Gene YVH1
YVH1
Species: S.cerevisiae
Alias: YVH1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of YVH1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | YVH1.AA | Family.DSP.PD | 10-170 | 28 | 1.9e-31 | 100.3 | In-house | 105-246 (387) | Show / Hide |
Range on Protein: 10-170 Range on HMM: 105-246/387 Sequence Identity: 28% (46 aa) EEVTRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKFQVIPEYliRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQclfpneveysprlvdfKKKpQ .....|| ..|||. . ... .| .| ..|.|... . . .. ..| . .||||| .... ..|.. .||.. ... . gkpseilphlylgsllaaknlewl-kelgvtkivnltddkpqftk--elgikylripidDhnapplenlfekaidfiee----------------gnd-s RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKP-SVEPNENFMEQLHLFEKM .| |. ||.||..|| | |.||||...||.|. |.. |. |.| .. ||..|..||. .||. kgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdleke |
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| Phosphatase | YVH1.AA | DSPc | 11-170 | 26 | 8.8e-61 | 209.16 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 11-170 Range on HMM: 1-172/172 Sequence Identity: 26% (51 aa) EVTRILGGIYLGGIRPII-DHRPLGAEFNITHILSVIKFQVIPEYLIRK--------------GYTLKNIP-IDD-------DDVTDVLQYFDETNRFID ....|....|||. . .. .. .. ...||||...|............| ... ..|| ||| ..|...|||.|...||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH QCLFPNEVEYSPRLVDFKKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAV-----KRKK-PSVEPNENFMEQLHLFEKM .| . ..| |. |||||.|||.|...||||.....|...|.|.| |... |.. ||.||. ||...|.. DC-----------------RQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | YVH1.AA | Subfamily.DSP12.PD | 12-171 | 50 | 1.4e-57 | 184.4 | In-house | 2-142 (143) | Show / Hide |
Range on Protein: 12-171 Range on HMM: 2-142/143 Sequence Identity: 50% (72 aa) VTRILGGIYLGGIRPIIDhRPLGAEFNITHILSVIKFQViPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFpneveysprlvdfkkkpQRG |..||.|.||||...... | | .|..|||.|||||... ||. ..||.. |.|.|.|.. .|.|...||..|||...|..|||..||.||.|||||... vseilpglylggleavqe-rellkelkithvlsvikeel-pelqkekgvkskliqilDepeedlLshldeavrFieegle-----------------keg AVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMG ||||....|||..|...||.||...||||.|.|||.|||||. avlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiepNegFleQLklfekmk |
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| Phosphatase | YVH1.AA | DSPc | 19-170 | 26 | 1.6e-31 | 111.5 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 19-170 Range on HMM: 1-151/151 Sequence Identity: 26% (45 aa) IYLGGIRPII-DHRPLGAEFNITHILSVIKFQVIPEYLIR---KGYTLKNIP-IDD---------DDVTDVLQYFDETNRFIDQCLFPNEVEYSPRLVDF .|||. . | ..| ....|||...... . . .... ..|| ..| .|.. |||.. |||.| LYLGSYPHHMADPAFL-QKHGITHVINCTMECPNN---WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDC--------------- KKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAV-----KRKK-PSVEPNENFMEQLHLFEKM . . | | |||||.|||.....||||.....|...|.. | | .. |.. || ||. || .|.. --RQKGGKVLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | YVH1.AA | Subfamily.DSP19.PD | 13-169 | 35 | 1.9e-27 | 86.3 | In-house | 3-138 (139) | Show / Hide |
Range on Protein: 13-169 Range on HMM: 3-138/139 Sequence Identity: 35% (50 aa) TRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIkFQvIPEYlIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfKK-KpqrG ... .||| . |.. | . .|||||.| . .|. | .| |.|.| |.. |..|.|..|. ||.... . |.|. ||.|| |||... aevkprlylgsqdvaadkeil-kklkitHilnva-vg-vpnv-fpkdftyksieilDlpetkllsylkealdFieea---------------rskd---g AVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK ..|||| . |||. |.. |. ..|...||| |..||. .|. rvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | YVH1.AA | Subfamily.DSP6.PD | 14-170 | 35 | 8.2e-26 | 80.9 | In-house | 4-141 (141) | Show / Hide |
Range on Protein: 14-170 Range on HMM: 4-141/141 Sequence Identity: 35% (50 aa) RILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKfQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRGAV .|| .||| . . | ....| ..| | . .. . . . |.|||.| ... ..| |. .|||... . .|. || ||.||||| ..| eilpllylGsakdasnlevl-kklkikyvlnvts-nlpnkfeesgelkykqipiedhlsqnlakffPeaiefidea-----------------rskkskv FAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM ||| .. ||| | . ||.||... || |||.|| ||.. lvhclaGvsrsvtvtlaylmkklalslndaydlvkkkksnisPnfnfmgqlldfers |
