Gene nvec_GAK
nvec_GAK
Species: N.vectensis
Alias: nvec_GAK
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of nvec_GAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | nvec_GAK.AA | GAK | 33-306 | 53 | 2e-166 | 557.14 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 33-306 Range on HMM: 1-277/277 Sequence Identity: 53% (150 aa) LKIKRVIAEGGYGFVFVAQDGKTGKEYALKRLMAGDEAANKNILQEINMLKRLRGHPNVVQFYSAASLGEKESGHGMTEYLILTELCTGGEMIKILQ--E . ...||||||..||.|||| .||.||||||.. |..||. | .||.|.|.| ||.|.||| .|.. . || . |||.|.|.| .. .| | YRVRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRME RDGQPFSPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKGQIKLCDFGSATTEPLTPDDSWTALNRSLAEDEIQRNTTPMYRAPEMVDLYSN . |||.| .|||||| |||| ||| |.|||||||.||||.|||....|||||||||||. . || || |. ||. |||. |.|||||| |||.||||| CYK-PFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSN LPVTEKADIWALGCVLFYLCFMEHPFEDSAKLRIINAKYT--IPEMDREYTMYHDLINSTLVVHPEDRPCIRDILTQL |. .| ||||.|| | .|. .|||||.|||||||..|. ||. | .|. |||| | | |..|. | .. .. WPIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMCFHDLIRACLQVNPDERLDIAMVVEYM |
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| Kinase | nvec_GAK.AA | NAK | 33-306 | 42 | 2e-134 | 451.16 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 33-306 Range on HMM: 1-299/299 Sequence Identity: 42% (127 aa) LKIKRVIAEGGYGFVFVAQ-------DG--KTGKEYALKRLMAG-DEAANKNILQEINMLKRLRGHPNVVQFYSAASLGEKESGHGMTEYLILTELCTGG .......||||...|...| |. ..|..|||||. || ..... .||.|.|.|..|.|.||..... .. .| | .|...| |.| .| YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDS-NGTWEVFLLMEYCCHG EMIKILQERD---GQPFSPDQILRIFYQLCRAVSHMHKQSP--PIIHRDLKIENMLIGS---KGQIKLCDFGSATTEPLTPDDSWTALNRSLAEDEIQRN .. ....| |..|. |.||.||.. |..|..|| . | ||||||.|||| |... .|..|||||||.||. ..|. .| |..||...|.|... SLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKY TTPMYRAPEMVDLYSNLPVTEKADIWALGCVLFYLCFMEHPFED------SAKLRIINAKYT--IPEMDREYTMYHDLINSTLVVHPEDRPCIRDILTQL ||||||||||.|||||.|..||.|||||||.|. .|| .||||| |.||.|.|..|. ||. .| . |||| |.. || || | ..| || TTPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | nvec_GAK.AA | NAK-Unclassified | 33-308 | 24 | 4.2e-79 | 269.1 | In-house | 1-405 (405) | Show / Hide |
Range on Protein: 33-308 Range on HMM: 1-405/405 Sequence Identity: 24% (101 aa) LKIKRVIAEGGYGFVFVAQ--------D------GKTGKEYALKRLMAGDEAANKNILQEINMLKRLRGHPNVVQF--YSAASLGEKESGH-GMTEYLIL .| | .|||| .||.... | .... |.||| || .. ||. ||.|.|||.|. .... .| . . .|...| YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIM----RENHNNQSYEVFML TELCTGGEMIKILQ------ERD--GQPFSPDQILRIFYQLCRAVSHMHKQSP--------------------------------------------PII |.| .| . . . |. . |. .|.|... |.... || ..| |.| MEYCSRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLI HRDLKIENMLIG----------------------------------------------------------SKGQIKLCDFGSATTEPLTPDDSWTALNRS |||.|||| |. . | |||||||.... |. .. .. HRDIKIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIE---NRQEMQ LAEDEIQRNTTPMYRAPEMVDLYSNLPVTEKADIWALGCVLFYLCFMEHPFEDSAKLR-------IIN--AKYTIPEMDREYTMYHDLINSTLVVHPEDR ..|.| ..||| ||||||.|||...| || ||||||| |. .|| |||.. | |.. .||..| . | || |.. | | YLQDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQR PCIRDILTQLEA | | .| .. PNIYQVLNHICQ |
