Gene Nem1
Nem1
Species: S.cerevisiae
Alias: Nem1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of Nem1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | Nem1.AA | Subfamily.DULLARD.PD | 250-431 | 53 | 1.7e-76 | 244.8 | In-house | 1-172 (172) | Show / Hide |
Range on Protein: 250-431 Range on HMM: 1-172/172 Sequence Identity: 53% (97 aa) KKKKLVIDLDETLIHSASRSTTHSNSSQGHLVEVKFGLSGIR--TLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYR |.|.||.||||||||||..|.|.|....|. ...|. .. | .|....|||..||||..|||||||.||||||.|||..|.|.|.|......||||.. krktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsg-rgilkrryyr SDCVLRDGvGYIKDLSIVkdseengkgsSSSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDTDLLNLLPFLEAMRYSTDVR |.|..| .|.||||.| |..|..|||.|||||.|..|.||||....|||||.||.||||||||.|.|...||| qhCtlesg-kytkdlslv----------sedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdvr |
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| Phosphatase | Nem1.AA | NIF | 252-431 | 38 | 2.1e-68 | 238.33 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 252-431 Range on HMM: 1-189/189 Sequence Identity: 38% (79 aa) KKLVIDLDETLIHSA--SRSTTHSNSSQGHLVEVKFGLSGIRTLYFIHK-RPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSFPSS---F--SK | ||.||||||.|. .. . .|...|.... |... ....| ||||| || ..||.|...|.|||||||||||||.. | | .. KTLVLDLDETLVHCNPWWEPPN------WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPK---SKKYFDGHH RY---YRSDCV-LRDGVGY-I-KDLSIVKDSEENGKGSSS-SLDDVIIIDNSPVSYAMNVDNAIQVEG-WIS-----D-PTD--TDLLNLLPFL-EAMR- |. || .|. .|.|. | . |||||. . . .|..|||.|||| |. .. ||.|... |.. | | | . ||.||||| |... RLICWYREHCWLYRNGGNYYVKKDLSILW--------YNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLAL YS-TDVR . ||| QCLDDVR |
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| Phosphatase | Nem1.AA | CPDc | 250-412 | 32 | 7.7e-68 | 232.6 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 250-412 Range on HMM: 1-173/173 Sequence Identity: 32% (59 aa) KKKKLVIDLDETLIHS----------ASRSTTHSNSSQGHLVE----------VKFGLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPV |||.||.|||.||.|| ..... . ......... |... . ......|||... ||...||||....||..|..||||| KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDG--HPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPV IDWLESSFPSSFSKRYYRSDCVLRDGVGYIKD-LSIVKDSEENGKGSSSSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDT .|.|.. ...|.|| .||. .|. |.|| ||.|.. ..| .|||||.|| |.... .|||... |.... || LDMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNR---------CDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | Nem1.AA | Family.FCP.PD | 250-431 | 45 | 1.4e-53 | 170.4 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 250-431 Range on HMM: 1-164/164 Sequence Identity: 45% (82 aa) KKKKLVIDLDETLIHSasrstTHSNSSQGHLVEvKFGLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYRSD ||| ||.||||||.|| ....... ..| |. ...... ....|||..| ||.|||..|...|||||...|||||.|.|. . . |.||..| . kkklLVlDLdetLvhs-----elkpknkpdfvv-kveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpe-kklfkkrllrde CVLRDGvGYIKDLSIVkdseenGKgsssSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDTDLLNLLPFLEAMRYSTDVR ||| .| |.||||.. |. .|..|||||.|| ||..| ||||.|. . .||.||.||.||||||... ..||| cvlvkg-nyvkdLskl------gr----dlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedvr |
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| Phosphatase | Nem1.AA | Subfamily.SCP.PD | 251-430 | 40 | 9.5e-44 | 138.0 | In-house | 2-162 (163) | Show / Hide |
