Gene CDC14
CDC14
Species: S.cerevisiae
Alias: CDC14
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of CDC14.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | CDC14.AA | Subfamily.CDC14.PD | 73-335 | 41 | 1.8e-85 | 278.1 | In-house | 2-257 (258) | Show / Hide |
Range on Protein: 73-335 Range on HMM: 2-257/258 Sequence Identity: 41% (110 aa) PENANKAVVFYSSASTRQRANAACMLCCYMILVQAWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEH |.. .. . | ... . |.|||... . . . | .|.. | . ||| ||||| |. ... .. |. |...| .|.||.|.|.|..|...|. pqhkdqriyfctgtdmqvrsnaaaliglfavwclnmtdeqaiacldtakppfapfrdasyapvlyklhvryvisgayqallngfidvhtfdldtydhfer VEFGDFNVLTP-DFIAFASPQ--EDHPKGYlatkssHLNQPfKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAA || ||| .. | |||.|.|. .....|| .|..| ...|..|..|||. .||||..||..|.|.|.|..||||.|.|||.|. .|.|.|. .. vengdfttiipnkfialagphnkskvedGy------tllaP-eklleyfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfleit ETIikrGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQND |.. |.|||||||||||||.|||..||..|.|||.|.|..||..|||.|.||||..|. .|.| eka---eGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPGsvigpqqtylvekqad |
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| Phosphatase | CDC14.AA | DSPc | 190-335 | 21 | 1.4e-44 | 155.34 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 190-335 Range on HMM: 1-172/172 Sequence Identity: 21% (38 aa) SPQEDHPKGYLATKSSHL--NQPFKSVLNFFANNNVQLVVRLNSHL-------------YNKKHFEDIGIQHLDL-------IFEDGTCPDLSIVKNFVG .|.| .|. ||. ...|. |..|....|... ||. ....|.|. |...||. ..|...| ... ..... |..|. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH AAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFL-----RFIR-PGMVVG-PQQHWLYLHQND .. ...|||. |||.||. |...|. |.|........|... |. ...| |... ..|.|..... DC---RQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | CDC14.AA | Family.DSP.PD | 75-334 | 27 | 7.7e-42 | 135.3 | In-house | 4-240 (387) | Show / Hide |
Range on Protein: 75-334
Range on HMM: 4-240/387
Sequence Identity: 27% (73 aa)
NANKAVVFYSSASTRQRANAACMLCCYMILVQAWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVE
.. . | . . . |.||| .. . . . | | . |..| |.|.||||| | . . . | | |. .| || |.|.|..|...| || |
hkdqriyfctGtdmqvrsnaaaliGlfavwclnmtdeqaiacldtvkpkfapfrdasyapvlaklhvryvisgakqaelngfidvhtfdldtydhferve
FGDFNVLTPdfiafaspqedhpkgY--LATKSSHlNQpfksvLNFFANNNVQLVVRLNshlYNKKHFED-IGIQHLDLIFEDGTCPDLSIVknFVGAAEt
... .| |.. . .. | .....|. .|.|. ..|..|. ||..|.. ..|...|.|...|. | . .|.