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| Kinase | nvec_GAK.AA | BIKE | 33-305 | 37 | 1.6e-73 | 250.56 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 33-305 Range on HMM: 1-267/267 Sequence Identity: 37% (105 aa) LKIKRVIAEGGYGFVFVAQDGKTGKEYALKRLMAGDEAANKNILQEINMLKRLRGHPNVVQFYSAASLGEKESGHGMTEYLILTELCTGGEMIKILQERD . ..||||. ||...| . | .|||| | . |. ..| . || |.| . .. | |. | .||.| | . ...... .| VTVEEQLAEGGFAMVFLVRD-HKGNKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYI---NCIGNGVWECMILMEYCRH-QVVNMMNQRL GQP--FSPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKG--QIKLCDFGSATTEPLTPDDSWTALNRSLAEDEIQRNTTPMYRAPEMVDLY | | . .|.|| .| ||| .|. ||||||||.|| |. ..| ||||||||. | | | .|||...|| ||||||.||| QQGQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQK--HGVN--YVKDEIEKYTTMCYRAPEMIDLY SNLPVTEKADIWALGCVLFYLCFMEHPFEDSAKLRIINAKYTIPEMDREYTMYHDLINSTLVVHPEDRPCIRDILTQ | ...| ||||||||| |. ||| ||. | .| | . ..|||. . | || | . .| || | . SGKEITTKADIWALGCMLYKLCFFCLPFGES-QLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV |
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| Kinase | nvec_GAK.AA | S_TKc | 33-309 | 24 | 7.2e-62 | 212.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 33-309
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)
LKIKRVIAEGGYGFVFVAQDGKTGKEYALKRLMAGDEAANKNILQEINMLKRLRGHPNVVQFYSAASLGEKESGHGMTEYLILTELCTG--GEMIKILQE
.| |.| .|..| |. ... |||...|.|.. ..|..||..||. .|||.|..| . ... . .|.| | |.. .....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKK
RDGQP----FSPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKGQIKLCDFGSATTEPLTPDDSWTALNRSLAEDEIQRNTTPMYRAPEMVD
| ... |.. .. ...||.|.|. ..|.. ||||||| || |. . .||.||||.|. || |.|||..
RGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL-
LYSNLPVTE-KADIWALGCVLFYLCFMEHPFEDSAKLRIINAKYTIPEMDREYTMYHDLINSTLVVHPEDRPCIRDILT------QLEAL
. . |.|.|..||.|. .. . ||. .... |.|. |.. ||.|| . ..|. . . .
-----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | nvec_GAK.AA | TKL-ciliate1 | 112-306 | 26 | 1e-42 | 144.02 | In-house | 74-279 (279) | Show / Hide |
Range on Protein: 112-306 Range on HMM: 74-279/279 Sequence Identity: 26% (57 aa) YLILTELCTGGEMIKILQERDG--QPFSPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKGQIKLCDFGSATT--EPLTPDDSWTALNRSLA . | .|.| .| | |. . . ....|. . . . ....|. .|.||||||..|.| . | | |.|.. .. ... .| .. FYIIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDM----- EDEIQRNTTPMYRAPEMVD--LYSNLPVTEKADIWALGCVLFYLCFMEHPFEDSAKLRIINAKYTIPEMD------------REYTMYHDLINSTLVVHP |.|||||....||| | ...| |..||.||.|.| |.. ||| . ||. |. || ..| |.|. . | QNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQ--KMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNP EDRPCIRDILTQL .|| . |. | NKRPNFNEIIQIL |
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| Kinase | nvec_GAK.AA | Ciliate-E2 | 33-303 | 18 | 5.8e-41 | 138.33 | In-house | 1-360 (365) | Show / Hide |
Range on Protein: 33-303
Range on HMM: 1-360/365
Sequence Identity: 18% (74 aa)
LKIKRVIAEGGYGFVFVAQD-----------------------GKTGKEYALKRLMAGDEAANKN---ILQEIN------M---LKRLRGHPNVVQFYSA
|. ..| .|..| |. ... . ..|.||.|... . . |. |..||| . .... |||....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
ASLGEKESGHGMTEYLILTELCTGGEMIKILQER----------DGQPFSPDQILRIFYQLCR---------------AVSHMHKQSPPIIHRDLKIENM
... . . .|.| ||.. ...... | ..|. .|..|..|... |. ..|.. . |||||.| ||
FQEKDDNN------IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENI
LIGSKGQIKLCDFGSATTEP-----------------------------LTPDDSWTALNRSLAEDEIQRNT------TPMYRAPEMVDLYSNL------
|. ||..||| .. . || |. ||.| |||.. ..
