 (171) Show / Hide 
Range on Protein: 125-234
Range on HMM: 1-171/171
Sequence Identity: 24% (42 aa)

DPSK-LVEDLTRYYFYLQIKRDILTGRLPCLYDTAAELSSYILQAELG-DYD-PKLHLDGY-VSEF-------------------RFIP-----------
||.. . .. ||..||||.|.||| ||.||  ..|..| .|..|.|.| ||. |  | ..|  .|.                   |..|           
DPNRDIQDEVTRHQFYLQAKWDILEGRYPCSEEEALMLAAYQCQIEFGSDYNPPQKHKSDYMEKEWWEQQEGMEVWLRCDNEQQERYWPAHCRLASKGRT

--------------------------DQTDDFEERAAEFHKHHIGQ-TPADAEFNFLEVAKTLDLYGVDLH
                           .....|.| .| ||.|.|. .|..|. .......... |||...
MADSSYSEVSIRINPHCYVSPWYCKKMKQKQWEQRILEQHKNHRGMCSPEEAMLQYIQICQRWPMYGVHFF
FERM Nvec_PTPN3.AA FERM_N 39-123 35 2e-30 111.71 Pfam 1-93 (93) Show / Hide 
Range on Protein: 39-123
Range on HMM: 1-93/93
Sequence Identity: 35% (34 aa)

VELLDDSEFIIDVDKNAKGTVLLNEVFRHLDIQEKHYFGLQY--VSDSPDNMVGGAKE-QWLQDDKIIRKQKKG---------TPPYIFYFCVRFFV
| ||||..  ...||...| .|...|..||.|.|..|||||.  . |. .    |     ||..|| |.|| |          .||....|.|.|..
VHLLDDTQLECTCDKKTTGQELFDQVCQHLNIRECWYFGLQFCKQNDKKE----GNQHMHWLDPDKKICKQMKDGWKHKIKKKCPPCTLFFRVKFYP
FA Nvec_PTPN3.AA FA 330-376 47 4.8e-20 73.74 Pfam 1-48 (48) Show / Hide 
Range on Protein: 330-376
Range on HMM: 1-48/48
Sequence Identity: 47% (23 aa)

KRVL-RMGSKYRYKGKTEYQAIEESRTHARPEPKIVRTLSRRYSKRSD
||.. ..|||.||.|.|.||.||.|| | |. |...|..|.||..|..
KRFFCSWGSKFRYSGRTQYQTIEYSREHQRKPPQFHRSPSKRYPSRRS
PDZ Nvec_PTPN3.AA PDZ 458-543 30 5e-18 64.34 Pfam 1-86 (86) Show / Hide 
Range on Protein: 458-543
Range on HMM: 1-86/86
Sequence Identity: 30% (27 aa)

TVRMEPD-KEGRFGFNVQGGADIN--LPVIVSKIARGTPADLCMPQLQEGDEIIFINGQAMKGLIHQEIVDLIRSVSQSRSNTLILTIR
.|..|.. | |..||...|| |     ....|.. .| .|. . . ..||| || |||| . .. | ..|..|.. ..    .. |||.
QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKG---GEVHLTIQ
Phosphatase Nvec_PTPN3.AA PTPc 613-873 32 3.9e-109 369.78 SMART 1-308 (308) Show / Hide 
Range on Protein: 613-873
Range on HMM: 1-308/308
Sequence Identity: 32% (103 aa)

DLLVYFQELYRKKPGM---------AMDDARKPENL--PKNRYR-DILPYDETRVKLFKG---------SDYINANFVNMEVPSHGIVLRYIAAQGPLEK
 .  .|..|.| .|..          .. |..|||    ||||. ||..||.||||| ..         |||||||.....    .   |||..||||. 
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY----WRPKRYICTQGPLPH

TCGDFWQMIWEQESTLVIMLTTTMER--------GRVKCHQYWPEGEDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTTTL--------RSRVIIQLQY
|. |||.|.|.| .. ..||.. ||.        ||.|||||||.   ..|.|...| | .    ...|. |...||.|..          .| . ...|
TIEDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHY

LAWPDHDVPDDATDFLEFVHSVRHYREGT-------------------STPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQ
 .||||.||.....||.|.. |||...                     ..| |||||||.||.|..  |...  .||    | ....|..||.||  ..|
TNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGMVQ

TPGQFLFVCEATLKAYD
|. |..|.... |. . 
TEEQYIFCYRCILEYIK
PDZ Nvec_PTPN3.AA PDZ 467-546 23 1.3e-16 62.42 SMART 1-80 (80) Show / Hide 
Range on Protein: 467-546
Range on HMM: 1-80/80
Sequence Identity: 23% (20 aa)

GRFGFNVQGGADINLPVIVSKIARGTPADLCM----PQLQEGDEIIFING-QAMKGLIHQEIVDLIRSVSQSR-SNTLILTIRPNV
| .||...|      ....|.. .|.||. .     ..|..||.|. .|| | .... |...||.... ....   .. ||.... 
GGLGFSIVG------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
Phosphatase Nvec_PTPN3.AA Subfamily.N3.PD 614-873 65 7.50000000001e-134 436.1 In-house 2-261 (261) Show / Hide 
Range on Protein: 614-873
Range on HMM: 2-261/261
Sequence Identity: 65% (172 aa)

LLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKGS-DYINANFVNMEVPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLT
.|..|.||||||||.|.. |||||||.|||||||||||.||||| ... ||||||.||||.||.|.| ||||.||||.||. |||||.|||.|||..|||
vlaqfeelyrkkpglaisaarkpenlaknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlt

TTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIrDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHC
|..||||||||||||| ||...||...|.|.|  | . |||.||....|..| ..| |.||||||||||.||||..||||||..||..|.|...| ||||
tlverGrvkChqyWPetedelefgefsvrceke-detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAYD
|||.||.|||...|||. .|| |||||||..||.|||||..|.||..|. |||||.||||.
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtvsqykfvCeailkaye
Phosphatase Nvec_PTPN3.AA Y_phosphatase 638-870 37 2.1e-102 351.33 Pfam 1-243 (243) Show / Hide 
Range on Protein: 638-870
Range on HMM: 1-243/243
Sequence Identity: 37% (92 aa)

NLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGR-VK-CHQYWPE--
|..||||.||..|| |||||      ..|||||||....   ...   .||..|||...|..|||.|.|.| .| ..||.. ||.|| .| ||||||.  
NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDG---PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNK

GEDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTTT--LRSRVIIQLQYLAWPDHDVPDD-ATDFLEFVHSVRHYRE-GTST--PAVVHCSAGVGRSGVL
 ....|.|...| | .     | |. |.. ||. ..    .| . ...|..||||.||.. ....|.|.. ||.... . .   | |||||||.||.|..
EGQPMTYGDFQVTCVSEEH-CPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTF

MFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
. |...  ..|  . |  ...|..|| ||  ..||. |..|.... | 
CAIDIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE
Phosphatase Nvec_PTPN3.AA Subfamily.N13.PD 618-871 42 1e-79 259.0 In-house 6-257 (259) Show / Hide 
Range on Protein: 618-871
Range on HMM: 6-257/259
Sequence Identity: 42% (110 aa)

FQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKGSDYINANFVNMEVpsHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMER
|.||   ||    . ..| ||  |||||..|||||||||| . . ||||......|       .|||.|||| .|. |||||.|||......|.|.  |.
fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv--gedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekek

GRVKCHQYWPEGED-TWTFGN-LEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREgTSTPAVVHCSAG
|.||||.|||| .. . .  | |||   |. . . ..| |.. |.|. . .|| . .|.. .||||.||  |.....||  ||. ..  ..| |||||||
gkvkchrywPerknkklkvsnrlevellkvqkld-gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrllqt-dagPivvhcsaG

VGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
.||||||. |....|.||  ...   |.||..|.|| ...||  |..|| .|.|..
iGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
Phosphatase Nvec_PTPN3.AA Subfamily.RB.PD 624-870 36 4.8e-72 233.7 In-house 12-258 (261) Show / Hide 
Range on Protein: 624-870
Range on HMM: 12-258/261
Sequence Identity: 36% (92 aa)

KKPGMAMDDARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERG
.  .|.. |....|  |||.. |||||..||||      ...||||||..    | .     |||.||||..|  |||.|.||..|. ..|||..|.|..
vgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyi----pgynspreyiatqGPlpetvddfWrmvwekkssiivmltqlvEkg

RVKCHQYWPEGEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTlrSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGT--STPAVVHCSAGV
||..|||. |.. ..|...|  .. ..   ..| ||. ..  ..  .| ..|.....||||.||....  |.||..||.. | ...| ||||||||||.|
kekceeYWPadeepvlyGdikvtllaeke-ldewvirefkiekgke--krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGv

GRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
. . ... .  ||  . |  . .| ..| .| .|.||  |..|. |. |.    
GRtGtfialdrllqaieendyvdvfgvvaelReeRnllvqtekqyifiheclld
Phosphatase Nvec_PTPN3.AA Subfamily.R_Anemone_2.PD 618-869 37 5.2e-70 227.2 In-house 6-258 (262) Show / Hide 
Range on Protein: 618-869
Range on HMM: 6-258/262
Sequence Identity: 37% (97 aa)

FQELYRKKPG-MAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIML
...| |..   . .. | .| |  |||| .||.||.|||||      .||||||||...    ..     |||.|.|| .|. |||.|.|||.|....||
yerlsrseetsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkk----ayiatqaPlpetiedfWrmvWeqnsavivml

TTTMERGRVKCHQYWPEgEDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYR-EGTSTPAVV
| ..|||..|.|.|||. ... ..|.| |  ..  ..| .|| |.. |. | .  .|.. | .| .|||..||......|..| .|...  | . .| ||
tqeeergkakvhryWPs-kgsrsygklvvelkeevels-dyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgagpivv

HCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
|||||||| || . ... .  |.  . |  .. |...|.||  ..||  |. |... | 
hcsaGvGrtGvfiavdillerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvll
Phosphatase Nvec_PTPN3.AA Subfamily.N12.PD 619-869 40 8.5e-70 226.2 In-house 13-266 (270) Show / Hide 
Range on Protein: 619-869
Range on HMM: 13-266/270
Sequence Identity: 40% (104 aa)

QELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPShgivLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTT
.| |...  .. . ..|.||  ||||.||||||..||.| |     |||||||||..    .    |.|||||||| ||  |||.||||.. ..|.|.  
sekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegk----leyiaaqgPLpktlddfWrmiweknveivvmaCr

TMERGRVKCHQYWPEG-EDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTttLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHC
 .| |. ||..||||  |.. .||..|| ... . ..  .. | . |.      ||.. |..| |||||.||  |.. ||....||...|  ..| ||||
evelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkveaq--kesrkvyqfhytaWPDhgvPssaksllelielvrelqesedaPlvvhC