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| Phosphatase | YVH1.AA | Subfamily.DSP1.PD | 13-169 | 35 | 5.6e-25 | 78.5 | In-house | 3-138 (139) | Show / Hide |
Range on Protein: 13-169 Range on HMM: 3-138/139 Sequence Identity: 35% (50 aa) TRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKFqvIPEYlIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRGA ..|| .|||. ... | .| .||..| | . .|.. ... .. |.||..|.. .|....|.| . |||..| ..| |. |||||.||| |... veildfLyLGsaehasnlqlL-kelkitallnvsae--lpnv-feelfkyksipvednkkadisslfeeaidfidsv-----------------kkkgGr VFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK |||| . ..|. | . ||... ..|| .|..|| ||| vlvhCqaGisrsativlayLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | YVH1.AA | Subfamily.DSP10.PD | 12-169 | 37 | 4.2e-24 | 75.6 | In-house | 2-140 (141) | Show / Hide |
Range on Protein: 12-169 Range on HMM: 2-140/141 Sequence Identity: 37% (53 aa) VTRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKfqVIPEYLIRKGYT-LKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfKKkpQR ...|| ..|| . |. | ..|...| | . ..| . || . |.||. | . ... |.|.|. ||...| . ..|. ||.||.|||.| assilpflllGnekdaadkdal-drlgikyvlnvtt--svPnffeekglvrykripvsdsgkqnlkqkfeealefieea---------------rk--rg GAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK ..||.| .|||| | . || |.| . || ||| || ||| srvlvhchaGisrsatvviayvmkhlslslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | YVH1.AA | Subfamily.DSP15.PD | 12-169 | 35 | 7.9e-24 | 74.7 | In-house | 2-137 (138) | Show / Hide |
Range on Protein: 12-169 Range on HMM: 2-137/138 Sequence Identity: 35% (53 aa) VTRILGGIYLGGIRPIIDHRPLGaEFNITHILSVIKFqviPEYlIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveyspRLvdfkkkpQRG ....| |.|.|..| |. |. |..||||||. .. .... . . |...| .|. ..|.|.. || .| ||. |.|. || mnkvlpGlyvGnfrdakdkeqle-enkithilsihds---akp-lledikylcikaadsPdqdlskffkesidfihkc----------rl-------egg AVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK ||.||||| .|||.| || |..||| .. .|| | .||. ||| nvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | YVH1.AA | Subfamily.DSP8.PD | 12-169 | 34 | 2.9e-21 | 66.5 | In-house | 2-140 (143) | Show / Hide |
Range on Protein: 12-169 Range on HMM: 2-140/143 Sequence Identity: 34% (49 aa) VTRILGGIYLGGIRPIIDHRPLGaEFNITHILSVIKFQVIPEYLIRKGyTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRG .|||| .||| . .|. | . .|...| . . . . |... . ||. |. ..|..||.. |||... . | |. || || ||| | . ptrilpnlylGsqkdsldeellk-klgisyvlnisescpkdvellkes-rflriPvkDkyeekllpwfdkalefidka-----------------rsang AVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK .||.| . .|| | . || |.|...|| ||..|| .|| kvlvhclaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyek |
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| Phosphatase | YVH1.AA | Subfamily.DSP3.PD | 16-168 | 30 | 8.3e-21 | 64.9 | In-house | 6-146 (148) | Show / Hide |
Range on Protein: 16-168 Range on HMM: 6-146/148 Sequence Identity: 30% (43 aa) LGGIYLGGIRPIIDHRPLgAEFNITHILSVIKF------QVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFPneveysprlvdfkkkpQ ..|.|. |.. | ... |||.| . . .|. . . ....| .|. .||.| |||. |..| |. ||..|.||| | .. ypkvyvgdeavakdkekL-kklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsq----------------k RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKpSVEPNENFMEQLHLFE |||| | |.| |...|..|. .. ||| |..|| .. ngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkr-eilPneGflkqLleld |
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| Phosphatase | YVH1.AA | Subfamily.Slingshot.PD | 14-169 | 32 | 5.5e-20 | 62.1 | In-house | 4-138 (139) | Show / Hide |
Range on Protein: 14-169 Range on HMM: 4-138/139 Sequence Identity: 32% (45 aa) RILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKfqVIPEYLiRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRGAV .| .||| . | | ....|| | | | .. . .. .|| . |.. ||.|....|| .||...| . |. ||. |.||| . ..| kifdhlylGsewnasnleel-kengveyilnvtk--eidnff-pekfkylnirvydeeetdllkhwnetykfieka-----------------kekgskv FAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK | | .|.||| |.. ||... ..||..|..||. .| lvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnkgflkqlkvyeg |
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| Phosphatase | YVH1.AA | Subfamily.DSP14.PD | 109-169 | 42 | 1.5e-16 | 51.2 | In-house | 77-137 (138) | Show / Hide |