Range on Protein: 251-430 Range on HMM: 2-162/163 Sequence Identity: 40% (72 aa) KKKLVIDLDETLIHSASRSTTHSNssqgHLVEVKfgLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfpSSFSKRYYRSDC || ||.||||||.||. . .... .| |. . |. .. |||. | ||.||.. .....||||...|||||.| |. . . ...| .| | kkclvldldetlvhssfkpvenad----fvvpve--idgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkk--nvikarlfresc VLRDGvGYIKDLSIVkdseenGKgsssSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDTDLLNLLPFLEAMRYSTDV | .| |.|||| . |. |..|.|.|||| ||....|||. || | .|..||.||.|||.|| .. .|| vfhkg-nyvkdlsrl------Gr----dlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedv |
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| Phosphatase | Nem1.AA | Subfamily.HSPC129.PD | 252-431 | 39 | 1e-36 | 115.3 | In-house | 3-164 (164) | Show / Hide |
Range on Protein: 252-431 Range on HMM: 3-164/164 Sequence Identity: 39% (68 aa) KKLVIDLDETLIHSASRSTTHSNSSQghlvEVKFglSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYRSDCV ||.||||||.|. . ... |. .|.. . . ... ||. || .||| ...|.|||| | ||| ..|.|. .. .| .| || || fslvldldetlvhcslakledatlsf----kvey--qdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpe-kklvrhrlfrehcv LRDGvGYIKDLSIVkdseenGKgsssSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDTDLLNLLPFLEAMRYSTDVR |||||||. |. |. ||.|||| ..|....| | .| | .| .|..||.||||||.. ||| cvdg-nyikdlsil------Gr----dlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedvr |
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| Phosphatase | Nem1.AA | Group.HAD.PD | 251-428 | 28 | 2.3e-34 | 108.3 | In-house | 1-187 (190) | Show / Hide |
Range on Protein: 251-428
Range on HMM: 1-187/190
Sequence Identity: 28% (57 aa)
KKKLVIDLDETLIhsasrSTTHSNSSQGHLVEVKFGLSGIR----TLYFIHKR------------PYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLE
|. ||.|||..|. ..... .|... .|. . . . ....|| |..| ||..|...|.|..|||...||||||....
kdtlvlDldgvlw-----lhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavd
SSfPSSFSKRYYRSDCVLRDGvGYIK-------DLSIVKDSEengkgsSsslddVIIIDNSPVSYAM--NVDNAIQVEGWISDPTDTDLLNLLPFLEAM-
||.|..| .|| .| . . . .|.| | . |.||||.| ..|. | .||. .. .|.|. |. ||.|.|.||..
vg-deafsyrklrdacvylkg-pgalllatnrdlgalvrdle------k-----vviidnkpsvfafecnpenalmigdfiddildaellglipdlenid
-RYST
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vrfgk
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| Phosphatase | Nem1.AA | Subfamily.TIM50.PD | 294-427 | 27 | 2.1e-19 | 59.2 | In-house | 24-144 (150) | Show / Hide |
Range on Protein: 294-427 Range on HMM: 24-144/150 Sequence Identity: 27% (37 aa) YFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESsfPSSFSKRYYRSDCVLRDGVgYIKDLSIVKdseengkgssSSLDDVIIIDNSPVSYA . .||| | || .... .....||.. .| |.|| |. . . | .| . . || .|||| . .|. ||..| . |. wrfkkrPgvdafleelaelfeivvftseqgltaaplidkldP--kqlimyrlfrdatkyvdGe-hvkdlskln----------rdlskvivvdldkesvk MNVDNAIQVEGWISDPTDTDLLNLLPFLEAMRYS .. .||.... | .. |..||.||.||. . | lqpenalalkkwkGnaddrelldllaflktiats |
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| Phosphatase | Nem1.AA | Subfamily.FCP1.PD | 250-403 | 27 | 1.5e-18 | 56.7 | In-house | 1-141 (150) | Show / Hide |
Range on Protein: 250-403 Range on HMM: 1-141/150 Sequence Identity: 27% (43 aa) KKKKLVIDLDETLIHSASRSTTHSNSSQGHLVEvKFGLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYRSD .| ||.|||.||||.. .| ...... . .. || |. .. |....||.. ||.|.|| |.| |.| . ..||. . |. . . ||.| | rklvLvvDlDqtlihttkdptievkeeklkdik-kftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpe-kklFserilsrd CVLrDGVGYIKDLSIVKDSEEngkgsssslDDVIIIDNSPVSYaMNVDNAIQVE .| . .|.|... .... . |.|||. . .. .| |.|. ell-nassktkklkklfptgd---------smvviiDDredvW-nfaenlikvk |
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