Gene PPS1
PPS1
Species: S.cerevisiae
Alias: PPS1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PPS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PPS1.AA | Family.DSP.PD | 577-805 | 34 | 5.8e-38 | 121.6 | In-house | 98-271 (387) | Show / Hide |
Range on Protein: 577-805
Range on HMM: 98-271/387
Sequence Identity: 34% (56 aa)
NFVNLKGPLPSRILRHLYLGSLDHAQNPALLKSLGITHIVSVGevvswtlnkdkiahpvrphraitmtntnevagnttcnksrnradtvvS------Dkq
.| ... .||.|| |||||||..|.| || ||.|.||... |.....| ..||... || . ..|..|||.... ..|.|||||. |..||.|..||
hfervengkpseilphlylgsllaaknlewlkelgvtkivnlt-----------------------------------------------ddkpqftk--
engsnvviseNSGFQICQIeNLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLnVIIQPNLFF
.| . .. | |. .|| .|.|.|| |. .|....|. . .. . . ..| ..... ..
----------elgikylri-pidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRp-gvitpnqgf
VYELFKWWKKHYNREKDKTMDWHIICRGIAEVNMK
lkqlkdlekeklkvssevmelrfvissivqnlgsv
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| Phosphatase | PPS1.AA | DSPc | 585-780 | 31 | 1.2e-68 | 235.31 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 585-780 Range on HMM: 1-172/172 Sequence Identity: 31% (66 aa) LPSRILRHLYLGSLDHAQ--NPALLKSLGITHIVSVGEVVSWTLNKDKIAHPVRPHRAITMTNTNEVAGNTTCNKSRNRADTVVSDKQENGSNVVISENS ||.|. |||||| |.. ||..|| ..|||...|.....|....... . .... .|..|..|| GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQK-----------------------------------N-DMHY-TNEWIYHNS GFQICQIENLDD-------NGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFV-----RVRRLNVIIQPNLFF .||...| ..|| | .... .....| |||..... ||||||||. |.|||||.||| .|.| .... .|| || . || . ||.||. | HFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIHDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRR-CPIICPNFNF VYELFKWWKK ...|. |..| WHQLCEWERK |
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| Phosphatase | PPS1.AA | DSPc | 593-780 | 25 | 3.7e-25 | 89.4 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 593-780 Range on HMM: 1-151/151 Sequence Identity: 25% (51 aa) LYLGSLDHAQ-NPALLKSLGITHIVSVGEVVSWTLNKDKIAHPVRPHRAITMTNTNEVAGNTTCNKSRNRADTVVSDKQENGSNVVISENSGFQICQIEN ||||| |.. .||.|. .||||...... .... .. ||.|.. .| . LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN---------------------------------------------------WFYHNSHFHYMWIPH LDD---------NGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFV-----RVRRLNVIIQPNLFFVYELFKW ..| | . . .... |||.. .. ||||||||. |.||||..||| |.| .... || || . || .| || | | . VHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRC-PMISPNMNFWRQLCEY WKK .. ERQ |
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| Phosphatase | PPS1.AA | Subfamily.DSP1.PD | 691-779 | 39 | 2.5e-23 | 73.1 | In-house | 52-138 (139) | Show / Hide |
Range on Protein: 691-779 Range on HMM: 52-138/139 Sequence Identity: 39% (35 aa) NLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnVIIQPNLFFVYELFKWWK ...|| | . .......||| . ...||.||||| |.|||||...| |. .. | |. ||. || ||.||. || |... | pvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrr--siisPnfgfvgqLlefek |
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| Phosphatase | PPS1.AA | Subfamily.DSP10.PD | 686-777 | 42 | 3.4e-22 | 69.2 | In-house | 50-138 (141) | Show / Hide |
Range on Protein: 686-777 Range on HMM: 50-138/141 Sequence Identity: 42% (38 aa) ICQIeNLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnVIIQPNLFFVYELFKW .| .. |.||. | .. .. |.|| . .|..|||||. |.|||||| || |..|. | || ||. .| || ||| |. .|... ykri-pvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvkekr--PiisPnlnfmGqllef |
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| Phosphatase | PPS1.AA | Subfamily.DSP12.PD | 679-778 | 34 | 3.7e-21 | 66.1 | In-house | 43-139 (143) | Show / Hide |
Range on Protein: 679-778 Range on HMM: 43-139/143 Sequence Identity: 34% (33 aa) SENSGFQICQIENLDDNGKDPLFHqIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnVIIQPNLFFVYELFKWW ... | . .|. ||.. .| | | .|....||... ...|.|||||..|||||.|..|| |.. ...| .|. .|. . |.|||. | . qkekgvkskliqilDepeedlLsh-ldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekk--keiepNegFleQLklfe |