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQ----------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK
PVTEKADIWALGCVLFYLCFMEHPFEDSAKLRIINA-KYTIPEMDREYTMYH-----------------DLINS----TLVVHPEDRPC-IRDIL
. ..|.|||.||..|....| ..|| ...| |. .|. . . . |||. |.. || |. . .||
GYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
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| Kinase | nvec_GAK.AA | TKL | 39-306 | 18 | 9.3e-39 | 135.08 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 39-306 Range on HMM: 1-364/364 Sequence Identity: 18% (72 aa) IAEGGYGFVFVA--QD------GKTGKEYALKRLMAG------------------------DEAANKNILQEINMLKRLRG--HPNVVQFYSAASLGEK- | .||.| |. . . . |||. | |.. |. | .. .|.. .. .. |||.|||. .. ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -ESGH---GMTEYLILTELCTGGEMIKILQERDGQPFSPDQILRIFYQLCRAVSHMHKQS------PPIIHRDLKIENMLIGSKGQ-------------- ..| . ... | .|.| || .|. ..|..|. .. .|.....| . ||||||||| .| |. .... CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC IKLCDFGSATT------------------EPLTPDDSWTALNRSLAEDEIQRNTTPMYRAPEMVD---LYSN----------LPVTEKADIWALGCVLFY .|.|||| ... | . . .. . . || . |||. . |.. .. .||.|... | ||. CKICDFGLSRFMSQSGNMNDTMTTMMESAE----------HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWE LCFMEHPFEDSAKLRII---------NAKY------TIPE--------MDREYT--MYHDLINSTLVVHPEDRPCIRDILTQL .. ..|..| .| . .||. .. ... . .|. ||.|| .|| .| ILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Phosphatase | nvec_GAK.AA | CAMK | 38-189 | 19 | 1.2e-38 | 121.6 | In-house | 1-244 (425) | Show / Hide |
Range on Protein: 38-189 Range on HMM: 1-244/425 Sequence Identity: 19% (47 aa) VIAEGGYGFVFVAQDGKTG------------KEYALKRLMAG----------------------------DEAANKNILQEINMLKRLRG------HPNV .. .|..| |. ... .|. ...| | . .. ||...||...|.|.| |||. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQFYSAASLGEK--------ESGH-----GMTEYLIL--TELCTGGEM----IKILQERDG-------------QPFSPDQILRIFYQLCRAVSHMHKQS ...| . ... . . |... .|.|.|||. ..|. . |. .. |.| |.| || ..|.. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN PPIIHRDLKIENMLIGSK-----------------GQIKLCDFGSAT |.||||| || |. .. ..||..||| |. --IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFAN |
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| Kinase | nvec_GAK.AA | Pkinase | 33-188 | 30 | 1.7e-38 | 137.22 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 33-188 Range on HMM: 1-159/293 Sequence Identity: 30% (52 aa) LKIKRVIAEGGYGFVFVAQDGKTGKEYALKRLMAGDEAANKNILQ----EINMLKRLRGHPNVVQFYSAASLGEKESGHGMTEYLILTELCTGG----EM ..|.|.| .|..| |. ... .|||..|.|.. .| .|.. || ..||| .|||.|..| . ... . .|.| || . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDL IKILQERDGQPF--SPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKGQI----KLCDFGSA ... ... .| |.... ...||..|.. ..|.. ||||||| || || ..|.| |.||||.| FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | nvec_GAK.AA | CAMKL | 33-189 | 25 | 2.3e-35 | 110.23 | In-house | 1-177 (297) | Show / Hide |
Range on Protein: 33-189 Range on HMM: 1-177/297 Sequence Identity: 25% (47 aa) LKIKRVIAEGGYGFVFVAQD-GKTGKEYALKRLM----AGDEAANKN-----------ILQEINMLKRLR--GHPNVVQFYSAASLGEKESGHGMTE--- .| ... .|..| | |.. ||...| | . |. ..|| | .||. .|.|. .|||....| |. . YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEH-------DIET --YLILTELCTGGE--MIKILQERDG--QPFSPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKG--QIKLCDFGSAT . . .|.| ||| . .... . ....... |.| |.. ||...|.. |.|||.| || |. ..| .||..||| .. KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSN |
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| Kinase | nvec_GAK.AA | STE | 33-309 | 18 | 2.2e-33 | 115.29 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 33-309 Range on HMM: 1-359/359 Sequence Identity: 18% (72 aa) LKIKRVIAEGGYGFVFVAQDGK---------------TGKEYALKRLMAGDE-----------------AANKNILQEINMLKRLRG-HPNVVQFYSAAS ... ..| .|..| |. | . | ||. .| |.. .. ..||.||...|... |||.|..| . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF LGEKESGHGM-TEYLILTELCTGGEMIKILQ---ERDG---------QPFSPDQILRIFYQLCRA-VSHMHKQSPPIIHRDLKIENMLIGSKGQIKLCDF . .. |. .| | |.. || .|.. .. . ..|. .|| .| .|.... .. |.. |||||.| | |. .||||| KEGHN--HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDF GSAT-----------------TEPLTPDDSWTALNRSLAEDEIQRNT-----TPMYRAPEMVDLYS---NLPVTEKADIWALGCVLFYLCFMEHPF---E | .. . .| .. || . |||... . . . ..|.||| |||.. .. ..|. GVCGQLTDSMANIQSNNIIDCI------------------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMH DS-AKLRII----------------NAKYTIPE-----------------MDREYTMYHDLINSTLVVHPEDRPCIRDILTQ-LEAL . | ..|. . ..|. .. .| || |. |..|| . | . . PMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Phosphatase | nvec_GAK.AA | Subfamily.PTEN.PD | 398-570 | 25 | 2.2e-31 | 98.6 | In-house | 1-172 (305) | Show / Hide |
Range on Protein: 398-570 Range on HMM: 1-172/305 Sequence Identity: 25% (45 aa) DLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNV-SPRNYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRVIVIH |.||| . .||.|.|.| .| ...|..|. .|.... ... . .. . ... ....|| . . |.|| . ...... |||.|.|.|...| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGIGQKVAlTPSQERYLLYIAELINNpSMKPQKNSLYI | |. .||...|.... . .|... | .... | .. | ||| ||. | .|... |. | || . CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVt-iPSQrRYvqYfsklvks-svpyskvslnv |
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| Kinase | nvec_GAK.AA | Pkinase_Tyr | 33-186 | 24 | 8.6e-15 | 50.72 | Pfam | 1-156 (270) | Show / Hide |
Range on Protein: 33-186 Range on HMM: 1-156/270 Sequence Identity: 24% (40 aa) LKIKRVIAEGGYGFVFVAQDG----KTGKEYALKRLMAGDEAAN---KNILQEINMLKRLRGHPNVVQFYSAAS-LGEKESGHGMTEYLILTELCTGGEM ... ... || .| |. . .|. . | | | | . . ..|....| | |||.|..| . . || ...| .|.. .| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN------QIYIVMEYMPHGDL IKILQER--DGQPFSPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKGQIKLCDFG . |... |.||... ..| . .| ... .. . . .||||| | |.......| |||| LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFG |
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| Kinase | nvec_GAK.AA | TyrKc | 33-306 | 18 | 1e-13 | -0.99 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 33-306
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)
LKIKRVIAEGGYGFVFVAQDGKTGKEYALKRLMAGDEAANKNILQEINMLKRL-RGHPNVVQFYSAASLGEKESGHGM---TEYLILTELCTGGEMIKIL
.. .... || .| |. .. . | | | .. . ...|......| |||.|..| ... .. ..|..|.. .| . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYL
QERDGQPFSPDQILRIFYQLCRAVSHMHKQSPPIIHRDLKIENMLIGSKGQIKLCDFGSATTEPLTPDDSWTALNRSLAED-------EIQRNTT-PMYR
... .. ..... | . .| .. .. |.. ..||||| | |.|.....| .||| | | . .| . | .. .
RKHRPK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFG---------------LSRDIYDDDQQGESKDYYRKKEHKGGK
--------APEMVDLYSNLPVTEKADIWALGCVL---FYLCFMEHP------FEDSAKLRIINAKYTIPEMDR---------EYTMYHDLINSTLVVHPE
||| |.| |.|. | .. | .. . .| ... .. . . | | .. || .. . ||
TMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPE
DRPCIRDILTQL
|||. ..| ..
