nvec_PTEN
Species: N.vectensis
Alias: nvec_PTEN
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: PTEN
Protein domain

Protein domains of nvec_PTEN.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase nvec_PTEN.AA Family.DSP.PD 8-338 24 2.1e-39 127.2 In-house 79-385 (387) Show / Hide
Range on Protein: 8-338
Range on HMM: 79-385/387
Sequence Identity: 24% (82 aa)

VSKKKRRFQEDGFDLDlTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCserqYDPMRFHN-RVATY---PFDDHNAPPFELIkpF
......  .   |||| || . . |. | ||| |...|  ... .. . . |..   |. ||.    .|. .|..    .|   |.|||||||.|..  |
qaelngfidvhtfdld-tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--f

CDDVDeWLKASN--LNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTkEAMEYYGNARtrnaKGVTIPSQRrYVEYYGYLLRNCLTYVPTMVLLRGFEIIT
. ..| ... .|   .|. .||||||||.|..|.|||... ...   ||....  .|    .||..|.|. .....  |. . |.   ...||  .   .
ekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissi

IPNMQGGNCCPFYIIWQYKVKIHTSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKDTFGR-KERMFQFWFNTFFISTGANMTDSREgeptIHTFKe
.|..  ...          |.   .|     .   .. . . . ||. ||.|||.|.| .    .. .....|.| .|      ...|    ...     
vqnlgsvevsvsvlkkvatekakldrlkiLvideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkke----ldelh-

srnsdvrwfaipKQFVDKAHKDNKCKVFSPDFKVSNVF
          |. ... .||.  . .| .||.| ||  
------------kskifdvykdseaveiseefkisivf

Phosphatase nvec_PTEN.AA Subfamily.PTEN.PD 23-338 34 5.1e-80 260.3 In-house 1-303 (305) Show / Hide
Range on Protein: 23-338
Range on HMM: 1-303/305
Sequence Identity: 34% (108 aa)

DLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIH
|..|| .|......| |..|..... .... ..|. ..|. .|...|.......   |..|||.|||||||.|..||......|||.|||... ||...|
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH

CKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRNCLTYVPTM---VLLRGFEIITIPNMQGGNCCpFYIIWQ-
|||||||||||||||||..|..|...||...|...||.. ||||||||||||.|. .|..... |       . .|  |  ..|.   .|.   .. .  
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecs-isvlhds

YKVKIHTSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKDTfgrKERMFQFWFNTFFISTGANMTDSREGEPTIHTfkesrnsdvrwfaIPKQFVDK
  . .  .|       . |. | .   .|..||.|.|. .|      . . .||.||||.   .        .|||             . |  .|  ||
atenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkksp---dkiichfwlntffvrnyspcesdgtvnkyiht-------------lskseidd

AHKDNKCKVFSPDFKVSNVF
|.. | || .||.| ||   
vhkdsehkrfseefkisivf

Phosphatase nvec_PTEN.AA Subfamily.TPIP.PD 80-281 34 1.2e-37 121.1 In-house 1-211 (245) Show / Hide
Range on Protein: 80-281
Range on HMM: 1-211/245
Sequence Identity: 34% (71 aa)

FHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNA-----KGVTIPSQRRYV
|||||     |||| | .| .  |. .|.|||.. . || .|||| |||||| ..||.|.. . |. ..|...|.|. || ..     .|||||.|||.|
fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv

EYYGYLLRNCLTYVPTMVLLRgFEIITIPNMQGGNCC-PFYIIWQYKVKIHTSKLIESSKKGDT---SIKLELSQPLPICGDIKVEFFHKDTFGRK-ERM
.  . .     .|   .|   . . | ...|  |     .. . || . .. | . |   |     | ... .  |.  |.||.||  .      .  | 
gylaqvkhlynwnlpprrilf-ikrfiiysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydncp

FQFWFNTFFIST
||||| ||    
fffwfntsfiqn

Phosphatase nvec_PTEN.AA Subfamily.Tensin.PD 80-279 31 2.5e-32 103.4 In-house 1-204 (237) Show / Hide
Range on Protein: 80-279
Range on HMM: 1-204/237
Sequence Identity: 31% (64 aa)

FHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAK--GVTIPSQRRYVEYY
....|  . . |. |||.| .   |. .. ||||   || ..||| ||||.||.|.||. .    . ...|.. .   |  ..|  ||||||||||||. 
lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf

GYLLRNCLTYVPTMVLLRGFEIITIPNMQ-GGNCCPFYIIWQYKVKIHTSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKDTFGR-KERMFQFWFN
 || . .      ..|    . .|||.. .| | ||  |.|    ..|| . . . .. ... . . . | . ||. |..||.. .  .. .|.  | | 
sgllsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfh

TFFI
 |  
tgai

Phosphatase nvec_PTEN.AA PTEN_C2 187-334 32 2e-23 85.97 Pfam 1-135 (141) Show / Hide
Range on Protein: 187-334
Range on HMM: 1-135/141
Sequence Identity: 32% (52 aa)

YVPTMVLLRGFEI-ITIPNM-QGGNC-CPFYIIWQYKVKI-HTSKLIESSKKG--DTSIKLELSQPLPICGDIKVEFFHKD-T---FGRKERMFQFWFNT
. |  . |... .  .|||. |||.|  |.  | |...|. .|.|  .  ||   . ... .. ||.|..||.|....||. .     ..| ||.|||||
PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT

FFISTGANMTDSREGEPTIHTFKESRNSDVRWFAIPKQFVDKAHKDNKCKVFSPDFKV
.||..                     |. . .|  ||.  |||.|| | | |.|||||
CFIEH---------------------NNNRLTF--PKNELDKAWKDKKWKRFPPDFKV

Phosphatase nvec_PTEN.AA Subfamily.PRL.PD 51-158 26 2e-11 35.1 In-house 13-121 (140) Show / Hide
Range on Protein: 51-158
Range on HMM: 13-121/140
Sequence Identity: 26% (29 aa)

EVYRFLEQKHKDSYKVYNLCSERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHfkDT
.| .|.|. .|.. |    . | .||  ....   .|  ..||| ..|| |... . . . |  | .. ..  .|| || ||. |...  |..|   ...
tvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--ky

KEAMEYYGNAR
.|.|.  . | 
edavefirekr

Phosphatase nvec_PTEN.AA Subfamily.DSP11.PD 72-159 28 3.7e-11 34.2 In-house 32-123 (141) Show / Hide
Range on Protein: 72-159
Range on HMM: 32-123/141
Sequence Identity: 28% (26 aa)

ERQYDPMRFHNRVATY---PFDDHNAPPFELIKPFCDDVDEWLK--ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNART
.| |..  ....  .|       |. |  | .| |.. |.|.|.  . | ..  .||  |  ||| .|| ||..   .. ...|.| . .|| 
dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeearG

Phosphatase nvec_PTEN.AA Subfamily.PTPDC1.PD 83-172 26 4.2e-11 34.0 In-house 136-218 (229) Show / Hide
Range on Protein: 83-172
Range on HMM: 136-218/229
Sequence Identity: 26% (24 aa)

RVATYPFDDHNAPPFELIKPFCDDVDEWLkaSNLNVAiIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYygnARTRNAKGVTIPSQRR
.  ....|..... | |      ||  |  .. ..| .|| ||.|||||.|..||... ... ..||..     | . .| .   .| . 
yfynfglkDygvasleriLdivkvvdfal--eegkia-vHCHAGlGRtGvliacylvyakrlt-aeeaikl---vrskrpksiqtreqve

Phosphatase nvec_PTEN.AA Subfamily.CDC14.PD 23-158 25 4.3e-11 34.2 In-house 106-239 (258) Show / Hide
Range on Protein: 23-158
Range on HMM: 106-239/258
Sequence Identity: 25% (36 aa)

