Gene TEP1
TEP1
Species: S.cerevisiae
Alias: TEP1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of TEP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | TEP1.AA | Subfamily.PTEN.PD | 43-255 | 43 | 3.1e-72 | 233.7 | In-house | 1-162 (305) | Show / Hide |
Range on Protein: 43-255
Range on HMM: 1-162/305
Sequence Identity: 43% (92 aa)
DISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYkdndligiaakfeskdfeiqelrstlinDGKIPISPIDletr
|||||||||||.||||.||.|||||||||||||.||||.|||..||.|.||||||||. ||.....|.|
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdf----------------------------dgrvavypfd----
tlveeetnnvicerigwlDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLG-EARLIFMQARFKYGmtNGVTIPSQ
||.||..|||||||......|...|..|...||..||||.|....|||.|..... . ||. |....|.|.. .|||||||
------------------DhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekRtkdk--kGVtiPSQ
LRYLRYHEFFITHE
.||..|......
rRYvqYfsklvkss
|
|||||||||
| Phosphatase | TEP1.AA | Family.DSP.PD | 45-253 | 28 | 3.3e-24 | 76.1 | In-house | 95-245 (387) | Show / Hide |
Range on Protein: 45-253
Range on HMM: 95-245/387
Sequence Identity: 28% (46 aa)
SYILVNLIVCSYPVNTYPkLLYRNSLDDLILFLTVyHGKGNFRIFNFRgekedsdykD------Ndligiaakfeskdfeiqelrstlindgkipispid
.| .. . ...|.. .| || ||.. . . . . .| .| | | ..... ||.. ||..||.|. .|...| ||.
tydhfervengkpseilp-hlylgsllaaknlewl-kelgvtkivnlt---------ddkpqftk-----------------------------------
letrtlveeeTNNVICERIGWLDHFPPPFEL-LEEIVDGIENYLsVSkNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARfkygmtNGVT
.| . |.. || .||||||....|||||. .. | || . ..|.||..|.| .|.... .
----------elgikylripidDhnapplenlfekaidfieegn-ds-kgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskR------pgvi
IPSQLrYLRYHEFFIT
tpnqg-flkqlkdlek
|
|||||||||
| Phosphatase | TEP1.AA | Subfamily.Tensin.PD | 156-252 | 37 | 1.7e-16 | 50.6 | In-house | 7-104 (237) | Show / Hide |
Range on Protein: 156-252 Range on HMM: 7-104/237 Sequence Identity: 37% (37 aa) RIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYlMKYLQCPLGE--ARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFI .|| |.. ||.| | |.. .| .|. ..| ||||. |||| |.. || |.| . .. | .| || ..||| ||| ||..| . .. dlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisay-mhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgll |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.TPIP.PD | 155-249 | 30 | 1.1e-11 | 35.1 | In-house | 6-104 (245) | Show / Hide |
Range on Protein: 155-249 Range on HMM: 6-104/245 Sequence Identity: 30% (30 aa) ERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQAR-FKYGM---TNGVTIPSQLRYLRYHE .|| || | .| | . ....|. ...| ..||. |||| | | |.|.. .. | | .. | .. || |||||. | . srimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgyla |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.PTPMT1.PD | 157-227 | 33 | 7.1e-10 | 29.1 | In-house | 58-127 (146) | Show / Hide |
Range on Protein: 157-227 Range on HMM: 58-127/146 Sequence Identity: 33% (24 aa) IGWLDHFP-PPFELLEEIVDGIENYLSvSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQAR . |.. | .| ||| |. ||.. | ...| | ||. |..||. . .|||| .. || .. . | latvDfteapslekleegvefiekvas-kgssvYv-HCkAGrtRsatlvacylmkkkklspeeavkflkkkR |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP12.PD | 169-228 | 34 | 1.1e-09 | 28.8 | In-house | 66-123 (143) | Show / Hide |
Range on Protein: 169-228 Range on HMM: 66-123/143 Sequence Identity: 34% (20 aa) LLEEIVDGIENYLsvSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARF |.|.|. ||. | .|.. . || .| || | .|||||. ...| .| . ... hldeavrFieegl--ekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkk |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP23.PD | 146-215 | 27 | 1.6e-08 | 25.0 | In-house | 28-95 (128) | Show / Hide |
Range on Protein: 146-215 Range on HMM: 28-95/128 Sequence Identity: 27% (19 aa) EEETNNVICERIGWLDHFPPPFELLEEIVDGIENylSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCP .| .... .||. |. || | ....| .|. . |. .|| .| ||.| . ||.| . seaapsltlrridipdfcPPaleqvarlvrivee--aekkeeavgvhcalGlGrtGtllacylvkeegla |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP10.PD | 184-221 | 36 | 3e-08 | 23.9 | In-house | 79-116 (141) | Show / Hide |
Range on Protein: 184-221 Range on HMM: 79-116/141 Sequence Identity: 36% (13 aa) SKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARL ... . ..||. | || ...||.||.|. | || krgsrvlvhchaGisrsatvviayvmkhlslslseayk |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP14.PD | 170-221 | 38 | 4.5e-08 | 23.5 | In-house | 64-113 (138) | Show / Hide |