DRPTFSEIHECF
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| Phosphatase | nvec_GAK.AA | CAMK | 216-303 | 20 | 1.5e-12 | 36.04 | In-house | 282-420 (425) | Show / Hide |
Range on Protein: 216-303 Range on HMM: 282-420/425 Sequence Identity: 20% (28 aa) TPMYRA-PEMVDLYS-----------NLPVTEKADIWALGCVLFYLCFMEHPFEDS-----------------AKLRIINAKYT-IPEM--------DRE || | | ||.. . . ....|.|.|..|..|. . . ||... . .|...||. .|.. . | TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE YTM-------------YHDLINSTLVVHPEDRPCIRDIL . |||.. |.| ||.|. | ..| WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCL |
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| Kinase | nvec_GAK.AA | Pkinase | 216-306 | 19 | 4.6e-10 | 36.65 | Pfam | 174-293 (293) | Show / Hide |
Range on Protein: 216-306 Range on HMM: 174-293/293 Sequence Identity: 19% (24 aa) TPMYRAPEMVDLYSNLPVTEKADIWALGCVLFYLCFMEHPFEDS------AKLRIINAKYT------IPEMDREY-----------------TMYHDLIN || |.||| . .. . . |.|.|..||.|..... . || .. .. .|. . .|. .... |.|. TPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK STLVVHPEDRPCIRDILTQ--L . | . |..|| ...|| . WCLCKDPKKRPTAEQILQHPWF |
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| Kinase | nvec_GAK.AA | CAMKL | 236-303 | 28 | 8.9e-07 | 17.49 | In-house | 216-292 (297) | Show / Hide |
Range on Protein: 236-303 Range on HMM: 216-292/297 Sequence Identity: 28% (23 aa) KADIWALGCVLFYLCFMEHPFEDSA-----------KLRIINAKYTIP---EMDREYTMYHDLINSTLVVHPEDRPCIRDIL |.|||..| .|. . . . ||.| ...|. | .| ... . .||| . |.| ||.|| | .|. KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-D---CRDLIRKMLQVNPEKRPTIHQIM |
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| Phosphatase | nvec_GAK.AA | Subfamily.Tensin.PD | 455-687 | 32 | 1.5e-38 | 121.9 | In-house | 2-222 (237) | Show / Hide |
Range on Protein: 455-687 Range on HMM: 2-222/237 Sequence Identity: 32% (75 aa) STRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRR-CGIGQKVALTPSQERYLLYIA ..|| || |||| . |.|... ||| | .|.|.|| |. || .||. . |. . .. |.|.|...| . . . ||| ||. |. . nekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfs ELINNpSMKPQKNSLYIKSVTLNPVPAFNkARNGCRPFIEMYQGNQRVLTTvqEIEKMREFTLSDGKVTFPVNLTLQGDVTIIVYHGRStlggkvQGkMA |... |.| . . |... | |. .|.|. .. |||||. .||. | | |. . .. . .| | |.|||. || . .. . gllsg-siklnssplflhyvilhgipnfd-skggcrpflkiyqalqlvyts--gvynvagedterlcitiepalllkgdvlvkcyhkkl------rs-tt SMRVFLLQFHTGFINpnATKLKYSREELDIAKED || .||||| |. .|| ...|.|| | .| rdvvfrvqfhtgaik--dlklvfekedldealkd |
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| Phosphatase | nvec_GAK.AA | PTEN_C2 | 563-703 | 27 | 3.1e-28 | 103.17 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 563-703 Range on HMM: 1-141/141 Sequence Identity: 27% (40 aa) PQKNSLYIKSVTL-NPVPAFNKARNGC-RPFIEMYQGNQRVLTTVQEIEKMREF-TLSDGKVTFPVNLTLQGDVTIIVYHGR-STLGGKVQGKMASMRVF |.. |....... ..| | |...|| ||.|. ||..| |..| .. ..... . .... || ....|||| | .|| . |.| ... .. .| PPPKPLFLHCIIMDHGIPNF-KQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDL-PWMYEEC----MF LLQFHTGFINPNATKLKYSREELDIAKEDV--VKFSSRFAMTLDVTI ..|.|.|| | . |. ...|||.| | .|.. |.... . RFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | nvec_GAK.AA | Family.DSP.PD | 412-683 | 18 | 9.2e-19 | 57.3 | In-house | 107-357 (387) | Show / Hide |
