Gene nvec_Laforin
nvec_Laforin
Species: N.vectensis
Alias: nvec_Laforin
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of nvec_Laforin.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | nvec_Laforin.AA | Family.DSP.PD | 126-314 | 19 | 4.8e-24 | 76.0 | In-house | 82-249 (387) | Show / Hide |
Range on Protein: 126-314 Range on HMM: 82-249/387 Sequence Identity: 19% (39 aa) KTGQVNEYEYTTRFMCHVERQQIMHYCKIFENIWLGSCPRLrSHIMDLKSQGITAVISLQtasdiqkhcS------GiyrynqnlpitlkklykEEGISY . |... . ..|.|| . . .|.....|||. . .. || |.|....|. |.|| | lngfidvhtfdldtydhfervengkpseilphlylgsllaa-knlewlkelgvtkivnlt---------ddkpqftk-----------------elgiky IWLPMEDLsTESRIEN-LPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRP-VAFIDGRaLITAEKDFIQKFGQ . .|..| ... .|| . . . .. .....|.|||..|.|||. ... .||. ...| . . . |||| |. . . ||... . lripidDh-napplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqg-flkqlkdlekeklk |
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| Phosphatase | nvec_Laforin.AA | Subfamily.Laforin.PD | 150-311 | 77 | 5.6e-103 | 332.3 | In-house | 1-165 (165) | Show / Hide |
Range on Protein: 150-311 Range on HMM: 1-165/165 Sequence Identity: 77% (128 aa) HYCKIFENIWLGSCPRLRSHI-MDLKSQ-GITAVISLQTASDIQKHCSGIYRYNQNL-PITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGL ||.||.|||||||||||..|. .||||. ||||||||||.|||.|..|||||||.|| ||||||||||||..|||||.||||||||.|||||.|||||.| hyskileniwlgscprlvehvtidlkselgitavislqtesdivknssgiyrynenltpitlkklykeeglayiwlptedlstesrvenlpqavyllhal LNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFIDGRALITAEKDFIQK |..||.||||||.|||||||||||||.|||.||||||||....||||..||..|||.|||||.|| lekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdffqk |
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| Phosphatase | nvec_Laforin.AA | Subfamily.PTPMT1.PD | 154-296 | 25 | 2.7e-21 | 66.5 | In-house | 2-132 (146) | Show / Hide |
Range on Protein: 154-296 Range on HMM: 2-132/146 Sequence Identity: 25% (36 aa) IFENIWLGSCPrLRSHIMDL-KSQGITAVISLQTASDIQKHCSGIYRynqnlpitlkklYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHR | |.. ||. | .||.. .| . . . ||.|| ....... .|..|. .. |.. |. . |.| .|| ... ..|.. idetvilGalP-frsltkeLvekenvkavvslneeyelkalanstee------------wkklGveqlqlatvDfteapslekleegvefiekvaskgss VYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFI ||||| | .||...| .||. ..| . . . .||| . vYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirl |
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| Phosphatase | nvec_Laforin.AA | Subfamily.PTPDC1.PD | 171-308 | 26 | 8.4e-14 | 42.2 | In-house | 92-223 (229) | Show / Hide |
Range on Protein: 171-308 Range on HMM: 92-223/229 Sequence Identity: 26% (36 aa) MDLKSQGITAVISLQTASDiQKHCsGIYRYNQNLPITLKKLyKEEGISYIWLPMEDLSTESrIENLPQGVYLLHGLLNNGhRVYVHCNGGVGRSTAIVCG ..|..||.||| ||.| . || | .. . .| ...|| . ...| .. | .|.. . | .. |..| .. ||| ||| ... .| ekfkesGikavinLqeage-hahC-GagleesGfsYdpeel-mrqgiyfynfglkDygvas-leriLdivkvvdfaleeg-kiavHCHAGlGRtGvliac FLMYVLHWSLAKVQYNICSKRPVAfIDGRALITAEKDF .|. . . .. . |||| . | | . ..| ylvyakrltaeeaiklvrskrpks-iqtreqvelveeF |
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| Phosphatase | nvec_Laforin.AA | DSPc | 158-280 | 20 | 3.3e-13 | 47.83 | Pfam | 1-115 (151) | Show / Hide |
Range on Protein: 158-280 Range on HMM: 1-115/151 Sequence Identity: 20% (28 aa) IWLGSCPRLRSHIMDLKSQGITAVISLQ-----TASDIQKHCSGIYRYNQNLPITLKKLYKEEGISYIWLP-MEDL--------STESRIEN-LPQGVYL ..|||.|. . |. |||.||... . .|. ... |.|.| ..| .... | . .|. . LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN-----------------------WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDF LHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSL .. . ..|..|.|||. |. || .... .||. ..|. IDDCRQKGGKVLVHCQAGISRSACLCIAYLMKYRNMSY |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP19.PD | 206-293 | 25 | 4.6e-13 | 39.9 | In-house | 36-122 (139) | Show / Hide |