Range on Protein: 170-221 Range on HMM: 64-113/138 Sequence Identity: 38% (19 aa) LEEIVDGIENYlsVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARL ..|..| ||. .|. ...|| .| || ...|||||| . | || fdevadkieev--kkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayk |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.PTPDC1.PD | 150-210 | 26 | 4.9e-08 | 22.9 | In-house | 133-190 (229) | Show / Hide |
Range on Protein: 150-210 Range on HMM: 133-190/229 Sequence Identity: 26% (16 aa) NNVICERIGWLDHFPPPFELLEEIVDGIENYLsvSKNRVAVlHCRMGKGRSGMITVAYLMK .... .|. |. .. | . .|| .. | .. ..|| || |.|| |.. .||. qgiyfynfglkDygvasleriLdivkvvdfal--eegkiav-HCHAGlGRtGvliacylvy |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP6.PD | 183-219 | 44 | 1e-07 | 21.9 | In-house | 78-114 (141) | Show / Hide |
Range on Protein: 183-219 Range on HMM: 78-114/141 Sequence Identity: 44% (16 aa) VSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEA ||. ..|| | || .|.|||||.|.. | .| rskkskvlvhclaGvsrsvtvtlaylmkklalslnda |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP8.PD | 183-219 | 40 | 1.2e-07 | 22.1 | In-house | 78-114 (143) | Show / Hide |
Range on Protein: 183-219 Range on HMM: 78-114/143 Sequence Identity: 40% (15 aa) VSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEA .|.| ..|| |. || . .||.||.|. | || rsangkvlvhclaGisrsatvaiayimktlemsldea |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP19.PD | 169-220 | 42 | 1.6e-07 | 21.6 | In-house | 64-113 (139) | Show / Hide |
Range on Protein: 169-220 Range on HMM: 64-113/139 Sequence Identity: 42% (21 aa) LLEEIVDGIENYLSVSkNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEAR |.|..| ||. .| .|| | ||. | || . .||||| . | .| ylkealdFieearskd-grvlv-HCnAGvSRsasvviaylmkdeelslekal |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP1.PD | 170-221 | 42 | 1.6e-07 | 21.7 | In-house | 65-114 (139) | Show / Hide |
Range on Protein: 170-221 Range on HMM: 65-114/139 Sequence Identity: 42% (21 aa) LEEIVDGIENyLSVSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEARL .||..| |.. . .. || | ||..| || | .||||| .. | || feeaidfids-vkkkgGrvlv-hCqaGisrsativlayLmkekkvrleeafe |
|||||||||
| Phosphatase | TEP1.AA | DSPc | 192-229 | 34 | 1.9e-07 | 27.86 | Pfam | 91-134 (151) | Show / Hide |
Range on Protein: 192-229 Range on HMM: 91-134/151 Sequence Identity: 34% (15 aa) HCRMGKGRSGMITVAYLMKYLQCPLGEARLIF-----MQAR-FK ||..| ||. ...|||||| .... || .. | | . HCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPM |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.DSP3.PD | 172-220 | 39 | 7.1e-07 | 19.5 | In-house | 76-123 (148) | Show / Hide |
Range on Protein: 172-220 Range on HMM: 76-123/148 Sequence Identity: 39% (19 aa) EIVDGIENYLSVSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEAR | .| |.. || .. .| | ||..| || . .|||| . . | || eaadfidealsqkngkvlv-hcvvGisRsatlvlayLmirrkltlkeai |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.RNGTT.PD | 171-228 | 26 | 8.4e-07 | 19.0 | In-house | 64-121 (140) | Show / Hide |
Range on Protein: 171-228 Range on HMM: 64-121/140 Sequence Identity: 26% (15 aa) EEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARF .. . ....|. . ..| || | | |.. ||||.. ... . .| .| .|| klfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarp |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.Slingshot.PD | 187-220 | 41 | 2.5e-06 | 17.6 | In-house | 80-113 (139) | Show / Hide |
Range on Protein: 187-220 Range on HMM: 80-113/139 Sequence Identity: 41% (13 aa) RVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEAR ...||.|| || . .|| || .. | || skvlvhckmGvsrsastviayamkeyelsleeal |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.LRR-DSP.PD | 189-229 | 35 | 4.2e-06 | 16.9 | In-house | 80-120 (137) | Show / Hide |
Range on Protein: 189-229 Range on HMM: 80-120/137 Sequence Identity: 35% (14 aa) AVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFK ..||| | || ...|||||. . . || . .. | . vlihcragvsrsatlviaylmkknslkfkealdlvikkrpr |
|||||||||
| Phosphatase | TEP1.AA | Subfamily.CDC14.PD | 186-213 | 32 | 5.5e-06 | 16.4 | In-house | 198-225 (258) | Show / Hide |
Range on Protein: 186-213 Range on HMM: 198-225/258 Sequence Identity: 32% (9 aa) NRVAVLHCRMGKGRSGMITVAYLMKYLQ . ...||. | || |.. .||.|. . eGaiavhCkaGLGrtgtligcylikhyr |
|||||||||