Range on Protein: 109-169 Range on HMM: 77-137/138 Sequence Identity: 42% (26 aa) QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK . |... || || ||| ....|||| ||| | ..|| ..| ..|| | .|| .|| kgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidyEk |
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| Phosphatase | YVH1.AA | Subfamily.STYX.PD | 12-169 | 29 | 4.9e-16 | 49.4 | In-house | 2-145 (146) | Show / Hide |
Range on Protein: 12-169 Range on HMM: 2-145/146 Sequence Identity: 29% (44 aa) VTRILGGIYLGGIRPIID-HRPLGAEFNITHILSVIkfQVIPEYLIR----KGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLfpneveysprlvdfKk . || |..|| . . . | ||||. . | | ||. . . . . |. | ....|. ... |||..|. . | |. | .|| mqeilpglflgpysaamksklevlkehgithivcir--qnieanlikpnfpdrfrylvldvadntveniirylptvkefiddsl--------------q- kpQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK .||| ....||.| ||| |.. |.... ..||| |..||. .| --kggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea |
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| Phosphatase | YVH1.AA | Subfamily.LRR-DSP.PD | 109-169 | 44 | 7.3e-16 | 48.8 | In-house | 76-136 (137) | Show / Hide |
Range on Protein: 109-169 Range on HMM: 76-136/137 Sequence Identity: 44% (27 aa) QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK ..| |. ||.||.||| | ..|||| . | . |. |..|.| . ||. |..||. ||| ekggvlihcragvsrsatlviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | YVH1.AA | Subfamily.STYXL1.PD | 103-170 | 38 | 5.1e-15 | 46.4 | In-house | 77-143 (143) | Show / Hide |
Range on Protein: 103-170 Range on HMM: 77-143/143 Sequence Identity: 38% (26 aa) DFKKKpQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM . || . .|. . |.|||.. |.||||| . ..| |.. .|. |. |.|| .|.|||. .||. ekhkk-egevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkckenvkPnrafveqlseWekq |
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| Phosphatase | YVH1.AA | Subfamily.PTPMT1.PD | 106-169 | 29 | 4.8e-12 | 36.4 | In-house | 82-145 (146) | Show / Hide |
Range on Protein: 106-169 Range on HMM: 82-145/146 Sequence Identity: 29% (19 aa) KKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK .. .. .|. ||.|| .|| | . .|||... || |....|.|.| . ... .. |. |.. vaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke |
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| Phosphatase | YVH1.AA | Subfamily.LRR-DSP.PD | 14-88 | 33 | 4.1e-10 | 30.2 | In-house | 4-73 (137) | Show / Hide |
Range on Protein: 14-88 Range on HMM: 4-73/137 Sequence Identity: 33% (25 aa) RILGGIYLGGIRPIiDHRPLGAEFNITHILSVIKFQviPeyLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQ |. ..|||. ... . |.||||.| .|. | | . . | |.| | .|. |.|.|.| |||. liidklylgcresa-mnksilkdnnvthilavadfk--p--lypdlfkyliidiedvdeadiyqhfkemnafide |
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| Phosphatase | YVH1.AA | Subfamily.PTPDC1.PD | 109-168 | 30 | 3.1e-09 | 27.1 | In-house | 165-224 (229) | Show / Hide |
Range on Protein: 109-168 Range on HMM: 165-224/229 Sequence Identity: 30% (18 aa) QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFE . |.. || ||| | | .||.| |. . |.. |. |.| . .| .. |. eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelveeFa |
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| Phosphatase | YVH1.AA | Subfamily.CDC14.PD | 110-152 | 32 | 1.5e-08 | 25.1 | In-house | 198-240 (258) | Show / Hide |
Range on Protein: 110-152 Range on HMM: 198-240/258 Sequence Identity: 32% (14 aa) RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKP .||. ||.||| | |.| .||...|... . .. .. .| eGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarP |
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| Phosphatase | YVH1.AA | Subfamily.Laforin.PD | 112-154 | 35 | 1.3e-06 | 18.7 | In-house | 106-148 (165) | Show / Hide |
Range on Protein: 112-154 Range on HMM: 106-148/165 Sequence Identity: 35% (15 aa) AVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSV |. ||.||. || . .. .|.| | ||. . . |.| | ivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv |
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| Phosphatase | YVH1.AA | Subfamily.DSP23.PD | 108-158 | 33 | 3.8e-06 | 17.5 | In-house | 64-115 (128) | Show / Hide |
Range on Protein: 108-158 Range on HMM: 64-115/128 Sequence Identity: 33% (17 aa) PQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKP-SVEPNE . .|| || || |. |.. ||. ||. . |. |..... |.| | kkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGsietve |
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