Gene MSG5
MSG5
Species: S.cerevisiae
Alias: MSG5
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of MSG5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | MSG5.AA | Family.DSP.PD | 177-377 | 20 | 2e-23 | 74.5 | In-house | 80-251 (387) | Show / Hide |
Range on Protein: 177-377
Range on HMM: 80-251/387
Sequence Identity: 20% (42 aa)
STPISSTREGTLDSTDVNRFSNQKNMQTTLIFPeedsdlnidmvhaeiyqrtvyldgpllvlppNLYLYSEPKLE-----DILSFDLVINVAKEIPNLEF
. .. . .|.| . . | .| . . |.| .||| | . . | ..|.... |. ..
aelngfidvhtfdldtydhfervengkpseilp-------------------------------hlylgsllaaknlewlkelgvtkivnltddkpqftk
lippemAHKIKYYHIEWTHT--SKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK-DISPNMGLIFQLME
..|||..| . .. ... . . . ..|..........||||. |..||..||.||.| ..||.|..|.. .. . . | ||| . ||...
------elgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkd
WGTMLSKNS
...| |
lekeklkvs
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| Phosphatase | MSG5.AA | DSPc | 242-372 | 34 | 1.5e-58 | 205.48 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 242-372 Range on HMM: 1-151/151 Sequence Identity: 34% (52 aa) LYLYSEPKLE------DILSFDLVINVAKEIPN---------LEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRS |||.|.| . .......|||...|.|| . . ||. . |... |||.|.|...|.......| .|......|.|.|||||.|.||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHY-YHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRS ASLIVAYIMRYYGLSLNDAYNKL-----KGVA-KDISPNMGLIFQLMEWGTM |.|..||.|.|...|.|.||. . | .. |||||....||.|.... ACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | MSG5.AA | DSPc | 233-372 | 31 | 3.1e-58 | 200.69 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 233-372 Range on HMM: 1-172/172 Sequence Identity: 31% (56 aa) GPLLVLPPNLYLYSEPKLE-------DILSFDLVINVAKEIP-----------------------NLEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLT || ..| |||.|.| ... ...||||..|.| . . ||. .. | ||||.|.|...|........ GPSEITPH-LYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDD--I-YYHIRWNHCTNISQYFPEVY RIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKL-----KGVA-KDISPNMGLIFQLMEWGTM ..||.....|.|.|||||.|.||||.|..||.|.|...|.||||. . | .. |.||.....||.|| .. DFIHDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | MSG5.AA | Subfamily.DSP10.PD | 252-369 | 30 | 4.8e-25 | 79.3 | In-house | 24-138 (141) | Show / Hide |
Range on Protein: 252-369 Range on HMM: 24-138/141 Sequence Identity: 30% (37 aa) DILSFDLVINVAKEIPNLEflippEMAHKIKYYH--IEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKL | |. . |.||....|| | . ...| . .. ... .. . .. |. |...|...||||. |.|||| ...||.|.. .|||..||. . drlgikyvlnvttsvPnff-----eekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfv KGVAKDISPNMGLIFQLMEW | ||||.... ||.|. kekrPiisPnlnfmGqllef |
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| Phosphatase | MSG5.AA | Subfamily.DSP12.PD | 275-372 | 30 | 6.7e-25 | 79.1 | In-house | 46-141 (143) | Show / Hide |
Range on Protein: 275-372 Range on HMM: 46-141/143 Sequence Identity: 30% (30 aa) PEMAHkiKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM ... . |. .| . . ... | . .| |. . ......||||. |||||.....||.|....|||..|....| . |.|.|| | . || . | kgvks--kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiepNegFleQLklfekm |
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| Phosphatase | MSG5.AA | Subfamily.DSP6.PD | 255-369 | 35 | 6.3e-23 | 72.2 | In-house | 27-138 (141) | Show / Hide |
Range on Protein: 255-369 Range on HMM: 27-138/141 Sequence Identity: 35% (41 aa) SFDLVINVAKEIPNLeFlippEMAHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGV . |.||....|| | | ....||..| ... .. | . . | |.|. .|.|||| ||||| ....||.|... |||||||. .| kikyvlnvtsnlpnk-f----eesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkk AKDISPNMGLIFQLMEW .||||. .. ||... ksnisPnfnfmgqlldf |
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| Phosphatase | MSG5.AA | Subfamily.DSP14.PD | 256-369 | 34 | 1.3e-22 | 71.6 | In-house | 27-135 (138) | Show / Hide |
