Gene nvec_PTEN
nvec_PTEN
Species: N.vectensis
Alias: nvec_PTEN
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of nvec_PTEN.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | nvec_PTEN.AA | Family.DSP.PD | 8-338 | 24 | 2.1e-39 | 127.2 | In-house | 79-385 (387) | Show / Hide |
Range on Protein: 8-338
Range on HMM: 79-385/387
Sequence Identity: 24% (82 aa)
VSKKKRRFQEDGFDLDlTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCserqYDPMRFHN-RVATY---PFDDHNAPPFELIkpF
...... . |||| || . . |. | ||| |...| ... .. . . |.. |. ||. .|. .|.. .| |.|||||||.|.. |
qaelngfidvhtfdld-tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--f
CDDVDeWLKASN--LNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTkEAMEYYGNARtrnaKGVTIPSQRrYVEYYGYLLRNCLTYVPTMVLLRGFEIIT
. ..| ... .| .|. .||||||||.|..|.|||... ... ||.... .| .||..|.|. ..... |. . |. ...|| . .
ekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissi
IPNMQGGNCCPFYIIWQYKVKIHTSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKDTFGR-KERMFQFWFNTFFISTGANMTDSREgeptIHTFKe
.|.. ... |. .| . .. . . . ||. ||.|||.|.| . .. .....|.| .| ...| ...
vqnlgsvevsvsvlkkvatekakldrlkiLvideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkke----ldelh-
srnsdvrwfaipKQFVDKAHKDNKCKVFSPDFKVSNVF
|. ... .||. . .| .||.| ||
------------kskifdvykdseaveiseefkisivf
|
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| Phosphatase | nvec_PTEN.AA | Subfamily.PTEN.PD | 23-338 | 34 | 5.1e-80 | 260.3 | In-house | 1-303 (305) | Show / Hide |
Range on Protein: 23-338 Range on HMM: 1-303/305 Sequence Identity: 34% (108 aa) DLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIH |..|| .|......| |..|..... .... ..|. ..|. .|...|....... |..|||.|||||||.|..||......|||.|||... ||...| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRNCLTYVPTM---VLLRGFEIITIPNMQGGNCCpFYIIWQ- |||||||||||||||||..|..|...||...|...||.. ||||||||||||.|. .|..... | . .| | ..|. .|. .. . CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecs-isvlhds YKVKIHTSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKDTfgrKERMFQFWFNTFFISTGANMTDSREGEPTIHTfkesrnsdvrwfaIPKQFVDK . . .| . |. | . .|..||.|.|. .| . . .||.||||. . .||| . | .| || atenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkksp---dkiichfwlntffvrnyspcesdgtvnkyiht-------------lskseidd AHKDNKCKVFSPDFKVSNVF |.. | || .||.| || vhkdsehkrfseefkisivf |
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| Phosphatase | nvec_PTEN.AA | Subfamily.TPIP.PD | 80-281 | 34 | 1.2e-37 | 121.1 | In-house | 1-211 (245) | Show / Hide |
Range on Protein: 80-281 Range on HMM: 1-211/245 Sequence Identity: 34% (71 aa) FHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNA-----KGVTIPSQRRYV ||||| |||| | .| . |. .|.|||.. . || .|||| |||||| ..||.|.. . |. ..|...|.|. || .. .|||||.|||.| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv EYYGYLLRNCLTYVPTMVLLRgFEIITIPNMQGGNCC-PFYIIWQYKVKIHTSKLIESSKKGDT---SIKLELSQPLPICGDIKVEFFHKDTFGRK-ERM . . . .| .| . . | ...| | .. . || . .. | . | | | ... . |. |.||.|| . . | gylaqvkhlynwnlpprrilf-ikrfiiysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydncp FQFWFNTFFIST ||||| || fffwfntsfiqn |