DLTYIKPN-IVAMGFP--SEKLEGVYRNHMDEVYRFLeQKHKDSYKVYNLCsERQYDPMRFHNRVAT---YPFDDHNAPPFELIKPFCDDVDEWlkasnL
|.| | || ..|.  |  ..|.|  |  .  | .     ....  ..  |  .. ||  .| .         | |   |. ...| | . ...       
dfttiipnkfialagphnkskvedGytllaPeklley-frknnvttivrLn-kklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----e

NVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNAR
  ...||||| ||||..| .||... .|.  .|.. .   ||
GaiavhCkaGLGrtgtligcylikhyrft-aaetiawlriar

Phosphatase nvec_PTEN.AA Subfamily.RNGTT.PD 93-159 34 7.3e-09 26.7 In-house 56-121 (140) Show / Hide
Range on Protein: 93-159
Range on HMM: 56-121/140
Sequence Identity: 34% (23 aa)

NAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNART
.||  | .| |   |.|.|| .  .|  .||  |  ||| .|.|||... .. . ..|.. . .|| 
eaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedw-sveaavalfakarp

Phosphatase nvec_PTEN.AA Subfamily.N5_RR.PD 34-136 23 5.6e-08 23.7 In-house 112-217 (265) Show / Hide
Range on Protein: 34-136
Range on HMM: 112-217/265
Sequence Identity: 23% (24 aa)

MGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPM--RFHNRVATYPfdDHNAP-PFELIKPFCDDVDEWLKASNLN--VAIIHCKAGKG
. || ..   .  ...|   .. | .... |.| .|  . . . .    |   . .|  ||..|   . .  ....|.|  ...| ...|| || ||||.
vyfPdaedyeiserygdveikveeiverndysvrklvlkylerversvkhywytdWP--dhksPddintlldlvleveesreeenaklaPvvvhcsaGiG

RTGVMICA
.|..    
rtGcfiai

Phosphatase nvec_PTEN.AA Subfamily.PTPMT1.PD 94-155 23 7.7e-08 23.5 In-house 66-124 (146) Show / Hide
Range on Protein: 94-155
Range on HMM: 66-124/146
Sequence Identity: 23% (14 aa)

APPFELIKPFCDDVDEWLkaSNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYG
|| .| ..   . ...    |. .   .|||||..| . .. .||... ... ..||...  
apslekleegvefiekva--skgssvYvHCkAGrtRsatlvacylmkkkkls-peeavkflk

Phosphatase nvec_PTEN.AA Subfamily.DSP23.PD 89-145 27 1.2e-07 23.1 In-house 41-95 (128) Show / Hide
Range on Protein: 89-145
Range on HMM: 41-95/128
Sequence Identity: 27% (15 aa)

FDDHNAPPFELIKPFCDDVDEWlKASNLNVAiIHCKAGKGRTGVMICAYLLHNGHFK
.|.  |  | .. .   |.|  ....  |. .||  | |||| ..  ||...  .  
ipdfcPPaleqvarlvriveea-ekkeeavg-vhcalGlGrtGtllacylvkeegla

Phosphatase nvec_PTEN.AA Subfamily.DSP19.PD 105-158 25 2.9e-07 21.7 In-house 70-120 (139) Show / Hide
Range on Protein: 105-158
Range on HMM: 70-120/139
Sequence Identity: 25% (14 aa)

DDVDEWLKASnlNVAIIHCKAGKGRTGVMICAYLLHNgHFKDTKEAMEYYGNAR
| ..| ...   .. ..||.||  |.  .. |||... . .....|.|.  .||
dFieearskd--grvlvHCnAGvSRsasvviaylmkd-eelslekalekvrear

Phosphatase nvec_PTEN.AA Subfamily.N_Fungi_PTP1.PD 109-149 25 6.7e-07 19.8 In-house 253-295 (343) Show / Hide
Range on Protein: 109-149
Range on HMM: 253-295/343
Sequence Identity: 25% (11 aa)