Range on Protein: 412-683 Range on HMM: 107-357/387 Sequence Identity: 18% (51 aa) PAEGIESTYKNNIDDVREFLEAKHYEQYFVVNVSPRNYRAD-KLSTRVLHQCWPVNRLPPLESIisLCRkIFVWLKK--DSSRVIVIHCMDGRVASGVLV | | ... | . ... .. . |.. .||.. . . . .|. ..|. .. . ||||.. ... .. .... ||. |...||. |. ||.|. pseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenl--fek-aidfieegndskgvVlVHCkaGkgRsgtli SAFFVFCK-LFKNpnGAADMFSIRRcgigqKVALTPSQErYLLYIAELINNpSMKPQKNSLYIKSVTLNPVPAFNKaRNGCRPFIEMYQGNQRVLTTVQE .|...... | .. | |.....| . .||.|. .| . .| .. .|.... . .. |. . |. . . ... .. ......|. .. iaYlmksegltle--ealdwvrskR-----pgvitpnqg-flkqlkdleke-klkvssevmelrfvissivqnlgs-vevsvsvlkkvatekakldrlki --IEKMREFTLsdgkvTFPVNLTLQGDVTIIVYHgrstlggKVQGKMASMRVFLLQFHTGFINPNATKLkySREELDI |... . . | | |.||| . ... | |. .. .|.|..|. . | ..||| Lvideqekvvi-----tikdglplsgDVkvelfk-------knldkiirdiilntfFvtnyikdeslvl--vkkelde |
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| Phosphatase | nvec_GAK.AA | Subfamily.TPIP.PD | 468-573 | 28 | 6.8e-17 | 51.2 | In-house | 15-125 (245) | Show / Hide |
Range on Protein: 468-573 Range on HMM: 15-125/245 Sequence Identity: 28% (32 aa) LPPLESIISLCRKIFVWLKKDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGIGQK----VALTPSQERYLLYIAELINNPSM-K .| || ........ ||.|| ..|..||| |. | .| |... ..|.. . . | |. || . ||||.||. |.|.... . vPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgylaqvkhlynwnl PQKNSLYIKSV | . |.|| . pprrilfikrf |
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| Phosphatase | nvec_GAK.AA | Subfamily.RK.PD | 431-549 | 22 | 6.2e-07 | 18.1 | In-house | 138-256 (267) | Show / Hide |
Range on Protein: 431-549 Range on HMM: 138-256/267 Sequence Identity: 22% (27 aa) LEAKHYEQYFVVNVSPRNYRADKLSTRVLHQCWPVNRLPPL--ESIISLCRKIFVWLKKDSSRVIVIHCMDGRVASGVLVsAFFVFCKLFKNpNGAADMF |.|. . | |. |.. . .. .. . || | | .|...| |.. . .... ||.||..| ||. . | . ... .. .| |.| ldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfi-aidivlemier-egvvdvf SIRRCGIGQKVALTPSQERYL . . .|| . .|.| navktlrnrkvnmveteeqyk |
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| DnaJ | nvec_GAK.AA | DnaJ | 1260-1321 | 29 | 3e-06 | 28.17 | SMART | 1-72 (72) | Show / Hide |
Range on Protein: 1260-1321 Range on HMM: 1-72/72 Sequence Identity: 29% (21 aa) EDRWNPVGMHQLVQPDQVKKAYRKAVLCVHPDKLTGEPH----------EALARAIFMELNEAWSLFEESGC .| . | .. .|..|||||| .. .|||| .| | .. | |.|.|||.. RDYYEILGVPRDADDDEIKKAYRKLAKKYHPDKNPGDPERSCWKLCWEEKEEAEEKFKEINEAYEVLSDPEK |
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| DnaJ | nvec_GAK.AA | DnaJ | 1274-1314 | 43 | 9.1e-08 | 31.81 | Pfam | 14-53 (65) | Show / Hide |
Range on Protein: 1274-1314 Range on HMM: 14-53/65 Sequence Identity: 43% (18 aa) PDQVKKAYRKAVLCVHPDKLTGEPHEALARAIFMELNEAWS ....|||||| .| .|||| ..| . | |.|.|||.. DEEIKKAYRKLALKYHPDKNPDDPE-EEAEEKFKEINEAYE |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| nvec_GAK.AA | Protein | None | 1325 | None | Fasta, JSON |
| nvec_GAK.NA | RNA | None | 3975 | None | Fasta, JSON |
| nvec_GAK.AA.PD_454-557 | Protein Phosphatase Domain | None | 104 | None | Fasta, JSON |