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| Phosphatase | nvec_PTEN.AA | Subfamily.Tensin.PD | 80-279 | 31 | 2.5e-32 | 103.4 | In-house | 1-204 (237) | Show / Hide |
Range on Protein: 80-279 Range on HMM: 1-204/237 Sequence Identity: 31% (64 aa) FHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAK--GVTIPSQRRYVEYY ....| . . |. |||.| . |. .. |||| || ..||| ||||.||.|.||. . . ...|.. . | ..| ||||||||||||. lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf GYLLRNCLTYVPTMVLLRGFEIITIPNMQ-GGNCCPFYIIWQYKVKIHTSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKDTFGR-KERMFQFWFN || . . ..| . .|||.. .| | || |.| ..|| . . . .. ... . . . | . ||. |..||.. . .. .|. | | sgllsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfh TFFI | tgai |
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| Phosphatase | nvec_PTEN.AA | PTEN_C2 | 187-334 | 32 | 2e-23 | 85.97 | Pfam | 1-135 (141) | Show / Hide |
Range on Protein: 187-334 Range on HMM: 1-135/141 Sequence Identity: 32% (52 aa) YVPTMVLLRGFEI-ITIPNM-QGGNC-CPFYIIWQYKVKI-HTSKLIESSKKG--DTSIKLELSQPLPICGDIKVEFFHKD-T---FGRKERMFQFWFNT . | . |... . .|||. |||.| |. | |...|. .|.| . || . ... .. ||.|..||.|....||. . ..| ||.||||| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT FFISTGANMTDSREGEPTIHTFKESRNSDVRWFAIPKQFVDKAHKDNKCKVFSPDFKV .||.. |. . .| ||. |||.|| | | |.||||| CFIEH---------------------NNNRLTF--PKNELDKAWKDKKWKRFPPDFKV |
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| Phosphatase | nvec_PTEN.AA | Subfamily.PRL.PD | 51-158 | 26 | 2e-11 | 35.1 | In-house | 13-121 (140) | Show / Hide |
Range on Protein: 51-158 Range on HMM: 13-121/140 Sequence Identity: 26% (29 aa) EVYRFLEQKHKDSYKVYNLCSERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHfkDT .| .|.|. .|.. | . | .|| .... .| ..||| ..|| |... . . . | | .. .. .|| || ||. |... |..| ... tvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--ky KEAMEYYGNAR .|.|. . | edavefirekr |
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| Phosphatase | nvec_PTEN.AA | Subfamily.DSP11.PD | 72-159 | 28 | 3.7e-11 | 34.2 | In-house | 32-123 (141) | Show / Hide |
Range on Protein: 72-159 Range on HMM: 32-123/141 Sequence Identity: 28% (26 aa) ERQYDPMRFHNRVATY---PFDDHNAPPFELIKPFCDDVDEWLK--ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNART .| |.. .... .| |. | | .| |.. |.|.|. . | .. .|| | ||| .|| ||.. .. ...|.| . .|| dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeearG |
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| Phosphatase | nvec_PTEN.AA | Subfamily.PTPDC1.PD | 83-172 | 26 | 4.2e-11 | 34.0 | In-house | 136-218 (229) | Show / Hide |
Range on Protein: 83-172 Range on HMM: 136-218/229 Sequence Identity: 26% (24 aa) RVATYPFDDHNAPPFELIKPFCDDVDEWLkaSNLNVAiIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYygnARTRNAKGVTIPSQRR . ....|..... | | || | .. ..| .|| ||.|||||.|..||... ... ..||.. | . .| . .| . yfynfglkDygvasleriLdivkvvdfal--eegkia-vHCHAGlGRtGvliacylvyakrlt-aeeaikl---vrskrpksiqtreqve |
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| Phosphatase | nvec_PTEN.AA | Subfamily.CDC14.PD | 23-158 | 25 | 4.3e-11 | 34.2 | In-house | 106-239 (258) | Show / Hide |