ngkpseilp---------------hlylgsllaa-kn-----lewlkelgvtkivnlt---ddkpqftkelgikylripidDhnapplenl--fekaid-
IIKR----GGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPgMVVGPQQHwlYLHQN
.|...||||||.||.| || | |.. .|.|..|.. ..| || |. |.|. .|.|
fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRp-gvitpnqg--flkql
|
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| Phosphatase | CDC14.AA | DSPc | 198-335 | 20 | 5.1e-41 | 144.54 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 198-335 Range on HMM: 1-151/151 Sequence Identity: 20% (31 aa) GYLATKSSHL-NQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDL---------IFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGL ||. ...|. ...| .........|.. .. | ..|...||....|.|.. ... ..... ...|. .. ...|||. |||.||. LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN-WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDC---RQKGGKVLVHCQAGI GRTGCLIGAHLIYTYGFTANECIGFL-----RFIR-PGMVVG-PQQHWLYLHQND |..||. |.|........||.. |. .. | |... ....|. .... SRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | CDC14.AA | Subfamily.PTPDC1.PD | 181-323 | 27 | 3.6e-18 | 57.2 | In-house | 70-213 (229) | Show / Hide |
Range on Protein: 181-323 Range on HMM: 70-213/229 Sequence Identity: 27% (39 aa) LTPDFIAFASPQEDHPKGYLATKSsHLNQPFKSVLNFFANNNV---QLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIkRGG .| . .|.|.|. .. . | . .. |.|.| . . .. . |.. .. || . ..| . | . . |.. . . ||| vtenilalarpsselldqykllek-fkesGikavinLqeagehahCGagleesGfsYdpeelmrqgiyfynfglkDygvasleriLdivkvvdfal-eeg KIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVG |||| ||||||| || ..|.|. .||.| | ..| || . kiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqt |
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| Phosphatase | CDC14.AA | Subfamily.PRL.PD | 214-329 | 30 | 6.4e-18 | 56.3 | In-house | 17-133 (140) | Show / Hide |
Range on Protein: 214-329 Range on HMM: 17-133/140 Sequence Identity: 30% (36 aa) VLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIK--RGGKIAVHCKAGLGRTGCLIGAHLIYtYGFTANECIG .. . ..||. ||| |. ..... ||. ||| |.||. | ..|.... .. | . .|||| |||||. |. || |.. .. . | fieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalie-aGmkyedave FLRFIRPGMVVGPQQHWL .| | | . | ..| firekrrgainskqlkfl |
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| Phosphatase | CDC14.AA | Subfamily.PTPMT1.PD | 210-326 | 27 | 2.5e-16 | 51.2 | In-house | 12-136 (146) | Show / Hide |
Range on Protein: 210-326 Range on HMM: 12-136/146 Sequence Identity: 27% (34 aa) PFKSVLNF-FANNNVQLVVRLNSHLY------NKKHFEDIGIQHLDLIFEDGTC-PDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYT ||.| . . ..||. || || ....... |...| | | | |.| ... | |.....| .. |||||| .| .|....|.... PfrsltkeLvekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkk YGFTANECIGFLRFIRPGMVVGPQQ ....| . ||. .|| . . .| kklspeeavkflkkkRpqirlkskq |
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| Phosphatase | CDC14.AA | Subfamily.DSP23.PD | 215-326 | 26 | 6.9e-14 | 43.4 | In-house | 6-116 (128) | Show / Hide |
Range on Protein: 215-326 Range on HMM: 6-116/128 Sequence Identity: 26% (30 aa) LNFFANNNVQLVVRLNSHLY-NKKHFEDIGIQHLDLifEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFL ..|.|.. .. .| | . ... ...... .|. .| . | | |...| | |... ..||| |||||| |. .|. . |..|.. | . vqfladqGirvlvslttegapyseaapsltlrridi--pdfcPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaev RFIRPGMVVGPQQ | |.| . .| rkrrkGsietveq |
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| Phosphatase | CDC14.AA | Subfamily.DSP11.PD | 220-314 | 29 | 2.3e-11 | 35.0 | In-house | 19-119 (141) | Show / Hide |
Range on Protein: 220-314 Range on HMM: 19-119/141 Sequence Identity: 29% (29 aa) NNNVQLVVRLN--SHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIK----RGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFL |... ||. | |.||...| |... | . |. .||.| | . .. . |.||| |. ||| || .|| . |.... | . nkklGLvidltntdryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieaf R e |
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| Phosphatase | CDC14.AA | Subfamily.PTEN.PD | 241-306 | 31 | 4.8e-11 | 33.9 | In-house | 57-124 (305) | Show / Hide |
Range on Protein: 241-306 Range on HMM: 57-124/305 Sequence Identity: 31% (21 aa) DIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGK--IAVHCKAGLGRTGCLIGAHLIYTYGFTA |. . |.| . | |......| .. .| . .||||||| |||| .| |.|... .. dfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikks |
