Gene nvec_200601
nvec_200601
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of nvec_200601.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1K.PD | 80-183 | 58 | 5.2e-51 | 163.2 | In-house | 1-103 (264) | Show / Hide |
Range on Protein: 80-183 Range on HMM: 1-103/264 Sequence Identity: 58% (61 aa) KSFLHNVSIDSVGFNSLQGKKFVNEDRFKLLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHrDGENDLEKILVQAFEECDTELKRHLEYLVSEK .......|.||||..||.||...|||||||.|||||..||||||||||.|.|.|.||||.|||||.. ..|.|||..|.|||||.|..|||.||..|.|. gkpipkisvdsvGkdsliGkraenedrfklkeldpdllyfavfdGhgGssaadfvhdkleeivrrll-ekekdleevlkqafeeldkklkrylefsvaea DTQE .... ells |
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Phosphatase | nvec_200601.AA | Family.PPM.PD | 86-172 | 32 | 1.3e-15 | 46.7 | In-house | 12-113 (495) | Show / Hide |
Range on Protein: 86-172 Range on HMM: 12-113/495 Sequence Identity: 32% (33 aa) VSIDSVGFNSLQGKKFVNEDRFK-LLELDP--DFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGE------------NDLEKILVQAFEECDTELKR .. ..|..| ||.. .||... . .|. ||..|.||||||| . ||||..|||.|. . .. . ......| .||.|.|.||.. snglrygvasmqgwrsemeDahvvvenlennedfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeelse HL .| el |
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Phosphatase | nvec_200601.AA | Group.PPM.PD | 80-171 | 28 | 2.8e-15 | 45.7 | In-house | 29-139 (459) | Show / Hide |
Range on Protein: 80-171 Range on HMM: 29-139/459 Sequence Identity: 28% (31 aa) KSFLHNVSIDSVGFNSLQGKKFVNEDRF-KLLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGE------------------NDLEKILVQA .|. ... ..|..| ||.. .|||. ...| . .|.||||||| . ||||..||..|. . .. . ....| |.|| essagsgnglrygvasmqgwrkemEDrhvivenfdnndsffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsa FEECDTELKRH |.|..|... fleldedlsee |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1G2.PD | 90-172 | 40 | 4.7e-14 | 42.0 | In-house | 11-99 (275) | Show / Hide |
Range on Protein: 90-172 Range on HMM: 11-99/275 Sequence Identity: 40% (35 aa) SVGFNSLQGKKFVNEDRFKL----LE--LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEKILVQAFEECDTELKRHL || |.|| .. || | || |.. .||||||||| . |..| ||.... . . |. ||.|| .|| |.|.|| .. avgvssmqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkde |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1G.PD | 90-170 | 37 | 1.2e-13 | 40.8 | In-house | 11-92 (482) | Show / Hide |
Range on Protein: 90-170 Range on HMM: 11-92/482 Sequence Identity: 37% (30 aa) SVGFNSLQGKKFVNEDRFK-LLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEKILVQAFEECDTELKR |.|. ..|| . || . .|.|| | |||.||||| |... .|| .... . |.|.|| | .|| ..|..|. sygasamqGWRvsmeDahncildldedtslfavyDGhGGkevakycakklPdllkeskaykegdvekaleeaflkvDkkllt |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1E.PD | 112-170 | 36 | 1.4e-12 | 37.2 | In-house | 43-100 (269) | Show / Hide |
Range on Protein: 112-170 Range on HMM: 43-100/269 Sequence Identity: 36% (21 aa) LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDgENDLEKILVQAFEECDTELKR ... .|||||||||| .|..| .||| . | ... ..| .. | .||...|. . . dekeraffavfDGHgGveaakyaaahlhellvrqekl-kedpaealkeafkltDerflq |
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Phosphatase | nvec_200601.AA | PP2C | 89-166 | 30 | 2.9e-10 | 38.44 | Pfam | 1-92 (284) | Show / Hide |
Range on Protein: 89-166 Range on HMM: 1-92/284 Sequence Identity: 30% (28 aa) DSVGFNSLQGKKFVNEDRFKLLE-------LDPDFYYFAVFDGHGGVSSAEFAHDKLH----EIVRRMHRDGEN---DLEKILVQAFEECDT . .||...|| . .||. .. ......|||||||||. |.... .|| .|. . . | |.|..| .|.|||| WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDT |
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Phosphatase | nvec_200601.AA | Subfamily.LRR-PP2C.PD | 90-170 | 30 | 4.2e-10 | 29.2 | In-house | 11-94 (257) | Show / Hide |