Range on Protein: 206-293 Range on HMM: 36-122/139 Sequence Identity: 25% (22 aa) ITLKKLYKEEgISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV . ..... .. ..| ... ||. .. .. |.. . .. .... ||.|||| || ||...| ..|| . || | .. ..|| vgvpnvfpkd-ftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpc |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP12.PD | 153-292 | 24 | 1e-12 | 39.0 | In-house | 4-123 (143) | Show / Hide |
Range on Protein: 153-292 Range on HMM: 4-123/143 Sequence Identity: 24% (34 aa) KIFENIWLGSCPRLRShIMDLKSQGITAVISLQTASDiqkhcsgiyrynqnlpitlKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHR .| ....||. . . . ||. ||.|.|... . ..| ||.| . ... | .| ...|.. | .. |... eilpglylggleavqe-rellkelkithvlsvikeel-------------------pelqkekgvkskliqilDepeedlLshldeavrFieeglekega VYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRP |.|||. || || .|| .||. ..|| | . .|.. vlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkk |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP6.PD | 200-288 | 26 | 3.3e-11 | 33.7 | In-house | 30-118 (141) | Show / Hide |
Range on Protein: 200-288 Range on HMM: 30-118/141 Sequence Identity: 26% (24 aa) YNQNLPITLKKLYKEEG-ISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVqYNIC | |. | . ..|.| . | .|.|| .. . .|. . .. .. | ||| || || ... .|| |. || . |.. yvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslnda-ydlv |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP3.PD | 207-294 | 22 | 3.3e-11 | 33.9 | In-house | 45-133 (148) | Show / Hide |
Range on Protein: 207-294 Range on HMM: 45-133/148 Sequence Identity: 22% (20 aa) TLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLN-NGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVA | .. ||. .|.|. ....|. . . . . .. |. .. .|.|||. |. ||...| .|| . .| . .. .|| . tdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkreil |
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| Phosphatase | nvec_Laforin.AA | Subfamily.STYX.PD | 157-276 | 26 | 1e-10 | 32.3 | In-house | 8-112 (146) | Show / Hide |
Range on Protein: 157-276 Range on HMM: 8-112/146 Sequence Identity: 26% (31 aa) NIWLGSC-PRLRSHIMDLKSQGITAVISLQtasdiqkhcsgiyrynQNLPITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYV ..|| ..|.. ||..||| .. .. ||. .| | .. . |. | . | ..| | ||. .. . |..| .| || glflgpysaamksklevlkehgithivcir----------------qnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlv HCNGGVGRSTAIVCGFLMYVL | |. ||.|.| ...| hgnagisrsaalviayimety |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP1.PD | 215-292 | 25 | 1.1e-10 | 32.4 | In-house | 44-121 (139) | Show / Hide |
Range on Protein: 215-292 Range on HMM: 44-121/139 Sequence Identity: 25% (20 aa) EGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRP | .| ..|.|| ... . . . . .. . ..| ||.|||. |. ||..|| .|| ...| . . ..| elfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrs |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP10.PD | 210-293 | 25 | 1.9e-09 | 28.2 | In-house | 40-124 (141) | Show / Hide |
Range on Protein: 210-293 Range on HMM: 40-124/141 Sequence Identity: 25% (22 aa) KLYKEEG-ISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV . ..|.| . | .|..| ... ... . . .. ..| || |||. |. ||...| ..| |. || . . .|||. nffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvkekrPi |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP15.PD | 215-294 | 25 | 1.4e-08 | 25.4 | In-house | 43-122 (138) | Show / Hide |