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| Phosphatase | PPS1.AA | Subfamily.DSP14.PD | 684-777 | 36 | 5e-21 | 65.6 | In-house | 45-135 (138) | Show / Hide |
Range on Protein: 684-777 Range on HMM: 45-135/138 Sequence Identity: 36% (34 aa) FQICQIeNLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnVIIQPNLFFVYELFKW .. .| ...|. . | . |.| | | . ...|||.||||. ||||||....| |.| . |. || .|. .| ||.|| | .|.. vktvki-kveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaR--piirPnvGFwkqlidy |
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| Phosphatase | PPS1.AA | Subfamily.DSP8.PD | 692-780 | 42 | 1.6e-20 | 63.9 | In-house | 55-141 (143) | Show / Hide |
Range on Protein: 692-780 Range on HMM: 55-141/143 Sequence Identity: 42% (38 aa) LDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnVIIQPNLFFVYELFKWWKK . |. .. | .|| |.|| ... |||||||. | |||||| || |..|. .| .|| ||. .| |.||| |. |... |. vkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekr--ptispnlnflgqLleyeke |
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| Phosphatase | PPS1.AA | Subfamily.DSP6.PD | 679-777 | 33 | 1.6e-18 | 57.1 | In-house | 43-138 (141) | Show / Hide |
Range on Protein: 679-777 Range on HMM: 43-138/141 Sequence Identity: 33% (33 aa) SENSGFQICQIEnLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNviIQPNLFFVYELFKW |. .. || ..|. . | . . . ..|| .. . ||||||. ||||| ||..| |..|.. | .|| .|. .. | | ||. |. | .. eesgelkykqip-iedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkkksn--isPnfnfmgqlldf |
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| Phosphatase | PPS1.AA | Subfamily.Slingshot.PD | 684-774 | 36 | 3.6e-18 | 56.1 | In-house | 46-133 (139) | Show / Hide |
Range on Protein: 684-774 Range on HMM: 46-133/139 Sequence Identity: 36% (33 aa) FQICQIENLDDNgKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnVIIQPNLFFVYEL |. ..| |.. .. |... .. .||... ..| |||||| .||||||.. || |. ...| .|. .|. || ||.|| |. | fkylnirvydee-etdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerr--siikpnkgflkql |
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| Phosphatase | PPS1.AA | Subfamily.DSP19.PD | 682-774 | 39 | 9.3e-18 | 54.8 | In-house | 44-133 (139) | Show / Hide |
Range on Protein: 682-774 Range on HMM: 44-133/139 Sequence Identity: 39% (36 aa) SGFQICQIENLDDNGKDpLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNviIQPNLFFVYEL . |....|| ||.. .. | ......|||| .. ..| ||||| ||||||.| || |. . .| .|. || | . |.|| |.| kdftyksieilDlpetk-llsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpc--ikPneGFikqL |
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| Phosphatase | PPS1.AA | Subfamily.DSP3.PD | 700-776 | 38 | 2e-13 | 40.8 | In-house | 70-144 (148) | Show / Hide |
Range on Protein: 700-776 Range on HMM: 70-144/148 Sequence Identity: 38% (30 aa) LFHQIDKVLDFISNSEAT-GGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnvIIQPNLFFVYELFK | . .. ||| .. .. .|||||||.||.|||||. .| | . . .| .| || .| |.|| |. |.. lskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkr---eilPneGflkqLle |
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| Phosphatase | PPS1.AA | Subfamily.STYX.PD | 689-775 | 36 | 4.1e-13 | 39.8 | In-house | 57-141 (146) | Show / Hide |
Range on Protein: 689-775 Range on HMM: 57-141/146 Sequence Identity: 36% (31 aa) IENLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLnvIIQPNLFFVYELF . .. || . . . .| .|| .| .||||||| |.||||.. || | .|...|. ||. |.|| || .| vldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrf--cinpnegfvsqlk |
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| Phosphatase | PPS1.AA | Subfamily.STYXL1.PD | 685-779 | 31 | 1.6e-12 | 38.3 | In-house | 51-142 (143) | Show / Hide |
Range on Protein: 685-779 Range on HMM: 51-142/143 Sequence Identity: 31% (30 aa) QICQIeNLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNviIQPNLFFVYELFKWWK .. .| ...|. . |......| .|| . . .| ||| |.||||.| || | . . | .|| ... . | ..|| || |.| | kllhi-avedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkcken--vkPnrafveqlseWek |