SAGVGRSGVLMFIETAFGMIEGAEP---VYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
|||||| |... |. .  ...       .   .|| ..| || .|.||  |. .| .| .
saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykava
Phosphatase Nvec_PTPN3.AA Subfamily.N_Choan_1.PD 618-871 34 7e-68 220.1 In-house 6-260 (262) Show / Hide 
Range on Protein: 618-871
Range on HMM: 6-260/262
Sequence Identity: 34% (89 aa)

FQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLT
...|.    . .   ....||  ||||..|  || ||||.      | .||||||||.    .     .|||.|||. ... .||||.|||. ....|.|
yeklaeigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvp----gykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvt

TTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIRDfSPSYVYREMYVtDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE-GTSTPAVVH
  .| |..|||.|||... . ..|.. |  .. .. ...|. |.. . ....  .| . ||.|.||||| ||......||| . |.....  | .| |.|
reieagklkChryWPdenselklgdvtvkslseee-kktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktkaplvih

CSAGVGRSGVLMFIETAFGMIEGAEPV-YPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
|||||||.|. . .....  .|  ...  . ..|. .| .|  ..||  |. ||  | |.|
CsaGvGrtGtyialDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvykavlda
Phosphatase Nvec_PTPN3.AA Subfamily.N14.PD 617-868 36 3.1e-66 214.6 In-house 5-270 (275) Show / Hide 
Range on Protein: 617-868
Range on HMM: 5-270/275
Sequence Identity: 36% (95 aa)

YFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKG----SDYINANFVNMEVPShgIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLT
.... .|.    .. |. ||| .|||..|.|||...||.|       ..||||  ... | .    . ||.||||||.|. |||||.|||..|..||| .
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvgg--kersyivaqgPleltvqdfwqmvweqgvqlivmlt

TTMERGRVKCHQYWPEG---EDTWTFGNLEVVcNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFV---HSVRHYREGTS-
 | |. |...|.|.    ..| .||. .|. .| .. |.|.. . . .    . . | .. |||  ||||.||.| ..||.|..|||.  . ..      
eeeedgkeksfkylPkleskkktvefgkfkvt-tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnseve

------TPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
  | .|||||||||.|||.  .     .|  | .   . ..|.| || .|.|| .|. || ..      
svkeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLrkqrmllvqtlaqykfvykvl
Phosphatase Nvec_PTPN3.AA Subfamily.R_Sponge_2.PD 623-869 33 3.9e-65 211.2 In-house 10-258 (262) Show / Hide 
Range on Protein: 623-869
Range on HMM: 10-258/262
Sequence Identity: 33% (84 aa)

RKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK----GSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERG
.|.  . ...|...||..|||...|||||..||.| .    .||||||.||.     .     |||.||||..| .||| |.||.... ..||| . |.|
eketefslsiaklkenvgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvdgykrrk----ayiatqgPlketveDfWRmvweykvstivmltnleeng

RVKCHQYWPEG-EDTWTFGNLeVVCNKIRDFSPSYVYREMYVTDTTTLRSRV-IIQLQYLAWPDHDVPDDATDFLEFVHSVRHY-REGTSTPAVVHCSAG
. ||..||||  ... ..|.  .|  | .  .. |. |.. ......  ... . | ...|||.|.||.|||.||....|..  ..  ... .|.||.||
kekcakYWPekvdeeveygkf-kvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdg

VGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
||.|  . ... .  ..  | .   |... .| .|  |.|.  |. |. .| | 
vgrtGtfialdsvlerlkaeeeidvfevlktlrtkriglvqdaaqYvfihdall
Phosphatase Nvec_PTPN3.AA Subfamily.R_Anemone_1.PD 618-871 35 5.2e-64 207.6 In-house 6-256 (258) Show / Hide 
Range on Protein: 618-871
Range on HMM: 6-256/258
Sequence Identity: 35% (91 aa)

FQELYrKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVpshGIvLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLT
||.|  ... . .. |||.||  |||| ||...|..|| | |      |||||| ...      .    .||.|.|||.|..|||.|.|..... ..|||
fqrlk-eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasd---kt-rafiatqapleetvedFWrmvwqekigviVmLt

TTMERGRVKCHQYWPEgeDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHC
. .|    |||||||.   | ..|.|.|  .|  .|.  |. |.. .. ... ..| ..|.... |||.||. ||. |.....|.. ..  ..| |||||
nliegekkkchqYwPd--stekygelrvslrkkevfa-dyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqksslagarpvvvhC

SAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
|||||.|. . |.. .  .   . |   . |...| .|  ..||  |..|. .|.|.| 
saGvgRtGaflvidamleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavlea
Phosphatase Nvec_PTPN3.AA Subfamily.N6.PD 625-867 35 6.3e-64 207.3 In-house 27-289 (295) Show / Hide 
Range on Protein: 625-867
Range on HMM: 27-289/295
Sequence Identity: 35% (94 aa)

KPGMAMDDARKPENLPKNRYRDILPYDETRVKLF------KGSDYINANFV--------NMEVPS-HGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVI
.  .  ....|.||  ||||..|||.|.|||.|       .||||||||..        . |..  .    ||||.||.|..|  |||.|.|...|....
eklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvwqensrviv

MLTTTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIrDFSPSYVYREMYVTDT-TTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGT--ST
|.|  .|||. || .|||. |.. ..|...| . .  .   .|. ||. |.   .  ..| |.|... |||||.|| |.  .|.|..|.. .|    . |
mttkevergknkCarYWPdeetkketGvitvtsisE-kstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqeelekag

PAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLEL---VRRMRDQRGSLIQTPGQFLFVCEA
 |||||||.|| | .. |..   .||     .....   ....| ||  |.||  |. ||  | 
pivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvyka
Phosphatase Nvec_PTPN3.AA Subfamily.N1.PD 629-869 37 2.4e-62 202.1 In-house 19-264 (268) Show / Hide 
Range on Protein: 629-869
Range on HMM: 19-264/268
Sequence Identity: 37% (94 aa)

AMDDARKPENLPKNRYRDILPYDETRVKLFKGS-DYINANFVNMEVpshgIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
. .|..||| ..|||||. ||| .|.|| ... |||||..|..|     .  ||| .|||| .|.. ||||.|||.|  ||||   .|....||.||||.
etreaklpenrglnryrdvspydhsrikleradvdyinaslvelee----akrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCaqywp

EGEDT--WTFGNLEVVCNKIR-DFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYR--EGTSTPAVVHCSAGVGRSGVL
.|..   .. . .   . |. ...  .. | . ..| .| ..|.|.. .|  |||  ||.  . ||.|.. ||.        .|||.|||||.|||| |.
qeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpavihCsagigrsgtl

MFIETAFGMIEGAEPVYPLELVR---RMRDQRGSLIQTPGQFLFVCEATL
...| .  ||  . .  ... .    .| .|  ||||| |  |   | | 
slvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiail
Phosphatase Nvec_PTPN3.AA Subfamily.N9.PD 619-869 37 1.3e-60 196.4 In-house 7-271 (275) Show / Hide 
Range on Protein: 619-869
Range on HMM: 7-271/275
Sequence Identity: 37% (101 aa)

QELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPSHGivlrYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTT
... ....   .. .... || |||| |.| |||||||| |      |||||||||.     ..    .||.||||.||. |||.|.||||..| | ..|
adirnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkka----fiatqGplkktvsdfwrmvweqevlvivmttr

TMERGRVKCHQYWPEG-EDTWTFGNLEVVCNKIRdFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG---------
|||.|| ||||.. |..  ||.|.|   ...  .  |. | . .....| .|| ..  |.|.|||. ||..|...|.... ||...              
vvergrlkcgqywpleeessaefgdlsvsnveve-veedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdes

----TSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
 .  | |||||||.||.| .. .. .   .|  . |   | |...| ||   |||| |. |   | |   
kghlsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
Phosphatase Nvec_PTPN3.AA Subfamily.RA.PD 629-872 35 1.8e-60 195.8 In-house 18-265 (266) Show / Hide 
Range on Protein: 629-872
Range on HMM: 18-265/266
Sequence Identity: 35% (90 aa)

AMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCH
.. | |.||  |||. .||||| .|| |      . |||||| |..     .    ..||||||.|.|  |||.|||||.|. ..|||   ||.. ||.|
klrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekd----kfiaaqGpkeetvedfwrmiweqksativmltelkerkeekca

QYWPEgEDTWTFGNLEVVCNKIrDFSPSYVYREMYVTD---T-TTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTST-PAVVHCSAGVGR
|||. | ..|.|.. |  ..    . .|  |.. ||.   .    .||.. |. . .||.  || ..   |.... |.. .. ..| ||||||||||.| 
qywpd-eGlvtyGeirvevkde-tvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanhpivvhcsaGvGr

SGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
.. ... . ...  . .   | |.|.| ||  ..||  |. |. .. |. .   
tGtfivldavlervkaerkldvfeavkrlrlqrpqmvqtleqyefiykvlleyi
Phosphatase Nvec_PTPN3.AA Subfamily.R_Ecdysozoa.PD 627-869 37 8.7e-58 186.8 In-house 16-265 (269) Show / Hide 
Range on Protein: 627-869
Range on HMM: 16-265/269
Sequence Identity: 37% (94 aa)

GMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVk
. | ||. ||||.|| ..|.||||| |      ||||||.|..    ..    ..||||.|.| | ||||.||.|||.||..||.   |  |  |..|||
skstkvsekkenalknryedikafDktrvkLkkingkedsdyinasfik----gykekkkfiaaqdPveatigDfWrmiaeqevtlivmlsnlteknrk-

CHQYWPEGeDTWTFGNLEVVCNKIRdFSPSYVYREMYVTDTT---TLRSRVIIQLQYLAWP-DHDVPDDATDFLEFVHSVR-HYRE----GTSTPAVVHC
.  |.  .|.. | . . . . . |. ||..|. .       || ..| .| .|. |  ||. |.  |.... || .|.     |. .| ||||||||||
cakyWpie-devqygdilvklvsee-khsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnklsgsrsPivvhC

SAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
||... ..  .  ..  . |  .| |. .| ||  |.|   |. |.  |.       
saGvgrsgifvaldlllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyrala
Phosphatase Nvec_PTPN3.AA Subfamily.RK.PD 629-871 33 4.3e-57 184.5 In-house 20-265 (267) Show / Hide 
Range on Protein: 629-871
Range on HMM: 20-265/267
Sequence Identity: 33% (83 aa)

AMDDARKPENLPKNRYRDILPYDETRVKLFK----GSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTT-MERGRVKCH
.| | |..|  |||. |||.|| ..|.|       ||||||...     |.     .|..||||..|  |||......... ..|||   .|.||||| .
dcdiakkdrnreknrsmdilaydrslvflisvdgdssdyinaali----dsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkCl