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| Phosphatase | CDC14.AA | Subfamily.RNGTT.PD | 222-313 | 26 | 5.5e-10 | 30.5 | In-house | 20-116 (140) | Show / Hide |
Range on Protein: 222-313 Range on HMM: 20-116/140 Sequence Identity: 26% (26 aa) NVQLVVRLN--SHLYNKKHFEDIGIQHLDLIF-EDGTCPDLSIVKNFVGAAETIIKRG--GKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFL ...||. | | |.|...|. |... | | .|. .|.|. .. .|. |.||| | ||| || |.|. . .. .. . . klglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalf |
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| Phosphatase | CDC14.AA | Subfamily.DSP3.PD | 235-316 | 28 | 1.2e-07 | 23.0 | In-house | 46-129 (148) | Show / Hide |
Range on Protein: 235-316 Range on HMM: 46-129/148 Sequence Identity: 28% (24 aa) NKKHFEDIGIQHLDLIFEDGtcPDLSIVKNFVGAA----ETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFI ... ..|..|..| . .| |. . | | || |.. ...||. |||..|. |. |. |.|. . .|..| | | daefYkdleikylGvevsDv--pefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkk |
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| Phosphatase | CDC14.AA | Subfamily.DSP12.PD | 269-318 | 20 | 3.5e-07 | 21.8 | In-house | 74-123 (143) | Show / Hide |
Range on Protein: 269-318 Range on HMM: 74-123/143 Sequence Identity: 20% (10 aa) AETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRP | ....|.. |||.||. | .. |.|...... .. . ... ... ieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkk |
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| Phosphatase | CDC14.AA | Subfamily.DSP1.PD | 220-317 | 20 | 3.7e-07 | 21.6 | In-house | 25-120 (139) | Show / Hide |
Range on Protein: 220-317 Range on HMM: 25-120/139 Sequence Identity: 20% (20 aa) NNNVQLVVRLNSHlyNKKHFEDIgIQHLDLIFEDGTCPDLS-IVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIR . .. .. . .. ...||.. .. . || . |.| ... . ... |.||.. |||.||. |. .. |.|. . .. .||.. | elkitallnvsae--lpnvfeel-fkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrr |
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| Phosphatase | CDC14.AA | Subfamily.STYX.PD | 260-312 | 33 | 4e-07 | 21.3 | In-house | 73-122 (146) | Show / Hide |
Range on Protein: 260-312 Range on HMM: 73-122/146 Sequence Identity: 33% (17 aa) SIVKNFVgaaETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGF ||.|. .. ...|||. || .||. |. .|. |... |||. |. . ptvkefi---ddslqkggkvlvhgnagisrsaalviayimetyglkyreafay |
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| Phosphatase | CDC14.AA | Subfamily.TPIP.PD | 279-313 | 44 | 6.3e-07 | 20.6 | In-house | 40-75 (245) | Show / Hide |
Range on Protein: 279-313 Range on HMM: 40-75/245 Sequence Identity: 44% (16 aa) IAVHCKAGLGRTGCLIGAHLIYTYGF-TANECIGFL .|.||| | |||| .. | ||.. | ||.|.. .. vaihckGGkgrtGtivcalliaseifltaeesldyf |
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| Phosphatase | CDC14.AA | Subfamily.N5_RR.PD | 271-298 | 39 | 2.1e-06 | 18.7 | In-house | 192-219 (265) | Show / Hide |
Range on Protein: 271-298 Range on HMM: 192-219/265 Sequence Identity: 39% (11 aa) TIIKRGGKIAVHCKAGLGRTGCLIGAHL . .. . . ||| ||.||||| |.... eenaklaPvvvhcsaGiGrtGcfiaisi |
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| Phosphatase | CDC14.AA | Subfamily.N13.PD | 253-321 | 30 | 2.6e-06 | 18.5 | In-house | 167-241 (259) | Show / Hide |
Range on Protein: 253-321 Range on HMM: 167-241/259 Sequence Identity: 30% (23 aa) DGTCPDLSI-VKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYT-----YGFTANECIGFLRFIRPGMV | | .. . .|| .. . | |.||| ||.||.| || . . | .| . || | |.| dhgvPssaaelvqfvaevrllqtdagPivvhcsaGiGrsGvlitidvvlglierdkefdvkeivrklreqrqgvv |
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| Phosphatase | CDC14.AA | Subfamily.DSP19.PD | 258-319 | 25 | 3e-06 | 18.5 | In-house | 64-122 (139) | Show / Hide |
Range on Protein: 258-319 Range on HMM: 64-122/139 Sequence Identity: 25% (15 aa) DLSIVKNFVGAAEtiiKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPG |. . .|. | ...| . |||.|| |. .. |.|. . . .... .| || ylkealdFieear---skdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpc |
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| Phosphatase | CDC14.AA | Subfamily.Laforin.PD | 239-321 | 25 | 9.3e-06 | 16.8 | In-house | 66-149 (165) | Show / Hide |
Range on Protein: 239-321 Range on HMM: 66-149/165 Sequence Identity: 25% (21 aa) FEDIGIQHLDLIFED-GTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMV . . |. .. | || | . . . | .....| .. |||.||.||. ... .| | |.. . || || . ykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvy |
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