Range on Protein: 256-369 Range on HMM: 27-135/138 Sequence Identity: 34% (39 aa) FDLVINVAKEIPNLEFlipPEMAhKIKYyHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKD . |..||. |.|. .. .... ..| ..| ....|. . . . . |......| |.|||| ||||||||..||.|.| |||..||. .| itlivnvttelpetkl---edvk-tvki-kveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpi ISPNMGLIFQLMEW | ||.| ||... irPnvGFwkqlidy |
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| Phosphatase | MSG5.AA | Subfamily.DSP1.PD | 257-370 | 33 | 1.6e-21 | 68.0 | In-house | 29-137 (139) | Show / Hide |
Range on Protein: 257-370 Range on HMM: 29-137/139 Sequence Identity: 33% (37 aa) DLVINVAKEIPNLeFlippEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDI ..||..|.|| | | .| | ..| .....| . .. |......| ..||||| |.||||....||.|. ..|..|...| . |||| tallnvsaelpnv-f----eelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrsii SPNMGLIFQLMEWG .|.. ||.|. sPnfgfvgqLlefe |
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| Phosphatase | MSG5.AA | Subfamily.DSP19.PD | 259-369 | 36 | 2.6e-21 | 67.2 | In-house | 31-136 (139) | Show / Hide |
Range on Protein: 259-369 Range on HMM: 31-136/139 Sequence Identity: 36% (41 aa) VINVAKEIPNLeFliPPEmaHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISP ..||| ..||. | | . ..| .| . |... |.. . |. |.|.. .||||. |||||||...||.|. |||..|..|.. . |.| ilnvavgvpnv-f--pkd--ftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpcikP NMGLIFQLMEW | | | || |. neGFikqLkey |
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| Phosphatase | MSG5.AA | Subfamily.Slingshot.PD | 257-369 | 36 | 2.8e-21 | 67.0 | In-house | 29-136 (139) | Show / Hide |
Range on Protein: 257-369 Range on HMM: 29-136/139 Sequence Identity: 36% (42 aa) DLVINVAKEIPNleFlippeMAHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK . ..||.||| | | ..|.||..| .......| . . |..|...| |.||||. ||||||| ..|| |. |.|||..|.. .| . eyilnvtkeidn--f-----fpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrs DISPNMGLIFQLMEW | || |.. || .. iikpnkgflkqlkvy |
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| Phosphatase | MSG5.AA | Subfamily.DSP8.PD | 255-371 | 30 | 3.5e-21 | 66.9 | In-house | 27-140 (143) | Show / Hide |
Range on Protein: 255-371 Range on HMM: 27-140/143 Sequence Identity: 30% (35 aa) SFDLVINVAKEIPNLEFLIPPEMAHKIkyyHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK . |.|.... | |.. . ..| .. ... |.. . . . | |.|. .|.|||| | ||||....||||.. .||..||. .| . | gisyvlnisescpkdvellkesrflri---PvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrp DISPNMGLIFQLMEWGT |||. . ||.|. tispnlnflgqLleyek |
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| Phosphatase | MSG5.AA | Subfamily.STYXL1.PD | 235-370 | 27 | 1.3e-18 | 58.8 | In-house | 3-141 (143) | Show / Hide |
Range on Protein: 235-370 Range on HMM: 3-141/143 Sequence Identity: 27% (38 aa) LLVLPPNLYLYS-----EPKLEDILSFDLVINVAKEIPNLEFLIpPEmAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASL ||| .||| .|... | ..||... .| . .. . |. ..| . ..... |... . |.. . .|. .||. |.||||..|.|| vevlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagl-ad-vakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaav IVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWG .| .. ..|..||..|| ... || ... || || iiaylmyskkitlkkaykylkkckenvkPnrafveqlseWe |
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| Phosphatase | MSG5.AA | Subfamily.STYX.PD | 272-370 | 33 | 3.3e-17 | 53.9 | In-house | 44-144 (146) | Show / Hide |
Range on Protein: 272-370 Range on HMM: 44-144/146 Sequence Identity: 33% (33 aa) LIPPEMAHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW || |.. ....| .. . . .|.. | . .| .. ..| |.||| ..|.||||.|..|||| ||| .|.. .. |.|| |.. ||.|. likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey G e |
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| Phosphatase | MSG5.AA | Subfamily.DSP3.PD | 280-368 | 35 | 1.2e-16 | 52.1 | In-house | 54-144 (148) | Show / Hide |
Range on Protein: 280-368 Range on HMM: 54-144/148 Sequence Identity: 35% (33 aa) KIKYYHIEWT--HTSKIVKDLSRLTRIIHTAHSQ-GKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGvAKDISPNMGLIFQLME .||| .| . .... | .. . |. | || . |.||||. |.|||| |..||.| . |.|..| .. . ..| ||.|.. ||.| eikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrk-kreilPneGflkqLle |
