Gene FCP1
FCP1
Species: S.cerevisiae
Alias: FCP1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of FCP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | FCP1.AA | CPDc | 173-349 | 30 | 4.3e-64 | 220.17 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 173-349 Range on HMM: 1-173/173 Sequence Identity: 30% (56 aa) KKLILVVDLDQTIIHCGVDPTIAEWKNDPNNPNFETLRDVKSFTLDEELVLPLMYMNDDGSMLRPPPVRKCWYYVKVRPGLKEFFAKVAPLFEMHIYTMA ||..||.|||.|..|. ..||...|. ...... .| ||. ..|... ... | . . .. . ...||| ||...|| ... ..|||..||. KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWF-HMC---M-I---VEIDG--HPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMG TRAYALQIAKIVDPTGELFGDRILSRDENGSLTTKS----LAKLFPT-DQSMVVVIDDRGDVWNWCP-NLIKVVPYNFFVGVG .| || ..... ||....|..|.|.||. .. |. . .|.. |.|||..|||. |.|.|.| |.|.. |...| . . MRMYADPVLDMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | FCP1.AA | Subfamily.FCP1.PD | 173-348 | 55 | 9.1e-65 | 206.5 | In-house | 1-149 (150) | Show / Hide |
Range on Protein: 173-348 Range on HMM: 1-149/150 Sequence Identity: 55% (99 aa) KKLILVVDLDQTIIHCGVDPTIaEWKNdpnnpnfETLRDVKSFTldeelvlplmymnddgsmLrppPVRKCWYYVKVRPGLKEFFAKVAPLFEMHIYTMA .||.||||||||.||...|||| |.|. |.|.|.|.|| | |..|..||||.||.||||..|...|.|.|||||. rklvLvvDlDqtlihttkdpti-evke-------eklkdikkft------------------l---peekevyyvklRpnlkeFleklsklyelhiytmg TRAYALQIAKIVDPTGELFGDRILSRDE--NGSLTTKSLAKLFPTDQSMVVVIDDRGDVWNWCPNLIKVVPYNFFVGV ||||| |||||.||...||..||||||| | | .||.|.|||||..||||.||||.||||...||||| ||.|| || traYaeqiakilDpekklFserilsrdellnassktkklkklfptgdsmvviiDDredvWnfaenlikvkpykfFkgv |
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| Phosphatase | FCP1.AA | Family.FCP.PD | 173-343 | 35 | 5.6e-44 | 138.9 | In-house | 1-139 (164) | Show / Hide |
Range on Protein: 173-343 Range on HMM: 1-139/164 Sequence Identity: 35% (62 aa) KKLILVVDLDQTIIHCgvdptiaEWKNDpNNPNFETlrdvkSFTLDEELvlplmymnddgsmlrpppvrkCWYYVKVRPGLKEFFAKVAPLFEMHIYTMA ||..||.|||.|..|. |.|.. |.|.|.. ....|| ...|||.||.|.||..||..|.|..|.|.. kkklLVlDLdetLvhs-------elkpk-nkpdfvv-----kveidele---------------------etvyvkkRPhldeFLekvselyeiviftas TRAYALQIAKIVDPTGELFGDRILsRDE----NGsLTTKSLAKLfPTDQSMVVVIDDRGDVWNWCP-NLIKVVPYN ||.|| ..|.|.||...|| .|.| ||| .| ..|.|.|| ..|.|.|..|||. |.....| |.||| ... trkyadpvadiLDpekklfkkrll-rdecvlvkg-nyvkdLskl-grdlskviiiDdspdsyklnpdnaikvksfk |
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| Phosphatase | FCP1.AA | NIF | 175-345 | 21 | 2.6e-26 | 97.44 | Pfam | 1-153 (189) | Show / Hide |
Range on Protein: 175-345 Range on HMM: 1-153/189 Sequence Identity: 21% (40 aa) LILVVDLDQTIIHCG--VDPTIAEWKNDPNNPNFETLRDVKSFTLDEELVLPLMYMNDDGSMLRPPPVRKCWYYVKV-RPGLKEFFAKVAPLFEMHIYTM ..|| ||| |..|| .|.. . |... . . ... .||.. ||...|| ... ..|..|.|. KTLVLDLDETLVHCNPWWEPPN-----------------WHDFIVPIPF-----------------NGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTA ATRAYALQIAKIVDPT-GELF-GDRIL---SRDENG------SLTT-KSLAKL-FPT-DQSMVVVIDDRGDVWNWCP-NLIKVVPYNFF ... || .. .. || . .| |...| .|.. . . | | .| |.| |. .|.. ..| ..| |.|.. || .. SMKEYADPVIDYIDPKSKKYFDGHHRLICWYREHCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPY-WY |
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| Phosphatase | FCP1.AA | Group.HAD.PD | 175-354 | 19 | 7.1e-21 | 64.1 | In-house | 2-169 (190) | Show / Hide |
Range on Protein: 175-354
Range on HMM: 2-169/190
Sequence Identity: 19% (37 aa)
LILVVDLDQTII-HCGVDPTIAEWKNDPNNPNFETlrdvksftldeelvlplmymnddgsmlrppPVRKCWYYVKVR------------PGLKEFFAKVA
||.|||.... |.. .| ........ .. . | .|.. | |.| || ..| .|
dtlvlDldgvlwlhgspepleglrskgkvlifltn------------------------------natksrlyllkrlallgflveevephldeflervg
PLFEMHIYTMATRAYALQIAKIVDPTgELFGDRILSRDENGSLTT---KSL-----AKLFPTDQSMVVVIDDRGDVWN---WCPNLIKVVPYnffvgVGD
.|....|..||.|| .....||. ... .. . ||. | ..| .. |...||.||.. .|.. . .| . . ..||..