QYWPEGEDTwTFGNLEVVCNKIrDFSPSYVYREMYVTD--TTTLRSRVIIQLQYLAWPDH-DVPDDATDFLEFVHSVRHYREG-TSTPAVVHCSAGVGRS
||||  .. ..|...| . .  .    .| | . |.    .    |.. |.|.|.||.. |||. .. .|.... | . .|  .  .||||.|| ||||.
kyWPedtev-rygdikvelvea-eldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrs

GVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
 . |..   |||  . |   . |. .|...  ...|  |. || .. | |  
Gtfiaidivlemieregvvdvfnavktlrnrkvnmveteeqykfvydvilea
Phosphatase Nvec_PTPN3.AA Subfamily.RG.PD 618-870 32 6.9e-55 177.5 In-house 6-261 (264) Show / Hide 
Range on Protein: 618-870
Range on HMM: 6-261/264
Sequence Identity: 32% (83 aa)

FQELYR-KKPGMAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIML
|.|. . |.  . .. ..|.||  |||. .|......||||      .|.|||||....    |.     ||..||||..|. |||.||||.......||
feeiqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrsk----eyivtqgplketiedFWrmiWehnaqiivml

TTTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIRDFsPSYVYREMYVTDTTTLRS--RVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAV
|   |.|| ....|||. ... ....|.|   .   .  .|. |.. . .| . ..  ||. |..|  |||...|. ....| ||.. .. .. | |||.
tdldekgrrdedvyWPkkdeplelealkvtllskekl-skytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkkeeaankeeaGPiv

VHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
||||||.|... ..|    .|  | |  .......| .|  |..|  |. |. .| |.   
vhdsaGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydalle
Phosphatase Nvec_PTPN3.AA Subfamily.N5_RR.PD 631-867 34 1.8e-54 176.2 In-house 16-259 (265) Show / Hide 
Range on Protein: 631-867
Range on HMM: 16-259/265
Sequence Identity: 34% (82 aa)

DDARKPENLPKNRYRDILPYDETRVKLFK------GSDYINANFVNMEvpsHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQ
.. . . .  ||||..||| ...|| | .       |.|||||..      ..    |.|.|||| .|  |||.||...|.....||||. | ||..|.|
eelevfgsqtknryktilPnensrvllesessededssyinanyikGy---deeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcav

YWPEGEDT---WTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTLRsRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG---TSTPAVVHCSAGVGR
. ||.    ..|..|.  ..| .    |  |..... .. .. | ..   | .||||..|||.. .|..|. |.. ||.| |||||||.|| |. . |. 
yfPdaedyeiserygdveikveeive-rndysvrklvlkylerve-rsvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGr

SGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEA
|   ..  . |  |..| ..| .|| ..||  |. .. .|         
tGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihra
Phosphatase Nvec_PTPN3.AA Subfamily.RN.PD 628-868 35 6.2e-54 174.2 In-house 17-259 (264) Show / Hide 
Range on Protein: 628-868
Range on HMM: 17-259/264
Sequence Identity: 35% (88 aa)

MAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHGIvlrYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKC
. . |....|. |||....||||..||||      . |||||| ..  . | . .   |||.|||| .|  |||||.||| ......||.  ||  .|..
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa---yiatqgplsstiadfwqmvweqGvvvivnltrleeegvkqc

HQYWPE-GEDTWTFGNLEVVCNKIrdFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGV
|||. |.... . ....| ..|  ..  |. | .|. .  | ..| . |. .|.||...||  |  .|||   |     | |.| |||||.|.||.|| .
krywpdeGsevyhiyevhlvsehi--wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGv

LMFIETAF-GMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
 |.     .. |.  .     .  .||||  |..|  || |.  |   
yilidlvlerllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
Phosphatase Nvec_PTPN3.AA Subfamily.N_Choan_2.PD 641-868 34 7.6e-53 170.6 In-house 24-261 (266) Show / Hide 
Range on Protein: 641-868
Range on HMM: 24-261/266
Sequence Identity: 34% (82 aa)

KNRYRDILPYDETRVKLFK-----GSDYINANFVNmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEG-EDTWT
|||.||||  .|||.| .      . |||||.|.     .|   .||||.|||. |  .||.||||...| ..|.|  .|.|| ||.|||.  ... .. 
lnRyndiLPsPatRvrleeleedsataYinAnyvr---GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

F--GNLEVvCNKIRDFSPSYVYREMYVTDTTTlrSRVIIQLQYLAWPDHDVPDDAT------DFLEFVHSVRHYREGTS--TPAVVHCSAGVGRSGVLMF
 |...| ..     .  |. ... ..   .  .| .   .| .|||| || ..       . |. .. ||.|. ..  .| .|||||||||.|.|. |..
ladgkikv-lalseekeegyiltrlrlekkge--trrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRtGtlia

IETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
|. ..|  . | .|......| .|  |.|.| |. .. .|    
iDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykav
Phosphatase Nvec_PTPN3.AA Subfamily.N20.PD 628-869 36 1.9e-51 166.3 In-house 16-253 (257) Show / Hide 
Range on Protein: 628-869
Range on HMM: 16-253/257
Sequence Identity: 36% (88 aa)

MAMDDARKPENLPKNRYRDILPYDETRVKLFKGSDYINANFVNMevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
..   .| |  ||||||||||| ||| | |  |||||... .     |    |||.||||  |  |||||. |..| .. |.|  .| | .||..|||  
gefnsgnqpsnreknryrdilpydstrvplgkskdyinasyiri--vncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywp

EGE-DTWTFGNLEVVCNKIRdFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRegTSTPAVVHCSAGVGRSGVLMFIE
      .  . |. .. .     .. | . | . .|  |. . |||.  ||||  |  |  |.....  |. .   . | |||||||.||.||.. ..  
islkkplelkhfrvflenyq-ilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryarksh--ltgpmvvhcsagigrtgvflcvd

TAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
|  |     .  ...| .||.||  ..||  |. |. .  |  
vvfcaivkncsfnimdivaqmreqrsgmvqtkeqyhfcydivl
Phosphatase Nvec_PTPN3.AA Subfamily.RC.PD 615-871 29 5.9e-50 161.4 In-house 3-286 (288) Show / Hide 
Range on Protein: 615-871
Range on HMM: 3-286/288
Sequence Identity: 29% (85 aa)

LVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKL------------------------FKGSDYINANFVNmevpSHGIVLRYIAAQGPLE
.  ||.| . .  ...  |||.||  |||| |.||||  ||.|                         .||.|||| |..    |.    .||||||||.
eaefqrlpsvrskrtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfid----sykkpekyiaaqGplk

KTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWpeGEDTWTFGNLEVVCNKiRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDF
.| .|||.||.|.  ....|||   |  | || .||  .| . ..|..||  .. .| |..|. | . . .     || . |.|| .|.....|..   .
etvddfwrmiferkvkvivmltelkeGdrekcaeyw--eeGkrayGdvevdlkd-tdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkel

LEF----------VHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
|..           .|.  ...  ||| .|||..|..|.|. . ... .  .|  | |   ..|...| .|  ....  |... ..  .  
lkliqvvkqklpqkrsseafknfkstpllvhcrdGsqrtGifiallallesleaeekvdvfqvvkklrkarplmvsveeqyillydvlvet
Phosphatase Nvec_PTPN3.AA Subfamily.N23.PD 659-870 32 5.9e-50 161.5 In-house 129-347 (350) Show / Hide 
Range on Protein: 659-870
Range on HMM: 129-347/350
Sequence Identity: 32% (71 aa)

KGSDYINANFVNMEVPShgiVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGED-TWTFGNLEVVCNKIRDfSPSYVYREM
. .||||| ..   .|       .||.|||...| .|||.|.||| | ...|||.  |... ||.||||. |. | .||.|.| ... |. |... | . 
qqddyinatylkeltpm---sPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvslkslrs-segwiervl

YVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYR---EGTST------PAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYP-LELVRRM
.. . .   | . .|.. .|... ||.   |.|.|.. |...      | |      | ..||||||||.|..  . .|   .....   ...|||.| |
hlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltagngiiniprvvrrl

RDQRGSLIQTPGQFLFVCEATLK
|   .|.  .. .. || |.   
rqqRkymvqkkvilkklyeavle
Phosphatase Nvec_PTPN3.AA Subfamily.N_Nematode_1.PD 618-868 31 4.4e-48 155.1 In-house 6-260 (265) Show / Hide 
Range on Protein: 618-868
Range on HMM: 6-260/265
Sequence Identity: 31% (80 aa)

FQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKL---FKGSDYINANFVNMEVPShgivLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTT
|..| . ..   ..  .. ..  ||||.|.   |..||||      |||| ||.| . . .     |.| ||.||.||. ||||.  ..   ..||  ..
fralkkfndeekvkafkeaqeadknrykdvgcldknrvklaeeplpsdyihanyvgtptnp----krficaqaPldktiadfwymvlqekveaivmlckl

MERGRVKCHQYWPEGE-DTWTFGNL--EVVC-----NKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHyregTST
|.|..||..|.|  | .. .| .   ...       | .. . . .   .   . .  ..| . ..|.  |||. ||      ||....||.      .|
iekgkkkcaeyfpakegeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavrg----skg

PAVVHCSAGVGRSGVLMFIETAFG-MIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
 |||||||.||.| .. ||     ..|| .     .||...|.||   ||||.|||       
PivvhCsaGiGrtGtivaieyildkllegkqiedmeklvkkireqrnysiqtdaqylfvhrvl
Phosphatase Nvec_PTPN3.AA Subfamily.N_Nematode_4.PD 637-865 34 6.6e-45 144.8 In-house 25-256 (264) Show / Hide 
Range on Protein: 637-865
Range on HMM: 25-256/264
Sequence Identity: 34% (80 aa)

ENLPKNRYRDILPYDETRVKLFKG---SDYINANFVNMEvpshgIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDT-
.|  ||||.|||  ||||| | .     ||| |... |         |||..||||..|  ||| |....  . |.|| . .||  || .|.|| ...  
knsdknryadilcidetrvvlknrdpdndyihaswmrmP-----dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcaryypeksekv

WTFGNLEVV-CNKIRDFSPSYVYREMYVTDTT-----TLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHyrEGTSTPAVVHCSAGVGRSGVLMFIE
.||. ..   .|        ... . || |      . .  |.  .|.  |.|.  | ||.  ...|..  .  ..| ||||||||||.  |. |. |  
vkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk--kkkekPivvhcsaGvGrtatlvGid

TAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVC
.|     .  |..||..|  |   .|.  ||||.     
yatirirenseievldivrelramrlkavqshlqflfll
Phosphatase Nvec_PTPN3.AA Subfamily.R_Nematode_2.PD 638-869 29 7.7e-43 137.9 In-house 29-257 (261) Show / Hide 
Range on Protein: 638-869
Range on HMM: 29-257/261
Sequence Identity: 29% (67 aa)

NLPKNRYRDILPYDETRVKLFKG---SDyINANFVNMevpsHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPE-GEDTW
.  |.|| |.   .||.|.       .. | ||.|.     .|   |.||.||||| |. ||| |.  ..   ..||. ..|.. ||..|.|   ... .
pkdkhRypdvPCkpetavevivdgkrvp-ihanwvpt----agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkl

TFGNLEVVCNKIRDFSPSYVY-REMYVTDTTT-LRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHyregTSTPAVVHCSAGVGRSGVLMFIETAFGM
.|....   . .   .  .. | . |.|.|  . .| .  .||  |||..||.  ..  | .. |..| |||||||.||.. .. .|     .|  . . 
dlgrfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkk----sekPivvhCsaGiGRtmafigteylare

IEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
  |... .|..|   |||  |....  ..|        
veadptieltealkelrehRwkgiqtesqlywltlgal
Phosphatase Nvec_PTPN3.AA Subfamily.R_Nematode_3.PD 637-865 27 7.7e-37 118.3 In-house 22-259 (267) Show / Hide 
Range on Protein: 637-865
Range on HMM: 22-259/267
Sequence Identity: 27% (68 aa)

ENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMevPsHGivLRYIAAQGPL--------EKTCGDFWQMIWEQESTLVIMLTTTME---RGRV
... ..|. ... . .|||.| .      .|.|.||.|..  | .|  |. | .|.|.        ..|.  ||.|| .....|.||   .|   ..  |
kkvsedrrvevpllektrvvLkgygkrfkddfihAnvvec--p-ng--lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfveedgeeee

KCHQYWPEGEDT-WTFGNLEVVC-NKIRDFSPSYVYREMYVtDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRegtsTPAVVHCSAGVGR
| .|.|| .|.  .|....| | .. ...| . . |.. |          .  |.| .|... .|...  .|| .. |....    ||.|||||.|..||
kcseYypekvdgelkfegvsvkctdikkelsedvekrtlvv-tfekkkeftvthllykgWkelnapeepkealelikfveksk----tpvvVHCsdGisR

SGVLMFIETAFGMIEGAE-PVYPLELVRRMRDQRGSLIQTPGQFLFVC
..| .|| .. .|   .  .  |.|.  .| ||   |||. .. ||  
satlaaielgyqliikskgkldllslikelrkqRagaiqtelelafvi
Phosphatase Nvec_PTPN3.AA Subfamily.N_Nematode_6.PD 639-868 29 1.8e-36 117.1 In-house 25-248 (253) Show / Hide 
Range on Protein: 639-868
Range on HMM: 25-248/253
Sequence Identity: 29% (65 aa)

LPKNRYRDILPYDETRVKLFKGS-DYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEG-EDTWTFG
.|||..|  .| .|.||      || ||.|..   ..    |.| .|.|||.|. .||.||  . .. ..||   .|.|. |. .| ..   |.  ...|
kdrnrytniqCcdagrlkladdedfyihanlvkistkpr----rlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvGdarkit

NLEVVCNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRegtsTPAVVHCSAGVGRSGVLMFIETAFGMIEGAE
  | .  |.     . | . .   .. .. ..  ... .|||| |||. .  | ..  |.. .| |||||||||| | | .|....  .  ..     .|
klctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvkkdk----kPivvhCsaGvGrtGtlaliliilealrlpd

PVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
. ..|..|   .||  |.|..           
fqgvkdllvklreerfravqtevqylyalrcv
Phosphatase Nvec_PTPN3.AA PTPc_motif 769-870 32 1.3e-33 118.89 SMART 1-92 (92) Show / Hide 
Range on Protein: 769-870
Range on HMM: 1-92/92
Sequence Identity: 32% (35 aa)

VIIQLQYLAWPDH-----DVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLF
 . ...|..||||      ||.   ..|||...||.       | |||||||.||.|... |...  .      |  ...|..||.||  ..||  |..|
TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQYIF

VCEATLK
.... |.
CYRCILE
Phosphatase Nvec_PTPN3.AA Subfamily.N_Nematode_5.PD 637-869 24 4e-33 106.0 In-house 24-254 (258) Show / Hide 
Range on Protein: 637-869
Range on HMM: 24-254/258
Sequence Identity: 24% (58 aa)

ENLPKNRYRDILPYDETRVKLFK-GSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKChQYWPEGEDTW-T
.|| |||. |.  .||||||| .  ..||||. ....  ..    ..| .| || .|  |||.|. ... |.|..|... |  ... ...|. .... ..
knlkknrskdvkilDetrVkltdeddsYinaskiklddlek----kliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffpletgdyln

FGNLEVVCNKIRDFSPSYvyrEMYVTDTTTL---RSrVIIQ-LQYLAWPDHDVPDDATDFLE-FVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAF
|.. . . |.   .  .   ..|.  .       | |...  ..  |... |||. .. ..  ...|.   |...|.||....|.||.| ......|.  
lgkmfinnrkvevkedek---keytvevlpegcses-vfakvyhlttWkkkkvPdkvkkvikraiekvlskkqgknapvvvvsdlGlgRagtflllsvai

GMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
..  . .   |... .|.||   ...  |...| .|.|  
eqlnngkepnideilkkirsqRpgavesliqyasvyaavl
Phosphatase Nvec_PTPN3.AA Subfamily.N_Fungi_PTP1.PD 640-730 37 5.5e-28 89.2 In-house 47-152 (343) Show / Hide 
Range on Protein: 640-730
Range on HMM: 47-152/343
Sequence Identity: 37% (39 aa)

PKNRYRDILPYDETRVKLF-------------KGSDYINANFVNMEVPSHGIV--LRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQ
||||..||||. .||||              ...||||||.......|  |    .|||.|.|| .|  ||...| . . .....||. .| .. ||..|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPEGE
|.||. 
YWqegs
Phosphatase Nvec_PTPN3.AA Subfamily.N_Nematode_egg.PD 627-865 24 7.9e-24 75.7 In-house 15-249 (257) Show / Hide 
Range on Protein: 627-865
Range on HMM: 15-249/257
Sequence Identity: 24% (60 aa)

GMAMDDARKPENLPKNRYRDILPYDETRVKL-FKGS----DYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERgrVK
...  | . ..| | | . .   . .|||| ..      |.| ||.|.     . ..  .| || ||  |  |||.|.....   ..|||...|    .|
eislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvk----Gkpllnefilaqaplkntvedfwrmvfqekvqyivmltsakes--er

CHQYWPEGE-DTWTF--GNLEVVCNKIRDF-SPSYVYREMYVTDTTtlrsrviIQLQYLAWPDHDVpDDATDFLEFVHSVRHYREgTSTPAVVHCSAGVG
. |||  | ..  .  |.|.. . |. .   | .   .. .  .         . ..||| . ..|    .. .|. |.  |.|.||..  || ....|.
ceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgd-------deelflehwqgdv-nylsdvysplrvlrklrn-lskpvvvqdilGvs

RSGVLMFIETAF-GMIEGaePVY--PL-ELVRRMRDQRGSLIQTPGQFLFVC
 ||.|.  .. |  |..  .. . |  .| .|   ......|||        
kaatlvaieiallsllrG--pitkslvlravvflrlrrrlsvesvllylfvy
Phosphatase Nvec_PTPN3.AA Subfamily.N_Nematode_eak.PD 620-795 21 6.4e-18 56.3 In-house 8-180 (281) Show / Hide 
Range on Protein: 620-795
Range on HMM: 8-180/281
Sequence Identity: 21% (38 aa)

ELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKG----SDYINANFvnMEVPShgIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTM
.| .... ...  ... |.. .||  .|.|.|   |.|         ||||    .| .   .  .|| .  . |.    ||||. || |  ...|   .
dlddyqrllsirvtarleavnrnrvvkivpqdrylvrltssqlnrdGyinasl--aefse--vGrkyiltGiasedkvfafwqmvleqkspaivqlledv

ERGRVKCHQYWPEGEDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTTTlrSRVIIQLQYLAWPDHDVPDdATDFLEFVH
| .  |  .|.|.  . . .| |.| . .       . .| . ..      .  .   ..  |. ..|    ||| . . 
eekleksdkyfpdktevlkyGildverkeyavkrniletrllilrkGne--thrvlhykvfGwtettlpk-yedflalrk
Phosphatase Nvec_PTPN3.AA Subfamily.N_Fungi_PTP1.PD 767-869 29 4.7e-10 30.2 In-house 212-339 (343) Show / Hide 
Range on Protein: 767-869
Range on HMM: 212-339/343
Sequence Identity: 29% (35 aa)

SRVIIQLQYLAWPDH---DVPDDATDFLE-------FVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFG------MIEG--------AEPVYPL-
.. |||.  |.|      | .    ||          .  |. .  |.| .||||||||| |.|. ..  .       ...|.   ..  .| ..| || 
pyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

ELVRRMRDQRGSLIQTPGQFLFVCEATL
|..|.  ||.|. || |           
iivnelrkqrismvqnldqfifiYeall
Phosphatase Nvec_PTPN3.AA Family.DSP.PD 770-823 28 5.5e-08 23.7 In-house 151-203 (387) Show / Hide 
Range on Protein: 770-823
Range on HMM: 151-203/387
Sequence Identity: 28% (15 aa)

IIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREgTSTPAVVHCSAGVGRSGVLM
|.   ....|| .|. .  | ...  .   .. ..  ..||| ||.||||.|  
gikylripidDhnapplenlfekaidfieegnd-skgvVlVHCkaGkgRsgtli
Phosphatase Nvec_PTPN3.AA Subfamily.PTPDC1.PD 773-866 28 1.9e-06 18.8 In-house 137-222 (229) Show / Hide 
Range on Protein: 773-866
Range on HMM: 137-222/229
Sequence Identity: 28% (25 aa)

LQYLAWPDHDVPDdATDFLEFVHSVRHYRegTSTPAVVHCSAGVGRSGVLMFIETAFgmiegAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCE
...|..|.   .  |. |  |      .     ||| || || |||.     .     |. . . | .. .|..|   ||| .|.| |      
fynfglkDygvas-leriLdivkvvdfal--eegkiavHCHAGlGRtGvliacylvy-----akrltaeeaiklvrskrpksiqtreqvelvee
Sequence
Name Sequence Type Origin Length Description Download
Nvec_PTPN3.AA Protein None 883 None Fasta, JSON
Nvec_PTPN3.NA RNA None 2649 None Fasta, JSON
Nvec_PTPN3.AA.PD_613-873 Protein Phosphatase Domain None 261 None Fasta, JSON