Gene PSR1
PSR1
Species: S.cerevisiae
Alias: PSR1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PSR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PSR1.AA | CPDc | 256-399 | 42 | 2.7e-74 | 254.06 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 256-399 Range on HMM: 1-173/173 Sequence Identity: 42% (73 aa) GKKCLILDLDETLVHS--------------SFKYLRSADFVLS----------VEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLD .||.|.||||.||||| |||. ...||. ||||...| .|| |||.|.|||.|..|..|..|||.. .|.||.|| KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD ILD-TD-KVIHHRLFREACYNYEGN-YIKN-LSQIGR-PLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDN .|| . ..|..||.|..| ...|. |.|. || ..| .||..||.|.||.|. .||..||||..||.. ||. MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | PSR1.AA | Subfamily.SCP.PD | 257-415 | 62 | 1.2e-85 | 274.1 | In-house | 2-160 (163) | Show / Hide |
Range on Protein: 257-415 Range on HMM: 2-160/163 Sequence Identity: 62% (100 aa) KKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHHRLFREACYNYEGNYI ||||.|||||||||||||....||||..||||..||.|||.||| |.|||..||.|||||.||||...|.||..|.||. .||..|||||.|....|||. kkclvldldetlvhssfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknvikarlfrescvfhkgnyv KNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLSVKT |.||..|| |....|.|||||||||||..|.|..|||.|..|.||||..||||.|| .. kdlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskve |
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| Phosphatase | PSR1.AA | NIF | 258-420 | 39 | 6.4e-75 | 260.0 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 258-420 Range on HMM: 1-189/189 Sequence Identity: 39% (76 aa) KCLILDLDETLVHSS--FKYLRSADFVLSVEIDDQVHNVYVIK-RPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDT--DKVI--HHRL---FREA |.|.|||||||||.. ... ||.. . ...| |..||.| ||...|||... |..|.|..||| ..| ||..|..|. |.. |||| .||. KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYREH CY-NYEG-NY-I-KNLSQI--GR-PLSDIIILDNSPASYIFHPQHAIPISS-WFS-----D-THD--NELLDIIPLL-EDLSVKTS-LDVG | ..| || . |.|| . .| .||..||.|||| |. ..|...|||.. |.. | .| |||||..|.| | |. ... || CWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLA-LQCLDDVR |
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| Phosphatase | PSR1.AA | Family.FCP.PD | 257-412 | 52 | 5.9e-60 | 190.9 | In-house | 2-158 (164) | Show / Hide |
Range on Protein: 257-412 Range on HMM: 2-158/164 Sequence Identity: 52% (82 aa) KKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDT-DKVIHHRLFREACYNYEGNY ||.|.||||||||||..| ...|||..||||.. ..||| |||...||||.|..|.|.|.|||| ..| ||..||||. |....||.|..| ..|||. kklLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkgny IKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLS |.||..|| ||..||.|.||.|| ..|. ||...|...|..|.||||..|.||.|. vkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpflesla |
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| Phosphatase | PSR1.AA | Subfamily.HSPC129.PD | 257-414 | 52 | 3.5e-55 | 175.2 | In-house | 2-160 (164) | Show / Hide |
Range on Protein: 257-414 Range on HMM: 2-160/164 Sequence Identity: 52% (84 aa) KKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTD-KVIHHRLFREACYNYEGNY . .|.|||||||||.|.. | .| ... || .|....||| || ..|||||| |||||..|||| | | |||.|| . | ..|||||| | .||| efslvldldetlvhcslakledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgny IKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLSVK ||.|| .||.|| ||.|||| .. . . |||.|||.|..|.|||...|.||.| | ikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaek |
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| Phosphatase | PSR1.AA | Subfamily.DULLARD.PD | 257-412 | 42 | 3.7e-51 | 162.1 | In-house | 2-166 (172) | Show / Hide |
Range on Protein: 257-412 Range on HMM: 2-166/172 Sequence Identity: 42% (69 aa) KKCLILDLDETLVHS--------SFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDT-DKVIHHRLFREA .| |.|||||||.|| . | . ||.|.| |... ..||.||| |..||..| | ...|.||||. |.....| ||......|..|. | rktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqh CYNYEGNYIKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLS .|.|.|.|| . ||..||||||| .| .|. ||||.||.||..|..||...|.|. | CtlesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalr |
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| Phosphatase | PSR1.AA | Group.HAD.PD | 257-420 | 34 | 7.8e-44 | 139.0 | In-house | 1-190 (190) | Show / Hide |
Range on Protein: 257-420 Range on HMM: 1-190/190 Sequence Identity: 34% (64 aa) KKCLILDLDETLV-HSSFKYLRSADFVLSVEIDDQV----HNVYVIKR------------PGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDT-DKV |..|.||||..|. |.|...|..... .|.|.... ...|..|| |...|||||||.|.|.|||||. .| ||.....||.... kdtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdea IHHRLFREACYNYEGNYIK------NLSQIGRPLSDIIILDNSPASYIF--HPQHAIPISSWFSDTHDNELLDIIPLLEDLSVKTSLDVG .|..|.|| . |.. . .|. ..| |. ..|.||.|....| .|. |..| ....| .| |||. || || ..|.. ||| fsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrfgkdvg |
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| Phosphatase | PSR1.AA | Subfamily.TIM50.PD | 260-419 | 34 | 4.1e-32 | 100.3 | In-house | 5-149 (150) | Show / Hide |
Range on Protein: 260-419 Range on HMM: 5-149/150 Sequence Identity: 34% (54 aa) LILDLDETLVHSSFKYlrsadfvlsveiddqVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHHRLFREACYNYEGNYIKNL |.|.|...|||. ..| . . |||||. |||....|||.||||.. . ||.| || ...|..||||.|..|. .|.||.. lvlelkdvlvhpewty---------------ktGwrfkkrPgvdafleelaelfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdl SQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLSVKTSLDV | || .|..| ..|. ..|. |. .. | ...|.||||....|. .. .. || sklnrdlskvivvdldkesvklqpenalalkkwkGnaddrelldllaflktiatsevedv |
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| Phosphatase | PSR1.AA | Subfamily.FCP1.PD | 257-376 | 27 | 1.5e-15 | 46.8 | In-house | 2-128 (150) | Show / Hide |
Range on Protein: 257-376 Range on HMM: 2-128/150 Sequence Identity: 27% (34 aa) KKCLILDLDETLVHSSFK-----YLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHH-R-LFREACY | .|..|||.||.|.. . . .. . . .. . .. || .||...||||.. ||.|. ..| . | . . ||| .| . . || |. . | klvLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdell NYEgNYIKNLSQI-GRPLSDIIILDNSP . . .|.|... . | ..|.|. nas-sktkklkklfptgdsmvviiDDre |
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