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| Phosphatase | MSG5.AA | Subfamily.DSP15.PD | 281-370 | 36 | 2.5e-15 | 47.9 | In-house | 45-136 (138) | Show / Hide |
Range on Protein: 281-370 Range on HMM: 45-136/138 Sequence Identity: 36% (33 aa) IKYYHI--EWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWG ||| | . . ...| .. ||.. .|...|||| |.||| .|.||||| || .|| . .| ||.|. ||.|. ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | MSG5.AA | Subfamily.LRR-DSP.PD | 278-369 | 29 | 1.2e-14 | 45.6 | In-house | 42-134 (137) | Show / Hide |
Range on Protein: 278-369 Range on HMM: 42-134/137 Sequence Identity: 29% (27 aa) AHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKkILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW . .||. |. .. .| . . .. .|. .| .|.||. ||||||.|..||.|.. | ...|.. . | ||.|..|| . pdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkknslkfkealdlvikkrpriypnrgfldqlkkf |
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| Phosphatase | MSG5.AA | Subfamily.PTPMT1.PD | 294-356 | 32 | 1.4e-11 | 35.6 | In-house | 68-130 (146) | Show / Hide |
Range on Protein: 294-356 Range on HMM: 68-130/146 Sequence Identity: 32% (20 aa) IVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDI .. |.. ..|.. .|.|... |||. | .|||.|. .|.|. . || ..| . || . | slekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqi |
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| Phosphatase | MSG5.AA | Subfamily.CDC14.PD | 301-345 | 29 | 5.6e-09 | 27.2 | In-house | 190-231 (258) | Show / Hide |
Range on Protein: 301-345 Range on HMM: 190-231/258 Sequence Identity: 29% (13 aa) LTRIIHTAhsQGkKILVHCQCGVSRSASLIVAYIMRYYGLSLNDA ..|. .| .| .| |||. |. | ..|| .|....|... ... fleiteka--eG-aiavhCkaGLGrtgtligcylikhyrftaaet |
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| Phosphatase | MSG5.AA | Subfamily.R_Nematode_3.PD | 277-332 | 20 | 5e-08 | 23.8 | In-house | 163-218 (267) | Show / Hide |
Range on Protein: 277-332 Range on HMM: 163-218/267 Sequence Identity: 20% (11 aa) MAHKIKYYHIE-WTHtSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVA .... .... |.. . . .. .. .|. ... . ..||| |.||||.| .. keftvthllykgWke-lnapeepkealelikfveksktpvvVHCsdGisRsatlaai |
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| Phosphatase | MSG5.AA | Subfamily.DSP23.PD | 296-347 | 32 | 1.8e-07 | 22.6 | In-house | 50-101 (128) | Show / Hide |
Range on Protein: 296-347 Range on HMM: 50-101/128 Sequence Identity: 32% (16 aa) KDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYN . ..|| ||.. |. ... . ||| |. |. .|. |... ||. .|| eqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaia |
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| Phosphatase | MSG5.AA | Subfamily.Laforin.PD | 291-344 | 28 | 7.8e-07 | 20.1 | In-house | 83-136 (165) | Show / Hide |
Range on Protein: 291-344 Range on HMM: 83-136/165 Sequence Identity: 28% (15 aa) TSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLND | |. | . ..|. .|... |||..|| ||..... ... | ||. tesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslak |
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| Phosphatase | MSG5.AA | Subfamily.PTPDC1.PD | 277-346 | 24 | 1.1e-06 | 19.5 | In-house | 131-200 (229) | Show / Hide |
Range on Protein: 277-346 Range on HMM: 131-200/229 Sequence Identity: 24% (17 aa) MAHKIKYYHIEWT-HTSKIVKDLSRLTRIIHTAHSQGkKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAY | ..| .| . .. . .. .. . . ... | ..| || ||| | | .|| .|.. |. ..| mrqgiyfynfglkDygvasleriLdivkvvdfaleeg-kiavHCHAGlGRtGvliacylvyakrltaeeai |
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| Phosphatase | MSG5.AA | Subfamily.DSP11.PD | 298-349 | 29 | 4e-06 | 17.9 | In-house | 67-118 (141) | Show / Hide |
Range on Protein: 298-349 Range on HMM: 67-118/141 Sequence Identity: 29% (15 aa) LSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKL ..... ... . ..| | ||| || |. || |.. |.| .|| ... keavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieaf |
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