Range on Protein: 215-294 Range on HMM: 43-122/138 Sequence Identity: 25% (20 aa) EGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVA |.|.| ....| .. . . . ..| .|. |.||| |. ||...| ..| | ..| .. . . |.|| edikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsva |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP14.PD | 214-293 | 25 | 2.8e-08 | 24.5 | In-house | 42-121 (138) | Show / Hide |
Range on Protein: 214-293 Range on HMM: 42-121/138 Sequence Identity: 25% (20 aa) EEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV |..... ...|| .... | . . . .. . ..| .. ||| || || ..| .|| . ||.. . |.||. ledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpi |
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| Phosphatase | nvec_Laforin.AA | Subfamily.Slingshot.PD | 203-293 | 19 | 3.6e-08 | 23.9 | In-house | 33-122 (139) | Show / Hide |
Range on Protein: 203-293 Range on HMM: 33-122/139 Sequence Identity: 19% (18 aa) NLPITLKKLYKeEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV |. ... .. | ..|. . . | .... ... . .. ..| .| ||| || ||...| . | ..|| . . ..| . nvtkeidnffp-ekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsi |
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| Phosphatase | nvec_Laforin.AA | Subfamily.DSP8.PD | 214-292 | 21 | 5.2e-08 | 23.6 | In-house | 45-123 (143) | Show / Hide |
Range on Protein: 214-292 Range on HMM: 45-123/143 Sequence Identity: 21% (17 aa) EEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRP .. .. .|..| .| .. ... . . .. .| ||| | ||.... ...| |. || . . .||| lkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrp |
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| Phosphatase | nvec_Laforin.AA | DSPc | 150-307 | 21 | 2.4e-07 | 24.69 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 150-307 Range on HMM: 1-172/172 Sequence Identity: 21% (39 aa) HYCKIFENIWLGSCPRLR-SHIMDLKSQGITAVISLQTASDI-----QKHCSGIYRYNQNLPITLKKLYKEEGISYIWLPMEDL-------STESRIEN- .| ....|||.|. .. || .||.||... .. || | | . .|. .. |...|| | .... | . GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQK--------N-DMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQY LPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNI-----CSKR-P-----VAFIDGRALITAEKD .|. . .| . ..|..|.||| |. || .... .||. ..|. . . ..| | . |. . |. |. FPEVYDFIHDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFW--HQLCEWERK |
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| Phosphatase | nvec_Laforin.AA | Subfamily.STYXL1.PD | 220-284 | 28 | 2.2e-06 | 18.6 | In-house | 53-117 (143) | Show / Hide |
Range on Protein: 220-284 Range on HMM: 53-117/143 Sequence Identity: 28% (18 aa) IWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQ . ...|| . .|.| . | ... ..|. | | | |. ||.|.. ..||| ...| | lhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkay |
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| Phosphatase | nvec_Laforin.AA | Subfamily.PTEN.PD | 251-281 | 32 | 8.5e-06 | 15.9 | In-house | 95-125 (305) | Show / Hide |
Range on Protein: 251-281 Range on HMM: 95-125/305 Sequence Identity: 32% (10 aa) HRVYVHCNGGVGRSTAIVCGFLMYVLHWSLA . | ||| | ||. ..| .|.. .. . | nVvavHCkaGkGRtGvmicayLlksgikksa |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| nvec_Laforin.AA | Protein | None | 324 | None | Fasta, JSON |
| nvec_Laforin.NA | RNA | None | 972 | None | Fasta, JSON |
| nvec_Laforin.AA.PD_150-307 | Protein Phosphatase Domain | None | 158 | None | Fasta, JSON |