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| Phosphatase | PPS1.AA | Subfamily.DSP15.PD | 692-777 | 30 | 4.3e-12 | 36.6 | In-house | 52-135 (138) | Show / Hide |
Range on Protein: 692-777 Range on HMM: 52-135/138 Sequence Identity: 30% (26 aa) LDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRlnVIIQPNLFFVYELFKW .| . .| . .. ||| .. ||.|||||. |.||| |...| | . . | |.. | . .||. | | .. aadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaar--svanPnvGfrrqlqef |
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| Phosphatase | PPS1.AA | Subfamily.LRR-DSP.PD | 685-779 | 31 | 6e-12 | 36.0 | In-house | 46-136 (137) | Show / Hide |
Range on Protein: 685-779 Range on HMM: 46-136/137 Sequence Identity: 31% (30 aa) QICQIeNLDDNGKDPLFHQIDKVLDFISNSEATGGkVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNviIQPNLFFVYELFKWWK . | ...| . .. .... || . || ||.|| |||||||. || |.. . . |. .| .| . |.|| |. .| |. | kylii-diedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkknslkfkealdlvikkrpr--iypnrgfldqlkkfek |
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| Phosphatase | PPS1.AA | Subfamily.PTPMT1.PD | 681-774 | 21 | 8e-11 | 32.3 | In-house | 50-142 (146) | Show / Hide |
Range on Protein: 681-774 Range on HMM: 50-142/146 Sequence Identity: 21% (20 aa) NSGFQICQIENLdDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNVIIQPNLFFVYEL . | . |. | .. | .... . ..||.. | .| ||| | .||||. .. |. .. .| |.. .| .. .. . .. . klGveqlqlatv-DfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqe |
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| Phosphatase | PPS1.AA | Subfamily.LRR-DSP.PD | 585-621 | 37 | 3.4e-08 | 23.8 | In-house | 1-37 (137) | Show / Hide |
Range on Protein: 585-621 Range on HMM: 1-37/137 Sequence Identity: 37% (14 aa) LPSRILRHLYLGSLDHAQNPALLKSLGITHIVSVGEV .|. |. .||||... |.| ..||....|||..|... vpdliidklylgcresamnksilkdnnvthilavadf |
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| Phosphatase | PPS1.AA | Subfamily.DSP1.PD | 586-621 | 51 | 7.3e-08 | 22.9 | In-house | 2-37 (139) | Show / Hide |
Range on Protein: 586-621 Range on HMM: 2-37/139 Sequence Identity: 51% (18 aa) PSRILRHLYLGSLDHAQNPALLKSLGITHIVSVGEV |..|| .||||| || | .|||.|.||... | . pveildfLyLGsaehasnlqlLkelkitallnvsae |
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| Phosphatase | PPS1.AA | Subfamily.R_Nematode_3.PD | 703-739 | 35 | 5.2e-07 | 19.6 | In-house | 186-219 (267) | Show / Hide |
Range on Protein: 703-739 Range on HMM: 186-219/267 Sequence Identity: 35% (13 aa) QIDKVLDFISNSEatgGKVLVHCMVGVSRSATVCIAE .. ....|. .|. |.|||. |.||||| .| ealelikfveksk---tpvvVHCsdGisRsatlaaie |
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| Phosphatase | PPS1.AA | Subfamily.DSP19.PD | 589-622 | 47 | 7.5e-07 | 19.5 | In-house | 5-38 (139) | Show / Hide |
Range on Protein: 589-622 Range on HMM: 5-38/139 Sequence Identity: 47% (16 aa) ILRHLYLGSLDHAQNPALLKSLGITHIVSVGEVV . .||||| | |.. ||.|.||||..|. | vkprlylgsqdvaadkeilkklkitHilnvavgv |
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| Phosphatase | PPS1.AA | Subfamily.CDC14.PD | 707-772 | 21 | 1e-06 | 18.9 | In-house | 187-252 (258) | Show / Hide |
Range on Protein: 707-772 Range on HMM: 187-252/258 Sequence Identity: 21% (14 aa) VLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNVIIQPNLFFVY . |.. .| . |.. ||| |. | .|. . ... . | . ..|. | .| | ... lkkfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPGsvigpqqtylv |
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| Phosphatase | PPS1.AA | Subfamily.DSP23.PD | 689-742 | 22 | 2.4e-06 | 18.0 | In-house | 39-90 (128) | Show / Hide |
Range on Protein: 689-742 Range on HMM: 39-90/128 Sequence Identity: 22% (12 aa) IeNLDDNgKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMR | ...| | .|..... . ..|. .. | |||..|. |. |. .. i-dipdf-cPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvk |
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