Range on Protein: 23-158 Range on HMM: 106-239/258 Sequence Identity: 25% (36 aa) DLTYIKPN-IVAMGFP--SEKLEGVYRNHMDEVYRFLeQKHKDSYKVYNLCsERQYDPMRFHNRVAT---YPFDDHNAPPFELIKPFCDDVDEWlkasnL |.| | || ..|. | ..|.| | . | . .... .. | .. || .| . | | |. ...| | . ... dfttiipnkfialagphnkskvedGytllaPeklley-frknnvttivrLn-kklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----e NVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNAR ...||||| ||||..| .||... .|. .|.. . || GaiavhCkaGLGrtgtligcylikhyrft-aaetiawlriar |
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| Phosphatase | nvec_PTEN.AA | Subfamily.RNGTT.PD | 93-159 | 34 | 7.3e-09 | 26.7 | In-house | 56-121 (140) | Show / Hide |
Range on Protein: 93-159 Range on HMM: 56-121/140 Sequence Identity: 34% (23 aa) NAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNART .|| | .| | |.|.|| . .| .|| | ||| .|.|||... .. . ..|.. . .|| eaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedw-sveaavalfakarp |
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| Phosphatase | nvec_PTEN.AA | Subfamily.N5_RR.PD | 34-136 | 23 | 5.6e-08 | 23.7 | In-house | 112-217 (265) | Show / Hide |
Range on Protein: 34-136 Range on HMM: 112-217/265 Sequence Identity: 23% (24 aa) MGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPM--RFHNRVATYPfdDHNAP-PFELIKPFCDDVDEWLKASNLN--VAIIHCKAGKG . || .. . ...| .. | .... |.| .| . . . . | . .| ||..| . . ....|.| ...| ...|| || ||||. vyfPdaedyeiserygdveikveeiverndysvrklvlkylerversvkhywytdWP--dhksPddintlldlvleveesreeenaklaPvvvhcsaGiG RTGVMICA .|.. rtGcfiai |
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| Phosphatase | nvec_PTEN.AA | Subfamily.PTPMT1.PD | 94-155 | 23 | 7.7e-08 | 23.5 | In-house | 66-124 (146) | Show / Hide |
Range on Protein: 94-155 Range on HMM: 66-124/146 Sequence Identity: 23% (14 aa) APPFELIKPFCDDVDEWLkaSNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYG || .| .. . ... |. . .|||||..| . .. .||... ... ..||... apslekleegvefiekva--skgssvYvHCkAGrtRsatlvacylmkkkkls-peeavkflk |
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| Phosphatase | nvec_PTEN.AA | Subfamily.DSP23.PD | 89-145 | 27 | 1.2e-07 | 23.1 | In-house | 41-95 (128) | Show / Hide |
Range on Protein: 89-145 Range on HMM: 41-95/128 Sequence Identity: 27% (15 aa) FDDHNAPPFELIKPFCDDVDEWlKASNLNVAiIHCKAGKGRTGVMICAYLLHNGHFK .|. | | .. . |.| .... |. .|| | |||| .. ||... . ipdfcPPaleqvarlvriveea-ekkeeavg-vhcalGlGrtGtllacylvkeegla |
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| Phosphatase | nvec_PTEN.AA | Subfamily.DSP19.PD | 105-158 | 25 | 2.9e-07 | 21.7 | In-house | 70-120 (139) | Show / Hide |
Range on Protein: 105-158 Range on HMM: 70-120/139 Sequence Identity: 25% (14 aa) DDVDEWLKASnlNVAIIHCKAGKGRTGVMICAYLLHNgHFKDTKEAMEYYGNAR | ..| ... .. ..||.|| |. .. |||... . .....|.|. .|| dFieearskd--grvlvHCnAGvSRsasvviaylmkd-eelslekalekvrear |
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| Phosphatase | nvec_PTEN.AA | Subfamily.N_Fungi_PTP1.PD | 109-149 | 25 | 6.7e-07 | 19.8 | In-house | 253-295 (343) | Show / Hide |