elyelvvftagtreyadpvvgavdvg-deafsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdf-----idd
INSN
ilda
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| BRCT | FCP1.AA | BRCT | 499-580 | 27 | 3.3e-14 | 54.94 | Pfam | 1-84 (84) | Show / Hide |
Range on Protein: 499-580 Range on HMM: 1-84/84 Sequence Identity: 27% (24 aa) LKQKVFQNCYFVFSGLIPLGTDIQRSDI--VIWTSTFGATSTPDIDYLTTHLI--TKNP-STYKAR-LAKKFNPQIKIVHPDWIFECL |.|..| |.. .. .|..| .|.. |..... |||.| ...| | . ..|.... |.|||||||..|. H-EKPFKGCTFCI---TGGFDNMNRDEIHWQEMIEKHGGKVTDSVSKQTTHVIPWVGEPHCTRTKKFYWKAKEWNIPIVHPDWIWDCI |
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| Phosphatase | FCP1.AA | Subfamily.HSPC129.PD | 245-296 | 36 | 2.2e-10 | 29.5 | In-house | 39-90 (164) | Show / Hide |
Range on Protein: 245-296 Range on HMM: 39-90/164 Sequence Identity: 36% (18 aa) YYVKVRPGLKEFFAKVAPLFEMHIYTMATRAYALQIAKIVDPTGELFGDRIL ||..|| |.||. .|. |||. ..| ... || .. ...|| .|. |. vyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlf |
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| Phosphatase | FCP1.AA | Subfamily.TIM50.PD | 244-326 | 32 | 2.3e-08 | 23.2 | In-house | 23-105 (150) | Show / Hide |
Range on Protein: 244-326 Range on HMM: 23-105/150 Sequence Identity: 32% (27 aa) WYYVKVRPGLKEFFAKVAPLFEMHIYTMATRAYALQIAKIVDPTGELFGdRiLSRDE----NGSlTTKSLAKLfPTDQSMVVVIDDR . .| |||.. |. ..|.|||. ..| . ..| .. .|| . . | | || .|. .| | || | | |.|.| GwrfkkrPgvdafleelaelfeivvftseqgltaaplidkldPkqlimy-r-lfrdatkyvdGe-hvkdlskl-nrdlskvivvdld |
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| Phosphatase | FCP1.AA | Subfamily.SCP.PD | 246-296 | 34 | 2.7e-08 | 22.6 | In-house | 40-89 (163) | Show / Hide |
Range on Protein: 246-296 Range on HMM: 40-89/163 Sequence Identity: 34% (17 aa) YVKVRPGLKEFFAKVAPLFEMHIYTMATRAYALQIAKIVDPTGElFGDRIL ||. || ..||. ||. |||. ..| . || ..|...|... . |. yvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknv-ikarlf |
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| Phosphatase | FCP1.AA | Subfamily.DULLARD.PD | 242-329 | 22 | 3.4e-08 | 22.3 | In-house | 44-132 (172) | Show / Hide |
Range on Protein: 242-329 Range on HMM: 44-132/172 Sequence Identity: 22% (19 aa) KCWYYVKVRPGLKEFFAKVAPLFEMHIYTMATRAYALQIAKIVDPTGELFGDRILSRD--ENGSLTTKSLAKLfPTDQSMVVVIDDRGDV .. .|| || . .|. .|. ... |.| ... || ... .| . ... | . .. . ||.|. . | | |...|. pvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhCtlesgkytkdlslv-sedlssviilDnspva |
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| BRCT | FCP1.AA | BRCT | 501-583 | 22 | 1.1e-11 | 46.01 | SMART | 1-93 (93) | Show / Hide |
Range on Protein: 501-583 Range on HMM: 1-93/93 Sequence Identity: 22% (22 aa) QKVFQNCYFVFSGLIPLGTDIQRSDIVIWTSTFGATSTPDIDY-------LTTHLITKNPSTYKAR--------LAKKFNPQIKIVHPDWIFECLVNW |.|..| |...| .. .... . . .... . . . . |||.|. .|.. | ..|.. |.|||||||..|. .| MKPFKGCTFCITG-DDIEGNFD-M-RDELKEMIEMHGGKVT-SVSRKRCPDTTHVIC-SPENPKYETWNRMMTKYMKAIAWGIWIVHPDWIWDCIKKW |
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