Range on Protein: 90-170 Range on HMM: 11-94/257 Sequence Identity: 30% (25 aa) SVGFNSLQGKKFVNEDRFKLL---ELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEKILVQAFEECDTELKR ||| . |.. ||.. . . ..| |.|.|||||| ..|.|| ..|. |.. . . . .|.| .|..| .| .. kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPlkslkkaykeistqise |
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Phosphatase | nvec_200601.AA | Subfamily.ILKAP.PD | 117-168 | 37 | 4.6e-10 | 29.1 | In-house | 48-104 (298) | Show / Hide |
Range on Protein: 117-168 Range on HMM: 48-104/298 Sequence Identity: 37% (21 aa) YYFAVFDGHGGVSSAEFAHDKLHEIVR-RMHRD----GENDLEKILVQAFEECDTEL |.||||||.| ..|||..|||. . .. .. .....| ||.||.. | |. syyavfDGhaGsrasefaaeklhkviveklpkedvsakdkeikkclvdafkktDeef |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1A.PD | 97-173 | 23 | 4.9e-10 | 28.9 | In-house | 18-105 (309) | Show / Hide |
Range on Protein: 97-173 Range on HMM: 18-105/309 Sequence Identity: 23% (21 aa) QGKKFVNEDRFK----LLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRM-------HRDGENDLEKILVQAFEECDTELKRHLE || . || . | . .| .|||||||.| . .... ..|.|.. . ... ...... | ..| |.| ..... | qgwRvemEDahtavidlpsklkdwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDekirklve |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1L.PD | 89-156 | 35 | 2e-09 | 27.1 | In-house | 12-82 (273) | Show / Hide |
Range on Protein: 89-156 Range on HMM: 12-82/273 Sequence Identity: 35% (25 aa) DSVGFNSLQGKKFVNEDRFKLLELD---PDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEKI . | |..|.. ||||.. | . .||||||||| .||||.|.| . ... . ..| |. qnvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkent |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1D.PD | 113-176 | 25 | 2.8e-09 | 26.5 | In-house | 38-104 (311) | Show / Hide |
Range on Protein: 113-176 Range on HMM: 38-104/311 Sequence Identity: 25% (17 aa) DPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRM---HRDGENDLEKILVQAFEECDTELKRHLEYLV . . ..|||||||| |.||...| . ... . ..|. . . .|| .. ...|..|. . eaeaafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkklaeWp |
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Phosphatase | nvec_200601.AA | Subfamily.TAB1.PD | 103-181 | 27 | 6.4e-09 | 25.0 | In-house | 24-103 (336) | Show / Hide |
Range on Protein: 103-181 Range on HMM: 24-103/336 Sequence Identity: 27% (22 aa) NEDRFKLlELDPDFYYFAVFDGHGGVSSAEFAHDKLH-EIV-RRMHRDGENDLEKILVQAFEECDTELKRHLEYLVSEKDT |||.. . . | . .|||||. | ..|||.. .| |.. . . | . ...| |..|| . .. .... | |... nedkvfs-rteddiilyavfdGydGekaaefveqrLvaelllgdlseeaeaepkllllqvieeverkffesiddavaerad |
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Phosphatase | nvec_200601.AA | Subfamily.PPM1H.PD | 114-148 | 35 | 2.3e-07 | 19.8 | In-house | 62-96 (402) | Show / Hide |
Range on Protein: 114-148 Range on HMM: 62-96/402 Sequence Identity: 35% (12 aa) PDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRD ...||..||||.| . | | .||..... .| lplayfglfDGhaGsgaalvaskllhkhlkekled |
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Phosphatase | nvec_200601.AA | Subfamily.PDP.PD | 87-142 | 30 | 9.6e-06 | 15.0 | In-house | 8-63 (409) | Show / Hide |
Range on Protein: 87-142 Range on HMM: 8-63/409 Sequence Identity: 30% (17 aa) SIDSVGFNSLQGKKFVNEDRFKLLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIV .| .. | |. . . .|. |. . . |.||||||| .|| ..| . | ailrydtnqLasNePiEDrrseakllesngvlfgvfDGHggaacaeavskrLlkyv |
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
nvec_200601.AA | Protein | None | 411 | None | Fasta, JSON |
nvec_200601.NA | RNA | None | 1233 | None | Fasta, JSON |
nvec_200601.AA.PD_89-166 | Protein Phosphatase Domain | None | 78 | None | Fasta, JSON |