Range on Protein: 109-149 Range on HMM: 253-295/343 Sequence Identity: 25% (11 aa) EWLKASNLNVAIIHCKAGKGRTGVMIC-AYLLHN-GHFKDTKE ..|. .... ..|| || ||||... .||.. .. ... shldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk |
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| Phosphatase | nvec_PTEN.AA | Subfamily.RB.PD | 61-141 | 22 | 1.1e-06 | 19.5 | In-house | 137-218 (261) | Show / Hide |
Range on Protein: 61-141 Range on HMM: 137-218/261 Sequence Identity: 22% (19 aa) KDSYKVYNLCSERQYDpMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGVMICAYLLHN .|.. . .. |.. . .| ... . ||. | . . |. |.|..... . . ..|| || ||||. | | . ldewvirefkiekgke-krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllq |
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| Phosphatase | nvec_PTEN.AA | Subfamily.R_Anemone_2.PD | 96-136 | 33 | 1.5e-06 | 19.2 | In-house | 175-214 (262) | Show / Hide |
Range on Protein: 96-136 Range on HMM: 175-214/262 Sequence Identity: 33% (13 aa) PFELIKpFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICA . .|.. . .|... . |. .. ..|| || ||||| | gaslld-lvrqvekaqqesgagpivvhcsaGvGrtGvfiav |
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| Phosphatase | nvec_PTEN.AA | Subfamily.DSP1.PD | 111-158 | 29 | 5.8e-06 | 17.6 | In-house | 75-120 (139) | Show / Hide |
Range on Protein: 111-158 Range on HMM: 75-120/139 Sequence Identity: 29% (14 aa) LKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNAR .|... | ..||.|| |. .. |||... ... .|| |. . | vkkkgGrv-lvhCqaGisrsativlayLmkekkvr-leeafefvkqrr |
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| Phosphatase | nvec_PTEN.AA | PTPc_motif | 80-182 | 16 | 9e-06 | 16.77 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 80-182 Range on HMM: 1-92/92 Sequence Identity: 16% (18 aa) FHNRVATYPFDDH-----NAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGN-ARTRNAKGVTIPSQRRY ..... . || ..| . | |.. | . ..|| || ||||.......... . .. . |. . . . | TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQ--------VDIFQTVKEMRKQRPGMVQTEEQY VEYYGYLLR . | .| IFCYRCILE |
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| Phosphatase | nvec_PTEN.AA | Subfamily.N6.PD | 60-137 | 23 | 9.9e-06 | 16.3 | In-house | 164-245 (295) | Show / Hide |
Range on Protein: 60-137 Range on HMM: 164-245/295 Sequence Identity: 23% (19 aa) HKDSYKVYNLCSERQ--YDPMR--FHNRVATYPfdDHNAPP-FELIKPFCDDVDEWLKA-SNLNVAIIHCKAGKGRTGVMICAY ....|.. .. ... ...| |. . ..| ||. | . . | .||.. .. .. ..|| || |||| .| stadYtlRefsvshkdkdkeareifqyhfkaWP--dhgvpkdpgvvlnfledvnkkqeelekagpivvhcsaGiGrtGtfivid |
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| Phosphatase | nvec_PTEN.AA | Subfamily.N14.PD | 119-140 | 60 | 1e-05 | 16.1 | In-house | 210-231 (275) | Show / Hide |
Range on Protein: 119-140 Range on HMM: 210-231/275 Sequence Identity: 60% (12 aa) AIIHCKAGKGRTGVMICAYLLH ..|| || |||||.| . || vlvhCsaGvGrtGvlilsdlli |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| nvec_PTEN.AA | Protein | None | 338 | None | Fasta, JSON |
| nvec_PTEN.NA | RNA | None | 1014 | None | Fasta, JSON |
| nvec_PTEN.AA.PD_80-182 | Protein Phosphatase Domain | None | 103 | None | Fasta, JSON |