EWLKASNLNVAIIHCKAGKGRTGVMIC-AYLLHN-GHFKDTKE
..|. ....  ..|| || ||||...   .||..   .. ...
shldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk

Phosphatase nvec_PTEN.AA Subfamily.RB.PD 61-141 22 1.1e-06 19.5 In-house 137-218 (261) Show / Hide
Range on Protein: 61-141
Range on HMM: 137-218/261
Sequence Identity: 22% (19 aa)

KDSYKVYNLCSERQYDpMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGVMICAYLLHN
.|.. . ..  |.. . .|  ...    . ||. |   . .  |.  |.|..... . .  ..|| || ||||. |    | .
ldewvirefkiekgke-krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllq

Phosphatase nvec_PTEN.AA Subfamily.R_Anemone_2.PD 96-136 33 1.5e-06 19.2 In-house 175-214 (262) Show / Hide
Range on Protein: 96-136
Range on HMM: 175-214/262
Sequence Identity: 33% (13 aa)

PFELIKpFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICA
. .|.. .  .|... . |. .. ..|| || ||||| |  
gaslld-lvrqvekaqqesgagpivvhcsaGvGrtGvfiav

Phosphatase nvec_PTEN.AA Subfamily.DSP1.PD 111-158 29 5.8e-06 17.6 In-house 75-120 (139) Show / Hide
Range on Protein: 111-158
Range on HMM: 75-120/139
Sequence Identity: 29% (14 aa)

LKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNAR
.|...  | ..||.||  |.  .. |||... ...  .|| |.  . |
vkkkgGrv-lvhCqaGisrsativlayLmkekkvr-leeafefvkqrr

Phosphatase nvec_PTEN.AA PTPc_motif 80-182 16 9e-06 16.77 SMART 1-92 (92) Show / Hide
Range on Protein: 80-182
Range on HMM: 1-92/92
Sequence Identity: 16% (18 aa)

FHNRVATYPFDDH-----NAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGN-ARTRNAKGVTIPSQRRY
.....  .   ||     ..|  . |  |.. | .          ..|| || ||||..........         .  ..   . |. .   . .   |
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQ--------VDIFQTVKEMRKQRPGMVQTEEQY

VEYYGYLLR
.  |  .| 
IFCYRCILE

Phosphatase nvec_PTEN.AA Subfamily.N6.PD 60-137 23 9.9e-06 16.3 In-house 164-245 (295) Show / Hide
Range on Protein: 60-137
Range on HMM: 164-245/295
Sequence Identity: 23% (19 aa)

HKDSYKVYNLCSERQ--YDPMR--FHNRVATYPfdDHNAPP-FELIKPFCDDVDEWLKA-SNLNVAIIHCKAGKGRTGVMICAY
....|.. ..  ...   ...|  |. .  ..|  ||. |   . .  | .||..  .. ..    ..|| || |||| .|   
stadYtlRefsvshkdkdkeareifqyhfkaWP--dhgvpkdpgvvlnfledvnkkqeelekagpivvhcsaGiGrtGtfivid

Phosphatase nvec_PTEN.AA Subfamily.N14.PD 119-140 60 1e-05 16.1 In-house 210-231 (275) Show / Hide
Range on Protein: 119-140
Range on HMM: 210-231/275
Sequence Identity: 60% (12 aa)

AIIHCKAGKGRTGVMICAYLLH
..|| || |||||.| . ||  
vlvhCsaGvGrtGvlilsdlli

Sequence
Name Sequence Type Origin Length Description Download
nvec_PTEN.AA Protein None 338 None Fasta, JSON
nvec_PTEN.NA RNA None 1014 None Fasta, JSON
nvec_PTEN.AA.PD_80-182 Protein Phosphatase Domain None 103 None Fasta, JSON